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EFFECT OF THE ACTIVATION TIME OF PLATELET RICH PLASMA AND COLLAGEN ON THE LEVELS OF FIBROBLAST GROWTH FACTOR IN GINGIVAL CREVICULAR FLUID Adisty Restu Poetri; Kwartarini Murdiastuti; Sudibyo sudibyo
ODONTO : Dental Journal Vol 9: Special Issue 1. April 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.9.0.162-169

Background: Gingival recession is a condition that occurs when the gingival margin is more apically than the cemento-enamel junction and causes the tooth root to open, so a root closure procedure is required. Platelet rich plasma (PRP) contains growth factors, including Fibroblast growth factor which plays a role in the process of angiogenesis and cell proliferation. The activation time is known to affect platelet count and FGF expression. The purpose of this study was to determine the effect of the activation time of platelet rich plasma and collagen on the expression of fibroblast growth factor in the gingival crevicular fluidMethod: The research sample was gingival crevicular fluid which was taken using paper point #30 for 30 seconds as many as 18 samples. Samples were taken before surgery, day 5 and day 7 after surgery. The samples were divided into 2 groups based on the activation time, 1 hour and 24 hours PRP-collagen. Changes in FGF levels were examined using ELISA. Repeated Meassure ANOVA test was conducted to compare the differences in each time observation and post hoc was performed to compare the differences between groups for each time observation.Result: There was no significant difference in FGF levels in the gingival crevicular fluid at each time and between groups.Conclusion: There was no effect of the activation time of platelet rich plasma and collagen on the levels of fibroblast growth factor in gingival crevicular fluid

THE DIFFERENCE OF EFFECTIVITY BETWEEN MANGOSTEEN PEEL EXTRACT AND METRONIDAZOLE ON FIBROBLAST PROLIFERATION Adinda Nur Atiqah; Adisty Restu Poetri; Moh Husnun Niam
ODONTO : Dental Journal Vol 8, No 1 (2021): July 2021
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.8.1.80-85

Background: The disease of the oral cavity is quite common in the society is periodontitis. The main cause of this condition is a certain bacterial infection found in dental plaque. In general, metronidazole gel will be given as additional therapy to treat bacterial colonization. Mangosteen peel extract gel contains xanthones and flavonoids which are known to be antibacterial and anti-inflammatory. This research aims to specify the differences in the effectiveness of anti-inflammatory between mangosteen peel extract and metronidazole gel on fibroblast proliferation.Method: This is a laboratory experimental design using post-test only design consisted of 50% mangosteen peel extract gel group, 75% mangosteen peel extract gel group, 25% metronidazole gel group and metronidazole plus gel group. This research used male Wistar rats induced periodontitis by ligation for 7 days as samples.Results: The results reveal that there was a differences in effectiveness between the 4 groups against the proliferation of fibroblast were analyzed using One Way ANOVA with a significance of 0.000 (p<0.05).Conclusion: It can be concluded that there was differences in the effectiveness of mangosteen peel extract gel and metronidazole gel as anti-inflammatory on proliferation of fibroblast in periodontitis healing process.

EKSTRAK DAUN SALAM DALAM MENINGKATKAN EKSPRESI FIBROBLAST GROWTH FACTOR PADA ULKUS TRAUMATIK RONGGA MULUT Amrina Rosada; Rochman Mujayanto; Adisty Restu Poetri
ODONTO : Dental Journal Vol 7, No 2 (2020): December 2020
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.7.2.90-96

Background: Traumatic ulcers are lesions of the oral mucosa caused by mechanical, chemical, and temperature trauma. Traumatic ulcer treatment aims to reduce inflammation, accelerate the healing process, and reduce pain. Bay leaf has anti-inflammatory pharmacological activities. This study aims to determine the effect of bay leaf extract on the expression of fibroblast growth factor in traumatic ulcer oral mucosa in Wistar rats.Method: This is an experimental research with a post-test only control group design, consisting of four groups with 20 sample of male Wistar rats. All animals were injured using a hot burnisher attached to the labial mucosa for 1 second. The gel was applied twice daily until the 3rd and 5th day after the ulcer has formed. Rat mucosal tissues were analyzed by immunohistochemical staining for FGF expressions. Statistical analysis using SPSS Mann-Whitney test.Result: The results showed the mean of cells expressing FGF in the bay gel extract group on the 3rd and 5th days were 8.4 ± 0.8, and 13.6 ± 0.5. Mann Whitney test results showed P<0.05 there is a significant differential expression of FGF traumatic ulcer oral mucosa of experimental animals on days 3 and 5 compared control group.Conclusion: Bay leaf extract increased FGF expression on days 3 and 5

Periodontal Splinting Choises For Patient With Edentulous Adisty Restu Poetri; Helmi Fathurrahman; Anggun Amanda Saveria
Denta Journal Kedokteran Gigi Vol 15 No 2 (2021): Agustus
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/denta.v15i2.4

Background: Mobile tooth is a problem that often occurs and result in tooth loss. It caused by disease or periodontal tissue’s injury. Splint is a device that is made to stabilize or tighten mobile tooth due to a trauma or disease. It works by distribute the occlusion pressure to reduce tooth mobility. Removable partial denture frame is one treatment for missing teeth and permanent splints. Objective: The aim of this treatment is to explained effect of periodontal splints for edentulous patient. Case: First case: A woman complained mobile teeth on the incisors. Intraoral examination showed remaining teeth couldn’t be abutment. Second case: A woman complained mobile teeth on the incisors. Intraoral examination showed remaining teeth could be abutment. Case management: First case: Patient was given initial therapy and continued with rehabilitative therapy by removable partial denture metal frame. Second case: Patient was given initial therapy splinting using fiber reinforced composite. A week post treatment patient felt comfortable. Conclusion: It can be concluded periodontal splinting reduced teeth mobility and prevent further damage to the periodontal tissue og Edentulous patient.

EFFECTS OF MANGOSTEEN SKIN GEL EXTRACTS ON INCREASING THE NUMBER OF FIBROBLASTS IN THE HEALING PROCESS OF RATS PERIODONTITIS Adisty restu Poetri; Anggun Feranisa; Adhiatarika Rismadianti
Jurnal Medali Vol 4: Special Issue 1. Desember 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/medali.4.3.77-83

Background: Periodontitis is one of the most common periodontal diseases in Indonesia. Inflammation and the bacteria that cause periodontitis can be treated by providing additional therapy in the form of a gel by the dentist. Mangosteen peel extract gel contains xanthones which function as antibacterial and anti-inflammatory that will accelerate the inflammatory phase. This study aims to determine the effectiveness of a gel made from mangosteen peel extract to increase the number of fibroblast cells on the healing process of periodontitis in Wistar rats.Methods: This is an experimental laboratory with post test only design. The treatment group composed of 50% mangosteen peel extract gel, 75% mangosteen peel extract gel, 25% metronidazole gel, and metronidazole plus mefenamic acid gel which were applied to Wistar rats after periodontitis induced.Results: The research data were analyzed by One Way ANOVA and exhibited a significance score of p = 0.000 (p<0.05) which indicated a significant difference. In the inter-group test with Bonferroni post hoc, it was found that there was no significant difference between the 75% mangosteen peel extract gel group and 25% metronidazole gel group with a score of p = 0.709 (p>0.05).Conclusion: The conclusion of this research showed that mangosteen peel extract gel was effective in increasing the number of fibroblast cells in the recupiration process of periodontitis

DESCRIPTION OF BIOLOGICAL AGE ESTIMATION WITH THE DEMIRJIAN METHOD USING DIGITAL PANORAMIC RADIOGRAPHY IN SEMARANG Niluh Ringga Woroprobosari; Adisty Restu Poetri; Hamizul Fuad
Jurnal Medali Vol 4: Special Issue 1. Desember 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/medali.4.3.45-55

Background: Age estimation is forensic science to help victims of disasters, accidents, or criminal cases. Age estimation using panoramic radiographs can be an option. The use of panoramic radiographs in age estimation requiring some methods, one of them is Demirjian method. The assement of tooth age by the Demirjian method is based of the tooth maturation process approach as the indicator.This study aim was to determine the description of biological age estimation using the Demirjian method in the city of Semarang.Method:The design of this research was a cross-sectional study with a total sample 152 (71 boys and 81 girls). The estimated age of the Demirjian method used 7 left mandibular teeth except for the third molar. The age assessment was based on 8 stages of crown calcification to the root, after each tooth score has been added and the maturation score is calculated, and subsequent maturation scores are converted into the age of the tooth to determine the age of 3-16 years. Data analysis using the SPSS program and analyzed by descriptive test.Result: The results obtained by the average difference in biological age and chronological age was 1.1 years and there was 87 data that under estimation, 57 data over estimation, and 8 data on estimation.Conclusion: The depiction of biological age in Semarang, the age group between 3-26 years the average Demirjian method is 1.1 years.

Application Of Tooth Coronal Index (TCI) Benindra Method In Estimating Biological Age at Sultan Agung Dental Hospital Semarang Niluh Ringga Woroprobosari; Dinda Vinca Rosa; Adisty Restu Poetri
Denta Journal Kedokteran Gigi Vol 17 No 1 (2023): Februari
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/denta.v17i1.6

Background: Age estimation through dental approaches is often an option for establishing identity in forensic cases. Age estimation can clarify statements of death, legal and civil matters. One way to identify victims is using periapical radiographs. The use of periapical radiographs in age estimation requires certain methods, one of them is using TCI (Tooth Coronal Index) Benindra method modified from Drusini's TCI method. Tooth age assessment using the Benindra TCI method was based on pulp chamber height measurements. Objective: The research was carried out to clarify the possibility of the TCI Benindra method application in estimating biological age in the Sultan Agung Dental Hospital Semarang population. Methods: This study used 23 periapical radiographs from 7 male and 16 female patients of Sultan Agung Dental Hospital Semarang. The age estimation by Benindra TCI method was performed at the age of 9-21 years towards the mandibular premolar tooth. Tooth age assessment was based on measuring the pulp chamber height using the TCI formula. Results of TCI measurements were entered into the prediction age formula to determine the patient’s biological age. Results: The difference between the average estimated biological age using the Benindra method and the average chronological age was up to 0,46 years in the 9-21 years age group. 7 data were underestimated, 6 data were overestimated, and 10 data were accurately estimated. Conclusion: The application of the Benindra TCI method showed precise results for dental patients in Semarang, so that could be used to estimate the biological age of the general population.

EFFECT OF MANGOSTEEN PEEL EXTRACT (Garcinia mangosteen) TO FIBROBLAST NUMBER AS PERIODONTAL DISEASE THERAPY Adisty Restu Poetri; Rosa Pratiwi; Adhiatarika Rismadanti
Denta Journal Kedokteran Gigi Vol 17 No 1 (2023): Februari
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/denta.v17i1.1

Background: In Indonesia, periodontitis is among the most prevalent periodontal disease. The dentist may administer extra adjunctive therapy as a gel to treat inflammation and the bacterium that causes periodontitis. The antibacterial and anti-inflammatory xanthones included in mangosteen peel extract gel speed up the inflammatory phase. Objective: This study aimed to determine the effectiveness of mangosteen peel extract gel in increasing the number of fibroblast cells in the healing process of periodontitis in Wistar rats (Rattus norvegicus). Material and Method: This research was an experimental laboratory design with a post-test-only design divided into four groups, 50% mangosteen peel extract gel group, 75% mangosteen peel extract gel group, metronidazole gel group, and metronidazole plus gel group. Result: The research data were analyzed using the One Way ANOVA test and showed a significant value difference with a p=0.000 (p<0.05). However, in the inter-group test with Bonferroni post hoc, it was found that there was no significant difference between the 75% mangosteen peel extract gel group and the metronidazole gel group with a value of p = 0.709 (p>0.05). Conclusion: This study concludes that mangosteen peel extract gel effectively increases fibroblast cells' number in the periodontitis healing process.

THE DIFFERENCE OF EFFECTIVITY BETWEEN MANGOSTEEN PEEL EXTRACT AND METRONIDAZOLE ON FIBROBLAST PROLIFERATION Adinda Nur Atiqah; Adisty Restu Poetri; Moh Husnun Niam
Odonto : Dental Journal Vol 8, No 1 (2021): July 2021
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Background: The disease of the oral cavity is quite common in the society is periodontitis. The main cause of this condition is a certain bacterial infection found in dental plaque. In general, metronidazole gel will be given as additional therapy to treat bacterial colonization. Mangosteen peel extract gel contains xanthones and flavonoids which are known to be antibacterial and anti-inflammatory. This research aims to specify the differences in the effectiveness of anti-inflammatory between mangosteen peel extract and metronidazole gel on fibroblast proliferation.Method: This is a laboratory experimental design using post-test only design consisted of 50% mangosteen peel extract gel group, 75% mangosteen peel extract gel group, 25% metronidazole gel group and metronidazole plus gel group. This research used male Wistar rats induced periodontitis by ligation for 7 days as samples.Results: The results reveal that there was a differences in effectiveness between the 4 groups against the proliferation of fibroblast were analyzed using One Way ANOVA with a significance of 0.000 (p<0.05).Conclusion: It can be concluded that there was differences in the effectiveness of mangosteen peel extract gel and metronidazole gel as anti-inflammatory on proliferation of fibroblast in periodontitis healing process.

EFFECT OF THE ACTIVATION TIME OF PLATELET RICH PLASMA AND COLLAGEN ON THE LEVELS OF FIBROBLAST GROWTH FACTOR IN GINGIVAL CREVICULAR FLUID Adisty Restu Poetri; Kwartarini Murdiastuti; Sudibyo sudibyo
Odonto : Dental Journal Vol 9: Special Issue 1. April 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Background: Gingival recession is a condition that occurs when the gingival margin is more apically than the cemento-enamel junction and causes the tooth root to open, so a root closure procedure is required. Platelet rich plasma (PRP) contains growth factors, including Fibroblast growth factor which plays a role in the process of angiogenesis and cell proliferation. The activation time is known to affect platelet count and FGF expression. The purpose of this study was to determine the effect of the activation time of platelet rich plasma and collagen on the expression of fibroblast growth factor in the gingival crevicular fluidMethod: The research sample was gingival crevicular fluid which was taken using paper point #30 for 30 seconds as many as 18 samples. Samples were taken before surgery, day 5 and day 7 after surgery. The samples were divided into 2 groups based on the activation time, 1 hour and 24 hours PRP-collagen. Changes in FGF levels were examined using ELISA. Repeated Meassure ANOVA test was conducted to compare the differences in each time observation and post hoc was performed to compare the differences between groups for each time observation.Result: There was no significant difference in FGF levels in the gingival crevicular fluid at each time and between groups.Conclusion: There was no effect of the activation time of platelet rich plasma and collagen on the levels of fibroblast growth factor in gingival crevicular fluid

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