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All Journal E-Jurnal Medika Udayana ISM (Intisari Sains Medis) : Jurnal Kedokteran Cermin Dunia Kedokteran Journal of Global Pharma Technology Cermin Dunia Kedokteran
I Gusti Ngurah Wien Aryana
Departemen Orthopaedi Dan Traumatologi Fakultas Kedokteran Universitas Udayana
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Journal : Journal of Global Pharma Technology

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Correlation between Body Mass Index and Cartilage Oligomeric Matrix Protein Levels in Woman with Postmenopausal Symptomatic Osteoarthritis IGN Wien Aryana
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

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Abstract

Background: Measurement of serum cartilage oligomeric matrix protein (sCOMP) concentration is expected to be new approach  for osteoarthritis early detection. Osteoarthritis has been linked to obesity as its risk factor. This study aimed to determine relationship between BMI and sCOMP in woman with symptomatic osteoarthritis. Methods: : A cross-sectional study was done using consecutive sampling. The study population comprised of female patients age 50-70 y.o who had menopause since last 1 year and symptomatic knee arthritis. Osteoarthiris were comfirmed by genu imaging. sCOMP concentration were determined in Clinical Phatology Laboratorium of Sanglah Hospital using ELISA technique. The body mass index was calculated using the standarized formula. Correlation test was used to determine the correlation between body mass indexes with sCOMP level. Results: From total of 68 participants, the mean age was 73.66 (SD 9.356), the mean BMI was 21.97 (SD 4.66), and the mean sCOMP concentration was 7.935 (SD 10.11). Significant correlations (p <0.01) occured for this sample. However, Spearman’s rho was quite low (r = -0.382), indicating only weak correlations. A higher BMI was associated with lower sCOMP concentration. Conclusion: The results prove the relationship between BMI and sCOMP concentration. Further research is needed to reveal causality between both variables.Keywords: Osteoarthitis, Women, BMI, sCOMP concentration.
Co-Authors Aakash Aakash Agus Desiartama Anak Agung Gde Yuda Asmara Anak Agung Wiradewi Lestari Eka Wiratnaya Elysanti Dwi Martadiani Febyan Gede Dehandra Dipastraya Wikananda Gede Kambayana Gusti Ngurah Putra Stanu I Gusti Lanang Ngurah Agung Artha Wiguna I Ketut Suyasa I Putu Candra Yogiswara I Wayan Subawa I Wayan Suryanto Dusak Ida Bagus Anom Krishna Caitanya Kardi Rahayu Ketut Gede Mulyadi Ridia Ketut Siki Kawiyana Made Surya Dharmawan Ni Kadek Sulistyaningsih Ni Putu Diah Rakasiwi Putu Astawa Putu Kermawan Setiawan, I Gede Budhi Try Parama Arthika