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Predictor Factors of Atherosclerosis and Atherosclerosis Plaque in Rheumatoid Arthritis Patients Pambudi, Joko Rilo; Isbagio, Harry; Mulyadi, Rahmad; Abdullah, Murdani
Indonesian Journal of Rheumatology Vol 8, No 2 (2016)
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (334.45 KB)

Abstract

Background: Atherosclerosis and cardiovascular diseases have been known as the cause of increasing mortality among rheumatoid arthritis (RA) patients. Carotid intima media thickness (CIMT) measurement by ultrasound has been used as surrogate marker of atherosclerosis and cardiovascular disease.Methods: A cross sectional study of 86 RA patients fulfills EULAR/ACR 2010 critera for RA was conducted to study proportion and predictor factors of atherosclerosis and atherosclerosis plaque in rheumatoid arthritis patients.Results: Atherosclerosis and plaque was found in 47,7% and 29 % of patients. Age ≥ 40 yo, hypertension and duration of illness ≥ 24 mo were associated with atherosclerosis in multivariate logistic regression analysis with OR 10.70 (95% CI: 2.93-39.10), 4.99 (95% CI: 1.15-21.61) and 3.66 (95% CI: 1.11-11.99) respectively. Whereas hypertension, presence of antiCCP antibody and age ≥ 40 yo, were associated with plaque formation with OR 3.96 (95% CI: 1.15-13.57), 3.20 (95% CI: 1.11-9.24) and 3.61 (95% CI: 1.03-12.63) respectively.Conclusions: Age ≥ 40 yo, hypertension and duration of illness ≥ 24 mo was the predictors ofatherosclerosis, while hypertension, presence of antiCCP antibody and age ≥ 40 yo was the predictors of atherosclerosis plaque.Key words: atherosclerosis, intima media thickness, predictor, rheumatoid arthritis, ultrasonography.
Association Between Adiponectin Levels with Markers of Atherosclerosis In Patients with Rheumatoid Arthritis Meriza, Tanggo; Isbagio, Harry; Mulyadi, Rahmad; Abdullah, Murdani
Indonesian Journal of Rheumatology Vol 5, No 1 (2014)
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (147.86 KB)

Abstract

Background: Several studies have shown that atherosclerosis underlying processes of Cardiovascular disease (CVD), increased in rheumatoid arthritis (RA) and occurred early (premature). The cause of accelerated atherosclerosis in RA are still unknown.Adipokines have known that the adipokines play a role in the pathophysiology of RA and CVD. Accumulation of visceral fat associated with dysregulation of adipokinesthat influence the development of the atherosclerotic and disruption plaque. Obesity and pathological changes in fat mass and fat dysfunction as well as a change inthe pattern of secretion of proinflammatory adipokines, may have a correlation between heart disease and rheumatic diseases. Adiponectin is one of the mostwidely-studied adipokines. In RA, adiponectin is involved in the pathophysiology of RA that produces of various proinflammatory and prodestructive molecules. So far, adiponectin has been known to provide antiatherosclerotic effects in patients with non-RA. But, several recent studies in RA patients get opposite results in which increased levels of adiponectin are associated with increased prevalence of atherosclerosis. The effect of adiponectin on atherosclerosis in patient with RA is still unknown.Objective: to determine the relationship of adiponectin with atherosclerosis in patients with rheumatoid arthritis. Methods: This is a cross-sectional study conducted on outpatients of the  rheumatology clinic at Cipto Mangunkusumo General Hospital from January untilApril, 2013. Subjects consisted of 50 patients were diagnosed based on ACR 1987/EULAR 2010 criteria. The collection of data obtained by consecutive sampling and evaluated the patients’ medical data that included age, long-suffering of RA, body mass index (BMI), lipid profile, rheumatoid factor levels, levels of anti-cyclic citrullinated peptide (anti-CCP), C-reactive protein (CRP), erythrocyte sedimentation rates (ESR), blood pressure, fasting blood glucose, 2 hour post prandial blood glucose, ECG, examination of serum adiponectin levels and bilateral carotid ultrasound to measure the carotid artery intima media thickness.Results: From the results of the 50 patients studied, obtained 28 (56%) of patients had increased levels of adiponectin. Atherosclerosis was found in 13 (26%) subjects. The median value was 9.46 μg / ml with the lowest levels of 4 μg/ml and the highestlevels of 24μg/ml. The Spearman’s test showed no significant correlation between adiponectin serum and atherosclerosis in patients with RA (p = 0706 and r = 0.055). The analysis results of the correlation of adiponectin with atherosclerosis based on age, disease duration, ESR, rheumatoid factor, DAS 28, CRP, BMI, dyslipidemia showed no significant correlation.Conclusion : From this study, researchers found no statistically significant correlation between adiponectin levels with marker of atherosclerosis (CIMT) in patients with rheumatoid arthritisKeywords : Adiponectin, Atherosclerosis
CORRELATION OF PROSTATIC VOLUME MEASUREMENT BETWEEN TRANSABDOMINAL ULTRASOUND AND CT SCAN Sujana, Biddulth; Mulyadi, Rahmad; Birowo, Ponco; Prihartono, Joedo
Indonesian Journal of Urology Vol 22 No 2 (2015)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v22i2.86

Abstract

Objective: This study aims to determine correlation between measurement of prostatic volume and dimensions using transabdominal ultrasound (TAUS) and Computed Tomographic scan (CT scan) in male population ages 50 years and above. Material & method: Research was conducted at Radiology Department, Cipto Mangunkusumo Hospital, Jakarta. Twenty two patients who underwent whole abdominal CT from Desember 2013 to January 2014, were enrolled and examined using TAUS. Results: The calculation shows there is strong correlation between volume measurement, width, and height dimensions between TAUS and CT scan, where the Spearman correlation indicates r = 0.80 with p = 0.000 for volume measurement and r = 0.81 with p = 0.000 for width dimension and r = 0.64 with p = 0.001 for height dimension. There are also regression formula for estimating volume and dimensions measurements using TAUS. Conclusion: This study show strong correlation between volume and dimensions measurement using TAUS and CT scan.
PERILAKU PEMILIH DALAM PEMILIHAN WALI NAGARI DI KENAGARIAN RABI JONGGOR, GUNUNG TULEH, PASAMAN BARAT, SUMATERA BARAT TAHUN 2014 Rahmad Mulyadi; Raja Muhammad Amin
Jurnal Online Mahasiswa (JOM) Bidang Ilmu Sosial dan Ilmu Politik Vol 5, No 1: WISUDA APRIL 2018
Publisher : Fakultas Ilmu Sosial dan Ilmu Politik Universitas Riau

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Abstract

Choosing is an autonomous activity, in the sense of non-pressure and coercion from others. The sociological approach tends to place voting in relation to the social context. The concrete of one's choice in elections is influenced by demographic and socioeconomic backgrounds, such as gender, residence (city-village), occupation, education, class, income and religion. The sociological approach explains, social characteristics and groupings are factors that influence voter behavior.The research method used in this research is descriptive research with qualitative analysis method. This study aims to see how the behavior of voters in the election Wali Nagari in Kenagarian Rabi Jonggor, Mount Tuleh, West Pasaman, West Sumatra Year 2014 that affect the election of one candidate in Pilwana. This study is also to find out how the shift in voter behavior in the context of the social structure of society in Rabi Jonggor kenagarian previously held by other elite groups. So that the influence of various social factors greatly influence voter behavior in determining the choice that make an elite group in government is shifted by other elite group in Kenagarian Rabi Jonggor.The selection of Wali Nagari in Rabi Jonggor Kenagarian Year 2014 shows that the main factor of voters in determining their choice based on sociological approach can be seen from education side, family background or kinship and social class. These three sides determine the voter's behavior in determining the choice because the other side of the sociological approach is not very influential in determining voter behavior, so that the three sides of voter behavior becomes a reference in determining how voters behavior in the election of Wali Nagari Year 2014.Keywords: Pilwana, Nagari, Sociological Approach, Voter Behavior
Intratumoral and Peritumoral Apparent Diffusion Coefficient and MGMT mRNA Expression in Different Meningioma Histopathological Grade Rahmad Mulyadi; Mochamma Hatta; Andi Asadul Islam; Bachtiar Murtala; Jumraini Tammase; Muhammad Firdaus; Eka Susanto; Joedo Prihartono
The Indonesian Biomedical Journal Vol 13, No 1 (2021)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v13i1.1338

Abstract

BACKGROUND: Histopathological examination is the gold standard for diagnosing meningioma and determining the treatments. However, it is invasive in nature. This study was conducted to identify intratumoral and peritumoral apparent diffusion coefficient (ADC) value and mRNA O6-methylguanine-DNA methyltransferase (MGMT) expression in meningioma.METHODS: Data were collected from 39 patients who were clinically diagnosed with meningioma. However, only 37 patients met the inclusion criteria. These subjects then underwent examinations and received treatment from October 2017 to September 2018. Magnetic resonance imaging (MRI) data with diffusion-weighted imaging-apparent diffusion coefficient (DWI-ADC) sequence, histopathological diagnosis of meningioma, and results of MGMT mRNA expression were obtained.RESULTS: The most frequent type of low-grade and overall tumor was meningioma not otherwise specified (56.8%). For high-grade tumor, there were two atypical cases: atypical meningioma (2.7%) and rhabdoid meningioma (2.7%). Meningothelial meningioma had the highest mean value of minimum intratumoral ADC at 864.57±219 x10-3 mm2/s, whereas rhabdoid meningioma had the lowest at 417 x10-3 mm2/s. For minimum peritumoral ADC, rhabdoid meningioma had the highest mean value at 1,651 x10-3 mm2/s, while atypical meningioma has the lowest at 1,281 x10-3 mm2/s. For MGMT mRNA, meningothelial meningioma had the highest mean value at 10±1.2 fold change, whereas rhabdoid meningioma had the lowest mean at 6.18 fold change.CONCLUSION: WHO grade I meningiomas had higher minimum intratumoral ADC values and higher MGMT mRNA expression than the high-grade tumors. Minimum peritumoral ADC values differed across the histopathological grades.KEYWORDS: meningioma, RNA, messenger, MRI, methyltransferases, RT-PCR, ADC, MGMT mRNA
Association Between Adiponectin Levels with Markers of Atherosclerosis In Patients with Rheumatoid Arthritis Tanggo Meriza; Harry Isbagio; Rahmad Mulyadi; Murdani Abdullah
Indonesian Journal of Rheumatology Vol. 5 No. 1 (2014): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (147.86 KB) | DOI: 10.37275/ijr.v5i1.47

Abstract

Background: Several studies have shown that atherosclerosis underlying processes of Cardiovascular disease (CVD), increased in rheumatoid arthritis (RA) and occurred early (premature). The cause of accelerated atherosclerosis in RA are still unknown.Adipokines have known that the adipokines play a role in the pathophysiology of RA and CVD. Accumulation of visceral fat associated with dysregulation of adipokinesthat influence the development of the atherosclerotic and disruption plaque. Obesity and pathological changes in fat mass and fat dysfunction as well as a change inthe pattern of secretion of proinflammatory adipokines, may have a correlation between heart disease and rheumatic diseases. Adiponectin is one of the mostwidely-studied adipokines. In RA, adiponectin is involved in the pathophysiology of RA that produces of various proinflammatory and prodestructive molecules. So far, adiponectin has been known to provide antiatherosclerotic effects in patients with non-RA. But, several recent studies in RA patients get opposite results in which increased levels of adiponectin are associated with increased prevalence of atherosclerosis. The effect of adiponectin on atherosclerosis in patient with RA is still unknown.Objective: to determine the relationship of adiponectin with atherosclerosis in patients with rheumatoid arthritis. Methods: This is a cross-sectional study conducted on outpatients of the  rheumatology clinic at Cipto Mangunkusumo General Hospital from January untilApril, 2013. Subjects consisted of 50 patients were diagnosed based on ACR 1987/EULAR 2010 criteria. The collection of data obtained by consecutive sampling and evaluated the patients’ medical data that included age, long-suffering of RA, body mass index (BMI), lipid profile, rheumatoid factor levels, levels of anti-cyclic citrullinated peptide (anti-CCP), C-reactive protein (CRP), erythrocyte sedimentation rates (ESR), blood pressure, fasting blood glucose, 2 hour post prandial blood glucose, ECG, examination of serum adiponectin levels and bilateral carotid ultrasound to measure the carotid artery intima media thickness.Results: From the results of the 50 patients studied, obtained 28 (56%) of patients had increased levels of adiponectin. Atherosclerosis was found in 13 (26%) subjects. The median value was 9.46 μg / ml with the lowest levels of 4 μg/ml and the highestlevels of 24μg/ml. The Spearman’s test showed no significant correlation between adiponectin serum and atherosclerosis in patients with RA (p = 0706 and r = 0.055). The analysis results of the correlation of adiponectin with atherosclerosis based on age, disease duration, ESR, rheumatoid factor, DAS 28, CRP, BMI, dyslipidemia showed no significant correlation.Conclusion : From this study, researchers found no statistically significant correlation between adiponectin levels with marker of atherosclerosis (CIMT) in patients with rheumatoid arthritisKeywords : Adiponectin, Atherosclerosis
Predictor Factors of Atherosclerosis and Atherosclerosis Plaque in Rheumatoid Arthritis Patients Joko Rilo Pambudi; Harry Isbagio; Rahmad Mulyadi; Murdani Abdullah
Indonesian Journal of Rheumatology Vol. 8 No. 2 (2016): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (334.45 KB) | DOI: 10.37275/ijr.v8i2.56

Abstract

Background: Atherosclerosis and cardiovascular diseases have been known as the cause of increasing mortality among rheumatoid arthritis (RA) patients. Carotid intima media thickness (CIMT) measurement by ultrasound has been used as surrogate marker of atherosclerosis and cardiovascular disease.Methods: A cross sectional study of 86 RA patients fulfills EULAR/ACR 2010 critera for RA was conducted to study proportion and predictor factors of atherosclerosis and atherosclerosis plaque in rheumatoid arthritis patients.Results: Atherosclerosis and plaque was found in 47,7% and 29 % of patients. Age ≥ 40 yo, hypertension and duration of illness ≥ 24 mo were associated with atherosclerosis in multivariate logistic regression analysis with OR 10.70 (95% CI: 2.93-39.10), 4.99 (95% CI: 1.15-21.61) and 3.66 (95% CI: 1.11-11.99) respectively. Whereas hypertension, presence of antiCCP antibody and age ≥ 40 yo, were associated with plaque formation with OR 3.96 (95% CI: 1.15-13.57), 3.20 (95% CI: 1.11-9.24) and 3.61 (95% CI: 1.03-12.63) respectively.Conclusions: Age ≥ 40 yo, hypertension and duration of illness ≥ 24 mo was the predictors ofatherosclerosis, while hypertension, presence of antiCCP antibody and age ≥ 40 yo was the predictors of atherosclerosis plaque.Key words: atherosclerosis, intima media thickness, predictor, rheumatoid arthritis, ultrasonography.
Strategy to Improve Employee Security Awareness at Information Technology Directorate Bank XYZ Halida Ernita; Yova Ruldeviyani; Desiana Nurul Maftuhah; Rahmad Mulyadi
Jurnal RESTI (Rekayasa Sistem dan Teknologi Informasi) Vol 6 No 4 (2022): Agustus 2022
Publisher : Ikatan Ahli Informatika Indonesia (IAII)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (339.312 KB) | DOI: 10.29207/resti.v6i4.4170

Abstract

Bank handles private information like customer financial transactions and personal data. There was a 63% increase in cyberattacks attempted against Bank XYZ in 2021, and 1,323 attempted attacks on corporate email Bank XYZ. Therefore, implementing security awareness training for all employees is crucial for Bank XYZ. The information security awareness program must be assessed to determine the program's efficiency and the level of information security awareness among employees. Therefore, this study assesses the information security awareness at Bank XYZ, especially the Information Technology (IT) Directorate using the Human Aspect of Information Security Questionnaire (HAIS-Q) method. The findings of this study revealed that employees at Bank XYZ in the information security work unit had a "Good" level of awareness. In contrast, the results from other IT work units were “Medium”. Based on the assessment results, Bank XYZ's security awareness strategy recommendation is to align awareness content with information security policies and procedures, use a variety of media awareness, and focus on the "Internet Use" and "Information Handling" awareness areas. As a way of determining the achievement of information security Key Performance Indicators (KPI), security awareness measurement must be done regularly, for example, once a year.
A Case of Covid-19 Patient Presenting with Gastrointestinal-Specific Symptoms in Indonesia Daniel Martin Simadibrata; Cleopas Martin Rumende; Rahmad Mulyadi; Marcellus Simadibrata
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 21, No 2 (2020): VOLUME 21, NUMBER 2, August 2020
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (264.939 KB) | DOI: 10.24871/2122020153-157

Abstract

Coronavirus disease 2019 (COVID-19) is an emerging infectious disease officially declared as a pandemic on 11 March 2020 by the World Health Organization (WHO). Indonesia’s COVID-19 case fatality rate remain consistently high, approximately twice the global case fatality rate available. Patients typically present with fever, dry cough and dyspnea. However, there were reports of atypical COVID-19 symptoms such as myalgia, fatigue, diarrhea, nausea, and vomiting. These atypical presentations were suggested to indicate a more severe COVID-19. Here, we present a case of COVID-19 patient presenting with gastrointestinal-specific symptoms in Indonesia.
The Role of Endovascular Intervention in Post Liver Hemorrhagic Blunt Trauma Rahmad Mulyadi; Prijo Sidipratomo; Indrati Suroyo; Jakub Pandelaki; Sahat Matondang; Krishna Pandu Wicaksono; Heltara Ramandika
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 21, No 1 (2020): VOLUME 21, NUMBER 1, April 2020
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (242.106 KB) | DOI: 10.24871/211202059-63

Abstract

The liver is the most commonly injured organ in blunt abdominal trauma, and liver trauma is the leading cause of death in abdominal injuries. Liver trauma is associated with high morbidity and mortality, hence thediagnosis and clinical assessment of hepatic trauma play an important role in the management of abdominal liver trauma. Although it is only suitable for patients with stable hemodynamic status, computed tomography(CT scan) is the gold standard for evaluating patients with blunt abdominal trauma, because it can acquire high quality images quickly. For these stable patients, nonsurgical management or endovascular intervention has become the treatment of choice in the majority of liver injuries.