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All Journal Medical Journal of Indonesia Indonesian Journal of Rheumatology The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia
Harry Isbagio
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Medicine & Pharmacology

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Journal : Jurnal Penyakit Dalam Indonesia

 1 
Correlation between Disease Duration, Disease Activity Scoreand Disability Score with Diastolic Dysfunction in RheumatoidArthritis Women in Dr. Cipto Mangunkusumo Hospital Antono, Dono; Dhaki, Bernard Agus Sakti; Isbagio, Harry; Shatri, Hamzah
Jurnal Penyakit Dalam Indonesia Vol. 4, No. 2
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Introduction. There are only few studies about correlation between non traditional risk factor and diastolic dysfunction in RA patients. This study aims to determinate the correlation between non traditional risk factors, including disease duration, disease activity and disability score with the diastolic dysfunction of women with RA. Methods. A cross-sectional, consecutive sampling study was conducted to 52 RA women without any previous cardiovascular disease history. All participants underwent an echocardiography to assess diastolic dysfunction and other findings associated. Duration of disease was assesed by direct interview, while the disease activity by calculating DAS28 and disability score by HAQ-DI. Results. Diastolic dysfunction was found in 30.8 % of study participants (13.5 % for each low and moderate grade, while severe was 3.8% ). Median duration of disease was 26.5 months (range 2-240), mean DAS28-CRP score was 2.69±1.11 while median DAS28-ESR score was 3.65 (range 1.13-7.5), and median HAQ-DI score was 0.29 (range 0-2.38). LV hypertrophy was found in 34.61% participants. Mean EF was 66.7±5.76%. Valve abnormality was found in 34.6% study participants. Correlation between duration of disease, DAS28-CRP, DAS28-ESR and HAQ-DI score with E/A in sequence was r= -0.065 (p=0.89), r=0.393 (p=0.38), r=0.357 (p=0.43), r=0.630 (p=0.12); while with E/E’ in sequence was r=0.136 (p=0.77), r= - 0.536 (p=0.21), r= - 0.393 (p=0.38), r=0.374 (p=0.41). Conclusions. Duration of the disease, disease activity score, and disability score in rheumatoid arthritis women had no correlation with diastolic dysfunction.
Korelasi Trigliserida Pascaprandial dengan Penanda Biologis Aktivasi Endotel pada Artritis Reumatoid Utari, Amanda Pitarini; Isbagio, Harry; Darmowidjojo, Budiman; Effendi, Shuffrie
Jurnal Penyakit Dalam Indonesia Vol. 2, No. 2
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Pendahuluan. Terdapat peningkatan mortalitas akibat penyakit kardiovaskular (PKV) sebesar 50% pada pasien artritis reumatoid (AR). Trigliserida pascaprandial (TGPP) saat ini dikaitkan dengan risiko penyakit jantung iskemik, infark miokard, stroke iskemik, kematian, serta peningkatan kadar molekul adhesi. Kadar molekul adhesi yang meningkat merupakan tanda terjadinya aktivasi endotel, proses awal pada terbentuknya lesi aterosklerosis. Belum ada penelitian tentang peran TGPP dalam risiko kardiovaskular pada pasien AR. Penelitian ini ingin mengetahui hubungan antara TGPP dengan penanda biologis aktivasi endotel. Metode. Penelitian ini adalah studi potong lintang, yang menggunakan analisis korelasi dengan analisis multivariat. Sampel diambil dengan metode consecutive sampling. Pada subjek penelitian dilakukan pemeriksaan profil lipid dan penanda aktivasi endotel. Sebagai penanda biologis aktivasi endotel digunakan sICAM-1 dan sE-selectin. Dilakukan uji korelasi antara TGPP dengan sE-selectin dan sICAM-1. Hasil. Tidak terdapat korelasi antara TGPP dengan kadar sE-selectin dan sICAM-1 pada analisis multivariat. HDL mempengaruhi kadar sICAM-1 (R2=0,087). Sementara itu kadar sE-selectin dipengaruhi oleh DAS-28 (R2=0,174), indeks massa tubuh (R2=0,125), dan gula darah pascaprandial (R2=0,138). Simpulan. Tidak ditemukan kaitan antara TGPP dengan kadar sE-selectin dan sICAM-1 pada pasien AR.
Perbedaan Serotonin Plasma dan Kortisol Saliva terhadap Gejala Depresi pada Pasien Pasca Sindrom Koroner Akut Firmansyah, Irman; Shatri, Hamzah; Putranto, Rudi; Ardani, Yanuar; Ginanjar, Eka; koesnoe, sukamto; Rizka, Aulia; Isbagio, Harry; Yunir, Em
Jurnal Penyakit Dalam Indonesia Vol. 10, No. 3
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Introduction. Psychological disorders are closely associated with hormonal factors, including cortisol and serotonin. In patients with acute coronary syndrome (ACS), autonomic dysfunction and dysregulation of the hypothalamic-pituitaryadrenal (HPA) axis can occur, leading to an increase in cortisol levels that may worsen the prognosis of ACS patients. Therefore, it is important to understand the hormonal impact, namely cortisol and serotonin levels, on depressive symptoms, which will be examined in this study. Methods. This was a cross-sectional study to determine the impact of cortisol and serotonin in the incidence of depression in post-treatment ACS patients at the ICCU RSUPN dr. Cipto Mangunkusumo, Jakarta. Data collection from patients meeting the inclusion criteria was carried out 10-14 days post-treatment through interviews, HADS questionnaire completion, physical examinations, and laboratory tests. The Mann-Whitney test was used to examine the differences between serotonin and salivary cortisol levels in patients with and without depression. Results. Among the 73 ACS patients included in this study, the average age was 57.53 (9.97) years, with 68.5% was male. Posttreatment depression was observed in 15.1% of subjects. The median serotonin levels were lower in patients with depression [175 (147 – 227.64) ng/mL vs. 189.31 (152.87-235.44) ng/mL], while cortisol levels were higher in patients with depression [3.09 (1.46-6.26) ng/mL vs. 2.15 (0.92-3.91) ng/mL]. However, the statistical analysis showed no significant differences between plasma serotonin and depression (p=0.482) or saliva cortisol and depression (p=0.275). Conclusions. There were no significant differences in cortisol and serotonin levels concerning depressive symptoms among post-acute coronary syndrome patients. Nevertheless, this study holds clinical importance due to the observed lower plasma serotonin levels and higher saliva cortisol levels in ACS patients with depression.
Co-Authors Amanda Pitarini Utari Anna Ariane Ardani, Yanuar Aulia Rizka, Aulia Awalia Awalia Bambang Setyohadi Bernard Agus Sakti Dhaki, Bernard Agus Sakti Budiman Darmowidjojo, Budiman Chudahman Manan Chudahman Manan Cleopas Martin Rumende Deddy Nur Wachid Achadiono Diana, Nyimas Dono Antono Dwi Budi Darmawati E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Eka Ginanjar Em Yunir, Em Faisal Parlindungan Gede Kambayana Handono Kalim Herikurniawan, Herikurniawan I Nyoman Suarjana Irman Firmansyah Joewono Soeroso Kasjmir, Yoga I Laniyati Hamijoyo, Laniyati Meriza, Tanggo Murdani Abdullah Nyoman Suarjana Pambudi, Joko Rilo Pasha, Mochamad Pradana Soewondo Pramono, A Prathitasari, Rahma Anindya Rachmat Gunadi Wachjudi Rahmad Mulyadi, Rahmad Rakhma Yanti Hellmi Rudi Putranto Rudy Hidayat Rudy Hidayat Shuffrie Effendi, Shuffrie Siti Setiati Soegondo, S Sukamto Koesnoe Sumariyono Sumariyono Vera D. Joewono Zuljasri Albar