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All Journal Medical Journal of Indonesia Indonesian Journal of Rheumatology The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia
Harry Isbagio
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Medicine & Pharmacology

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Journal : Medical Journal of Indonesia

 1 
Comparison of urinary excretion of Deoxypiridinoline and value of serum Osteocalcin within the Knee Osteoarthritis grading Isbagio, Harry
Medical Journal of Indonesia Vol 13, No 2 (2004): April-June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (85.993 KB) | DOI: 10.13181/mji.v13i2.135

Abstract

The identification of molecular markers, which reflects differences in disease progression rates in Osteoarthritis (OA), would greatly facilitate clinical studies. Urinary Deoxypyridinoline (UDPD) and serum osteocalcin (OC) had been widely used for marker of bone metabolism, but the use for molecular marker in OA was lack of data. Recent studies show that there were conflicted results between urinary excretion of DPD and serum OC value within knee OA grading. The aim of this study is to compare of urinary excretion of DPD and the level of serum OC as destructive parameter of cartilage within the knee OA grading. This cross sectional study comprise of 69 patients with OA of knee joints. Kellgren and Lawrence scale was use for grading of OA. Group of patients with knee OA grade 2 call as group of early OA and group of patients with knee OA grade 3 and 4 calls as group of late OA. DPD in urine was measured using Immuno-chemilunescence, serum osteocalcin was measured using Elisa method. The mean value of urinary concentrations of DPD in OA patients was higher than normal value (9.79 ± 7.28 nM DPD/mM Creatinin), and the mean value of serum OC within normal value (8.49 ± 4.68 ng/mL). There were no significant differences of age, body mass index (BMI), duration of illness, urinary excretion of UDPD and serum OC level between early and late OA. In conclusion, there is no significant difference of urinary excretion of DPD and serum OC level within knee OA grading. The use of urinary DPD and serum OC as molecular markers of progression of OA needed to be explored by other longitudinal study. (Med J Indones 2004; 13: 96-101) Keywords: Knee osteoarthritis, deoxypiridinoline, osteocalcin
Use of anti-citrullinated peptide (Anti –CCP) antibodies in distinguishing patients with systemic lupus erythematosus and rheumatoid arthritis Isbagio, Harry
Medical Journal of Indonesia Vol 13, No 4 (2004): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (230.912 KB) | DOI: 10.13181/mji.v13i4.157

Abstract

Diagnosis of Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) can be confused in their initial stages. The joints, especially the hands, are commonly affected in both disorders, many patients with SLE are initially misdiagnosed as having RA Given that the outcome for the two diseases is diverse, it would be helpful to have serological marker to distinguish between them at onset. Anti-citrullinated peptide antibodies (anti-CCP) have recently been described as highly specific for RA. The objective of this study is to confirm the specificity of anti-CCP antibodies and to determine whether they might distinguish patients with RA from those with SLE. This study is a cross sectional study on a group of patients with RA (n=27), SLE with arthritis (n=20), other autoimmune diseases (non-rheumatic diseases, n = 8), and healthy adults (n=20). Anti-CCP was determined by a commercial Elisa test and Rheumatoid factor (RF) was determined by the standard slide latex test. The sensitivity and specificity of anti-CCP for the diagnosis of RA was 63.0% and 97.9% respectively, comparing with RF for RA that was 40.7 % and 85.4 %. Only 1 healthy adult was anti-CCP+, no anti-CCP was detected from SLE and other autoimmune disease. The mean of titer anti CCP in normal healthy adult, other autoimmune diseases, SLE and RA was 1.35 ± 2.04, 0.63 ± 0.59, 0.75 ± 0.59, and 38.17± 44.22 RU/ml, respectively. There was a highly significant difference between the mean of titer anti CCP for RA with others diseases (p <0.001). We conclude that detection of anti-CCP is very useful for the diagnosis of RA and distinguishing RA from SLE. (Med J Indones 2004; 13: 227-31)Keywords: Rheumatoid Arthritis, Systemic Lupus Erythematosus, anti-CCP antibodies
Co-Authors Amanda Pitarini Utari Anna Ariane Ardani, Yanuar Aulia Rizka, Aulia Awalia Awalia Bambang Setyohadi Bernard Agus Sakti Dhaki, Bernard Agus Sakti Budiman Darmowidjojo, Budiman Chudahman Manan Chudahman Manan Cleopas Martin Rumende Deddy Nur Wachid Achadiono Diana, Nyimas Dono Antono Dwi Budi Darmawati E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Eka Ginanjar Em Yunir, Em Faisal Parlindungan Gede Kambayana Handono Kalim Herikurniawan, Herikurniawan I Nyoman Suarjana Irman Firmansyah Joewono Soeroso Kasjmir, Yoga I Laniyati Hamijoyo, Laniyati Meriza, Tanggo Murdani Abdullah Nyoman Suarjana Pambudi, Joko Rilo Pasha, Mochamad Pradana Soewondo Pramono, A Prathitasari, Rahma Anindya Rachmat Gunadi Wachjudi Rahmad Mulyadi, Rahmad Rakhma Yanti Hellmi Rudi Putranto Rudy Hidayat Rudy Hidayat Shuffrie Effendi, Shuffrie Siti Setiati Soegondo, S Sukamto Koesnoe Sumariyono Sumariyono Vera D. Joewono Zuljasri Albar