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All Journal ILMU KELAUTAN: Indonesian Journal of Marine Sciences Dinamisia: Jurnal Pengabdian Kepada Masyarakat Current Research on Biosciences and Biotechnology Jurnal Sains dan Teknologi Pangan
Adryan Fristiohady
Faculty of Pharmacy, Universitas Halu Oleo
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Materials Science & Nanotechnology Medicine & Pharmacology Social Sciences Other

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Antioxidant and Cytotoxic Properties of Soft Coral Nepthea sp. Baru Sadarun; Nur Syifa Rahmatika; Agung Wibawa Mahatva Yodha; Adryan Fristiohady; Andini Sundowo; Syarul Nataqain Baharum; Idin Sahidin
ILMU KELAUTAN: Indonesian Journal of Marine Sciences Vol 27, No 1 (2022): Ilmu Kelautan
Publisher : Marine Science Department Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/ik.ijms.27.1.29-36

Abstract

Soft coral Nepthea sp. grows in the seas of South-East Sulawesi, Indonesia. However, information on the chemical and pharmaceutical aspects of this genus is still limited. Therefore, this research aims to explore the chemical contents and biological activities of Nepthea sp. The sample was collected from the waters of Saponda Island by SCUBA diving. It was extracted by ethyl acetate and fractionated using vacuum liquid chromatography. The chemical content was analyzed by phytochemical screening, LC-MS/MS analysis, Total Phenolics Content and Total Flavonoids Contents. Antioxidant potency was evaluated by DPPH (2,2-diphenyl-1-picrylhydrazyl) radicals and ABTS (2,2’-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid). Cytotoxicity property was analyzed by MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assays. The result showed that the fractionation of Nepthea ethylacetate extracts produced six fractions (A-F). Fractions A and B contain non-polar compounds. Based on LC-MS/MS data, the non-polar compounds in Fraction A and B include achillin, atractylenolide II, buthyl isobuthyl phthalate, rengyolester, 2a-acetoxycostic acid, ocotillol acetate, petasitolone and some unidentified compounds that are C33H58O4, C15H21NO, C21H33NO, and C16H20O4. In general, the antioxidant and cytotoxic properties of all samples are in the weak category, however, when examined for each sample, the antioxidant properties of fraction B is slightly better than fraction A based on the IC50 value of DPPH and ABTS. Cytotoxicity of Fraction A is better than Fraction B against Breast Cancer cell lines MCF-7. The non-polar fraction of Nepthea sp. can be developed as raw material for the discovery of new compounds, antioxidant and anticancer agents, especially breast cancer.
Nephroprotective effect of extract Etlingera elatior (Jack) R.M. Smith on CCl4-induced nephrotoxicity in rats Adryan Fristiohady; Wahyuni Wahyuni; Muhammad Ilyas Y; Mentarry Bafadal; La Ode Muhammad Julian Purnama; Firasmi Sangadji; Muhammad Hajrul Malaka; Fadhliyah Malik; Junli Hong; Agung Wibawa Mahatva Yodha; I Sahidin
Current Research on Bioscences and Biotechnology Vol. 1 No. 2 (2020)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/10.5614/crbb.2019.1.2/DAPM6106

Abstract

Reactive oxidative stress (ROS) can lead to cell damage, and one of them is the kidney's cell. Etlingera elatior (Jack) R.M. Smith can be utilized as an agent that can protect the cell from ROS. This study aimed to investigate the protective effect of E. elatior fruit on the kidney's cell. We used experimental animals which were treated with Na-CMC (Group I), Na-CMC (Group II), the extracts of E. elatior fruit 200, 300, 400 mg/kg BW for Group III, IV, and V, respectively, for seven days. The blood was collected after treatment. At day 8, group I, III, IV, and V were induced by CCl4. At day 9, blood was collected and the kidneys were harvested for histopathology analysis. Blood collected were measured for albumin, total protein, urea and creatinine levels. After treatment, albumin and total protein showed no increased levels; urea decreased at doses of 200, 300, and 400 mg/kg BW, respectively, and creatinine levels only decreased at the dose of 400 mg/kg BW (p<0.05). The dose of 200 and 300 mg/kg BW showed protecting effects in the tubular cells of renal. Therefore, the ethanol extract of E. elatior showed a nephroprotective effect by normalizing the urea and creatinine levels of rats and protecting tubular cells of renal.
Peranan Peserta KKN Tematik Dalam Meningkatkan Kepatuhan Penggunaan Masker Pada Masa Pendemi Covid-19 di Kota Kendari Adryan Fristiohady
Dinamisia : Jurnal Pengabdian Kepada Masyarakat Vol. 5 No. 1 (2021): Dinamisia: Jurnal Pengabdian Kepada Masyarakat
Publisher : Universitas Lancang Kuning

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31849/dinamisia.v5i1.4505

Abstract

The use of this mask has an important role in anticipating Covid-19 virus. If the community has knowledge about the use of masks, the community will also be obedient in the use of masks. Compliance is to describe the positive behavior of the people shown by using. Through this Thematic Community Service Program, the community can know the benefits of using masks in preventing Covid-19. the method used in the integrated community service activities of Thematic KKN is the method of socialization, the method for the environment of student residence, the method of media networking and reporting methods.Thematic KKN takes place in the city of Kendari, Sulawesi Tenggara
POTENSI ANTIDEPRESAN EKSTRAK ETANOL BUAH KUNDUR (Benincasa hispida) SEBAGAI PANGAN FUNGSIONAL: EVALUASI IN VIVO PERILAKU DEPRESI DAN KOORDINASI MOTORIK Yayat Jatnika; Nuralifah Nuralifah; Fadhliyah Malik; Parawansah Parawansah; Hariana Hariana; Nurull Hikmah; Wahyuni Wahyuni; ADRYAN FRISTIOHADY
Jurnal Sains dan Teknologi Pangan Vol. 11 No. 2 (2026): Jurnal Sains dan Teknologi Pangan
Publisher : Jurusan Ilmu dan Teknologi Pangan Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63071/f9ahq066

Abstract

Tujuan penelitian ini untuk mengetahui pengaruh pemberian ekstrak etanol buah kundur (Benincasa hispida) terhadap perilaku depresi pada mencit jantan menggunakan metode Elevated Plus Maze (EPM) Test serta mengetahui pengaruhnya terhadap koordinasi motorik melalui uji Rotarod. Mencit jantan dibagi menjadi enam kelompok: kontrol normal, kontrol negatif (Na CMC 0,5%), kontrol positif (amitriptilin 25 mg/kgBB), serta ekstrak buah kundur dosis 100, 200, dan 400 mg/kgBB. Parameter yang diamati meliputi persentase entri ke lengan terbuka (OAE) dan persentase waktu di lengan terbuka (TSOA), serta latency to fall, durasi terlama, dan frekuensi jatuh pada uji Rotarod. Hasil uji EPM menunjukkan bahwa ekstrak etanol buah kundur meningkatkan entri dan waktu berada di lengan terbuka secara signifikan pada dosis 400 mg/kgBB yang mendekati kontrol positif (p>0,05) menunjukkan penurunan perilaku depresi. Pada uji Rotarod, dosis 400 mg/kg BB menyebabkan peningkatan latency to fall, durasi dan frekuensi jatuh tetapi tidak signifikan, mengindikasikan efek samping gangguan motorik lebih rendah dibanding kontrol positif (p<0.05).
Co-Authors Andini Sundowo Bafadal, Mentarry Baru Sadarun Fadhliyah Malik Firasmi Sangadji Hariana Hariana I Sahidin Idin Sahidin Junli Hong La Ode Muhammad Julian Purnama Muhammad Hajrul Malaka Muhammad Ilyas Y Nur Syifa Rahmatika Nuralifah Nuralifah, Nuralifah Nurull Hikmah Parawansah Parawansah Syarul Nataqain Baharum wahyuni wahyuni Wahyuni Wahyuni Yayat Jatnika Yodha, Agung Wibawa Mahatva