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All Journal Nexus Kedokteran Klinik Magna Neurologica
Iqbal Imanuddin
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Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Hubungan Ibu Hamil Perokok Pasif dengan Persalinan Preterm di RSUD Dr. Moewardi Surakarta Imanuddin, Iqbal; Soetrisno, .; Suwandono, Adji
Nexus Kedokteran Klinik Vol 3, No 1 (2014): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.046 KB)

Abstract

Background: Exposure to secondhand smoke among passive smoking pregnant women was known to contain various toxic chemical substances such as Nicotine, Carbon Monoxide, Cadmium, and Polycyclic Aromatic Hydrocarbon. These substances are able to reduce the oxygen supply to the fetus and stimulate the myometrium contraction that could lead to preterm delivery. This study aims to prove the correlation between passive smoking pregnant women and preterm delivery cases. Methods: This study is an analytical observational study using case control approach. This study was conducted in Mawar I ward RSUD Dr. Moewardi, Surakarta. The subjects in this study are 60 who perform delivery in RSUD Dr. Moewardi. Subject preferences were performed using fixed disease-sampling method where subjects are divided into 2 groups, the group consisting of 20 pregnant women with preterm delivery cases and the control group consisting of 40 pregnant women with aterm delivery. Each group was given a questionnaire contains questions regarding passive smokers status as an independent variable, as well as antenatal care (ANC) status, age, and previous preterm delivery history as the confounding factors that will be controlled. Chi square tests and multiple logistic regression analysis were used to analyze the data. Results: The study revealed significant correlation between passive smoking pregnant women and preterm delivery. Pregnant women with secondhand smoke exposure have a preterm delivery risk 9.4 times greater when compared to pregnant woman with no exposure after controlling the confounding factors which is antenatal care and considering the history of previous delivery (p = 0.008; OR = 9.39). Conclusion: There is a significant correlation between passive smoking pregnant women and preterm delivery. Passive smoking pregnant women have a higher risk to experience preterm delivery compared to non-passive smoking pregnant women. Keywords: pregnant women, passive smoking, preterm delivery.  
Hubungan Ibu Hamil Perokok Pasif dengan Persalinan Preterm di RSUD Dr. Moewardi Surakarta Iqbal Imanuddin; . Soetrisno; Adji Suwandono
Nexus Kedokteran Klinik Vol 3, No 1 (2014): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.046 KB)

Abstract

Background: Exposure to secondhand smoke among passive smoking pregnant women was known to contain various toxic chemical substances such as Nicotine, Carbon Monoxide, Cadmium, and Polycyclic Aromatic Hydrocarbon. These substances are able to reduce the oxygen supply to the fetus and stimulate the myometrium contraction that could lead to preterm delivery. This study aims to prove the correlation between passive smoking pregnant women and preterm delivery cases. Methods: This study is an analytical observational study using case control approach. This study was conducted in Mawar I ward RSUD Dr. Moewardi, Surakarta. The subjects in this study are 60 who perform delivery in RSUD Dr. Moewardi. Subject preferences were performed using fixed disease-sampling method where subjects are divided into 2 groups, the group consisting of 20 pregnant women with preterm delivery cases and the control group consisting of 40 pregnant women with aterm delivery. Each group was given a questionnaire contains questions regarding passive smokers status as an independent variable, as well as antenatal care (ANC) status, age, and previous preterm delivery history as the confounding factors that will be controlled. Chi square tests and multiple logistic regression analysis were used to analyze the data. Results: The study revealed significant correlation between passive smoking pregnant women and preterm delivery. Pregnant women with secondhand smoke exposure have a preterm delivery risk 9.4 times greater when compared to pregnant woman with no exposure after controlling the confounding factors which is antenatal care and considering the history of previous delivery (p = 0.008; OR = 9.39). Conclusion: There is a significant correlation between passive smoking pregnant women and preterm delivery. Passive smoking pregnant women have a higher risk to experience preterm delivery compared to non-passive smoking pregnant women. Keywords: pregnant women, passive smoking, preterm delivery.
Olfactory Neuroblastoma with Intracranial Extension Nurwahyu Putra Romadhani, Andry; Imanuddin, Iqbal; Tejomukti, Teddy; Watanabe, Yasuhiro; Murakami, Takenobu; Tajiri, Yuki
Magna Neurologica Vol. 2 No. 2 (2024): July
Publisher : Department of Neurology Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v2i2.1164

Abstract

Background: Olfactory Neuroblastoma (ONB), so called esthesioneuroblastoma, is a rare malignant tumor of the sinonasal tract. ONB represents 6.3% of all sinonasal tract malignancies, with a prevalence of 0.4 cases per million population. These tumors are slow-growing and there may be intracranial extension of the tumor. Nasal obstruction, anosmia, recurrent epistaxis and pain are typical early manifestations. Imaging studies are essential in determining tumor extension and surgical planning of ONB. Endonasal biopsy is required to confirm the diagnosis of ONB. The case provides a basis for discussion of ONB and highlights the possibility of extension of this tumor. Case: A 45-year-old male presented with a generalized clonic seizure, conjugate eye deviation, and pre-seizure headache. Post-seizure, the patient was unconscious and incontinent, later appearing conscious but confused. The patient had a history of seizures at home and in the ER, along with occasional headaches over the past year. The patient described nasal congestion, decreased smell, and recurrent nosebleeds, having undergone ethmoidectomy in 2020 for papilloma. Discussion: The patient experienced symptoms of seizures, headache, and nasal disturbances. Olfactory neuroblastoma (ONB) tumor was detected after comprehensive examination. Treatment involves multimodal therapy, including surgery, chemotherapy, and radiotherapy, with prognosis depending on tumor stage and grade. Conclusion: Early diagnosis of ONB is necessary to prevent further tumor progression. Intracranial extension of the ONB should be carefully investigated. Imaging as well as histopathological and immunohistochemical examinations are very helpful in identifying the location, metastasis and degree of malignancy of the tumor.
A 61-Years-Old Female with Moyamoya Syndrome: A Case Report Savitri, Martha Oktavia Dewi; Fairuzya, Azmi Farah; Subandi; Imanuddin, Iqbal; Romadhoni, Andry Nur Wahyu Putra; Hosoya, Tomohiro
Magna Neurologica Vol. 3 No. 1 (2025): January
Publisher : Department of Neurology Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v3i1.1119

Abstract

Background: Moyamoya vasculopathy (MMV), like Moyamoya disease (MMD) and Moyamoya syndrome (MMS), is a rare chronic cerebrovascular angiopathy, especially in elderly patients. The incidence onset of MMV were unique with bimodal peak age: 5-10 years old and 25-49 years old. Case: A 61-year-old-female complaint of sudden onset left-sided hemiparesis one month before admission, headache, and forgetfulness. She had history of diabetes mellitus for 3 years. Neurological physical examination found left hemiparesis with motoric strength 4/5. Laboratory findings are unremarkable. Brain MRI with contrast showed infarcts at subcortical regions. Her cerebral DSA examination suggested diffuse multiple stenosis in the anterior circulation and total occlusion of left external and internal carotid artery. “Puff of smoke” and “champagne-bottle like neck sign” were found in DSA imaging, typical signs of MMD. She received aspirin 80 mg as her secondary prevention of another stroke event.  Discussion: MMV case at elderly onset which is similar to prior small study with mean age of 60 years old. Previous study mentioned hypertension (44%) and diabetes mellitus (16%) were found in older MMD patients. Patient was given aspirin 80mg daily. Precautions in this case include taking lifelong antiplatelet, managing diabetes mellitus, and implementing lifestyle modification. This treatment approach was directed to lower concomitant risk of ischemic stroke. Conclusion: We report a case of MMV which was considered as a rare case and a cause of stroke event. The management of this case was directed to control the coexisting condition of ischemic stroke using antiplatelet drug and risk factor management.
Co-Authors . Soetrisno Adji Suwandono Fairuzya, Azmi Farah Hosoya, Tomohiro Martha Oktavia Dewi Savitri Murakami, Takenobu Nurwahyu Putra Romadhani, Andry Romadhoni, Andry Nur Wahyu Putra Tajiri, Yuki Tejomukti, Teddy Watanabe, Yasuhiro