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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Farmasi Klinik Indonesia Jurnal Ilmiah Medicamento
Herleeyana Meriyani
Universitas Mahasaraswati Denpasar
Health Professions Medicine & Pharmacology Public Health

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Antibiotic consumption and resistance: a 3-years ecological study for four critical groups of bacteria in a general regional hospital Dwi Arymbhi Sanjaya; Nyoman Budiartha Siada; Rr Asih Juanita; I Putu Yudistira Mahaputra; Made Gek Adisti Kamalia; Herleeyana Meriyani
Pharmaciana Vol 14, No 1 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i1.27321

Abstract

Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae are the most critical groups of multi-drug resistant (MDR) bacteria that cause a threat in hospitals. This study identified the trend of antibiotic consumption, antibiotic resistance pattern, and the relationship between antibiotic consumption and antibiotic resistance in a critical group of bacteria in a general regional hospital. This ecological study was based on retrospective data from inpatient databases in a general regional hospital over three years (2017-2019). The trend for annual antibiotic consumption over 2017-2019 was defined as defined daily doses/100 bed-days. The relationship between total antibiotic consumption and the percentage of antibiotic resistance among four isolated critical bacteria was explored in time series analysis and linear regression. The most frequently used antibiotic was ampicillin (220.33 DDD/100 bed-days), ciprofloxacin (126.86 DDD/100 bed-days), and ampicillin-sulbactam (126.34 DDD/100 bed-days). There was a significant relationship between antibiotic consumption (ampicillin, ampicillin-sulbactam, ceftazidime, gentamicin, amikacin, and ciprofloxacin) in DDD/100 bed-days and antibiotic resistance in E. coli, K. pneumoniae, and P. aeruginosa (p<0.05) but not statically significant in A. baumannii (p=0.062). The annual usage fluctuated or remained stable, with no statistically significant trends change. The relationship between antibiotic consumption and antibiotic resistance was significant in three out of four critical groups of bacteria.
Co-Authors Dwi A. Sanjaya Dwi Arymbhi Sanjaya Fitria Megawati Fitria Megawati I Made Agus Sunadi Putra I Putu Yudistira Mahaputra Made Gek Adisti Kamalia Ni Kadek Ayu Sartikawati Ni Kadek Sukertiasih Ni Made Dharma Shantini Suena Ni Nyoman Wahyu Udayani Ni Putu Udayana Antari Ni Wayan Ciptawati Ni Wayan Sutariani Nyoman B. Siada Nyoman Budiartha Siada Putu Sukma Purnamasari RR. Asih Juanita Siluh Putu Astini Triska Ananda Rahayu Wardani, I Gusti Agung Ayu Kusuma Wintariani, Ni Putu Woro Enjang Santi Prihatin