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All Journal Majalah Kedokteran Bandung Health Science Journal of Indonesia Majalah Kedokteran The Indonesian Biomedical Journal Universa Medicina Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Kesehatan Vokasional Indonesian Journal of Rheumatology Journal of Stem Cell Research and Tissue Engineering The New Ropanasuri Journal of Surgery JOURNAL LA MEDIHEALTICO eJournal Kedokteran Indonesia The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia Journal Medical Informatics Technology
Murdani Abdullah
Division Of Gastroenterology Department Of Internal Medicine Faculty Of Medicine Universitas Indonesia/Dr. Cipto Mangunkusumo General National Hospital Jakarta
Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Predictor Factors of Atherosclerosis and Atherosclerosis Plaque in Rheumatoid Arthritis Patients Pambudi, Joko Rilo; Isbagio, Harry; Mulyadi, Rahmad; Abdullah, Murdani
Indonesian Journal of Rheumatology Vol 8, No 2 (2016)
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (334.45 KB)

Abstract

Background: Atherosclerosis and cardiovascular diseases have been known as the cause of increasing mortality among rheumatoid arthritis (RA) patients. Carotid intima media thickness (CIMT) measurement by ultrasound has been used as surrogate marker of atherosclerosis and cardiovascular disease.Methods: A cross sectional study of 86 RA patients fulfills EULAR/ACR 2010 critera for RA was conducted to study proportion and predictor factors of atherosclerosis and atherosclerosis plaque in rheumatoid arthritis patients.Results: Atherosclerosis and plaque was found in 47,7% and 29 % of patients. Age ≥ 40 yo, hypertension and duration of illness ≥ 24 mo were associated with atherosclerosis in multivariate logistic regression analysis with OR 10.70 (95% CI: 2.93-39.10), 4.99 (95% CI: 1.15-21.61) and 3.66 (95% CI: 1.11-11.99) respectively. Whereas hypertension, presence of antiCCP antibody and age ≥ 40 yo, were associated with plaque formation with OR 3.96 (95% CI: 1.15-13.57), 3.20 (95% CI: 1.11-9.24) and 3.61 (95% CI: 1.03-12.63) respectively.Conclusions: Age ≥ 40 yo, hypertension and duration of illness ≥ 24 mo was the predictors ofatherosclerosis, while hypertension, presence of antiCCP antibody and age ≥ 40 yo was the predictors of atherosclerosis plaque.Key words: atherosclerosis, intima media thickness, predictor, rheumatoid arthritis, ultrasonography.
Association Between Adiponectin Levels with Markers of Atherosclerosis In Patients with Rheumatoid Arthritis Meriza, Tanggo; Isbagio, Harry; Mulyadi, Rahmad; Abdullah, Murdani
Indonesian Journal of Rheumatology Vol 5, No 1 (2014)
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (147.86 KB)

Abstract

Background: Several studies have shown that atherosclerosis underlying processes of Cardiovascular disease (CVD), increased in rheumatoid arthritis (RA) and occurred early (premature). The cause of accelerated atherosclerosis in RA are still unknown.Adipokines have known that the adipokines play a role in the pathophysiology of RA and CVD. Accumulation of visceral fat associated with dysregulation of adipokinesthat influence the development of the atherosclerotic and disruption plaque. Obesity and pathological changes in fat mass and fat dysfunction as well as a change inthe pattern of secretion of proinflammatory adipokines, may have a correlation between heart disease and rheumatic diseases. Adiponectin is one of the mostwidely-studied adipokines. In RA, adiponectin is involved in the pathophysiology of RA that produces of various proinflammatory and prodestructive molecules. So far, adiponectin has been known to provide antiatherosclerotic effects in patients with non-RA. But, several recent studies in RA patients get opposite results in which increased levels of adiponectin are associated with increased prevalence of atherosclerosis. The effect of adiponectin on atherosclerosis in patient with RA is still unknown.Objective: to determine the relationship of adiponectin with atherosclerosis in patients with rheumatoid arthritis. Methods: This is a cross-sectional study conducted on outpatients of the  rheumatology clinic at Cipto Mangunkusumo General Hospital from January untilApril, 2013. Subjects consisted of 50 patients were diagnosed based on ACR 1987/EULAR 2010 criteria. The collection of data obtained by consecutive sampling and evaluated the patients’ medical data that included age, long-suffering of RA, body mass index (BMI), lipid profile, rheumatoid factor levels, levels of anti-cyclic citrullinated peptide (anti-CCP), C-reactive protein (CRP), erythrocyte sedimentation rates (ESR), blood pressure, fasting blood glucose, 2 hour post prandial blood glucose, ECG, examination of serum adiponectin levels and bilateral carotid ultrasound to measure the carotid artery intima media thickness.Results: From the results of the 50 patients studied, obtained 28 (56%) of patients had increased levels of adiponectin. Atherosclerosis was found in 13 (26%) subjects. The median value was 9.46 μg / ml with the lowest levels of 4 μg/ml and the highestlevels of 24μg/ml. The Spearman’s test showed no significant correlation between adiponectin serum and atherosclerosis in patients with RA (p = 0706 and r = 0.055). The analysis results of the correlation of adiponectin with atherosclerosis based on age, disease duration, ESR, rheumatoid factor, DAS 28, CRP, BMI, dyslipidemia showed no significant correlation.Conclusion : From this study, researchers found no statistically significant correlation between adiponectin levels with marker of atherosclerosis (CIMT) in patients with rheumatoid arthritisKeywords : Adiponectin, Atherosclerosis
The Role of Melatonin in Improving Hypoxia in Malignant Tumor: A Mini-Review Kartini, Diani; Taher, Akmal; Panigoro, Sonar S.; Setiabudy, Rianto; Jusman, Sri W; Haryana, Sofia M; Abdullah, Murdani; Rustamadji, Primariadewi
The New Ropanasuri Journal of Surgery Vol. 4, No. 2
Publisher : UI Scholars Hub

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Abstract

Correlation between Serum Uric Acid Level and Severity of Coronary Artery Stenosis in Patients with Acute Coronary Syndrome Diding Heri Prasetyo; Sally Aman Nasution; Idrus Alwi; Murdani Abdullah
Majalah Kedokteran Bandung Vol 53, No 1 (2021)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v53n1.2221

Abstract

Acute coronary syndrome (ACS) is a life-threatening disease which remains one of the causes of high morbidity and mortality despite the current advances in treatment. The relationship between the serum uric acid  (SUA) level and ischemic heart disease continues to be controversial and still has not been established as a cardiovascular risk factor. The cooperative interaction between the two factors has not yet fully understood. Prior epidemiological evidence of the causal relationship between the too is still argumentative. Various studies have been done using the same methods; yet, the outcomes were different. This study aimeds to conduct a meta-analysis to synthesize the results of recent studies in order to obtain accurate quantitative data. This systematic study followed the preferred reporting items for systematic reviews and meta-analysis (PRISMA) guideline and studies published in the period of  January 2010 to May 2020 were screened using the Cochrane Library, Ebsco, Medline/PubMed, ProQuest and Science Direct as the sources. Meta-analysis was conducted to synthesize the association between the SUA level and severity of coronary artery stenosis using random effect model to account for possible study heterogeneity. Heterogeneity was assessed using I2 and the meta-analysis was performed using Comprehensive Meta Analysis Version 3 (CMA3) software. Five studies (n = 601 subjects) identified a correlation between serum uric acid level and Gensini score (r = 0.548; p <0.001) in ACS patients. Heterogeneity bias was found in the analysis, whereas publication bias was not found. Thus, the severity of coronary artery stenosis in patients with ACS is positively correlated with serum uric acid level.
The effect of ethanolic leaves extract of soursop (Annona muricata L.) on human colorectal cancer cell line: cell viability and in silico study to cyclin D1 protein Murdani Abdullah; Debby Desmarini; Sofy Meilaini; Puji Sari; Luluk Yunaini; Fadilah Fadilah
Health Science Journal of Indonesia Vol 10 No 2 (2019)
Publisher : Sekretariat Badan Penelitian dan Pengembangan Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/hsji.v12i2.2441

Abstract

Latar Belakang: Kanker kolorektal merupakan transformasi patologis dari epitel kolon dan rektum normal menjadi massa jaringan abnormal, perubahan ini terjadi karena ekspresi berlebih dari protein cyclin D1 yang menginduksi proliferasi sel kolorektal secara berlebihan. Pengobatan dan pencegahan kanker kolorektal dapat dilakukan secara alami dengan mengonsumsi ekstrak daun Annona muricata L. (sirsak). Sirsak dikenal karena banyak komponen fitokimia yang berfungsi sebagai anti kanker. Metode: Penelitian ini menggunakan sel kanker kolorektal HT-29 yang diberi ekstrak etanol daun sirsak dan 5 Fluorourasil (5-FU). Tujuannya untuk menemukan konsentrasi sitotoksisitas yang dapat menghambat 50% populasi sel HT-29 (CC50) dan konsentrasi yang didapat sebelumnya akan diuji dengan metode uji MTT. Analisis docking molekuler dilakukan antara molekul-molekul dari ekstrak etanol daun sirsak terhadap protein Cyclin D1 menggunakan perangkat lunak molecular operating environment (MOE) 2013.08. Hasil: CC50 ekstrak etanol daun sirsak adalah 278 μg / mL dan 5-FU adalah 88 μg / mL. Persentase terendah sel HT-29 yang layak adalah 2 x CC50 setelah perlakuan ekstrak etanol daun sirsak (40,4 ± 1,3%) dibandingkan dengan 5-FU (52,8 ± 4,3%), kontrol pelarut ( 97,2 ± 1,4%), dan kontrol sel (100%). Analisis docking molekuler untuk protein cyclin D1 diperoleh asam N-hexadecanoic dan molekul phytol sebagai kandidat yang baik untuk menghambat protein cyclin D1. Kesimpulan: Ekstrak etanol daun sirsak dapat menurunkan viabilitas sel kultur kanker kolon HT-29 dan berdasarkan analisis molekular docking dilihat dari energi bebas gibbs (ΔG) dan afinitas tertinggi (pKi) diperoleh N-hexadecanoic dan molekul phytol sebagai penghambat protein cyclin D1. (Health Science Journal of Indonesia 2019;10(2):96-102) Kata Kunci: Kanker kolorektal HT-29, ekstrak etanol daun sirsak, viabilitas sel, molecular docking, cyclin D1 Abstract Introduction: Colorectal cancer is a pathological transformation of normal colon and rectum epithelial that becomes an abnormal tissue mass, due to the overexpression of cyclin D1 protein that inducing excessive proliferation of colorectal cell. The treatment and prevention of colorectal cancer could be done naturally by consuming leaves extract of Annona muricata L. (soursop). Soursop is known for many phytochemical components that serve as an anti-cancer. Methods: This study was used HT-29 colorectal cancer cell that treated with ethanolic leaves extract of soursop and 5-Fluorourasil (5-FU) to find the cytotoxicity concentration that can inhibit 50% of HT-29 cell population (CC50) and the next concentrations of them were treated for next treatment with MTT assay. Molecular docking analysis of the compounds of ethanolic leaves extract of soursop to cyclin D1 protein used molecular operating environment (MOE) 2013.08 software. Results: CC50 of ethanolic leaves extracts of soursop was 278 μg/mL dan 5-FU was 88 μg/mL. The lowest percentage of viable HT-29 cell was 2 x CC50 after ethanolic leaves extract of soursop treatment (40,4±1,3%) was compared to 5-FU (52,8±4,3%), solvent control (97,2±1,4%), and cells control (100%). Analysis of molecular docking to cyclin D1 protein was obtained N-hexadecanoic acid and phytol molecules as good candidates to inhibit cyclin D1 protein. Conclusions: The ethanolic leaves extract of soursop could be a good alternative treatment for colorectal cancer and its compounds had ability to inhibit cyclin D1 protein (the highest gibbs free energy (ΔG) and affinity (pKi)). (Health Science Journal of Indonesia 2019;10(2):96-102) Keywords: Colorectal cancer, ethanolic leaves extract of soursop, cell viability, molecular docking, cyclin D1
Effects of Annona muricate Extract on Short Chain Fatty Acid Level of Colorectal Cancer Patients Lili Indrawati; Purwantyastuti; Murdani Abdullah; Ingrid S Surono
Majalah Kedokteran UKI Vol. 36 No. 1 (2020): JANUARI-APRIL
Publisher : Fakultas Kedokteran Universitas Kristen Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/mk.v36i1.2985

Abstract

Annona muricata leaves contains phytochemical substances, such as alkaloids, tannins, flavonoids, saponins, anthraquinones and cardiac glycosides, ellagic acid, triterpenoids, β- sitosterol. Polyphenols are considered to be potential in providing health benefits via modulation the gut microecology. Alteration of the gut microbiota composition can be achieved by consuming of flavonol-rich foods that exerting prebiotic-like effects. Short chain fatty acids (SCFA) that are produced from highly fermentable fibers is considered to be protective against colon cancer. Subjects were assigned consecutively into two group: ethanolic extract of A. muricata, and maltose as placebo. Ssupplementation was conducted for 8 weeks in a capsule. SCFA level assessment was conducted at baseline and the end of the study period. Gas liquid chromatography was used to determine concentration of butyrate. Fiber intake was measured using food record. Concentrations of fecal butyrate levelwas not significantly different between Fraction of A. muricata water extract that is soluble in ethanol (FAMSE) and placebo (p=0.854). Level of others SCFA were also not significantly different. The low fiberintakeisconsistent with the finding on fecal butyrate concentration, as shown by no significant increase in both groups. There is no statistically significant effect of supplementation with ethanol-soluble fraction of A muricata leaves water extract on fecal SCFA level of colo rectal cancer (CRC) patients, andin line with fiber intake below recommended daily allowance throughout the study period. Keywords: phytochemical substances, fiber intake, gut microbiota Abstrak Daun sirsak (Annona muricata) mengandung senyawa fitokimia seperti alkaloid, tanin, flavonoid, saponin, antraquinon, cardiac glycosides, ellagic acid, triterpenoid, dan β-sitosterol. Polifenol memiliki potensi yang baik dalam kesehatan dengan cara memodulasi mikro-ekologi usus. Komposisi microbiota usus dapat berubah dengan cara mengkonsumsi makanan yang banyak mengandung flavonol yang memberikan efek seperti prebiotik. Asam lemak rantai pendek yang dihasilkan dari fermentasi tinggi serat dapat mencegah terjadinya kanker kolon. Subyek penelitian dibagi menjadi dua kelompok secara berurutan, yaitu ekstrak etanol Annonamuricata dan maltosa sebagai plasebo. Pemberian suplemen dilakukan selama 8 minggu dalam bentuk kapsul. Pengukuran kadar asam lemak rantai pendek dilakukan pada awal dan akhir masa studi ini. Pengukuran kadar asam butirat dilakukan dengan kromatografi gas. Asupan serat diukur berdasarkan catatan makanan. Konsentrasi kadar asam butirat pada feses tidak berbeda signifikan dengan fraksi ekstrak air Annona muricata yang larut di dalam etanol dan plasebo (p=0.854). Kadar dari asam lemak rantai pendek lainnya juga tidak berbeda nyata. Asupan serat yang rendah sejalan dengan pengukuran kadar asam butirat di feses yang menunjukkan tidak ada peningkatan secara signifikan pada kedua kelompok. Tidak terdapat pengaruh yang signifikan suplementasi dengan fraksi larut etanol ekstrak air daun Annona muricata pada konsentrasi asam lemak rantai pendek feses dari pasien kanker kolon dan hal itu sejalan dengan asupan serat dibawah rekomendasi harian yang dilakukan selama masa studi ini. Kata kunci: fitokimia, asupan serat, microbiota saluran cerna
Secretomes of Primary Cancer-associated Fibroblasts Upregulate the Expression of Stemness Markers in HT-29 Human Colorectal Carcinoma Cells Septelia Inawati Wanandi; Dwi Retna Lestari; Noza Hilbertina; Nurjati Chairani Siregar; Sri Widia Jusman; Murdani Abdullah
The Indonesian Biomedical Journal Vol 12, No 4 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i4.1295

Abstract

BACKGROUND: Cancer-associated fibroblast (CAF) is the most abundant tumor stroma. Our previous study has demonstrated that the secretomes of CAF isolated from colorectal carcinoma (CRC) patients could induce epithelial-mesenchymal transition in the HT-29 CRC cell line. However, the role of CAF secretomes in CRC stemness is needed to be further investigated. Therefore, the present study aimed to investigate the effect of CAF secretomes from CRC patients on the expression of stemness markers in HT-29 CRC cells in comparison with the secretomes from normal fibroblasts.METHODS: Fibroblasts were isolated from tumor (CAF) and their counterpart non-tumor (NF) areas of three CRC patients undergone surgical resection. Normal preputium fibroblasts (PF) were isolated during circumcision of three healthy boys aged 8 years. All fibroblasts were grown in free-serum culture medium for 24 hours to collect 50% (v/v) conditioned medium (CM). Then, CM was supplemented to HT-29 CRC cells for 72 hours. The effects of CAF- and NF-CM on the mRNA expression of CD44, CD133, OCT4, and ALDH1A1 were analysed using qRT-PCR. Cells proliferation was measured using the trypan blue exclusion assay.RESULTS: Supplementation of CAF-CM (50% v/v) significantly increased CD44, CD133, OCT4, and ALDH1A1 mRNA expressions compared to that of NF-CM and control without supplementation but had no effect on the proliferation of HT-29 cells.CONCLUSION: CAF secretomes from CRC patients upregulate the expression of CRC stemness.KEYWORDS: cancer-associated fibroblasts, ALDH1A1, OCT4, CD44, CD133, colorectal carcinoma
Culture-and nonculture-based antibiotics for complicated soft tissue infections are comparable Ronald Irwanto; Suhendro Suhendro; Khie Chen; Murdani Abdullah
Universa Medicina Vol. 32 No. 1 (2013)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2013.v32.20 - 28

Abstract

BACKGROUNDData collected in 2010 from Cipto Mangunkusumo Hospital indicate thatcomplicated skin and soft tissue infections accounted for more than 10% ofcases. Etiological diagnoses are based on the findings on bacterial culture andthus evaluation of the effectiveness of bacterial culture becomes a necessity.The purpose of this study was to evaluate the operational effectiveness ofbacterial culture for etiological diagnosis of complicated skin and soft tissueinfections.METHODSThis was a historical cohort study using secondary data of patients withcomplicated skin and soft tissue infections admitted for hospitalization to CiptoMangunkusumo Hospital, Jakarta from July 2011 to July 2012. The 90 subjectsmeeting the inclusion and exclusion criteria were divided into 2 groups of 45patients each. Group 1 comprised patients who received initial antibiotic therapyaccording to cultural results, while the patients in group 2 received initial antibiotictherapy without reference to cultural results. Successful diagnostic culture wasassessed by the absence of therapeutic failure. Therapeutic failure wasdetermined using 3 parameters that had to be fulfilled, viz. absence of antibioticescalation, repeat operations, and clinical deterioration. The latter parameterwas assessed by clinical judgement of the attending physician.RESULTSAfter controlling for confounding variables (age, severity of infection,comorbidity), there was no statistical difference in therapeutic success betweenculture-based and non-culture based initial antibiotic therapies (OR=0.45,p=0.085).CONCLUSIONThis study demonstrates the ineffectiveness of bacterial culture as a diagnosticcriterion for appropriate antibiotic therapy of complicated skin and soft tissueinfections.
Association Between Adiponectin Levels with Markers of Atherosclerosis In Patients with Rheumatoid Arthritis Tanggo Meriza; Harry Isbagio; Rahmad Mulyadi; Murdani Abdullah
Indonesian Journal of Rheumatology Vol. 5 No. 1 (2014): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (147.86 KB) | DOI: 10.37275/ijr.v5i1.47

Abstract

Background: Several studies have shown that atherosclerosis underlying processes of Cardiovascular disease (CVD), increased in rheumatoid arthritis (RA) and occurred early (premature). The cause of accelerated atherosclerosis in RA are still unknown.Adipokines have known that the adipokines play a role in the pathophysiology of RA and CVD. Accumulation of visceral fat associated with dysregulation of adipokinesthat influence the development of the atherosclerotic and disruption plaque. Obesity and pathological changes in fat mass and fat dysfunction as well as a change inthe pattern of secretion of proinflammatory adipokines, may have a correlation between heart disease and rheumatic diseases. Adiponectin is one of the mostwidely-studied adipokines. In RA, adiponectin is involved in the pathophysiology of RA that produces of various proinflammatory and prodestructive molecules. So far, adiponectin has been known to provide antiatherosclerotic effects in patients with non-RA. But, several recent studies in RA patients get opposite results in which increased levels of adiponectin are associated with increased prevalence of atherosclerosis. The effect of adiponectin on atherosclerosis in patient with RA is still unknown.Objective: to determine the relationship of adiponectin with atherosclerosis in patients with rheumatoid arthritis. Methods: This is a cross-sectional study conducted on outpatients of the  rheumatology clinic at Cipto Mangunkusumo General Hospital from January untilApril, 2013. Subjects consisted of 50 patients were diagnosed based on ACR 1987/EULAR 2010 criteria. The collection of data obtained by consecutive sampling and evaluated the patients’ medical data that included age, long-suffering of RA, body mass index (BMI), lipid profile, rheumatoid factor levels, levels of anti-cyclic citrullinated peptide (anti-CCP), C-reactive protein (CRP), erythrocyte sedimentation rates (ESR), blood pressure, fasting blood glucose, 2 hour post prandial blood glucose, ECG, examination of serum adiponectin levels and bilateral carotid ultrasound to measure the carotid artery intima media thickness.Results: From the results of the 50 patients studied, obtained 28 (56%) of patients had increased levels of adiponectin. Atherosclerosis was found in 13 (26%) subjects. The median value was 9.46 μg / ml with the lowest levels of 4 μg/ml and the highestlevels of 24μg/ml. The Spearman’s test showed no significant correlation between adiponectin serum and atherosclerosis in patients with RA (p = 0706 and r = 0.055). The analysis results of the correlation of adiponectin with atherosclerosis based on age, disease duration, ESR, rheumatoid factor, DAS 28, CRP, BMI, dyslipidemia showed no significant correlation.Conclusion : From this study, researchers found no statistically significant correlation between adiponectin levels with marker of atherosclerosis (CIMT) in patients with rheumatoid arthritisKeywords : Adiponectin, Atherosclerosis
Predictor Factors of Atherosclerosis and Atherosclerosis Plaque in Rheumatoid Arthritis Patients Joko Rilo Pambudi; Harry Isbagio; Rahmad Mulyadi; Murdani Abdullah
Indonesian Journal of Rheumatology Vol. 8 No. 2 (2016): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (334.45 KB) | DOI: 10.37275/ijr.v8i2.56

Abstract

Background: Atherosclerosis and cardiovascular diseases have been known as the cause of increasing mortality among rheumatoid arthritis (RA) patients. Carotid intima media thickness (CIMT) measurement by ultrasound has been used as surrogate marker of atherosclerosis and cardiovascular disease.Methods: A cross sectional study of 86 RA patients fulfills EULAR/ACR 2010 critera for RA was conducted to study proportion and predictor factors of atherosclerosis and atherosclerosis plaque in rheumatoid arthritis patients.Results: Atherosclerosis and plaque was found in 47,7% and 29 % of patients. Age ≥ 40 yo, hypertension and duration of illness ≥ 24 mo were associated with atherosclerosis in multivariate logistic regression analysis with OR 10.70 (95% CI: 2.93-39.10), 4.99 (95% CI: 1.15-21.61) and 3.66 (95% CI: 1.11-11.99) respectively. Whereas hypertension, presence of antiCCP antibody and age ≥ 40 yo, were associated with plaque formation with OR 3.96 (95% CI: 1.15-13.57), 3.20 (95% CI: 1.11-9.24) and 3.61 (95% CI: 1.03-12.63) respectively.Conclusions: Age ≥ 40 yo, hypertension and duration of illness ≥ 24 mo was the predictors ofatherosclerosis, while hypertension, presence of antiCCP antibody and age ≥ 40 yo was the predictors of atherosclerosis plaque.Key words: atherosclerosis, intima media thickness, predictor, rheumatoid arthritis, ultrasonography.
Co-Authors A.A. Ketut Agung Cahyawan W Aan Santi Aan Santi Aan Santi Aan Santi Abdul A. Rani Abdul Aziz Rani Abdul Aziz Rani Abdul Aziz Rani Abdul Aziz Rani Abdullah, Arman Adel Achmad Fauzi ACHMAD FAUZI Achmad Fauzi Achmad, Ibrahim Adang Bachtiar Adang Sabarudin Adeputri Tanesha Idhayu Adeputri Tanesha Idhayu Adiningsih Srilestari Adiningsih Srilestari Aditya Rachman Aditya Rachman Aditya Rachman, Aditya Adityo Susilo, Adityo Adli, Mizanul Afifah Is Afistianto, Muhammad Fikri Agus Sudiro Waspodo Ahmad Fauzi Ahmad Hazim Ahmad Soefyani Ahmar Abyadh Aida Lydia Akmal Taher Alexander, Reinaldo Ali Djumhana Ali Imron Yusuf Amanda P Utari, Amanda P Amanda Pitarini Utari Anastasia Yoveline Anastasia Yoveline Andri Sanityoso Andri Sanityoso Angraeni, Sri Anthony Eka Wijaya Anthony Eka Wijaya Ari F Syam Ari F Syam Ari F. Syam Ari Fahrial Syam Ari Fahrial Syam Ari Wijayanti Ariadi Humardani Arief Pattiiha Arif Mansjoer Arleni Bustami Arman A Abdullah Arman Adel Abdullah Arnelis Arnelis Artati Murwaningrum Artati Murwaningrum, Artati Ascobat, Purwantyastuti Asysyifa, Nisrina Aziz Rani Azzaki Abubakar Azzaki Abubakar, Azzaki Batara Bisuk Birry Karim Bisuk, Batara Bona Adhista Budhi Setianto Budi Tan Oto Budiman Budiman Bela Budiman Budiman Budimutiar, Felix C Martin Rumende C Martin Rumende C Martin Rumende Ceva W. Pitoyo Chairul R Nasution Chatarina Umbul Wahyuni Chudahman Manan Chudahman Manan Chudahman Manan Chyntia Olivia Maurine Jasirwan, Chyntia Olivia Maurine Chyntia Olivia MJ Cleopas Martin Rumende Cosphiadi Irawan Czeresna Heriawan Soejono Dadang Makmun Dadang Makmun Dadang Makmun Dadang Makmun Daldiyono Daldiyono Daldiyono Daldiyono Daldiyono Hardjodisasto Daldiyono Hardjodisastro Daniel Martin Simadibrata Daniel Martin Simadibrata Dante Saksono Dante Saksono Harbuwono Dasril Nizam Debby Desmarini Deddy Gunawanjati Dewantoro, Okto Dharmeizar Dharmeizar Dharmeizar Dharmeizar Dharmika Djojoningrat Diah Rini Handjari Diah Rini Handjari Diani Kartini Diany N Taher Diding Heri Prasetyo Diding Heri Prasetyo Djumhana A Dolly Dolven Kansera Donnie Lumban Gaol Dono Antono Dwi Retna Lestari Dyah Purnamasari E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri E. Mujaddid Edy Rizal Wahyudi Ekowati Rahajeng Ekowati Rahajeng Ellen Susanti Elli Arsita Elli Arsita Em Yunir Em Yunir, Em Ening Krisnuhoni Eric Daniel Tenda Evy Yunihastuti Fadilah Fadilah Fahmi Razi Darkuthni Fauzi Ahmad Muda Fiastuti Witjaksono Firsyada, Fajar Fransiska Hardi Fumiaki Kitahara Gaol, Donnie Lumban Giri Aji Giri Aji, Giri Guntur Darmawan Haloho, Raja Mangatur Harini Oktadiana Harini Oktadiana, Harini Harmani Kalim Harry Isbagio Harry Isbagio Harry Isbagio Haryana, Sofia M Haryanto Surya Hasan Maulahela Hasan Mihardja Hasan Mihardja Hasan Mihardja Hayatun Nufus Hazim, Ahmad Herdiman T Pohan Herdiman T. Pohan Herdiman T. Pohan Heri Wibowo Hilda Nurmalihah Hiroyuki Otsuka Hotmen Sijabat I. D.N. Wibawa Ibrahim Basir Ibrahim Basir Ibrahim Basyir Ibrahim, Febiansyah Idrus Alwi Idrus Alwi Idrus Alwi Idrus Alwi Ifransyah Fuadi Ifransyah Fuadi, Ifransyah Ika Prasetya Wijaya Ikhwan Rinaldi Ilum Anam Ilum Anam, Ilum Ilyas, Mohammad Imelda Maria Loho, Imelda Maria Indira Kemalasari Indra Marki Indra Marki Inge Sutanto Ingrid S Surono Ingrid S Surono Ingrid S. Surono Irfan Maulani Iris Rengganis Irsan Hasan Irwin Tedja Irwin Tedja Iskandar, Rizka Puteri Ivo Novita Sah Bandar Jacobus Albertus Jaffray DP Rambak Jamhari Jamhari Jane Estherina Jeanne Adiwinata Pawitan Jeffri Gunawan Jeffry Beta Tenggara Jimmy Posangi Joko Rilo Pambudi Jonlean, Reganedgary Joseph JY Sung Judo Prihartono Julwan Pribadi Jumhana Atmakusuma Jusman, Sri W Kahar Kusumawidjaja Kahar Kusumawidjaja, Kahar Kaka Renaldi Katharina Setyawati Kemalasari, Indira Kemalasari, Indira Khie Chen Khomimah Khomimah Khomimah Khomimah, Khomimah Kuntjoro Harimurti Laras Budiyani, Laras Lianda Siregar Liem, Isabella Kurna Liem, Isabella Kurnia Lies Luthariana Lili Indrawati Lili Indrawati Lili Indrawati Luluk Yunaini Lusiani Lusiani Lusiani Lusiani, Lusiani Lutfiah, Evah M Purnomo Isnaeni M Usman SM Maharani, Shabrina Mansur, M. Tasrif Marcellus Simadibrata K Margaluta, Ariansah Marthino Robinson Maruhum B.H. Marbun Masayuki A Fujino Masayuki A. Fujino Masdalina Pane Maulana Suryamin Maulana Suryamin, Maulana Meriza, Tanggo Minarma Siagian Moch Ikhsan Mokoagow Mochamad Iqbal Hassarief Putra Mochamad Iqbal Hassarief Putra, Mochamad Iqbal Hassarief Mohammad Adi Firmansyah Mondrowinduro, Prionggo Muhadi Muhadi Muhadi Muhadi, Muhadi Muhammad Artisto Adi Yussac Muhammad Artisto Adi Yussac MUHAMMAD SYAFIQ Muhammad Yamin Muhammad Yamin Muhammad Yamin Lubis Muhammad Yamin Lubis, Muhammad Yamin Mulia Mulia Mulia Mulia Mustikarani, Dewi Mutiara, Rizka Nababan, Saut Horas Hatoguan Nana Supriana Nana Supriana Nanda N. Muhammad Nanda N. Muhammad, Nanda N. Nata Pratama Hardjo Lugito Nikko Darnindro Novie Rahmawati Zirta Noza Hilbertina Nully Juariah M Nur Rasyid Nur Rasyid Nur Riviati, Nur Nurjati Chairani Siregar Nury Dyah Nury Dyah, Nury Oktarina, Caroline Okto Dewantoro Pambudi, Joko Rilo Pamela Abineno Pamela Abineno Damaledo Pangarapen Tarigan Pangestu Adi Parhusip, Santi Sumihar Rumondang Pattiiha, Arief Paulus Kusnanto Paulus Simadibrata Pradipta, Saraswati Primariadewi Rustamadji Prionggo Mondrowinduro Puji Sari Purwantyastuti Purwantyastuti Purwantyastuti Purwantyastuti Purwantyastuti Purwita W Laksmi, Purwita W Purwoko, Reza Yuridian Rabbinu Rangga Pribadi Raden Nur Ista Rahmad Mulyadi Raja Mangatur Haloho Raja Mangatur Haloho Ralph Girson Rambe, Dirga S. Ratu Ratih Kusumayanti Raymond R. Tjandrawinata Reinaldo Alexander Riahdo Saragih Rianto Setiabudy Rino A Gani Rio Zakaria Risa Ismadewi Risa Ismadewi, Risa Rizka Mutiara Rizka Puteri Iskandar Rizki Yaruntradhani Ronald Irwanto Roy Soetikno Rozaliyan, Anna Rudi Putranto Rumagesan, Djahalia Rumende, Cleopas M. Ryan Ranitya Sabarudin, Adang Saleha Sungkar Salius Silih Sally Aman Nasution Sari, Nina Kemala Sarwono Waspadji Sarwono Waspadji Saskia Aziza Nursyirwan Sedijono Sedijono Septelia I. Wanandi Seri Mei Maya Ulina Simadibrata, Daniel Martin Simanjuntak, Tiroy Sari Bumi Sirowanto Inneke Siti Setiati Sofy Meilaini Soleha, Winna Sonar Panigoro Sri Wahdini Sri Widia A.Jusman Starry H. Rampengan Steven Sumantri Sudirman Katu Sudirman Katu, Sudirman Sugita, Peter Suhardjono Suhardjono Suhardjono Suhardjono Suharko Soebardi Suharko Suharko Suhendro Suhendro Suhendro Suhendro Suhendro Suhendro Suhendro Suwarto Suhendro Suwarto Suhendro Suwarto, Suhendro Sukamto Koesnoe Sumariyono Sumariyono Sumariyono Sumariyono Surono, Ingrid S Suryantini Suryantini Suryantini Suryantini Susanto, Liana W SUWIJIYO PRAMONO Suzana Ndraha Suzanna Immanuel Syari, Lucky Novita Tadashi Sato Tanadi, Caroline Tandan, Manu Tandarto, Kevin Tanggo Meriza Telly Kamelia Tito Ardi Tjahjadi Robert Tedjasaputra Toman L Toruan Tonny Loho Tonny Loho TR Fitriyani TR Fitriyani, TR Tri Juli Edi T Ummi Ulfah Madina Ummi Ulfah Madina, Ummi Ulfah Ummu Habibah Ummu Habibah, Ummu Velma Herwanto Velma Herwanto Vera Yuwono Vesri Yoga Virly Nanda Muzellina Wijaya, Anthony Eka Wirasmi Marwoto Wirasmi Marwoto Wismandari Wisnu Wulyo Rajabto Yohana Sitompul Yohana Sitompul, Yohana Yohannessa Wulandari Yonathan, I Wayan Murna Yuichiro Kojima Yundari, Yundari Yustar Mulyadi Zubairi Djoerban Zubairi Djoerban