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All Journal Jurnal Kesehatan Andalas Jurnal Kesehatan Komunitas Jurnal Respirologi Indonesia Unri Conference Series: Community Engagement Respiratory Science
Yessy Susanty Sabri
Departemen Pulmonologi Dan Kedokteran Respirasi Fakultas Kedokteran Universitas Andalas
Humanities Health Professions Medicine & Pharmacology Public Health

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Journal : Respiratory Science

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The Relationship Between Smoking Status and Smoking Index Against COVID-19 Disease Course in Treated Patients at Dr. M Djamil General Hospital, Padang Yulia Helexandra; Yessy Susanty Sabri; Fenty Anggrainy
Respiratory Science Vol. 3 No. 1 (2022): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v3i1.58

Abstract

Background: Smoking is a risk factor for the development and worsening of respiratory diseases, including COVID-19 infection. Smoking can increase the risk of the severity of COVID-19 by two times because in smokers there is an increase in the expression of the ACE-2 gene by 25% compared to non-smokers. The purpose of this study was to determine the relationship between smoking status and smoking index on the course of COVID-19 disease treated at Dr. M Djamil General Hospital. Method: An observational analytic study with a retrospective cohort approach on COVID-19 patients who were treated at Dr. M. Djamil General Hospital. Data were taken from January to March 2021. The relationship between smoking status and smoking index on the course of COVID-19 was analyzed by Chi-Square. Results: This study found the most age was above 50 years with a vulnerable age of 50-59 years (28.4%) and female gender (56.7%). Non-smoker status (64.2%) and moderate smoking index (51.4%) were the most commonly found in this study. Clinically non-progressive COVID-19 (53.7%) was the most common. This study found that the maximum length of stay for COVID-19 patients was less than 21 days (53.7%) and the outcome of patients recovered (62.2%). This study found a significant relationship between the smoking index on the clinical progress of COVID-19 patients and there was a significant relationship between smoking status and the outcome of COVID-19 patients. This study found that smoking status and the smoking index had no significant relationship with the length of stay of COVID-19 patients. Conclusion: Smoking status is related to outcomes in COVID-19 patients and the smoking index is related to a progression in COVID-19 patients treated at Dr. M. Djamil General Hospital.
Association Between Comorbidities and Outcome of COVID-19 Patients at dr. M. Djamil General Hospital Padang Nova Indriyani; Yessy Susanty Sabri; Afriani Afriani
Respiratory Science Vol. 3 No. 1 (2022): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v3i1.59

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Background: COVID-19 has spread rapidly throughout the world with high morbidity and mortality estimated up to 20%. This number will increase with the presence of comorbidities. Comorbidities were associated with complex clinical management and impacted on COVID-19 disease outcomes. This study aims to determine the association between comorbidities and the outcome of COVID-19 patients at Dr. M. Djamil Hospital. Method: We conducted an observational study with a retrospective cohort design on COVID-19 patients treated at Dr. M. Djamil Hospital. Data were taken from medical records from January to March 2021. Association between comorbidities and the outcome of COVID-19 patients was analyzed by Chi-Square or Fisher Exact Test. Results: The majority patientss were female (56.4%) and ages above 50 years old (64.3%) were the majority of patients. The most common was hypertension (36.56%). The longest length of stay of COVID-19 patients was more than 21 days (52.9%).  The outcomes of COVID-19 patients were recovered (59.5%), recovered with sequelae (5.7%), and died (34.8%). Diabetes mellitus affected the end of treatment outcome. There was no relationship of type of comorbidity with length of stay. The more co-morbidities a patient suffers, the condition when infected with COVID-19 will get worse. Conclusion: The number of comorbidities affects the outcome of COVID-19 patients. Diabetes mellitus is most common that affects the end of treatment outcome for COVID-19 patients at Dr. M. Djamil Hospital.
Differences in IL-6 Levels Based on Clinical Severity and Outcome of COVID-19 Patients at Dr. M. Djamil Hospital Chicy Widya Morfi; Yessy Susanty Sabri; Dessy Mizarti
Respiratory Science Vol. 4 No. 1 (2023): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v4i1.94

Abstract

ground: A cytokine storm is defined by elevated levels of proinflammatory cytokines such as interleukin-6 (IL-6). In COVID-19 infection, IL-6 is superior to C-reactive protein (CRP) and other inflammatory markers in predicting respiratory failure. The IL-6 is the main cytokine triggered by T cells when a cytokine storm occurs. IL-6 is the most important driver of immune dysregulation and ARDS in COVID-19 infection. The purpose of this study is to assess differences of IL-6 levels based on clinical severity and outcomes in COVID-19 patients at Dr. M. Djamil Hospital. Method: The study took place at Dr. M. Djamil Hospital from November 2021 to November 2022. This is a retrospective cohort study in which patients were tested for IL-6 levels between January 1st, 2021 and December 31, 2021. The distribution of the frequency and proportion of each variable is included in univariate analysis; bivariate analysis determines the correlation between the independent variables (clinical severity, length of stay, and final status of hospitalization) and the dependent variable (IL-6 levels in COVID-19 patients). Results: Patients' characteristics in this study, the majority of patients aged 18-49 years. Women and patients with moderate disease were more common. The majority of patients were treated for less than 14 days, and the final status of hospitalization the patients showed that most of the patients recovered. IL-6 levels with median (min-max) was 32.00 (1.50-589.00). The IL-6 levels were higher in clinically critical COVID-19 patients (77.20 mg/L), in patients with a shorter length of stay (14 days) (36.00 mg/L), and at final status of hospitalization were death (58.90 mg/L). Conclusion: There were differences of IL-6 level based on clinical severity and final hospitalization status of COVID-19 patients, but not from the length of stay in COVID-19 patients at Dr. M. Djamil Hospital.
Co-Authors Afriani Afriani Afriani Afriani Afriani Afriani Chicy Widya Morfi Defi Eka Kartika Dessy Mirzati Dessy Mizarti Dewi Wahyu Fitrina Dewi Wahyu Fitrina Dimas Bayu Firdaus Dimas Bayu Firdaus Elsa Purnama Sari Ermayanti, Sabrina Fenty Anggraini Fenty Anggrainy Herman, Deddy Ilham Ilham Irvan Madison Irvan Medison Kornelis Aribowo Kornelis Aribowo Lusi Agustini Arda M. Hari Nandi Pinto Masrul Basyar Masrul Basyar Mega Senja Nova Indriyani Nova Indriyani Oea Khairsyaf Reni Prima Gusty Russilawati, Russilawati Yulia Helexandra