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All Journal Jurnal Ilmu Kimia Universitas Brawijaya The Journal of Pure and Applied Chemistry Research Jurnal Farmasi Indonesia Jurnal Kajian Ilmiah Kesehatan Dan Teknologi (JKIKT) Abdimas Toddopuli: Jurnal Pengabdian Pada Masyarakat Journal of Pharmacy Science and Technology Indonesian Journal of Science and Pharmacy Jurnal Dedikasi Masyarakat JI-KES (Jurnal Ilmu Kesehatan)

Vivi Shofia

Unknown Affiliation

Author-ID : 378911

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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STUDI PEMBERIAN EKSTRAK RUMPUT LAUT COKLAT (Sargassum prismaticum) TERHADAP KADAR MALONDIALDEHID DAN GAMBARAN HISTOLOGI JARINGAN GINJAL PADA TIKUS (Rattus norvegicus) DIABETES MELITUS TIPE 1 Shofia, Vivi; Aulanni'am, aulanni'am; Mahdi, Chanif
Jurnal Ilmu Kimia Universitas Brawijaya Vol 1, No 1 (2013)
Publisher : Jurusan Kimia, FMIPA Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (609.589 KB)

Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak rumput laut coklat (Sargassum prismaticum) terhadap kadar malondialdehid dan gambaran histologi jaringan ginjal tikus diabetes hasil induksi multiple low dose-streptozotocin (MLD-STZ) dengan dosis 20 mg/kgBB. Pada penelitian ini tikus putih dikelompokkan menjadi 6 kelompok yaitu kelompok kontrol tanpa terpapar MLD-STZ, kelompok diabetes melitus yang dipapar MLD-STZ, kelompok diabetes melitus yang dipapar MLD-STZ yang mendapat terapi ekstrak rumput laut coklat (Sargassum perismaticum) yang diberikan secara oral dengan variasi hari pemberian yaitu satu, tiga, lima dan tujuh hari. Pada penelitian ini dilakukan pengukuran kadar malondialdehid dengan menggunakan metode TBA (Thiobarbituric Acid) dengan pengukuran menggunakan spektrofotometri UV-Vis pada panjang gelombang 530 nm, dan gambaran histologi menggunakan metode pewarnaan Hematoksilin-Eosin. Hasil penelitian ini didapatkan kadar Malondialdehid berturut-turut berdasarkan pengelompokan perlakuan adalah 0,527; 0,93; 0,893; 0,803; 0,77 dan 0,676 µg/ml. Pemberian ekstrak rumput laut coklat dapat menurunkan profil malondialdehid pada ginjal tikus terapi dengan variasi hari 1, 3, 5 dan 7 berturut-turut adalah 3,98; 13,65; 17,2 dan 27,31%. Serta dapat memperbaiki histologi jaringan ginjal tikus diabetes melitus yang telah yang dipapar MLD-STZ yang mendapat terapi ekstrak rumput laut coklat (Sargassum prismaticum) . Kata Kunci: diabetes melitus, ginjal, histologi, malondialdehid

AKTIVITAS FRAKSI NONPOLAR DARI EKSTRAK ETANOL AKAR DADANGKAK (Hydrolea spinosa L) TERHADAP PENURUNAN KADAR GLUKOSA DARAH TIKUS JANTAN YANG DIINDUKSI ALOKSAN Muhammad Zaini; Jhudi Bonosari Soediono; Vivi Shofia; Amalia Ajrina
Jurnal Kajian Ilmiah Kesehatan dan Teknologi Vol 1 No 2 (2019)
Publisher : Politeknik Unggulan Kalimantan

Akar Dadangkak (Hydrolea spinosa L) secara empiris digunakan oleh masyarakat Kalimantan Selatan sebagai obat antidiabetes. Penelitian ini bertujuan untuk mengetahui efek antidiabetes fraksi nonpolar dari ekstrak etanol akar dadangkak. Penelitian dimulai dengan ekstraksi akar dadangkak (250 gram) secara maserasi dengan etanol, diperoleh ekstrak etanol (16,62 g). Ekstrak etanol difraksinasi dengan n-Heksan dan Petroleum Eter. Uji antidiabetes menggunakan tikus wistar jantan 20 ekor yang dibagi menjadi 4 kelompok Perlakuan. Kelompok I diberi akuades 2 mL/200 g BB ; kelompok II diberi Glibenklamid 0,45 mg/kgBB ; Kelompok III diberi fraksi n-heksan 100 mg/kg BB dan kelompok IV diberi fraksi Petroleum eter 100 mg/kg BB. Sebelum diberi perlakuan, tikus diinduksi Aloksan dengan dosis 150 mg/kg BB secara intraperitoneal. Hari ke-4 setelah induksi, tikus diberi perlakuan kontrol dan fraksi-fraksi selama 7 hari secara peroral. Pengukuran kadar glukosa darah dilakukan pada hari ke-1, 4 dan 12 menggunakan Gluco-DR. Kadar glukosa darah diuji dengan SPSS taraf kepercayaan 95 %. Hasil Penelitian menunjukkan rata-rata penurunan glukosa darah oleh fraksi n-heksan adalah 189,8 ± 13,59 mg/dL dan fraksi petroleum eter adalah 437,6 ± 8,98 mg/dL. Fraksi n-heksan mampu menurunkan kadar glukosa darah tikus secara signifikan (sig<0.05) dibandingkan terhadap kelompok kontrol. Sedangkan pemberian fraksi Petroleum eter tidak menujukkan penurunan glukosa darah yang signifikan (sig>0.05).

SKRINING FITOKIMIA EKSTRAK CARICA PAPAYA RADIX, PIPER ORNATUM FOLIUM DAN NEPHELIUM LAPPACEUM SEMEN ASAL KALIMANTAN SELATAN Muhammad Zaini; Vivi Shofia
Jurnal Kajian Ilmiah Kesehatan dan Teknologi Vol 2 No 1 (2020)
Publisher : Politeknik Unggulan Kalimantan

Penyakit Diabetes Mellitus merupakan penyakit dengan prevalensi tinggi dan menduduki peringkat 10 besar di dunia termasuk di Indonesia. Permasalahan besar yang dihadapi dunia kesehatan dewasa ini adalah Diabetes Mellitus tidak bisa disembuhkan secara total dengan obat antihiperglikemik konvensional. Penelitian perlu dilakukan dalam hal menelusuri potensi bahan alam yang biasa digunakan oleh masyarakat Kalimantan berdasarkan skrining fitokimia dari beberapa tumbuhan yang secara empiris digunakan sebagai antidiabetes yaitu Carica papaya radix (CPR), Nephelium lappaceum semen (NLS) dan Piper ornatum folium (POF). Tumbuhan obat yang diperoleh dilakukan ekstraksi maserasi dan diidentifikasi golongan senyawa dan profil kromatografinya.Kegiatan penelitian ini meliputi: 1) Pengambilan sampel tumbuhan,2) Pembuatan simplisia uji, 3) Pembuatan ekstrak etanol tumbuhan, 4) Uji kualitatif kandungan kimia tumbuhan, dan 5) Identifikasi secara kromatografi lapis tipis. Hasil dari penelitian dipilih dan dilakukan pengujian terhadap 3 ekstrak yaitu Carica papaya radix, Nephelium lappaceum semen dan Piper ornatum folium. Ekstrak Carica papaya radix diduga mengandung senyawa alkaloid (Rf : 0,53), saponin (Rf : 0,93), flavonoid (Rf : 0,38 ; 0,75) dan tanin (Rf : 0,52 ; 0,88). Ekstrak Piper ornatum folium diduga mengandung senyawa saponin (Rf : 0,89), steroid (Rf :0,20 ; 0,42) dan tanin (Rf : 0,52 ; 0,71 ; 0,85). Ekstrak Nephelium lappaceum semen menunjukkan hasil positif terhadap keberadaan senyawa alkaloid (Rf : 0,65 ; 0,82), flavonoid (Rf : 0,83) dan tanin (Rf : 0,79 ; 0,92).

Methanol Extracts Potential of Mas Ngur Shells (Atactodea striata) against Protease Profile and Description of Histopathology of Jejunum Rats Exposed by Indomethacin Vivi Shofia; Celcius Waranmasalembun; Sasangka Prasetyawan; Aulanni'am Aulanni'am
The Journal of Pure and Applied Chemistry Research Vol 4, No 2 (2015)
Publisher : Chemistry Department, The University of Brawijaya

Inflammatory Bowel Disease (IBD) is a multi-factorial disorder caused by genetic factors, environmental and immune response. One of the causes of IBD is a side effect of non-steroidal of anti-inflammatory drugs (NSAIDs). Indomethacin is an NSAID that activates macrophages and triggers increasing of protease activity. Mas Ngur shells (Atactodea striata) contains an antioxidant that inhibits the protease activity. This research used rats (Rattus norvegicus) induced by Indomethacin and treated with methanol extract of Mas Ngur shells (A. striata) at doses of 100 and 400 mg/kg of body weight (BW). Therapy potency of the Mas Ngur shells methanol extracts were identified by measuring protease activity and observed the Jejenum histopathology. Statistical analysis showed that the Mas Ngur shells therapy showed significant differences (p <0.05) by decreasing of protease activity and improve jejunum histopathology of IBD induced rats

Aktivitas Fraksi Nonpolar dari Ekstrak Etanol Akar Dadangkak (Hydrolea spinosa L.) terhadap Penurunan Kadar Glukosa Darah Tikus Jantan yang Diinduksi Aloksan Muhammad Zaini; Vivi Shofia; Amalia Ajrina
Jurnal Farmasi Indonesia Vol 15 No 1 (2018): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

The roots of Dadangkak (Hydrolea spinosa L.) empirically have been used by Kalimantan people to cure diabetes. The purpose of this research is to examine the effect of fractions ratio from ethanol extract. The research started from extraction of the roots of Dadangkak (250 grams) by materation using ethanol. From that extraction yielded 16.62 grams of ethanol extract. Ethanol extract had been fractionated with n-hexane and petroleum ether. The antidiabetic assay using 20 Wistar mice that had been divided into 4 groups : Aquadest 2 ml/200 grams of weight is given to the first group, Glibencalmide 0.45 mg/kg BW is given to the second group, n-hexane fraction 100 mg/kg BW is given to the third group and petroleum eter 100 mg/kg BW is given to the forth group. Before all of groups had been given treatments, the mice had been induced by Aloxan 150 mg/kg BW intraperitoneally. The forth day after being induced, mice also given control and fractions treatments for 7 days perorally. The measurement of blood glucose level had been done at the first, forth, and twelfth day after being induced using Gluco-DR. The blood glucose level had been tested by SPSS with 95% confidence level. The result of this research showed the average of blood glucose level by the n-hexane fraction is 189,8 ± 13,59 mg/dL and petroleum ether is 437,6 ± 8,98 mg/dL. n-hexane fraction could decrease the blood glucose level of mice significantly (sig<0.05) compared to the control group. On the other side, the giving of petroleum ether fraction is not showing the decrease of blood glucose level significantly (sig>0.05).

Antioxidant Activity Evaluation of Carrot (Daucus carota L.) Extract-Enriched Lip Balm: A Natural Approach for Lip Protection Hilmia Lukman; Vivi Shofia; Salsabila, Shinta Nova; Maysaroh, Titis
Indonesian Journal of Science and Pharmacy Vol. 2 No. 2 (2024): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v2i2.79

Lips are a part of the body that is vulnerable to free radicals and UV radiation, thus requiring special protection. One effort to protect the lips is through the use of lip balm containing antioxidants. However, synthetic antioxidants in cosmetics can pose health risks, necessitating natural alternatives. This study aims to develop and evaluate lip balm based on carrot extract (Daucus carota L.) as a source of natural antioxidants. The methods used include carrot extraction using the reflux method with 96% ethanol, lip balm formulation with varying concentrations of extract (10%, 15%, and 20%), and antioxidant activity testing using the DPPH method with UV-Vis spectrophotometry. The results showed that lip balm containing carrot extract exhibited good physical characteristics, including homogeneity, color variation depending on the extract concentration, and pH within the suitable range for lip cosmetics (4.5–6.5). Antioxidant testing revealed that the higher the concentration of carrot extract, the greater the antioxidant activity, as indicated by IC50 values of 5.9214 ppm (F1), 3.5381 ppm (F2), and 1.9427 ppm (F3), which are classified as very strong antioxidants. The conclusion of this study is that carrot extract has potential as a source of natural antioxidants in lip balm, with effectiveness increasing with higher extract concentrations. This product can serve as a safe and beneficial natural cosmetic alternative for protecting lips from free radical damage.

Edukasi pengelolaan Dismenore pada remaja putri di Pondok Pesantren Rofiatul Islam Narsih, Umi; Shofia, Vivi; Sulistyorini, Endah; Damayanti, Eva Alfina
Jurnal Dedikasi Masyarakat Vol. 8 No. 1 (2024): Jurnal Dedikasi Masyarakat
Publisher : P3HKI - Universitas Muhammadiyah Parepare

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31850/jdm.v8i1.3550

Adolescence is a transitional period characterized by physical, psychological, and biological changes, including menstruation, which may be accompanied by dysmenorrhea, a condition that causes abdominal pain and can affect daily activities. Knowledge about dysmenorrhea management among adolescent girls is often inadequate, especially in Islamic boarding schools. due to limited access to quality healthcare services, such as medical examinations, appropriate treatment, and timely care. This community service program aimed to enhance adolescent girls' knowledge of dysmenorrhea management and improve their quality of life by reducing the impact of menstrual pain. The program was conducted at Rofiatul Islam Islamic Boarding School in Sentong Village, Krejengan District. Activities included pre-test and post-test questionnaires, distribution of educational leaflets, and counseling sessions focusing on the causes of dysmenorrhea, risk factors, and management techniques. Data analysis was performed by comparing pre-test and post-test results to evaluate the improvement in participants' knowledge. A total of thirty participants took part in this program. The pre-test results showed that 73% of participants had good knowledge, while 27% had moderate knowledge. After the education and counseling sessions, the post-test results indicated an improvement, with 93% of participants demonstrating good knowledge and 7% showing moderate knowledge, signifying a significant increase in understanding. This program successfully enhanced participants' comprehension of dysmenorrhea and its management. Further education on this topic is recommended to increase awareness and encourage its practical application in daily life.

Analysis of Antioxidant Activity of Curcumin Extract from White Turmeric (Curcuma zedoria) and Yellow Turmeric (Curcuma longa) Using Soxhletation Method Vivi Shofia; Anggraeni, Adek Bela; Nurlaila, Hamida
Indonesian Journal of Science and Pharmacy Vol. 1 No. 3 (2024): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v1i3.49

Turmeric has been a staple in traditional medicine and cuisine in various countries. Tumeric contains the main bioactive compound, namely curcumin. Curcumin is recognized as antioxidants that can which donate one or more electrons to free radicals, effectively neutralizing them. The commonly used turmeric varieties are white turmeric (Curcuma zedoaria) and yellow turmeric (Curcuma longa). White turmeric is characterized by its white rhizome, while yellow turmeric has a yellow rhizome. Both varieties contain curcumin, but their antioxidant activities must be fully elucidated. The Soxhlet method is a common technique employed for curcumin extraction. This study investigated the antioxidant activity of white turmeric and yellow turmeric compared to vitamin C. The DPPH method was used to assess antioxidant activity. The findings revealed that white turmeric (Curcuma zedoaria) and yellow turmeric (Curcuma longa) extracts exhibited antioxidant activity with IC50 values of 12.39 µg/mL and 44.065 µg/mL, respectively. Conversely, vitamin C showed an IC50 value of 19.95 µg/mL. These results indicate that yellow turmeric curcumin extract possesses superior antioxidant activity compared to white turmeric and vitamin C, falling within the category of solid antioxidants with IC50 values below 50 µg/mL.

Perbandingan Kandungan Kurkumin Kunyit Kuning (Curcuma Longa) dan Kunyit Putih (Curcuma Zedoaria) Hasil Ekstraksi Soxhlet dengan Metode Spektrofotometri Visible Shofia, Vivi; Lukman, Hilmia
Jurnal Kajian Ilmiah Kesehatan dan Teknologi Vol 7 No 1 (2025)
Publisher : Politeknik Unggulan Kalimantan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52674/jkikt.v7i1.220

Tanaman kunyit merupakan tanaman herba perenial dan mempunyai rimpang yang masuk ke dalam famili jahe (Zingiberaceae). Kunyit dikenal sebagai curcuma longa. Namun, penelitian baru-baru ini menemukan cara kerja kunyit dan komponen bioaktifnya. Polifenol utama yang ditemukan secara alami dalam rimpang tanaman Curcuma longa, juga dikenal sebagai kunyit, adalah kurkumin (1,7-bis(4-hidroksi-3-metoksifenil)-1,6-heptadiena-3,5-dion), yang juga dikenal sebagai diferuloilmetana. Di negara-negara Asia, curcuma longa secara tradisional digunakan sebagai obat herbal karena sifat antioksidan, antiinflamasi, antimutagenik, antimikroba, dan antikankernya. Kunyit, yang merupakan sumber kurkumin, adalah tanaman herba berumbi tahunan dari keluarga jahe, yang dikenal sebagai curcuma longa. Umumnya, kunyit yang dikenal masyarakat berwarna kuning. Namun, terdapat pula jenis kunyit putih yang kurang dikenal dan dimanfaatkan. Tujuan penelitian ini untuk membandingkan kandungan kurkumin antara kunyit kuning (Curcuma longa) dan kunyit putih (Curcuma zedoaria) yang diekstraksi menggunakan metode Soxhlet dan dianalisis menggunakan spektrofotometri visible. Pada penelitian ini menggunakan kunyit kuning (Curcuma longa) dan kunyit putih (Curcuma zedoaria) dari probolinggo dan dilakukan pengukuran dan potensinya sebagai sumber kurkumin alternatif. Pada penelitian ini didapatkan kadar kurkumin pada kunyit kuning sebesar 74104,4±4745,97 mg/mL dan kunyit putih 265,37±21,25 mg/mL. Penelitian ini memberikan informasi untuk pemilihan bahan baku yang efektif dalam pengembangan obat herbal, perlu dilakukan penelitian lebih lanjut terhadap senyawa bioaktif kunyit putih.

REVIEW ARTIKEL : ANALISIS KANDUNGAN ASAM ASKORBAT PADA BEBERAPA TANAMAN Lukman, Hilmia; Shofia, Vivi
JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY Volume 4 No. 1: Desember 2023
Publisher : Prodi Farmasi Fakultas Kedokteran Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/pst.v4i2.88

Ascorbic acid or vitamin C is an essential organic compound for the body and has many health benefits. Vitamin C cannot be produced by the body, so it must be obtained from outside the body through food consumption. The vitamin C in plants varies considerably depending on the type, the part of the plant, and the growing environment. Vitamin C analysis can be carried out using qualitative and quantitative methods. This article review aims to review qualitative and the quantitative analysis of vitamin C using plant samples. The plants used in the study are plants that are widely consumed in Indonesia, namely matoa fruit (Pometia pinnata), water spinach (Ipomoea reptana Poir), spinach (Amaranthus spinosus), cucumber (Cucumis sativus L.), enau fruit (Arenga pinnata Merr.) and katuk leaves (Sauropus Androgynus). The qualitative analysis of vitamin C used FeCl3, KMnO4, Methylene blue and AgNO3 reagents, while the qualitative analysis uses the UV-Vis spectrophotometry method and several titration methods.

Co-Authors Amalia Ajrina Amalia Ajrina Anggraeni, Adek Bela Aulanni'am Aulanni'am Aulanni'am, Aulanni'am Azis, Fahmi Dimas Abdul Bela Khofidatu Tazkiyah Celcius Waranmasalembun Chanif Mahdi Damayanti, Eva Alfina Hilmia Lukman, Hilmia Jhudi Bonosari Soediono Maysaroh, Titis Muhammad Zaini Muhammad Zaini Narsih, Umi Nurlaila, Hamida Salsabila, Shinta Nova Sasangka Prasetyawan SULISTYORINI, ENDAH Wardatul Jannah

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