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All Journal Jurnal Kedokteran Brawijaya MNJ (Malang Neurology Journal)
Muhamad Rasjad Indra
Laboratorium Fisiologi Fakultas Kedokteran Universitas Brawijaya
Medicine & Pharmacology Neuroscience

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GRAPE’S LEATHER AND SEED EXTRACT (VITIS VINIFERA) IMPROVING THE FUNCTION OF WISTAR RATS’ MOTOR (RATTUS NORVEGICUS) ISCHEMIC STROKE MODEL Indra, Muhamad Rasjad; Lie, Zanella Yolanda
Malang Neurology Journal Vol 3, No 1 (2017): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (524.299 KB) | DOI: 10.21776/ub.mnj.2017.003.01.2

Abstract

Background. Grape peel and seed extract (Vitis vinifera), that has resveratrol, is one of many antioxidants that can pass through blood brain barrier and can induce release neurotrophic factor that contribute in ERK 1/2 pathway mechanism in post stroke.Objective. To prove that grape peel and seed extract can regenerate neuron in brain functional.Methods. True experimental design with five groups in this research. The five groups are negative control, positive control, grape peel and seed extract 50mg/KgBW, 100mg/KgBW, and 200mg/KgBW. rats are given grape peel and seed extract in variable dose to know how extract’s effect in neuron repairment. The repairment is monitored from ladder rung walking test score.Results. Range average score ladder rung walking test post stroke dan post treatment group N, K, Ra, Rb, dan Rc, were 0 ± 0, 0.001028933 ± 0.011664445, 0.123214286 ± 0.019834983, 0.064744427 ± 0.024296721, 0.03781401 ± 0.006888803. Statistical test used Annova significantly p;0,001.Dose 50mg/KgBW is effective in repairing neuron.Conclusion. Grape’s leather and Seed extract 50 mg/kgBW can improve neuron regeneration on animal model.
UCAO (UNILATERAL CEREBRAL ARTERY OCCLUSSION) METHOD INCREASES THE LEVEL OF MMP- 9 BRAIN TISSUE IN RATS MODEL OF ISCHEMIC STROKE Indra, Muhamad Rasjad; Gasmara, Cakra Parindra
Malang Neurology Journal Vol 2, No 2 (2016): July
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (517.47 KB) | DOI: 10.21776/ub.mnj.2016.002.02.1

Abstract

Background. UCAO (Unilateral Cerebral Artery Occlusion) is a stroke induction method by ligating mice’s carotid artery for 45 minutes. Thus giving a hypoxic condition similar to stroke attacks to human. This method is less complicated and far more efficient. MMP-9 is a stroke marker which is assayed by ELISA from the blood of test animal.Objective. To prove UCAO method is capable to raise MMP-9 concentration in mice’s blood.Methods. This research was an experimental laboratory research with post-test only controlled group design. 8 male rats (8-10 weeks) were divided into 2 groups. A day after the treatment group had been induced to stroke, both group were tested to measure the MMP-9 blood concentration through ELISA.Results. In this research, UCAO method had increased MMP-9 blood concentration in treatment group, compared to the control group. It is proved by the statistic tests, Mann-Whitney and Kruskal-Wallis, which showed a significant increase in treatment group (p < 0.05).Conclusion. UCAO method is accepted as a method to create an ischemic stroke mice model.
BETA AMYLOID POLYCLONAL ANTIBODY IMMUNOGENICITY AS EARLY DEVELOPMENT STUDY OF EARLY DIAGNOSIS FOR ALZHEIMER’S DISEASE Indra, Muhamad Rasjad; Marhaendraputro, Eko Arisetijono; Hidayat, Rudi Rakhmad
Malang Neurology Journal Vol 3, No 1 (2017): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (504.981 KB) | DOI: 10.21776/ub.mnj.2017.003.01.1

Abstract

Background. Alzheimer's disease is a progressive neurologic disease of the brain that triggers irreversible neuronal cell loss, which can interfere with social and occupational functioning. The theory of ACH (Amyloid Cascade Hypothesis) states there are deposits and misfolding of beta amyloid protein thus lead to the formation of plaques and tangles in neurons cells.Objective. To identify the immunogenicity of beta amyloid polyclonal antibodies that can be developed as a first step early diagnosis of Alzheimer's disease.Methods. Rrandomized group post test only design conducted on rabbits. Blood samples were taken from rabbits that had been injected antigen once a week for 5 weeks. Variables were found in this study is the formation of beta amyloid polyclonal antibody with detection levels using dot blot and ELISA methods.Results. It has been reproduced specific polyclonal antibody beta amyloid which has been evidenced by the bond between the antigen with the antibody in a dot blot.Conclusion. The beta amyloid antibodies can be produced through production techniques with a polyclonal antibody against beta amyloid antigen induced rabbit.
Keseimbangan Sitokin Th1/Th2 Berperan Dalam Proliferasi Mastosit Jaringan Paru Pasca Pemberian Diet Tinggi Lemak pada Tikus Rosita, Rita; Indra, Muhamad Rasjad; Widjajanto, Edi
Jurnal Kedokteran Brawijaya Vol 25, No 1 (2009)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (928.411 KB) | DOI: 10.21776/ub.jkb.2009.025.01.3

Abstract

ABSTRACTAsthma and obesity are prevalent disorders, each with a significant public health impact, and a large andgrowing body of literature suggests an association between the two. The systemic inflammatory milieu inobesity leads to metabolic and cardiovascular complications but this environment alters asthma risk orphenotype is not yet known. Studies that evaluated the effects of leptin and obesity on airway inflammationin response suggest that air way inflammation is enhanced by leptin. Leptin is stimulate a Th1 cytokineprofile and suppresses Th2 cytokine production. Whether resistance to the effects of the lung or on immunefunction is unknown, but such resistance might be expected to polarize to a Th2. The aim of this study isidentify effect of leptin to lung mast cell proliferation via shifting Th1/Th2 balance using diet-induced obesemice. Because there are contradictive between leptin immune function in leptin deficient and obese, tounderstand the effect of leptin in diet-induced obese mice on immune function, lung mast cell proliferationand correlation with IL-4 as represent cytokine Th2 and IL-2 represent cytokine Th1 has been studied.
Co-Authors Cakra Parindra Gasmara, Cakra Parindra Edi Widjajanto Eko Arisetijono Hidayat, Rudi Rakhmad Rita Rosita Zanella Yolanda Lie, Zanella Yolanda