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All Journal BALI MEDICAL JOURNAL (BMJ) Medical Journal of Indonesia Majalah Kedokteran Nusantara The Journal Of Medical School Narra J Jurnal Neuroanestesi Indonesia The Journal of Society Medicine (JSOCMED)
Suzy Indharty
Departement Of Neurosurgery, Faculty Of Medicine, Universitas Sumatera Utara, Medan, Indonesia
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Journal : Majalah Kedokteran Nusantara The Journal Of Medical School

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Hubungan antara reseptor progesteron dengan Ki-67 labeling index pada meningioma Steven Tandean; Rr Suzy Indharty; Iskandar Japardi; Sufida dr
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 46, No 1 (2013): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Introduction : Meningiomas are benign tumor and the most prevalent intracranial tumors which recur locally. Their morphologic grading do not always correlate with patient outcome and some of them associated with a less favorable clinical outcome. The incidence in women is approximately twice than in men. Progesterone receptors may play role in the proliferation and grading of meningiomas. Aims of this study isto evaluate the correlation of progesterone receptor status with proliferation marker ki67 in various grades of meningioma.Methods : A retrospective research of 30 paraffin-embedded sections of meningiomas was collected that was done histological typing and grading with hematoxylin and eosin. Immunodetection of Progesterone receptors was conducted with peroxidaseantiperoxidase complex and Ki-67 was achieved by streptavidin-biotin peroxidase complex. Progesterone receptors status considered positive if >50% of nuclei were stained with medium intensity or >10 of tumor cell’s nuclei were strongly stained. The Ki-67 is defined into three groups as no proliferation, low proliferation (<14%), and high proliferation (> 14%). Results : Progesterone receptors were positive in 13/27 (48.1%) of grade I tumors, 1/2 (50%) of grade II tumors, and 0/1 (0%) of grade III tumor. In grade I tumor, negative progesterone receptors with negative Ki-67 was 6/14 (42.9%) and low Ki-67 was 8/16 (57.1%). While, positive progesterone receptors with negative Ki-67 was 7/13 (53.8%), low Ki-67 was 4/13 (30.8%), and high Ki-67 was 2/13 (15.4%). In grade II tumor, negative progesterone receptors with negative Ki-67 and positive progesterone receptors with low Ki-67 expression. In grade III tumor, negative progesterone receptors with negative Ki-67 expression. Conclusion : There was a not significant relationship between Ki-67 and progesterone receptors status, but high Ki-67 expression was only found in positive progesterone receptors. Progesterone receptors may play role in proliferation of meningioma. Keywords : meningioma; progesterone; receptor; Ki-67 antige
Hubungan raeseptor estrogen dengan Ki-67 labeling index pada meninagioma intrakranial Abdurrahman Mouza; Iskandar Japardi; Suzy Indharty
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 50, No 2 (2017): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Introduction : Meningioma occurs more in women than men with ratio 2 : 1. Mitosis of meningioma is stimulatedbyfewgrowth factorsand one of itis estrogen. Expression of estrogen receptor on meningioma showsthat clinical meningioma has characteristic more aggressive. Proliferation Index can be measured by antibody of Mind Bomb (MIB-1) binding Ki-67 antigen. Ki-67 is showed on the cells which proliferating through cells cycle.Relation between estrogen receptor and cell proliferation is interesting because it has controversy.Method : This Study used Cross Sectional method for analising relation between estrogen receptor and Ki-67 in patients have been diagnosed meningioma. This study has been done at general hospital H. Adam Malik Medan and laboratorium of patologi anatomi at Murni Teguh hospital.This study did in Oktober-November 2013.Result : In this study is almost meningioma grade I stained Ki-67 not have mitosis with amount 13 sample (43.3%) or positive mitosis is 14 sample (45%). While immunohistochemistry staining of estrogen receptor on meningioma grade I has 25 negative sample (83.3%) and 14 positive sample (51.8%). All of grade I and II are negative.Relation of these staining was used Chi-Square with limit value p<0.05. This result is p=0.677 that shows no significance relation between estrogen receptor and labeling Index Ki-67.Conclusion : These histopatology have many frequents type that is 16 cases of meningothelial meningioma (53.3%), fibroblastic meningioma, and 4 cases transitional meningioma (13.3%). The result is no relation between estrogen receptor and Ki-67 with p=0.667 (p>0.05).Other results are no relation Ki-67 with age p=0.204 (p>0.05) and sex p=0.121 (p>0.05). Keywords : estrogen receptor, Ki-67, meningioma
Pengaruh kadar protein dan jumlah sel CSF terhadap angka kejadian malfungsi VP shunt di RS. H. Adam Malik Medan Indra Saputra; Rr. Suzy Indharty; A. Gofar Sastrodiningrat
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 47, No 2 (2014): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Background : Hydrocephalus is a disorder formation or absorption of fluid flow cerebrospinal. Number of cases of hydrocephalus in the world is quite high at around 0.5 -4 per 1000 live births while in Indonesia as much as 2-3 per 1000 live births. Ventriculoperitoneal shunt (VP shunt) is the main option in the treatment of hydrocephalus. One of the complications that occur in the installation of VP shunt was VP shunt malfunctions that happen as much as 25-40% especially in the first year after installation of VP shunt.Methods : The study was conducted on 169 hydrocephalus patients who performed the installation VP shunt in Haji Adam Malik Hospital Medan since January 2010 to December 2012. The data were analyzed using chi square and p values <0.05 were considered as significant.Results : In the 169 patients who performed the installation of VP shunt, 47 patients (27.8%) of them had VP shunt malfunction. Among the 47 patients who had malfunctions of VP shunt, 16 patients (40%) had shown increased of total cerebrospinal fluid protein and it had been statistically significant association between the incidence of VP shunt malfunction with cerebrospinal fluid protein levels (p = 0.049). While the examination of the number of cells in the cerebrospinal fluid of 47 patients who had VP shunt malfunctions, 14 patients (36%) had shown the increasing of number of cells in the cerebrospinal fluid and this indicates that the relationship of the incidence of VP shunt malfunction with the number of cells in the cerebrospinal fluid was not statistically significant (p =0.199).Conclusion : There is a significant correlation between cerebrospinal fluid protein levels with the incidence of VP shunt malfunction. While the number of cells in the cerebrospinal fluid showed no significant correlation with the incidence of VP shunt malfunctions.Keywords : Malfunction; VP shunt; protein; cel count; cerebrospinal fluid; Hydrocephalus
Co-Authors A. Gofar Sastrodiningrat Abdurrahman Mouza Adella, Cut A. Daulay, Elvita Rahmi Indra Saputra Irina, Rr Sinta Iskandar Japardi Iskandar Japardi Muhammad Fadhli Nagatri, Gabriela Ramoti, Natanael Siahaan, Andre Marolop Pangihutan Siahaan, Andre MP. Situmorang, Dicky Arjuna Sufida dr Tandean, Steven Zamzami, Muhammad Avicienna