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All Journal Jurnal Kimia (Journal of Chemistry) Jurnal Kartika Kimia FITOFARMAKA: Jurnal Ilmiah Farmasi
Fajar Fauzi Abdullah
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Medicine & Pharmacology

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STIGMASTANE-STEROID FROM THE BARK OF Chisocheton lasiocarfus (Meliaceae) Nurlelasari Nurlelasari; Fajar Fauzi Abdullah; Nadya Thufaila; Rani Maharani; Desi Harnet; Ace Tatang Hidayat; Unang Supratman
Jurnal Kimia (Journal of Chemistry) Vol. 11. No.2 Juli 2017
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (199.211 KB) | DOI: 10.24843/JCHEM.2017.v11.i02.p11

Abstract

Stigmastan-steroid, stigma-4-ene-3-on (1) has been isolated from the bark of Chisocheton lansiocarpus. The chemical structure of stigmastan-steroid was identified based on spectroscopic data and by comparison of spectral data obtained previously. The discovery of stigma-4-ene-3-on in C. lansiocarpus was shown in this study for the first time.
FORMULASI DAN UJI AKTIVITAS GEL EKSTRAK DAUN JERUK MANIS (Citrus x aurantium L.) TERHADAP BAKTERI Propionibacterium acnes Siti Hindun; Aji Najihudin; Siva Hamdani; Framesti Frisma Sriarumtias; Fajar Fauzi Abdullah
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 11, No 2 (2021): FITOFARMAKA | Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v11i2.2824

Abstract

Jerawat merupakan penyakit kulit yang menyerang lebih dari 85% kalangan remaja di seluruh dunia. Penyebab terjadinya jerawat yaitu bakteri Propionibacterium acnes (P. acnes).  Tujuan dari penelitian eksperimental ini yakni untuk membuat formulasi dan menganalisis aktivitas gel ekstrak daun jeruk manis terhadap bakteri P. acnes. Ekstrak daun jeruk manis diekstraksi kemudian dilakukan formulasi gel menggunakan gelling agent karbopol dengan berbagai konsentrasi 0,5%, 1%, 1,5%, dan 2%. Selanjutnya, dilakukan uji kestabilan dan aktivitas terhadap bakteri Propionibacterium acnes menggunakan metode difusi cakram. Hasil uji stabilitas sediaan menunjukkan bahwa formulasi gel dengan karbopol 2% dan konsentrasi ekstrak 20% merupakan yang paling stabil dibanding formulasi lainnya serta memiliki aktivitas daya hambat terhadap bakteri P. acnes kategori lemah dengan zona hambat 1,8 mm. Berdasarkan hasil dari penelitian ini, sediaan gel ekstrak daun jeruk manis memiliki aktivitas daya hambat terhadap bakteri P. acnes penyebab jerawat. Lebih jauh, tanaman ini dapat digunakan sebagai alternatif pengobatan untuk mengatasi jerawat.
Analysis Of Phytochemical Profile And Antioxidant Activities From Ethanol Extract Of Leaf, Stem Bark And Wood Clausena lansium L. Fajar Fauzi Abdullah; Ruchiyat Ruchiyat; Iqbal Musthapa
Jurnal Kartika Kimia Vol 3 No 1 (2020): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, Jenderal Achmad Yani University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (475.063 KB) | DOI: 10.26874/jkk.v3i1.48

Abstract

Wampi belongs to Rutaceae family. The shape of this plant is kind of bush or small tree and its fruits are similar to grapples or oranges. C. lansium was reported has the main biological activity as radical scavenger. The aim of this study to identify the content of secondary metabolites found in bark, woody stems and leaves of C. lansium plants, and to determine antioxidant activity through IC50 values. This research method begins with sample preparation, plant determination, simplicia characteristic examination, extraction, characterization with infrared spectroscopy, thin layer chromatography (TLC), then proceed with antioxidant activity assay using DPPH method (2.2 -Diphenyl-1-picrylhidrazyl) with a comparison of vitamin C. The results of this study showed that C. lansium contains alkaloids and kumarin. Furthermore, antioxidant activity assay measured absorption at a wavelength of 517 nm, obtained IC50 values ​​of vitamin C 6.22 ppm; bark 231.54 ppm (weak), wood stem 131.49 ppm (weak), and leaves 22,60 ppm (strong). Keywords: Clausena lansium, Antioxidant, phytochemical profile.
Co-Authors Ace Tatang Hidayat Aji Najihudin Desi Harnet Framesti Frisma Sriarumtias Hindun, Siti Iqbal Musthapa Nadya Thufaila Nurlelasari Nurlelasari Rani Maharani Ruchiyat Ruchiyat Siva Hamdani Unang Supratman