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Predictor Factors of Atherosclerosis and Atherosclerosis Plaque in Rheumatoid Arthritis Patients Pambudi, Joko Rilo; Isbagio, Harry; Mulyadi, Rahmad; Abdullah, Murdani
Indonesian Journal of Rheumatology Vol 8, No 2 (2016)
Publisher : Indonesian Rheumatology Association

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Abstract

Background: Atherosclerosis and cardiovascular diseases have been known as the cause of increasing mortality among rheumatoid arthritis (RA) patients. Carotid intima media thickness (CIMT) measurement by ultrasound has been used as surrogate marker of atherosclerosis and cardiovascular disease.Methods: A cross sectional study of 86 RA patients fulfills EULAR/ACR 2010 critera for RA was conducted to study proportion and predictor factors of atherosclerosis and atherosclerosis plaque in rheumatoid arthritis patients.Results: Atherosclerosis and plaque was found in 47,7% and 29 % of patients. Age ≥ 40 yo, hypertension and duration of illness ≥ 24 mo were associated with atherosclerosis in multivariate logistic regression analysis with OR 10.70 (95% CI: 2.93-39.10), 4.99 (95% CI: 1.15-21.61) and 3.66 (95% CI: 1.11-11.99) respectively. Whereas hypertension, presence of antiCCP antibody and age ≥ 40 yo, were associated with plaque formation with OR 3.96 (95% CI: 1.15-13.57), 3.20 (95% CI: 1.11-9.24) and 3.61 (95% CI: 1.03-12.63) respectively.Conclusions: Age ≥ 40 yo, hypertension and duration of illness ≥ 24 mo was the predictors ofatherosclerosis, while hypertension, presence of antiCCP antibody and age ≥ 40 yo was the predictors of atherosclerosis plaque.Key words: atherosclerosis, intima media thickness, predictor, rheumatoid arthritis, ultrasonography.
Association Between Adiponectin Levels with Markers of Atherosclerosis In Patients with Rheumatoid Arthritis Meriza, Tanggo; Isbagio, Harry; Mulyadi, Rahmad; Abdullah, Murdani
Indonesian Journal of Rheumatology Vol 5, No 1 (2014)
Publisher : Indonesian Rheumatology Association

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Abstract

Background: Several studies have shown that atherosclerosis underlying processes of Cardiovascular disease (CVD), increased in rheumatoid arthritis (RA) and occurred early (premature). The cause of accelerated atherosclerosis in RA are still unknown.Adipokines have known that the adipokines play a role in the pathophysiology of RA and CVD. Accumulation of visceral fat associated with dysregulation of adipokinesthat influence the development of the atherosclerotic and disruption plaque. Obesity and pathological changes in fat mass and fat dysfunction as well as a change inthe pattern of secretion of proinflammatory adipokines, may have a correlation between heart disease and rheumatic diseases. Adiponectin is one of the mostwidely-studied adipokines. In RA, adiponectin is involved in the pathophysiology of RA that produces of various proinflammatory and prodestructive molecules. So far, adiponectin has been known to provide antiatherosclerotic effects in patients with non-RA. But, several recent studies in RA patients get opposite results in which increased levels of adiponectin are associated with increased prevalence of atherosclerosis. The effect of adiponectin on atherosclerosis in patient with RA is still unknown.Objective: to determine the relationship of adiponectin with atherosclerosis in patients with rheumatoid arthritis. Methods: This is a cross-sectional study conducted on outpatients of the  rheumatology clinic at Cipto Mangunkusumo General Hospital from January untilApril, 2013. Subjects consisted of 50 patients were diagnosed based on ACR 1987/EULAR 2010 criteria. The collection of data obtained by consecutive sampling and evaluated the patients’ medical data that included age, long-suffering of RA, body mass index (BMI), lipid profile, rheumatoid factor levels, levels of anti-cyclic citrullinated peptide (anti-CCP), C-reactive protein (CRP), erythrocyte sedimentation rates (ESR), blood pressure, fasting blood glucose, 2 hour post prandial blood glucose, ECG, examination of serum adiponectin levels and bilateral carotid ultrasound to measure the carotid artery intima media thickness.Results: From the results of the 50 patients studied, obtained 28 (56%) of patients had increased levels of adiponectin. Atherosclerosis was found in 13 (26%) subjects. The median value was 9.46 μg / ml with the lowest levels of 4 μg/ml and the highestlevels of 24μg/ml. The Spearman’s test showed no significant correlation between adiponectin serum and atherosclerosis in patients with RA (p = 0706 and r = 0.055). The analysis results of the correlation of adiponectin with atherosclerosis based on age, disease duration, ESR, rheumatoid factor, DAS 28, CRP, BMI, dyslipidemia showed no significant correlation.Conclusion : From this study, researchers found no statistically significant correlation between adiponectin levels with marker of atherosclerosis (CIMT) in patients with rheumatoid arthritisKeywords : Adiponectin, Atherosclerosis
Association between varicocele grade and semen analysis parameter Ariyati, Ira; Mulyadi, Rahmad; Birowo, Ponco; Wiweko, Budi; Prihartono, Joedo
Medical Journal of Indonesia Vol 26, No 4 (2017): December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (660.212 KB) | DOI: 10.13181/mji.v26i4.1623

Abstract

Background: Varicocele is a condition characterized by elongation, dilatation and tortuousity of spermatic vein in pampiniform plexus. Approximately 50% of infertility cases among men are caused by varicocele. The varicocele may affect the components of sperm. This study aimed to determine the association between varicocele grade based on ultrasound Doppler examination and sperm concentration, sperm motility, and sperm morphology based on semen analysis examination.Methods: This was a descriptive, cross-sectional study which used secondary data from 85 patients that visited Department of Urology, Cipto Mangunkusumo Hospital, then underwent ultrasonography examination at Department of Radiology, Cipto Mangunkusumo Hospital and semen analysis examination at Department of Obstetrics and Gynecology, Cipto Mangunkusumo General Hospital.Results: Varicocele grade was significantly associated with sperm morphology, concentration and motility (all p<0.05). Significant association was found between maximum condition and semen analysis component.Conclusion: Varicocele grade may affect semen analysis component.
CORRELATION OF PROSTATIC VOLUME MEASUREMENT BETWEEN TRANSABDOMINAL ULTRASOUND AND CT SCAN Sujana, Biddulth; Mulyadi, Rahmad; Birowo, Ponco; Prihartono, Joedo
Indonesian Journal of Urology Vol 22 No 2 (2015)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v22i2.86

Abstract

Objective: This study aims to determine correlation between measurement of prostatic volume and dimensions using transabdominal ultrasound (TAUS) and Computed Tomographic scan (CT scan) in male population ages 50 years and above. Material & method: Research was conducted at Radiology Department, Cipto Mangunkusumo Hospital, Jakarta. Twenty two patients who underwent whole abdominal CT from Desember 2013 to January 2014, were enrolled and examined using TAUS. Results: The calculation shows there is strong correlation between volume measurement, width, and height dimensions between TAUS and CT scan, where the Spearman correlation indicates r = 0.80 with p = 0.000 for volume measurement and r = 0.81 with p = 0.000 for width dimension and r = 0.64 with p = 0.001 for height dimension. There are also regression formula for estimating volume and dimensions measurements using TAUS. Conclusion: This study show strong correlation between volume and dimensions measurement using TAUS and CT scan.
PENGARUH PENDIDIKAN AGAMA ISLAM DALAM KELUARGA TERHADAP KEDISIPLINAN BERIBADAH SISWA DI SD NEGERI 050677 BASILAM BL Sami'in, Sami'in; Wahidah, Wahidah; Mulyadi, Rahmad
Proceeding International Seminar of Islamic Studies INSIS 6 (February 2024)
Publisher : Proceeding International Seminar of Islamic Studies

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Abstract

Studi kasus ini berawal dari adanya pengaruh pendidikan agama dalam keluarga terhadap kedisiplinan beragama siswa di SDN 050677 Basilam BL. Penelitian ini merupakan penelitian kuantitatif dengan teknik analisis regresi sederhana. Teknik pengumpulan data dilakukan  dengan metode angket, metode angket digunakan untuk mengambil data tentang kedua variable, yakni untuk mengetahui pelaksanaan pendidikan agama dalam keluarga siswa dan kedisplinan beragama siswa. Pengujian hipotesis penelitian ini menggunakan analisis regresi sederhana. Variable penelitian ini yaitu Pendidikan Agama Islam dalam keluarga sebagai variabel bebas dan kedisiplinan beribadah siswa sebagai variabel terikat. Teknik pengumpulan data yang digunakan adalah angket untuk mengukur pengaruh pendidikan agama Islam terhadap kedisiplinan beribadah siswa. Hasil penelitian menunjukan bahwa pendidikan agama Islam dalam keluarga berpengaruh dengan representasi sebesar 45,2%. Sedangkan sisanya 54,8% dipengaruhi oleh variabel lain.
The Effectiveness of Centrifugal Pump Shaft Alignment Process Against Vibration Reduction Mulyadi, Rahmad; Darto, Darto; Iswantoko, Agus
TRANSMISI Vol 18, No 2 (2022): September 2022
Publisher : Universitas Merdeka Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26905/jtmt.v18i2.9209

Abstract

Centrifugal pump is one of the most important components that is widely used by industry and functions to move liquids in the form of water or other liquid. One of the things that often happens on centrifugal pumps is the occurrence of high vibrations and abnormal sounds. High vibration in the pump is something that should be anticipated because it can cause damage to the bearings, seals, and shafts. If the pump continues to operate in this condition, it will also cause damage to other pump components and cause the pump to stop operating. Therefore, the condition of the pump must be monitored regularly to ensure that the pump can operate properly. One of the most frequently used methods to find out where high vibrations come from is to use the aptitude analyst application that will produce a unique vibrational spectrum. Vibration analysis is done by observing the amplitude and frequency of the vibration signal. Vibration spectrum analysis can detect pump damage without having to disassemble the equipment and can provide early warning before major damage occurs and takes a large repair cost. The results showed that the existence of high vibration at the 11-PA-7131A pump was caused by the parallel misalignment that occurred at the pump shaft and motor. This is indicated by the high amplitude of vibration on orders 1x, 2x and followed by the presence of amplitude on orders 3x. Vibration data retrieval after the alignment process on the pump shaft and motor also proves that there is a very significant change in vibration amplitude on orders 1x, 2x, and on order 3x. Overall vibration also experienced a very significant decrease so that the pump can be operated normally.
The Correlation of Inflammatory Markers with Clinical Manifestation, Peritumoral Edema, and Recurrence in Meningioma Patients Aninditha, Tiara; Auliya, Putri; Mulyadi, Rahmad; Aman, Renindra Ananda; Andriani, Rini; Sofyan, Henry Riyanto
Indonesian Journal of Cancer Vol 19, No 2 (2025): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i2.1287

Abstract

Background: Meningiomas can induce inflammation in their tumorigenesis process, thereby linking inflammation with clinical symptoms, peritumoral edema, and recurrence of meningiomas. Easily accessible and cost-effective inflammatory markers include the neutrophillymphocyte ratio (NLR) and monocyte-lymphocyte ratio (MLR). This study aims to investigate the relationship between peripheral inflammation markers, specifically the NLR and MLR, and their association with clinical symptoms, peritumoral edema, and meningioma recurrence.Method: A retrospective cohort study was conducted at Cipto Mangunkusumo National General Hospital from January 2016 to December 2019, utilizing a consecutive non-probability sampling method. Inclusion criteria were patients aged 18 years or older with meningiomas(gradesI-III), first surgery. Peripheral inflammatory markers were derived from differential blood counts, peritumoral edema data from radiological reports, and other data from medical records. The cut-off valuesfor NLR and MLR were determined to be 2.415 and 0.295, respectively. Bivariate analyses using ChiSquare and Mann-Whitney tests were followed by multivariate logistic regression analysis. Results: 173 patients were eligible for analysis. Of these, 27 had preoperative CT scans, 126 had MRIs, and 20 had no preoperative radiology data. Clinical and recurrence analyses were performed on all 173 patients, with radiology and tumor size analyses conducted on subsets of 153 and 126 patients, respectively. The majority of meningiomasin thisstudy were grade I, found in 94.2% of subjects, with the remainder being grade II and III. Higher NLR and MLR values were significantly associated with headaches (p 0.001). Elevated NLR and MLR were also correlated with peritumoral edema (p 0.001). MLR was independently associated with recurrence, with an adjusted odds ratio (aOR) of 12.647 (95% CI 2.355–67.919); p = 0.003.Conclusion: NLR and MLR as peripheral inflammatory markers demonstrated higher median values in meningioma patients with headaches and peritumoral edema. Additionally, inflammation in meningiomas was associated with the occurrence of recurrence.
Indonesia’s COVID-19 Trend After the End of a Public Health Emergency of International Concern: Preparation for an Endemic Novarisa, Nessa; Helda, Helda; Mulyadi, Rahmad
Kesmas Vol. 18, No. 5
Publisher : UI Scholars Hub

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Abstract

Three years into the pandemic, the World Health Organization revoked the COVID-19 public health emergency of international concern on May 5, 2023. This decision sparked debate, notably around the possibility of a surge in cases due to the SARS-CoV-2 mutations. To manage this transition, the Indonesian government enacted stringent controls on case numbers. This case series study provided an overview of COVID-19 case trends in Indonesia following the revocation of public health emergency of international concern status by the World Health Organization. Data were collected for 5 weeks after the statement (May 6–June 10, 2023) from the COVID-19 Task Force’s official online platform of the Indonesian Ministry of Health. The trends were monitored in daily confirmed, active, recovered, and death cases, and analyzed the data using Microsoft Excel and Stata 16. The findings indicated a positive trend for Indonesia, with decreased daily confirmed cases (89.42%) and active cases (44.16%). Recovered cases accounted for 97.47%, higher than the global average (96%). Unfortunately, the death rate (2.38%) exceeded the global statistic (1%). These results highlighted the need for sustained vigilance, enhancement of the 3T strategy (testing, tracing, and treatment), and wider vaccination coverage. It remains critical to uphold the 3M protocols—mask-wearing, physical distancing, and hand hygiene—to prevent a potential rebound in cases, even without the public health emergency of international concern status,as the situation transitions toward endemic COVID-19.