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All Journal journal of internal medicine Jurnal Kedokteran Brawijaya International Journal of Integrated Health Sciences Majalah Kedokteran Bandung Infokes : Info Kesehatan
Ponpon Idjradinata
Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Padjadjaran/Rumah Sakit Dr. Hasan Sadikin Bandung
Health Professions Medicine & Pharmacology

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Penerapan Model Pembelajaran Asuhan Nifas Terintegrasi Untuk Menciptakan Bidan yang Berkompeten Dalam Menjawab Kebutuhan Wanita Hartiningtiyaswati, Setiya; Idjradinata, Ponpon; Husin, Farid
Infokes Vol 7 No 01 (2017): Jurnal Info Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Surabaya

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Abstract

Objective: This study aims to analyze the effect of applying an integrated postpartum care learning model on the improvement of student competence. Design: This study used pre-post quasi-experimental design in the second years of midwifery student. Method Experimental group (n = 25) was given the integrated postpartum care learning model, while control group (n = 24) was given the conventional learning model (learning model that is normally used). Competency score was measured from a combination of knowledge, skill, and attitude related to postpartum. Result The result of the study showed that there were differences in the improvement of knowledge [control: mean (SD) = 2.19 (8.52); experimental = 5,9 (8.93)], attitude [control: mean (SD) = 18.15 (23.92); esperimental = 49.14 (20.96)], and skill [control: mean (SD) = 8.16 (19.17); experimental = 41.33 (19.53)] between control and experimental groups (p < 0.5). a combination of these scores showed there were signifcant differences in the improvement of competency between control and experimental groups (p < 0.05). Conclusion The integrated postpartum care learning model was better in improving student competence than the conventional learning model. It was a way to create a generation of competent midwives to meet the needs of women during postpartum.
ANEMIA PADA PENDERITA HIV-AIDS DI POLIKLINIK TERATAI RS HASAN SADIKIN- BANDUNG Sumantri, Rachmat; Wicaksana, Rudi; Ariantan, Agnes R; Supandiman, Iman; Idjradinata, Ponpon; Creven, Reinout van-; der Ven, Andre van
journal of internal medicine Vol. 10, No. 3 September 2009
Publisher : journal of internal medicine

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Abstract

The prevalence of anemia in HIV-infection ranging between 1.3 ? 95% depend on the stadium of infection. Anemiamakes bad impact on morbidity and mortality, and anemia is an independent risk factor for death in HIV-infected patients. Across-sectional study has been done in Teratai Clinic Hasan Sadikin Hospital to evaluate the prevalence and the etiology ofanemia between 1 January to 30 June 2008. Inclusion criteria were all patients who signed the informed consent. There were534 patients, 222 were anemic, prevalence of anemia was 41.6% (95% CI: 37.4 ? 45.8%), men 167 (72.2%). 188 were mildanemia (Hb 10 ?12/14 g/dl), 26 moderate anemia (Hb 8 ? 10 g/dl), and severe anemia in 6 patients (Hb < 8 g/dl). Anemia ofchronic disease or anemia of in! ammation were found in 142 (64.5%) cases, zidovudine related anemia 32 (14.5%) cases, ironde" ciency 14 (6.4%), hemolytic anemia 15 (6.8%) cases, thallassemia 8 (3.6%) cases, and megaloblasic 9 (4.1%) cases. All ofanemic patients showed low (< 2) reticulocyt index, high ferritin, low sTfR, and high hs-CRP.
Respon Imun terhadap Vaksin Influenza pada Remaja Dhamayanti, Meita; Rusmil, Kusnandi; Idjradinata, Ponpon
Jurnal Kedokteran Brawijaya Vol 27, No 2 (2012)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (514.659 KB) | DOI: 10.21776/ub.jkb.2012.027.02.9

Abstract

Influenza merupakan penyakit yang mudah menular dengan mortalitas dan morbiditas tinggi serta sering menimbulkan kejadian  luar biasa, epidemi, dan pandemi. Pada anak  sekolah,  influenza menyebabkan  tingginya angka absensi dan remaja merupakan  sumber  penularan  terbesar .  Penelitian  dilakukan  untuk menilai  respons  imun    terhadap  vaksin influenza pada kelompok remaja 12–18 tahunpada bulan Juni–September 2008, di Puskesmas Garuda Bandung. Desain dilakukan dengan  intervensional,  longitudinal, acak sederhana, dan tersamar tunggal. Vaksin  influenza yang mengandung 3 jenis virus A/H1N1, A/H3N2 dan B, disuntikkan intramuskular. Pengambilan darah dilakukan pra dan pasca vaksinasi. Pemeriksaan kadar antibodi dilakukan dengan metode hemaglutinasi inhibisi (HI). Respons imun dinilai berdasarkan nilai serokonversi, dan peningkatan geometric mean titer (GMT). Subjek dibagi 2 kelompok, 69 (52,7%) remaja pertengahan (12–15  tahun) dan 62  (47,3%)  remaja akhir  (16–18  tahun). Semua  subjek  telah mempunyai kadar antibodi protektif HI>1:40 pascavaksinasi. Nilai serokonversi kedua kelompok berbeda bermakna pada pra  (p=0,02) dan pascavaksinasi (p=0,02). Serokonversi  terhadap virus A/H3N2 antara remaja pertengahan dan akhir berbeda bermakna pada pravaksinasi (p=0,02). Pada pra dan pascavaksinasi  terdapat peningkatan GMT bermakna  terhadap ketiga  jenis virus  influenza  (Zw 9,73; 9,19; 9,59 dan p=0,00). Simpulan, vaksinasi influenza pada remaja menghasilkan kadar protektif. Respons imun remaja pertengahan dan akhir  tidak berbeda, namun  remaja pertengahan  tampak   lebih  responsif.Kata Kunci: Influenza,  remaja,  responsimun, vaksin
Relationship between C677T Methylenetetrahydrofolate Reductase Gene Polymorphism and Homocysteine in Cerebral Palsy Gamayani, Uni; Machfoed, M. Hasan; Idjradinata, Ponpon; Achmad, Tri Hanggono
International Journal of Integrated Health Sciences Vol 4, No 1 (2016)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective: To observe the relationship between methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and homocysteine levels in cerebral palsy (CP) children. Methods: This cross-sectional study was conducted in several hospitals, school for children with special needs, and rehabilitation centers in Bandung from March to November 2014, on children with CP aged 4–14 years who met the inclusion criteria. Genotyping was performed using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) and direct sequencing. Homocysteine serum level was measured using chemiluminescent microparticle immunoassay (CMIA) method. Statistical analysis was conducted using t test. Results: In this study, 150 CP children had MTHFR C677T gene polymorphism with a frequency of 18%, consisting of TT homozygotes (4%), CT heterozygotes (14%), and T allele (11%. The mean serum level of homocysteine in CP with C677T MTHFR gene polymorphism was 8.22 (±1.89) µmol/L, higher than those without polymorphism (p=0.046). Conclusions: A relationship between MTHFR C677T gene polymorphism and homocysteine level in children with cerebral palsy is found in this study. Keywords: Cerebral palsy, homocysteine, methylenetetrahydrofolate reductase polymorphism DOI: 10.15850/ijihs.v4n1.682
HUBUNGAN TIPE THALASSEMIA β SERTA POLIMORFISME C.-582 A>G PROMOTOR GEN HAMP DAN STATUS BESI THALASSEMIA β BERAT BARU Susanah, Susi; Idjradinata, Ponpon
Majalah Kedokteran Bandung Vol 47, No 3 (2015)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Kelebihan besi merupakan penyebab morbiditas dan mortalitas penderita thalassemia ? berat. Terdapat berbagai faktor yang memengaruhi status besi thalassemia ? berat. Penelitian ini bertujuan menganalisis  hubungan  tipe thalassemia ? serta polimorfisme c.-582 A>G promotor gen hepcidine antimicrobacterial peptide (HAMP) dengan status besi thalassemia ? berat baru. Penelitian dengan metode potong lintang dilakukan di Rumah Sakit Dr. Hasan Sadikin/Fakultas Kedokteran Universitas Padjadjaran Bandung selama November?Desember 2012. Subjek penelitian adalah penderita thalassemia ? berat yang baru didiagnosis berdasarkan pemeriksaan klinis dan laboratorium. Subjek belum pernah mendapatkan transfusi darah dan memiliki kadar C-reactive protein normal. Status besi dinilai dengan mengukur kadar feritin serum (FS) dan saturasi transferin (ST). Analisis statistik yang digunakan adalah uji-t, Uji Mann-Whitney, dan uji chi-kuadrat. Didapatkan 29 subjek thalassemia ? berat baru, 24 thalassemia ? mayor dan 5 thalassemia ?/HbE berat. Tidak ada perbedaan status besi antara kedua tipe thalassemia ? berat baru maupun antara yang mengalami polimorfisme dan yang tidak mengalami polimorfisme c.-582 A>G promotor gen HAMP (p>0,05). Simpulan, tipe thalassemia ? berat dan polimorfisme c.-582  A>G promotor gen HAMP tidak berhubungan dengan status besi penderita thalassemia ? berat yang baru didiagnosis. [MKB. 2015;47(3):192-98]Kata kunci: Feritin, polimorfisme c.-582 A>G promotor gen HAMP, saturasi transferin, thalassemia ? berat Association of ?-thalassemia Type and Polymorphisms of c.-582 A>G Promoter HAMP Gene and Iron Status in Newly Diagnosed Severe ?-thalassemiaAbstractIron overload is the common  cause of morbidity and mortality in severe ?-thalassemia patients. Many factors influence the  iron status in severe ?-thalassemia. This study aimed to analyze the association of ?-thalassemia type, polymorphism c.-582 A>G promotor hepcidine antimicrobacterial peptide (HAMP) gene,  and  iron  status in newly diagnosed severe ?-thalassemia. A cross-sectional study was performed at Dr. Hasan Sadikin General Hospital/Faculty of Medicine, Universitas Padjadjaran Bandung from November to December 2012. Subjects were newly diagnosed severe ?-thalassemia patients who were diagnosed based on clinical manifestation and laboratory examination. Subjects had not received any blood transfusion before and had normal CRP level. Transferrin saturation (TS) and serum ferritin (SF) levels indicate iron status. The statistical analysis was performed using t test, Mann-Whitney, and Chi square test. Twenty nine subjects were diagnosed as newly severe ?-thalassemia, 24 ?-thalassemia mayor and 5 with severe ?-thalassemia/HbE. There was no difference in the iron status between the two types of severe ?-thalassemia  and  between those with and without polymorphism of c.-582 A>G promotor HAMP gene in  newly  diagnosed severe  ?-thalassemia (p>0.05). In conclusiosn, the  ?-thalassemia type and polymorphism of c.-582 A>G  promotor HAMP  gene do  not  associate with the iron status  in  newly diagnosed severe ?-thalassemia patients.  [MKB. 2015;47(3):192-98]Key words: Ferritin, polymorphism of  c.-582 A>G  promotor HAMP gene, severe ?-thalassemia, transferrin ration DOI: 10.15395/mkb.v47n3.599
Kadar Interleukin-18 pada Kultur Limfosit Penderita Dermatitis Atopik yang Distimulasi Staphylococcal Enterotoxin B (SEB) Suwarsa, Oki; Sudigdoadi, -; Sutedja, Endang; Idjradinata, Ponpon
Majalah Kedokteran Bandung Vol 47, No 4 (2015)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Staphylococcus aureus (S. aureus) mempunyai peranan penting pada patogenesis dermatitis atopik (DA). Peran S. aureus tersebut tidak hanya sebagai pencetus DA, tetapi juga menyebabkan inflamasi kronik. Peran tersebut berhubungan dengan dihasilkannya protein antara lain toksin poten oleh S. aureus, yaitu Staphylococcal enterotoxin B (SEB). Interleukin-18 (IL-18) merupakan regulator penting dari produksi sitokin Th-1 yaitu interferon-γ (IFN-γ).  Tujuan penelitian ini adalah mengetahui kadar IL-18 pada kultur limfosit pasien DA yang distimulus dengan SEB. Penelitian ini dilakukan pada 20 orang penderita DA (7 laki-laki dan 13 perempuan) dan 20 orang sehat (9 laki-laki dan 11 perempuan) di Rumah Sakit Dr. Hasan Sadikin Bandung, merupakan penelitian eksperimental secara in vitro pada kultur ilmfosit yang distimulus dengan SEB di Laboratorium Penelitian dan Pengujian Terpadu Universitas Gadjah Mada. Terjadi peningkatan kadar IL-18 rata-rata pada kultur limfosit antara sebelum dipapar dan setelah dipapar SEB, baik pada kelompok DA maupun kelompok kontrol. Setelah dilakukan uji statistik perbandingan antara kadar IL-18 rata-rata sebelum dan sesudah dipapar SEB antara kelompok DA dan kontrol, didapatkan hasil kadar IL-18 kelompok DA lebih tinggi bermakna dibanding  dengan kelompok kontrol (p<0,05) sehingga dapat disimpulkan kadar IL-18 meningkat tinggi pada kelompok DA yang dipapar SEB. [MKB. 2015;47(4):249–54]Kata kunci: Dermatitis atopik, interleukin-18 (IL-18), Staphylococcus enterotoxin BInterleukin-18 Levels in Lymphocytes Cultures from Atopic Dermatitis Patients Stimulated by Staphylococcal Enterotoxin BAbstractStaphylococcus aureus (S. aureus) has an important role in the pathogenesis of atopic dermatitis (AD). S. aureus acts as a triggering factor for AD and also causes chronic inflammation. These roles of S. aureus are related to various proteins such as Staphylococcal enterotoxin B (SEB) as a potent toxin. Interleukin-18 (IL-18) is an important regulator of cytokine production of Th-1, which is interferon-γ (IFN-γ). The aim of this study was to reveal the levels of IL-18 in cultured lymphocytes from AD patients exposed by SEB. This study was conducted on 20 people with DA (7 men and 13 women) and 20 healthy volunteers (9 men and 11 women) in dr. Hasan Sadikin General Hospital. The in vitro experimental study on cultured lympocytes exposed with SEB was performed at the Integrated Research and Testing Laboratory of Gadjah Mada University. The average levels of IL-18 in cultured lymphocytes before and after being exposed to SEB increased both in AD group and control group. After the statistical tests was performed on the ratio of the average levels of IL-18 before and after being exposed to SEB between AD and control groups, it was shown that the levels of IL-18 AD group was significantly higher than the control group (p <0.05). Therefore, it can be concluded that the levels of IL-18 increased higher in AD group exposed by SEB. [MKB. 2015;47(4):249–54]Key words: Atopic dermatitis , interleukin-18, Staphylococcal enterotoxin BDOI: 10.15395/mkb.v47n4.620
Diet-Induced Changes in Serum Ganglioside Spectrum Patterns in 6-Month-Old Infants Gurnida, Dida A.; Idjradinata, Ponpon; Muchtadi, Deddy; Sekarwana, Nanan; Fong, Bertram; McJarrow, Paul; Rowan, Angela; Norris, Carmen
Majalah Kedokteran Bandung Vol 44, No 4 (2012)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Human milk contains higher levels of gangliosides when compared to infant formula. Gangliosides play a role in neuronal growth, migration, maturation, sinaptogenesis, and myelination. Seven of the identified gangliosides (GM1, GM2, GM3, GD3, GD1a, GD1b, and GT1b) are dominant gangliosides with different specific functions. Thus, the aim of the study was to understand the effects of ganglioside-enhanced diet and to compare the spectrum patterns of those seven classes of serum gangliosides in infants consuming standard infant formula (IF group), ganglioside-fortified infant formula (GA group) and exclusive breastfeeding (BF group). This study used liquid chromatography–mass spectrometry (LC-MS) method. This was a prospective study involving 30 infants in IF group, 29 in GA group and 32 in BF group. Subject recruitment was performed using consecutive admission  approach from March 2008 to February 2009 in Bandung. Statistical analyses using Wilcoxon test showed that there was a significant change in the spectrum patterns of GD3, GM1, GM2 and GT1b in IF group; of GD1a, GM1 and GM2 in GA group and of GD1a, GD1b, GM1 and GM3 in BF group. It is concluded that ganglioside-enriched diet extends spectrum patterns of gangliosides especially in seven of them, i.e. GM1, GM2, GM3, GD3, GD1a, GD1b, and GT1b, in 6-month old infants. [MKB. 2012;44(4):240–44]..Key words: Gangliosides, human milk, infants, infant formula, LC-MSPerubahan Pola Spektrum Gangliosida Serum yang Diinduksi Makanan pada Bayi Usia 6 BulanAir susu ibu (ASI) mengandung gangliosida yang kadarnya lebih tinggi dibandingkan dengan susu formula. Gangliosida berperan dalam pertumbuhan, migrasi, maturasi saraf, sinaptogenesis, dan mielinisasi. Tidak kurang dari 100 tipe gangliosida telah ditemukan, tujuh di antaranya (GM1, GM2, GM3, GD3, GD1a, GD1b, dan GT1b) merupakan kelas utama dengan fungsi yang berbeda. Penelitian ini bertujuan untuk mengetahui efek penambahan diet gangliosida serta membandingkan pola spektrum tujuh kelas gangliosida serum tersebut pada bayi yang mengonsumsi susu formula standar (kelompok infant formula/IF), susu formula difortifikasi gangliosida (kelompok GA), dan ASI eksklusif (kelompok breastfeeding/BF). Penelitian ini menggunakan metode liquid chromatography-mass spectrometry (LC-MS) untuk menghitung kadar ketujuh kelas gangliosida tersebut. Penelitian ini adalah penelitian prospektif yang melibatkan 30 bayi kelompok IF, 29 bayi kelompok GA, dan 32 bayi kelompok BF. Perekrutan subjek penelitian dilakukan dengan cara consecutive admission dari bulan Maret 2008 sampai bulan Februari 2009 di Bandung. Analisis statistik tes Wilcoxon menunjukkan perubahan bermakna pada pola spektrum GD3, GM1, GM2 dan GT1b pada kelompok IF; GD1a, GM1, dan GM2 pada kelompok GA; GD1a, GD1b, GM1, dan GM3 pada kelompok BF. Kesimpulan, penambahan diet gangliosida akan meningkatkan 7 spektrum gangliosida yaitu GM1, GM2, GM3, GD3, GD1a, GD1b, dan GT1b pada anak usia 6 bulan. [MKB.2012;44(4):240–44].Kata kunci: ASI, bayi, gangliosida, LC-MS, susu formula DOI: http://dx.doi.org/10.15395/mkb.v44n4.217
Co-Authors - Sudigdoadi, - Agnes R Ariantan Andre van der Ven Angela Rowan Bertram Fong Carmen Norris DEDDY MUCHTADI Dida A. Gurnida Endang Sutedja Hartiningtiyaswati, Setiya Husin, Farid Iman Supandiman Kusnandi Rusmil M. Hasan Machfoed, M. Hasan Meita Dhamayanti Nanan Sekarwana Oki Suwarsa Paul McJarrow Rachmat Sumantri Reinout van- Creven Rudi Wicaksana Susi Susanah Tri Hanggono Achmad Uni Gamayani, Uni