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All Journal Jurnal Farmasi Klinik Indonesia JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) JPSCR : Journal of Pharmaceutical Science and Clinical Research
Achmad Fudholi
Fakultas Farmasi, Universitas Gadjah Mada, Yogyakarta
Environmental Science Health Professions Medicine & Pharmacology Public Health

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Luaran Humanistik Pasien Kanker Serviks yang Menggunakan Regimen Cisplatin-Vinkristin-Bleomisin Suwendar Suwendar; Achmad Fudholi; Tri M. Andayani; Herri S. Sastramihardja
Indonesian Journal of Clinical Pharmacy Vol 10, No 4 (2021)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2021.10.4.249

Abstract

Luaran humanistik seperti kualitas hidup merupakan parameter yang sangat penting untuk menilai keberhasilan kemoterapi. Penelitian ini bertujuan untuk mengevaluasi dampak penggunaan regimen cisplatin-vinkristin-bleomisin pada kualitas hidup, sehingga dapat diketahui bagaimana perbedaan kualitas hidup sebelum dan setelah kemoterapi. Penelitian ini dilakukan menggunakan rancangan cross-sectional pada pasien rawat inap di RSUP Dr. Hasan Sadikin Bandung dari bulan Juni 2015 sampai dengan Maret 2016. Data diambil secara prospektif dengan observasi lapangan. Pengukuran kualitas hidup pasien dilakukan dengan menggunakan kuesioner European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C-30 (EORTC QLQ-C30). Perbedaan nilai domain sebelum dan setelah kemoterapi dievaluasi secara statistik dengan paired t-test (p<0,05). Hasil menunjukkan bahwa pada domain fungsional terdapat peningkatan dalam seluruh aspek, kecuali fungsi sosial. Pada domain gejala, terdapat kecenderungan penurunan kecuali penurunan nafsu makan (p=0,009).  Domain status kesehatan global meningkat secara bermakna setelah kemoterapi (p=0,000). Secara keseluruhan, penggunaan regimen cisplatin-vinkristin-bleomisin selama tiga siklus cenderung meningkatkan kualitas hidup pasien kanker serviks. Kata kunci: Kanker serviks, kualitas hidup, kuesioner EORTC QLQ-C30, regimen cisplatin vinkristin-bleomisin Humanistic Outcome of Cervical Cancer Patients Using Cisplatin-Vincristine-Bleomycin RegimenAbstractHumanistic outcomes such as quality of life are very important parameters for assessing the success of chemotherapy. Therefore, this study aimed to evaluate the impact of using the cisplatin-vincristin-bleomycin regimen before and after chemotherapy on quality of life. It was conducted using a cross-sectional design in inpatients at Dr. Hasan Sadikin Bandung from June 2015 to March 2016. The data were taken prospectively by field observation. The patient's quality of life was measured using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) questionnaire. Furthermore, the difference in domain values before and after chemotherapy was evaluated statistically by paired t-test (p<0.05). The results show an increase in all aspects of the functional domain, except social functions. There was a tendency to reduce the symptom domain except for decreased appetite (p=0.009). The domain of global health status increased significantly after chemotherapy (p=0.000). Overall, using the cisplatin-vincristin-bleomycin regimen for three cycles improves the quality of life of cervical cancer patients.Keywords: Cervical cancer, cisplatin-vincristine-bleomycin regimen, EORTC QLQ-C30 questionnaire, quality of life
PERSEPSI PRESEPTOR TERHADAP KEY INDICATORS KOMPETENSI PHARMACEUTICAL CARE PADA PRAKTEK KERJA PROFESI APOTEKER DI APOTEK Bondan Ardiningtyas; Marchaban Marchaban; Hari Kusnanto; Achmad Fudholi
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 7, No 1
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.362

Abstract

Praktek Kerja Profesi Apoteker adalah tahap penting untuk meningkatkan keterampilan pharmaceutical care mahasiswa. Tidaklah mudah bagi preseptor untuk menilai peningkatan kompetensi mahasiswa dalam waktu yang singkat, sehingga diperlukan key indicators.Penelitian ini bertujuan untuk mengetahui apa saja key indicators kompetensi pharmaceutical care pada Praktek Kerja Profesi Apoteker di Apotek berdasarkan persepsi preseptorditinjau dari tingkat kepentingan dan resiko kejadian medication error. Penelitian ini adalah penelitian deskriptif ekploratif menggunakan rancangan cross sectional observation menggunakan kuessioner. Subyek penelitian adalah seluruh preseptor PKPA di Daerah Istimewa Yogyakarta sebanyak 22 preseptor, dengan kriteria inklusi: mendapatkan rekomendasi dari organisasi profesi dan bersedia menjadi responden. Kriteria eksklusi adalah preseptor yang mengundurkan diri ketika penelitian berlangsung. Indikator kunci ditetapkan berdasarkan nilai mean rank tertinggi. Hasil penelitian diperoleh 11 indikator kompetensi ditinjau dari tingkat kepentingan (indikator nomor 13; 14; 19;12; 18; 1; 16; 22; 2; 15; dan 33) .dan 11 indikator kompetensi ditinjau dari tingkat resiko kejadian medication error(indikator nomor 14; 16; 12; 13; 22; 9; 15; 8; 23; 17; dan 19).Indikator hasil intersection (irisan) dari kedua kelompok indikator tersebut diperoleh 7 key indicator yaitu indikator nomor 12, 13, 14, 15, 16, 19 dan 22 sebagai key indicatorskompetensi pharmaceutical care pada PKPA di Apotek berdasarkan persepsi preseptor yaitu: menyerahkan obat disertai informasi obat, menyampaikan informasi obat dengan benar, menyiapkan obat dengan benar, melakukan peracikan obat bila diperlukan, membuat etiket obat,melakukan pelayanan informasi obatdan memberikan konseling kepada pasien.
COST ANALYSIS OF THERAPY FOR BREAST CANCER PATIENTS WITH HORMONE THERAPY Vina Purnamasari; Tri Murti Andayani; Achmad Fudholi
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 5, No 1
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.31

Abstract

One of the breast cancer management is done by hormone therapy. This study aimed to determine the main cost component of therapy, the cost of therapy both in outpatient and inpatient, and also the influence of patient characteristics, factor of therapy, and type of hormone therapy on breast cancer treatment costs at RSUP dr Wahidin Sudirohusodo. The research method was an analitic observational study from hospital perspective. The subjects were outpatient and inpatient with breast cancer in the period January-June 2014 at RSUP dr. Wahidin Sudirohusodo who met the inclusion criteria. The data was collected retrospectively which extracted from medical records and the treatment costdata from breast cancer patients. The data was analyzed by calculating the prevalence of breast cancer patients given hormone therapy, major components of costs, and expenses for each component, both for therapy outpatient or inpatient. The results showed that breast cancer patient which included in inclusion criteria were 105 patient. The range cost for inpatient surgerywas Rp 5.436.756 - Rp 5.646.678 with the largest cost component was the medical substance after use (BHP) which included in the cost of medical action 28,6%. The cost range for inpatient chemotheraphy was Rp 2.546.166 - Rp. 6.823.821 with the largest cost component was the cost of drugs namely 83,5%. The cost range for outpatient was  Rp 1.538.750 - Rp 4.202.935 with the largest cost component was the cost of drugs namely 63,57%. Patient characteristics that influenced the cost of breast cancer were stage (p = 0,001), medical action (p = 0.001), and cycles of therapy (p = 0,027). In addition, the type of hormone therapy also affects the cost of breast cancer (p = 0,047).Keywords: breast cancer, hormone therapy, cost of therapy
ANALYSIS OF OUTPATIENT SATISFACTION FOR CIVIL SERVANT DURING THE IMPLEMENTATION OF ASKES AND JKN Komang Trisnawati; Sumarni Sumarni; Achmad Fudholi
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 5, No 1
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.26

Abstract

Patient satisfaction is one of indicator in determining whether a program run by the government considered success or not. The study aimed to determine the significant difference of gap between expectations and perceptions, and patient satisfactions on the quality of outpatient services during the Health Insurance (Askes) and the National Health Insurance (JKN) in Dr. Sardjito Hospital. This study used a cross-sectional method with purposive sampling on 100 civil servant outpatients. The research instrument was a questionnaire with Likert scale. Patient satisfaction was measured using SERVQUAL method for comparing the patient’s expectations and perceptions of outpatient services. The differences between expectations and perceptions of Askes and JKN era were analyzed using the Wilcoxon test, while the differences in patient satisfaction tested using the Mann Whitney with 95% confidence level. The results showed that there was a significant difference between expectations and perceptions in each dimension of SERVQUAL during Askes and JKN era with p-value 0.000. The highest gap both in Askes and JKN era was the same dimension, reliability, with gap score -0,87 and -1,49 respectively. In addition, the results also revealed that there was a significant difference between respondent satisfaction during Askes and JKN era with p-value 0.004. The highest gap score between Askes and JKN was the dimention of reliability with the gap score 0,62.Keywords: satisfaction, health insurance, SERVQUAL
Ethanol Extract, Ethyl Acetate Extract, Ethyl Acetate Fraction, and n-Heksan Fraction Mangosteen Peels (Garcinia mangostana L.) As Source of Bioactive Substance Free-Radical Scavengers Liza Pratiwi; Achmad Fudholi; Ronny Martien; Suwidjiyo Pramono
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 1, No 2 (2016)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (201.449 KB) | DOI: 10.20961/jpscr.v1i2.1936

Abstract

Mangosteen peels (Garcinia mangostana L.) is well known as an excellent source of antioxidative compounds. The name of mangosteen is xanthone. Antioxidant of mangosteen  peels can be extracted by ethanol, etyl acetate and can be fractinated by etyl acetate and n-hexane. The aim of this research was to compare the antioxidant activity of the peel extract by ethanol and etyl acetate and fractinated by etyl acetate and n-hexane. Extract and fraction exhibited higher scavenging activity of DPPH. The purpose of this study was to compare antioxidant activity of ethanol extract, ethyl acetate extract, fraction of ethyl acetate and n-hexane fraction. The antioxidant activity test using DPPH method with UV-Vis spectrophotometer. Ethanol extract shown IC50 value 5,03 µg/mL, ethyl acetate extract shown IC50 value 41,56 µg/mL. Ethyl acetate fraction shown IC50 value 2,78 µg/mL, and n-hexane fraction with IC50 22,33 µg/mL. It means peel extract and fraction by mangosteen peels has very strong antioxidant activity and ethyl acetate fraction that its antioxidant activity higher that the other solvent.
Co-Authors Bondan Ardiningtyas Hari Kusnanto Herri S. Sastramihardja Komang Trisnawati Liza Pratiwi Marchaban Marchaban Ronny Martien Sumarni Sumarni Suwendar Suwendar Suwidjiyo Pramono Tri M. Andayani Tri Murti Andayani Vina Purnamasari