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Slamet Rahardjo
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PERBANDINGAN PROFIL FARMAKOKINETIK DOKSISIKLIN APLIKASI INTRAVENA DAN INTRAMUSKULER PADA ULAR SANCA ( PHYTON RETICULATUS ) Agustina Dwi Wijayanti; Slamet Rahardjo; Gagak Donny Satria
Jurnal Sain Veteriner Vol 27, No 1 (2009): JUNI
Publisher : Fakultas Kedokteran Hewan Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3313.913 KB) | DOI: 10.22146/jsv.306

Abstract

Penelitian farmakokinetik doksisiklin pada ular sanca (Phyton reticulatus) ini dilakukan untuk mengetahui profil fannakokinetik obat pemberian intravena dan intramuskuler serta untuk mengetahui tingkat efektivitasnya melalui perbandingan kadar dengan nilai MIC (Minimum Inhibitory Concentration) beberapa agen infeksi yang penting.Hewan yang digunakan adalah 6 ekor ular sanca dewasa yang dibagi menjadi 2 kelompok perlakuan. Kelompok 1 diberi doksisiklin dosis 25 mg/kg bb lewat vena palatina dorsalis dan kelompok 2 melalui muskulus bagian sepertiga anterior.Darah diambil secara intrakardia pada menit ke 30,jam ke-I, 2, 4, 8, 24, 48, 72, 96 dan 120 setelahpemberianobat. Plasma dikoleksi secara sentrifugasi dan diekstraksi menggunakan asam trikloroasetat. Selanjutnya plasma dianalisis dan dilakukan pengukuran kadar obat secara HPLC (High Peiformance Liquid Chromatography), menggunakan fase gerak larutan asam oxalat : metanol: asetonitril (6:3:I) dan kolom C18. Parameter farmakokinetikyang dihasilkan untuk intravena adalah AUC 7135,155 uglmL.menit, Clearence 3,5 mLimenit/kg, Cmax 95,465 uglmL,Tmax 30menit,Tl/2 44,42 jam dan Vd 13477,1mL/kg bb dan untuk intramuskuler AUC 1185,56f.lglmL.menit, Clearence 3,49mL/menit/kg, Tmax 24 jam, Cmax 0,191 ug, T1/220,6 jam, Vd 62500 mL /kg bb. Kadar rata-rata obathinggajam ke 120 (5 hari) masih di atas minimum inhibory concentration (MIC) beberapa agen infeksi yang penting pada reptilia.Untuk selanjutnya, diperlukan penelitian untuk mengetahui MIC agen-agen infeksi pada ular sanca untuk dapat secara tepat mengetahui efikasi doksisiklin.Kata kunci: profil farmakokinetik, doksisiklin, ular sanca
Korelasi Antara Panjang Tubuh Terhadap Berat Tubuh Ular Sanca Batik (Phytonreticulatus) Slamet Rahardjo; Albert Jackson Yang; Guntari Titik Mulayni; Soedarmanto Indarjulianto; Ida Tjahajati
Jurnal Sain Veteriner Vol 26, No 1 (2008): JUNI
Publisher : Fakultas Kedokteran Hewan Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2208.618 KB) | DOI: 10.22146/jsv.409

Abstract

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Profil Farmakokinetik Amikasin Pemberian Intravena Melalui Vena Sublingualis dan Coccygea pada Ular Sanca Batik (PHARMACOKINETIC PROFILE OF AMIKACIN ADMINISTERED INTRA VENOUSLY VIA SUBLINGUAL AND COCCYGEA VEINS IN BROGHAMMERUS RETICULATUS) Agustina Dwi Wijayanti; Slamet Rahardjo; Antasiswa Windraningtyas Rosetyadewi; Adi Tri Septyanto
Jurnal Veteriner Vol 15 No 1 (2014)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (100.492 KB)

Abstract

The research was conducted to find out the pharmacokinetic profile of amikacin in sanca batik snake(Broghammerus reticulatus) which is expected to be beneficial in the therapy management of reptiliaes.The eight of adult snakes with averages body weight of 2-14 kg were used and they were devided into twogroups (n=4). Amikacin (5 mg/kg bw) was given by sublingualis (anterior) or coccygea (posterior) venous ingroups, respectively. Blood samples were collected by intracardiac puncture to all snakes at minutes 1,5,10, 30, 60, 120, 240, 480, 960, 1440 (24 hours) and 2880 (48 hours) post administrations. Bloods werecollected using heparinized tubes and sentrifuged at 2500 G to obtain the plasma. The Plasma sampleswere stored at -200c. Plasma were firstly extracted with trichloroacetid acid solution 10% and then injectedinto High Performace Liquid Chromatography Shimadzu 6.1. The results of amikacin levels werestatistically lower on sublingualis vein administration as compared to that of coccygea vein administrationusing Student T-Test (P<0.05). The pharmacokinetic parameters were calculated with non compartementalmethod resulted for anterior application : Vd 3.6 L, clearance 0.066 mL/minute/kg, AUC 75.384 ug/mL.minute and for posterior application : Vd 0.78 L, T1/2 213.09 hours, clearance 0.427 mL/minute/kg,AUC 117.143,7 ug/mL/minute.
Diagnosis Feline Panleukopenia Berdasar Total Leukosit dan Uji Feline Parvovirus-Antigen pada Kucing-Kucing Diare Hary Purnamaningsih; Soedarmanto Indarjulianto; Yanuartono Yanuartono; Alfarisa Nururrozi; Irkham Widiyono; Slamet Rahardjo; Sri Hartati; Rusmihayati Rusmihayati
Jurnal Veteriner Vol 23 No 1 (2022)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (262.718 KB) | DOI: 10.19087/jveteriner.2022.23.1.36

Abstract

Feline panleukopenia (FPL) is one of the most common disease that causes diarrheal and leukopenia in cats. The purpose of this study was to diagnose FPL based on total leukocyte and detection of feline parvovirus antigen (FPV-Ag) in diarrhea cats. This study used blood samples and feces swabs from 21 cats that showed symptoms of diarrhea. Total leukocytes are calculated from blood samples and the presence of FPV antigens is detected from feces swabs using FPV-Ag-kit. The suitability of the FPL diagnosis based on leukopenia and a positive reaction to the FPV-Ag test was compared using the Cohen’s Kappa suitability test. The results showed that 14 out of 21 cats (66.7%) had leukopenia and 7 of 21 cats (33.3%) had normal total leukocytes. Results of FPV-Ag test showed that 11 of 21 cats (52%) were positive and 10 of 21 cats (48%) were negative. The both test has a good agreement with a 0.71 conformity value. Based on this study it was concluded that the diagnosis of FPL based on total leukocyte and FPV-Ag have a good agreement, so that both tests could be used as a basis for FPL diagnosis.
Co-Authors Adi Tri Septyanto Agustina Dwi Wijayanti Agustina Dwi Wijayanti Albert Jackson Yang Alfarisa Nururrozi Antasiswa Windraningtyas Rosetyadewi Gagak Donny Satria Guntari Titik Mulayni Hary Purnamaningsih Ida Tjahajati Irkham Widiyono Rusmihayati Rusmihayati Soedarmanto Indarjulianto Soedarmanto Indarjulianto Sri Hartati Yanuartono Yanuartono