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Aulanni'am Aulanni'am
Department Chemistry, University of Brawijaya
Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology Medicine & Pharmacology

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Effect Of Methyl Mercury towards Number of Microglia Cells and Expression of iNOS On The Brain in Rats (Rattus norvegicus) Yuli Kusuma Dewi; Aulanni'am Aulanni'am; Chanif Mahdi
The Journal of Pure and Applied Chemistry Research Vol 3, No 1 (2014)
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1095.103 KB) | DOI: 10.21776/ub.jpacr.2014.003.01.149

Abstract

Methyl mercury (MeHg) has the highest toxicity among the derivative of the organic mercury compounds. Rate of accumulation of MeHg in the body is very high because it is soluble in lipids. The ability of methyl mercury binds to proteins in the body causing MeHg to penetrate the blood-brain barrier easily, so that it can quickly disrupt the central nervous system and speed up nerve cell damage. This paper reported the effect of methyl mercury on the number of microglia cells and expression of iNOS in the brains of Rattus norvegicus. In this study, rats were divided into two groups: a control group with no exposure of MeHg and groups of rats exposed with MeHg at a dose of 0.6 mg/kg BW/day given orally for 21 days. Number of microglia cells is investigated using silver nitrate staining method and iNOS expression is determined by immunohistochemistry methods. The results showed that exposure with MeHg in a dose of 0.6 mg/kgBW can increase the number of microglia cells and iNOS expression respectively as mush as 151.63% and 918.08% . Keyword: Methyl mercury, microglia, brain, iNOS, immunohistochemistry
Methanol Extracts Potential of Mas Ngur Shells (Atactodea striata) against Protease Profile and Description of Histopathology of Jejunum Rats Exposed by Indomethacin Vivi Shofia; Celcius Waranmasalembun; Sasangka Prasetyawan; Aulanni'am Aulanni'am
The Journal of Pure and Applied Chemistry Research Vol 4, No 2 (2015)
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (865.907 KB) | DOI: 10.21776/ub.jpacr.2015.004.02.218

Abstract

Inflammatory Bowel Disease (IBD) is a multi-factorial disorder caused by genetic factors, environmental and immune response. One of the causes of IBD is a side effect of non-steroidal of anti-inflammatory drugs (NSAIDs). Indomethacin is an NSAID that activates macrophages and triggers increasing of protease activity. Mas Ngur shells (Atactodea striata) contains an antioxidant that inhibits the protease activity. This research used rats (Rattus norvegicus) induced by Indomethacin and treated with methanol extract of Mas Ngur shells (A. striata) at doses of 100 and 400 mg/kg of body weight (BW). Therapy potency of the Mas Ngur shells methanol extracts were identified by measuring protease activity and observed the Jejenum histopathology. Statistical analysis showed that the Mas Ngur shells therapy showed significant differences (p <0.05) by decreasing of protease activity and improve jejunum histopathology of IBD induced rats
Co-Authors Celcius Waranmasalembun Chanif Mahdi Sasangka Prasetyawan Vivi Shofia Yuli Kusuma Dewi