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All Journal International Journal of Integrated Health Sciences Althea Medical Journal Global Medical and Health Communication MNJ (Malang Neurology Journal) Sari Pediatri Cermin Dunia Kedokteran JURNAL KESEHATAN SAMODRA ILMU Jurnal Neuroanestesi Indonesia Jurnal Kesehatan Metro Sai Wawai Neurona
Uni Gamayani, Uni
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Biochemistry, Genetics & Molecular Biology Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health

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Undernutrition as Risk Factor of Hydrocephalus Prevalence in Children with Tuberculous Meningitis Sinaga, John Patria Maruli; Risan, Nelly Amalia; Gamayani, Uni
Althea Medical Journal Vol 4, No 1 (2017)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (622.901 KB)

Abstract

Background: Hydrocephalus is the most frequent neurological complication in children with tuberculous meningitis. Tuberculosis infection cannot be separated from nutritional status. Children with undernutrition have decreased immunity thus could affect clinical manifestation of tuberculous meningitis. This study was conducted to identify the relationship between undernutrition and the prevalence of hydrocephalus in tuberculous meningitis.Methods: An analytic observational study was carried out to 38 medical records of children with tuberculous meningitis in Dr. Hasan Sadikin General Hospital from 2007 to 2015. Variables that were studied included gender, age, advanced stage of disease, motoric paralysis, history of seizure, nutritional status and hydrocephalus. The collected data were analyzed using Chi-Square test. Results: Out of 21 subjects with undernutrition, 11 subjects were found to have hydrocephalus. The analysis using chi-square was statistically significant (p=0.009). Prevalence ratio=4.45 (CI 95% 1.14−45.43), meaning tuberculous meningitis children with undernutrition were at risk of hydrocephalus 4.45 times greater than children with normal nutritional status.Conclusions: Undernutrition may increase the risk of hydrocephalus in children with tuberculous meningitis. [AMJ.2017;4(1):143–7] DOI: 10.15850/amj.v4n1.1036
Relationship between C677T Methylenetetrahydrofolate Reductase Gene Polymorphism and Homocysteine in Cerebral Palsy Gamayani, Uni; Machfoed, M. Hasan; Idjradinata, Ponpon; Achmad, Tri Hanggono
International Journal of Integrated Health Sciences Vol 4, No 1 (2016)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective: To observe the relationship between methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and homocysteine levels in cerebral palsy (CP) children. Methods: This cross-sectional study was conducted in several hospitals, school for children with special needs, and rehabilitation centers in Bandung from March to November 2014, on children with CP aged 4–14 years who met the inclusion criteria. Genotyping was performed using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) and direct sequencing. Homocysteine serum level was measured using chemiluminescent microparticle immunoassay (CMIA) method. Statistical analysis was conducted using t test. Results: In this study, 150 CP children had MTHFR C677T gene polymorphism with a frequency of 18%, consisting of TT homozygotes (4%), CT heterozygotes (14%), and T allele (11%. The mean serum level of homocysteine in CP with C677T MTHFR gene polymorphism was 8.22 (±1.89) µmol/L, higher than those without polymorphism (p=0.046). Conclusions: A relationship between MTHFR C677T gene polymorphism and homocysteine level in children with cerebral palsy is found in this study. Keywords: Cerebral palsy, homocysteine, methylenetetrahydrofolate reductase polymorphism DOI: 10.15850/ijihs.v4n1.682
COGNITIVE IMPAIRMENT DETECTION IN ADULT THALASSEMIA PATIENT USING MOCA-INA Wardoyo, Chandra Calista; Gamayani, Uni; Ong, Anam; Rizal, Ahmad; Wibisono, Yusuf; Amalia, Lisda; Panigoro, Ramdan
MNJ (Malang Neurology Journal) Vol. 7 No. 1 (2021): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2021.007.01.6

Abstract

Background: Cognitive impairment in thalassemia patients are prevalent, therefore early detection of cognitive impairment in adult thalassemia patients is crucial for prevention. Montreal Cognitive Assessment (MoCA) is a public domain cognition screening tools that covers all cognitive domains in detecting mild cognitive impairments.Objective: To compare cognitive function between adult thalassemia patients and healty control by using Indonesia version of MoCA test (MoCA-Ina)Methods: This prospective observational analytic with case control study, compared the total scores and scores of each domain of cognition between adult thalassemia patients and healthy subjects at the Medical Hematology Oncology Clinic of Dr. Hasan Sadikin General Hospital, Bandung, Indonesia using MoCA-Ina from August to October 2018.Results: A total of 32 thalassemia subjects and 50 healthy subjects were conducted. A total of 16(50%) subjects in the case group had a value of MoCA-Ina <26, while only 1(2%) healthy control had a value of MoCA-Ina <26. The median total MoCA-Ina score in case and control groups were 25.5 and 27.50 (p <0.001). The median score of memory domains, executive functions and visuospatial of the case and control groups were 3 versus 4 (p <0.001), 3 versus 3.5 (p <0.001) and 3.53 ± 0.671 versus 3.88 ± 0.385 (p <0.003), respectively.Conclusion: Adults thalassemia patients have lower score in total MoCA-Ina, domains of memory, executive function and visuospatial score compared to healthy control.
Incidence of Peripheral Neuropathy in Major Beta-Thalassemia Patients at Hasan Sadikin General Hospital, Bandung, Indonesia Putri, Fanny Adhy; Gamayani, Uni; Lailiyya, Nushrotul; Panigoro, Ramdan
Cermin Dunia Kedokteran Vol 46, No 9 (2019): Neuropati
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (610.493 KB) | DOI: 10.55175/cdk.v46i9.416

Abstract

Bakground. Beta major thalassemia is the most common inherited blood disorder worldwide. It can lead to various neurological complications such as peripheral neuropathy. Toronto Clinical Neuropathy Score (TCNS) is helpful for peripheral neuropathy screening especially in diabetes mellitus. Objective. To investigate the prevalence of peripheral neuropathy in beta major thalassemia patient using Toronto Clinical Neuropathy Score (TCNS). Method. A descriptive study on beta major thalassemia patients aged more than 14 years who regularly underwent blood transfusions in Hasan Sadikin General Hospital Bandung, from July to August 2017. Normal TCNS values was < 4, mild neuropathy 5-7, moderate neuropathy 8-10 and severe neuropathy > 10. Results. Sixty subjects met the inclusion criteria, 48,3% were male with the mean (SD) age of 20,7 ± 7,6 years. Mean hemoglobin value was 6,7 ± 0,9 g/dL and median (IQR) blood ferritin serum was 2873 (1900-3859) μg/L. Thirty-two subjects had neuropathy; 19 (31,7%) with mild neuropathy and 13 (21,6%) with moderate neuropathy.Conclusion. The incidence of peripheral neuropathy in patients with thalassemia according to TCNS score is fairly high.Latar Belakang. Talasemia beta mayor adalah kelainan darah bawaan paling umum di dunia dan dapat menyebabkan berbagai komplikasi, salah satunya neuropati perifer. Toronto Clinical Neuropathy Score (TCNS) dapat digunakan untuk penilaian neuropati perifer yang disebabkan oleh berbagai penyakit sistemik. Objektif. Menyelidiki prevalensi neuropati perifer pada pasien talasemia beta mayor menggunakan Toronto Clinical Neuropathy Score (TCNS). Metode. Penelitian ini studi deskriptif skrining menggunakan TCNS pada pasien thalassaemia beta mayor berusia lebih dari 14 tahun yang secara teratur menjalani transfusi darah di Rumah Sakit Umum Hasan Sadikin Bandung, dari Juli hingga Agustus 2017. Nilai TCNS normal adalah <4, neuropati ringan 5-7, neuropati sedang 8-10 dan neuropati berat> 10. Hasil. Sebanyak 60 subjek memenuhi kriteria inklusi, 48,3% laki-laki dengan usia rata-rata (SD) 20,7 ± 7,6 tahun. Nilai hemoglobin rata-rata 6,7 ± 0,9 g / dL dan serum ferritin darah median (IQR) adalah 2873 (1900-3859) μg / L. Tiga puluh dua subjek memiliki neuropati; 19 (31,7%) neuropati ringan dan 13 (21,6%) neuropati sedang. Simpulan. Insiden neuropati perifer pada pasien dengan talasemia menurut skor TCNS cukup tinggi.
EFEKTIFITAS KOMPRES HANGAT DAN BIRTH BALL TERHADAP PENURUNAN RASA NYERI PADA IBU BERSALIN KALA 1 FASE AKTIF DI PMB MARTINI DAN PMB ROSLINA KABUPATEN ACEH UTARA Andriany, Eka; Gamayani, Uni; Arisanti, Nita
Jurnal Kesehatan Samodra Ilmu (JKSI) Vol 12 No 1 (2021): JURNAL KESEHATAN SAMODRA ILMU (JKSI)
Publisher : LPPM Sekolah Tinggi Ilmu Kesehatan Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (105.472 KB) | DOI: 10.55426/jksi.v12i1.142

Abstract

ABSTRAK Persalinan adalah suatu kondisi fisiologis yang dialami oleh ibu hamil di seluruh dunia. Persalinan normal (fisiologi) adalah proses dimana keluarnya janin cukup bulan (37-42 minggu) dan plasenta melalui jalan lahir secara spontan tanpa adanya masalah atau komplikasi. Di Indonesia diperkirakan angka persalinan naik 20% pada setiap tahunnya dan tercatat 90,32% ibu bersalin di Indonesia ditolong oleh tenaga kesehatan, yaitu seperti dokter dan bidan. Berdasarkan data Riskesdas 2013, jumlah ibu bersalin yang ditolong oleh bidan sebanyak 68,6%. Jumlah ibu bersalin di Provinsi Aceh pada tahun 2018 mencapai 121.924 orang dan diperkirakan kenaikan jumlah persalinan di Provinsi Aceh mencapai 10%. Nyeri persalinan mulai timbul pada tahap kala I fase laten dan akan berlanjut semakin bertambah kuat instensitas nyeri pada kala I fase aktif, apabila nyeri di kala I pada saat persalinan tidak terkontrol, yaitu 35% ibu mengalami partus lama, 12% perdarahan post partum, dan 10% bayi lahir dengan caput succedaneum. Upaya dalam menurunkan nyeri pada persalinan dapat dilakukan secara non farmakologi, yaitu kompres hangat dan bola kelahiran (birth ball). Penelitian ini bertujuan untuk mengetahui perbedaan efektifitas kompres hangat dan birth ball terhadap penurunan rasa nyeri pada ibu bersalin kala 1 fase aktif di PMB Martini dan PMB Roslina Kabupaten Aceh Utara. Penelitian ini menggunakan eksperimen semu (quasi eksperiment) dengan rancangan two group pretest posttest design. Teknik sampling yang digunakan yaitu consecutive sampling, maka sampel akhir yang diperlukan adalah 55 orang perkelompok. Analisis data menggunakan Independent T-Test. Hasil penelitian bivariabel menunjukkan terdapat perbedaan yang signifikan antara kompres hangat dan birth ball terhadap penurunan rasa nyeri pada pengujian hipotesis didapatkan nilai p 0,003 < 0,05. Penelitian ini menyimpulkan bahwa Kompres hangat lebih efektif dalam menurunkan respon nyeri pada ibu bersalin kala I fase aktif dibandingkan dengan Birth ball.
Implementasi Pelayanan Antenatal dalam Meningkatkan Pengetahuan dan Menurunkan Kecemasan Melalui Tele-edukasi dan Booklet pada Ibu Hamil Aprilia, Rizka; Anwar, Anita Deborah; Gamayani, Uni
Jurnal Kesehatan Metro Sai Wawai Vol. 16 No. 1 (2023): Jurnal Kesehatan Metro Sai Wawai
Publisher : Poltekkes Kemenkes Tanjung Karang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jkmsaw.v16i1.3517

Abstract

Introduction: The increased anxiety of pregnant women in the era of the COVID-19 pandemic is due to a lack of knowledge. Increased knowledge of pregnant women can be provided through education using booklets and tele-education media. Purpose: This study aims to determine the difference in improving the knowledge and anxiety of pregnant women through the provision of Tele-education and booklets during the COVID-19 pandemic. Methods: This study used a quasi-experimental design with a pretest-posttest approach with a control group design. The number of samples used was 30 respondents in the tele-education group and 30 respondents in the booklet group, with consecutive sampling techniques. Knowledge was measured using a questionnaire with right or wrong answer choices, while anxiety was measured using the Zung Self-rating Anxiety Scale (ZSAS) questionnaire. Both of these questionnaires have good validity and reliability. The Whitney test analyzed data. Results: The study found the use of tele-education media (p=0.0001) and booklets (p=0.015) had an effect on increasing the knowledge of pregnant women. The use of booklet media is more effective (rank mean = 36.77) than Tele-education media (rank mean = 24.23) to increase knowledge in pregnant women (p=0.004). Anxiety of pregnant women can be reduced using tele-education media (p=0.007) and booklet media during the COVID-19 pandemic (p=0.015). There is no difference (more effective) in the use of Tele-education media and booklets on reducing anxiety of pregnant women (p=0.195). Conclusion: Tele-education can be utilized as an alternative antenatal service during and after the COVID-19 pandemic to increase knowledge and other services for pregnant women and health workers. Latar Belakang: Peningkatan kecemasan ibu hamil pada era pandemi COVID-19 disebabkan kurangnya pengetahuan. Peningkatan pengetahuan pada ibu hamil dapat diberikan melalui edukasi menggunakan media booklet dan Tele-edukasi. Tujuan: Penelitian ini bertujuan untuk mengetahui efektifitas peningkatan perbaikan pengetahuan dan kecemasan ibu hamil melalui pemberian Tele-edukasi dan booklet saat pandemi COVID-19. Metode: penelitian ini menggunakan desain quasi eksperimental dengan pendekatan pretest-posttest with control group design. Jumlah sampel yang digunakan sebanyak 30 responden pada kelompok Tele-edukasi dan 30 responden pada kelompok booklet, dengan teknik consecutive sampling. Pengukuran pengetahuan dilakukan menggunakan kuisioner dengan pilihan jawaban benar atau salah, sedangkan kecemasan diukur menggunakan kuisoner Zung Self-rating Anxiety Scale (ZSAS). Kedua kuisioner ini memiliki validitas dan reabilitas yang baik. Data dianalisis dengan uji Mann whitney. Hasil: Studi menemukan penggunaan media tele-edukasi (p=0,0001) dan booklet (p=0,015) berpengaruh terdapat peningkatan pengetahuan ibu hamil. Penggunaan media booklet lebih efektif (rank mean = 36.77) dibandingkan media Tele-edukasi (rank mean = 24.23) terhadap peningkatan pengetahuan pada ibu hamil (p=0,004). Kecemasan ibu hamil dapat diturunkan menggunakan media tele-edukasi (p=0,007) dan media booklet pada masa pandemic COVID-19 (p=0,015). Tidak tidak ada perbedaan (lebih efektif) penggunaan media Tele-edukasi dan booklet terhadap penurunan kecemasan ibu hamil (p=0,195). Simpulan: Tele-edukasi dapat dimanfaatkan sebagai alternatif pelayanan antenatal baik pada masa pandemi maupun pasca pandemic COVID-19 untuk meningkatkan pengetahuan maupun layanan lainnya untuk ibu hamil bagi tenaga Kesehatan.
Perbandingan Luaran Klinis pada Pasien Stroke Iskemik Fase Akut dengan Satu atau Lebih Faktor Risiko Hidayat, Faqih; Gamayani, Uni; Wibisono, Yusuf; Berliana, Sobaryati; Amalia, Lisda
Jurnal Neuroanestesi Indonesia Vol 11, No 1 (2022)
Publisher : https://snacc.org/wp-content/uploads/2019/fall/Intl-news3.html

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2322.326 KB) | DOI: 10.24244/jni.v11i1.345

Abstract

Latar Belakang dan Tujuan: Stroke menurut WHO adalah terjadinya gejala penurunan fungsi neurologis secara tiba-tiba, fokal maupun global, berlangsung lebih dari 24 jam karena gangguan pasokan darah menuju ke otak. Stroke merupakan penyakit multifaktorial penyebab kematian dan disabilitas. Sebagian besar pasien stroke memiliki ? 2 faktor risiko. Tujuan penelitian ini adalah untuk membandingkan gambaran luaran klinis pada pasien stroke iskemik fase akut dengan satu atau lebih faktor risiko.Subjek dan Metode: Penelitian ini merupakan penelitian deskriptif retrospektif pada pasien stroke iskemik fase akut serangan pertama di Departemen Neurologi Rumah Sakit Hasan Sadikin Bandung periode 20152019.Hasil: Terdapat 176 subjek pada penelitian ini, 160 pasien (90,9%) dengan lebih dari satu faktor risiko dan 16 pasien (9,1%) dengan satu jenis faktor risiko. Faktor risiko paling banyak adalah hipertensi sebanyak 147 pasien (83,5%), dislipidemia 91 pasien (51,7%) dan penyakit kardiovaskular 56 orang (31,8%). Penelitian menunjukan luaran klinis yang diukur dengan skor National Institute of Health Stroke Scale (NIHSS) keluar RS pada kelompok lebih dari satu faktor risiko lebih bervariatif dari derajat ringan hingga sangat berat. Sedangkan, pada kelompok dengan satu faktor risiko skor NIHSS cenderung ringan hingga sedang.Simpulan: Pasien dengan lebih dari satu faktor risiko memiliki luaran klinis lebih buruk dibandingan pasien dengan satu faktor risiko.Comparison of The Clinical Outcomes between Single and Multiple Risk Factors in Acute Phase Ischemic Stroke PatientsAbstractBackground and Objective: Stroke according to WHO is a sudden symptom of neurological deficit, focal or global, lasting 24 hours due to disruption of blood supply to the brain. Stroke is a multifactorial disease that causes death and disbility. Most of stroke patients have ?2 risk factors. The aim of this study was to determine the comparison of clinical outcomes between single and multiple risk factor in acute phase ischemic stroke patients.Subjects and Methods: This study was retrospective descriptive study in patient with acute phase ischemic stroke in the Neurology Department Hasan Sadikin Hospital Bandung from 2015-2019.Results: There were 176 subjects in this study, 160 patients (90.9%) with multiple risk factor and 16 patients (9.1%) with single risk factor. The most common risk factors were hypertension in 147 patients (83.5%), dyslipidemia in 91 patients (51.7%) and cardiovascular disease in 56 pasien (31.8%). The study showed that the clinical outcomes as measured by National Institute of Health Stroke Scale (NIHSS) score for hospital discharge in multiple risk factors group varied from mild to very severe. Meanwhile, single risk factor groups the score tends to be mild to moderate.Conclusion: Multiple risk factor patients had a worse clinical outcome than single risk factor patients.
Faktor-faktor yang Berperan pada Status Epileptikus Non-konvulsivus di RSUP Dr. Hasan Sadikin Bandung Trislawati, Cristina; Gunadharma, Suryani; Gamayani, Uni; Wibisono, Yusuf; Sobaryati, Sobaryati; Amalia, Lisda
Jurnal Neuroanestesi Indonesia Vol 11, No 3 (2022)
Publisher : https://snacc.org/wp-content/uploads/2019/fall/Intl-news3.html

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24244/jni.v11i3.423

Abstract

Latar Belakang dan Tujuan: Status epileptikus merupakan kasus emergensi neurologis dengan mortalitas 57%, 63% merupakan status epileptikus non-konvulsivus (SENK). Diagnosis SENK tidak mudah karena pasien tidak menunjukkan bangkitan yang jelas sehingga diperlukan pemeriksaan elektroensefalografi (EEG). Penyakit serebrovaskular, infeksi susunan saraf pusat (SSP), tumor otak, penyakit autoimmun, dan gangguan metabolik dapat mengakibatkan SENK selain itu dapat memiliki gambaran klinis menyerupai SENK. Tujuan penelitian untuk melihat faktor-faktor yang berperan pada diagnosis SENK.Subjek dan Metode: Penelitian observasional analitik potong lintang retrospektif pada 132 pasien dengan diagnosis klinis SENK di RSUP dr. Hasan Sadikin Bandung selama periode Juli 2017 Juni 2020. Hasil: Dari 132 subjek dengan diagnosis klinis SENK, hanya 100 pasien yang memenuhi kriteria inklusi. Pemeriksaan EEG dilakukan pada semua pasien, sebagian besar dalam waktu 24 jam (82,4 87,9%), hanya 34 pasien yang terkonfirmasi sebagai SENK. Gangguan metabolik secara signifikan berperan pada SENK sebesar 29,4% (p=0,049). Pada pasien yang tidak terkonfirmasi SENK, penurunan kesadaran diakibatkan gangguan metabolik.Smpulan: Gangguan metabolik berperan pada kejadian SENK. Pasien dengan diagnosis klinis SENK memerlukan pemeriksaan EEG segera untuk menghindari diagnosis berlebihan
Autism Spectrum Disorder: a Two-center Evaluation of Pharmacological Intervention and Behavioral Therapies on Core Symptoms Solek, Purboyo; Gamayani, Uni; Rusmil, Kusnandi; Afriandi, Irvan; Prasetya, Taufan; Rizqiamuti, Anggia Farrah; Nurfitri, Eka; Burhan, Burhan; Sahril, Indra; Gunawan, Kevin
Global Medical & Health Communication (GMHC) Vol 12, No 3 (2024)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v12i3.14460

Abstract

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by chronic deficits in social communication and interaction, with sensory processing abnormalities affecting over 90% of individuals across different sensory areas. This study investigated the combined effects of aripiprazole and behavioral therapy (BT) on core symptoms of ASD in children aged 6–10. Utilizing the considerable neuroplasticity still present at this age, we hypothesized that this combined approach might yield superior outcomes compared to BT alone. The 12-week randomized, double-blind, placebo-controlled trial was conducted from February 2023 to January 2024 at two sites of Child Development Centers in Bandung city, involving 51 participants (22 intervention, 29 placebo). The intervention group received aripiprazole and BT, while the placebo group received saccharum lactis and BT. Both groups underwent BT comprising applied behavioral analysis (ABA) and discrete trial training (DTT). The Childhood Autism Rating Scale (CARS) assessed treatment effects. The independent 2-sample t-tests and Mann-Whitney tests showed no significant differences in overall CARS scores between groups. However, the analysis revealed significant improvements in three subcategories: VII (visual response, p=0.021), IX (taste-smell-touch response, p=0.035), and X (fear or nervousness, p=0.043). These findings suggest that the combined approach may enhance sensory processing and emotional regulation in children with ASD. The study highlights the potential benefits of a multimodal approach to ASD treatment, combining targeted pharmacological intervention with behavioral therapies. However, limitations such as study duration and sample size warrant further research to optimize treatment strategies for individuals across the autism spectrum.
HUBUNGAN KADAR HEMOGLOBIN DAN FERITIN DENGAN GAMBARAN KONDUKSI SARAF PADA ANAK TALASEMIA BETA MAYOR Dewi, Windy Krisanti Kusuma; Gamayani, Uni; Lailiyya, Nushrotul; Reniarti, Lelani; Sekarwana, Nanan
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 35 No 1 (2018)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v35i1.42

Abstract

    CORRELATION BETWEEN HAEMOGLOBINE AND FERRITIN LEVEL WITH NERVE CONDUCTION STUDY IN CHILDREN WITH BETA THALASSEMIA MAJORABSTRACTIntroduction: Beta thalassemia major is inherited hemoglobin synthesis disorder found in thalassemia belt, including Indonesia. Peripheral neuropathy is one of its underdiagnosed neurological complications results in poor management of the patients.Aims: To identify correlation between hemoglobin and ferritin serum with Nerve conduction study (NCS) in Beta thalassemia major patients.Methods: This was a cross-sectional study involving children with beta thalassemia major aged 8-14 years, who regularly underwent blood transfusions in Hasan Sadikin Hospital, Bandung. Nerve conduction study of motor and sensory nerves of all limbs were conducted to the patients. Data was analyzed using Spearman’s correlation analysis.Results: Fifty subjects were included in this study with the mean hemoglobin level (SD) of 6.99 (0.87)g/dL and the mean blood ferritin level (SD) of 3.925 (1.993)μg/L. Based on NCS, most of the subjects had polyneuropathy and 46.94% had axonal demyelinating lesions in sensory and motor nerves. Among patients with neuropathy, there was a statistically significant negative correlation  between mean hemoglobin level and the numbers of the abnormal  nerves and also a statistically significant positive correlation between mean blood ferritin level and the numbers of the abnormal nerves.Discussion: The lower ferritin serum level, the less nerve involved based on NCS.Keyword: Beta thalassemia, ferritin, hemoglobin, nerve conduction study, neuropathyABSTRAKPendahuluan: Talasemia beta mayor merupakan suatu kelainan sintesis hemoglobin yang herediter yang banyak ditemukan di wilayah tropis, termasuk Indonesia. Salah satu komplikasinya adalah neuropati perifer yang sering tidak terdiagnosis, sehingga penyandangnya tidak mendapatkan tata laksana yang adekuat.Tujuan: Mengetahui hubungan antara kadar hemoglobin dan feritin serum dengan gambaran konduksi saraf (nerve conduction study/NCS) pada penyandang talasemia beta mayor.Metode: Studi potong lintang terhadap penyandang talasemia berusia 8-14 tahun yang rutin menjalani transfusi darah di RSUP Dr. Hasan Sadikin, Bandung. Dilakukan pemeriksaan NCS motorik dan sensorik pada keempat ekstremitas. Data dianalisis menggunakan uji korelasi Spearman.Hasil: Diperoleh 50 subjek dengan rerata kadar hemoglobin 6,99+0,87g/dL dan kadar feritin serum 3.925+1.993μg/L. Berdasarkan pemeriksaan NCS, sebagian besar subjek mengalami polineuropati yang 46,94% di antaranya berupa gambaran demielinasi aksonal sensorik motorik. Pada subjek dengan neuropati perifer didapatkan korelasi negatif yang bermakna antara kadar hemoglobin dengan jumlah keterlibatan saraf pada NCS dan korelasi positif yang bermakna antara kadar feritin serum dengan jumlah keterlibatan saraf pada NCS.Diskusi: Semakin rendah kadar feritin serum, maka semakin sedikit jumlah saraf yang terlibat pada NCS, dan sebaliknya.Kata kunci: Feritin, hemoglobin, nerve conduction study, neuropati, talasemia beta mayor
Co-Authors -, Burhan ahmad rizal Ahmad Rizal Ganiem, Ahmad Rizal Aih Cahyani Anam Ong Anggia Farrah Rizqiamuti, Anggia Farrah Anita Deborah Anwar Berliana, Sobaryati Burhan Burhan, Burhan Cep Juli Dewi, Windy Krisanti Kusuma Eka Andriany Eka Nurfitri, Eka Gunadharma, Suryani Hidayat, Faqih Irvan Afriandi Kevin Gunawan Kusnandi Rusmil Lailiyya, Nushrotul Lelani Reniarti Lisda Amalia M. Hasan Machfoed, M. Hasan Mansur, Sobaryati Muhafidzah, Novi Fatni Nanan Sekarwana Nelly Amalia Risan, Nelly Amalia Nita Arisanti Ponpon Idjradinata Pranggono, Emmy Hermiyanti Prasetya, Taufan Putri, Fanny Adhy Ramdan Panigoro Rizka Aprilia, Rizka Sahril, Indra Sinaga, John Patria Maruli Siuliyanty, Siuliyanty Sobaryati, Sobaryati Solek, Purboyo Tri Hanggono Achmad Trislawati, Cristina Wardoyo, Chandra Calista Yusuf Wibisono