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Article Review Potensi Senyawa Ginkgolide dan Bilobalide dalam Ekstrak Daun Ginkgo Biloba sebagai Terapi Penyakit Parkinson Karima, Khaula; Gina Syafinatunnajah; Haditya Novan Kasprata; Irsyadina Hasana Bharata; Jihan Alifa Rahma; Herpan Syafii Harahap
Lombok Medical Journal Vol. 2 No. 3 (2023): Lombok Medical Journal Volume 2 Nomor 3
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/lmj.v2i2.3172

Parkinson's disease is a neurological disorder that can be a major source of disability throughout the world. Changes in conditions in the body, such as Î±-Syn mutations can increase the risk of developing Parkinson's disease. Î±-Syn mutations will cause the loss of large and selective dopaminergic neurons in the substantia nigra pars compacta (SNpc) thereby triggering the early symptoms of Parkinson's disease. The high risk of side effects in the use of modern pharmacological therapy, indicates that a new breakthrough in the form of herbal-based ethnomedicine therapy for patients with Parkinson's disease is urgently needed. Ginkgo leaf, from the Ginkgo biloba plant, has long been known as a popular herbal supplement in Europe, Asia and America. The content of active compounds in ginkgo leaves was found to have the potential to provide therapeutic effects in patients with Parkinson's disease. This article will discuss the potency, mechanism of action, extraction process, and comparison of the potency of the two compounds with previous therapies. The development of the potential of ginkgo leaves is expected to reduce the increasing number of cases and provide a better quality of life in patients with Parkinson's disease.

Status Gizi Ibu dan Berat Badan Lahir Bayi Karima, Khaula; Achadi, Endang Laksmining
Kesmas Vol. 7, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Berat badan lahir 2.500 gram yang hingga kini merupakan standar ukuran risiko morbiditas dan mortalitas bayi merupakan faktor risiko penting yang berdampak hingga usia dewasa. Saat ini, bayi dengan berat badan lahir di bawah 3.000 gram dihubungkan dengan risiko penyakit degeneratif pada usia dewasa. Penelitian ini bertujuan mengetahui hubungan berat badan lahir dengan status gizi ibu meliputi berat badan prahamil, pertambahan berat badan selama kehamilan, dan kadar hemoglobin ibu pada trimester ketiga kehamilan. Penelitian kuantitatif dengan desain cross sectional ini menggunakan sumber data sekunder rekam medis Rumah Sakit Ibu dan Anak Budi Kemuliaan Jakarta. Analisis dilakukan secara bivariat dan multivariat menggunakan metode uji chi square dan korelasi regresi. Hasil studi menunjukkan hubungan yang bermakna antara berat badan prahamil dan pertambahan berat badan ibu selama kehamilan dengan berat badan lahir. Setelah dikontrol berbagai variabel lain, analisis regresi logistik ganda menemukan berat badan ibu prahamil, pertambahan berat badan selama kehamilan, usia ibu, dan urutan kelahiran merupakan faktor yang memengaruhi berat badan lahir. Berat badan prahamil ibu merupakan faktor yang paling berpengaruh terhadap berat badan lahir (odds ratio, OR = 6,64). Oleh sebab itu, ibu dengan status gizi prahamil kurang yang sedang merencanakan kehamilan perlu lebih diperhatikan. The weight of 2.500 gram is still being used as the cut off point to predict the risk of baby’s morbidity and mortality. Recently birth weight of less than 3.000 gram is being rigorously assess as a risk factor for noncommunicable disease in adulthood. Therefore it is important to assess factors that are affecting the fetal growth and development. The objectives of this study is to determine the relationship between infant’s birth weight and mother’s nutritional status, i.e. pre-pregnancy weight, weight gain during pregnancy, and maternal haemoglobin level in the 3rd trimester as well as several other factors. The study design is cross sectional using secondary data from medical record of Budi Kemuliaan Hospital Jakarta. The result of chi square and correlation regression test shows there is significant relationship between prepregnancy weight and weight gain during pregnancy and birth weight. The multiple logistic regression test reveals that pre-pregnancy weight, weight gain during pregnancy, maternal age, and birth order are factors that are effecting birth weight significantly, with prepregnancy weight as the dominant factor (odds ratio, OR = 6,643). Therefore, it is imperative to give more attention to undernourished women who are planning their pregnancy.

PERAN JKN UNTUK ELIMINASI TUBERKULOSIS DI INDONESIA Karima, Khaula; Oktamianti, Puput
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 8 No. 1 (2024): APRIL 2024
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v8i1.24969

Global TB Report tahun 2023 mencatatkan Indonesia sebagai negara dengan jumlah penderita TBC terbanyak ke-dua di dunia. Indonesia berkomitmen menuju eliminasi TBC di tahun 2030. Program JKN yang salah satunya diselenggarakan BPJS Kesehatan telah mengalami perkembangan dan menerapkan sentralisasi dalam implementasinya. Peran dan capaian JKN membuat dukungan BPJS Kesehatan berpotensi untuk mendorong percepatan eliminasi TBC di tahun 2030. Tujuan penelitian ini untuk mengidentifikasi potensi dan upaya yang dilakukan oleh JKN bersama Program TBC Nasional untuk mendukung eliminasi TBC. Metode penelitian menggunakan scoping review dengan mengelaborasi data sekunder, kemudian dilakukan analisis isi. Hasil penelitian menunjukkan JKN berpotensi untuk mendorong eliminasi TBC yang juga akan berkontribusi pada keberlanjutan finansial program JKN. Potensi dan upaya yang dilakukan untuk mendukung eliminasi TBC diantaranya melalui penguatan promotif preventif TBC, penguatan kualitas pengobatan TBC melalui Strategic Health Purchasing, penguatan kerja sama dengan pihak swasta, dan peningkatan kualitas.

Article Review Potensi Senyawa Ginkgolide dan Bilobalide dalam Ekstrak Daun Ginkgo Biloba sebagai Terapi Penyakit Parkinson Karima, Khaula; Gina Syafinatunnajah; Haditya Novan Kasprata; Irsyadina Hasana Bharata; Jihan Alifa Rahma; Herpan Syafii Harahap
Lombok Medical Journal Vol. 2 No. 3 (2023): Lombok Medical Journal Volume 2 Nomor 3
Publisher : Faculty of Medicine, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/lmj.v2i2.3172

Parkinson's disease is a neurological disorder that can be a major source of disability throughout the world. Changes in conditions in the body, such as Î±-Syn mutations can increase the risk of developing Parkinson's disease. Î±-Syn mutations will cause the loss of large and selective dopaminergic neurons in the substantia nigra pars compacta (SNpc) thereby triggering the early symptoms of Parkinson's disease. The high risk of side effects in the use of modern pharmacological therapy, indicates that a new breakthrough in the form of herbal-based ethnomedicine therapy for patients with Parkinson's disease is urgently needed. Ginkgo leaf, from the Ginkgo biloba plant, has long been known as a popular herbal supplement in Europe, Asia and America. The content of active compounds in ginkgo leaves was found to have the potential to provide therapeutic effects in patients with Parkinson's disease. This article will discuss the potency, mechanism of action, extraction process, and comparison of the potency of the two compounds with previous therapies. The development of the potential of ginkgo leaves is expected to reduce the increasing number of cases and provide a better quality of life in patients with Parkinson's disease.

Meningkatkan Upaya Penanggulangan Tuberkulosis Melalui Penguatan Strategi Berbasis Komunitas: Tinjauan Sistematis Chriswanto, Alexander W.; Ayuningtyas, Dumilah; Karima, Khaula
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v9i4.15137

Manajemen penanggulangan TB berbasis komunitas memiliki dampak positif terhadap capaian program penanggulangan TB. Organisasi Kesehatan Dunia (WHO) telah menyusun kerangka strategi terkait peningkatan peran serta komunitas dan masyarakat dalam upaya penanggulangan TB yang diharapkan dapat diterapkan dan disesuaikan dengan kondisi unik tiap kelompok masyarakat. Tujuan penelitian ini adalah untuk mengeksplorasi bukti mengenai beragam intervensi manajemen penanggulangan TB berbasis komunitas. Penelitian ini melakukan tinjauan literatur sistematis menggunakan database ProQuest, Embase dan PubMed untuk menemukan artikel yang berkaitan dan diterbitkan dalam rentang lima tahun terakhir. Model PRISMA digunakan untuk menyaring judul dan abstrak, sehingga dari 198 total artikel yang ditemukan, didapatkan 13 artikel yang sesuai dengan kriteria inklusi. Kegiatan atau program penanggulangan TB yang melibatkan komunitas dan masyarakat secara langsung akan meningkatkan angka capaian program penanggulangan TB dari tahap pencegahan sampai hasil akhir pengobatan. Kesimpulannya, pemerintah perlu merancang strategi penanggulangan TB berbasis komunitas yang efektif dan komprehensif agar masyarakat dapat ikut berperan aktif dalam upaya penanggulangan TB dan mendapatkan hasil yang berkelanjutan.

EDUKASI GANGGUAN SARAF TEPI AKIBAT OBAT KEMOTERAPI PADA PASIEN POLI ONKOLOGI RUMAH SAKIT UMUM DAERAH (RSUD) PROVINSI NUSA TENGGARA BARAT Hunaifi, Ilsa; Briliansy, Briliansy; Anggoro, Joko; Bharata, Irsyadina Hasana; Adhima, Daffa Aulia Faza; Karima, Khaula; Kuta, Putu Cicilia Rarasati; Fitroningtyas, Elvika Aulia; Hidayati, Eriska; Moestafa, Rizka Febriya; Maharani, Baiq Nadya Putri
Jurnal Abdi Insani Vol 11 No 2 (2024): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v11i2.1522

Peripheral neuropathy is a disorder of peripheral nerve fibres secondary to various pathological processes such as diabetes mellitus, vitamin deficiencies or drugs such as chemotherapy regimen. Clinical symptoms include motor, sensory and autonomic disorders. Cancer patients undergoing chemotherapy are susceptible to experiencing symptoms of peripheral neuropathy caused by anatomical changes (such as distal axonal degeneration) or physiological changes. So, the education of regarding peripheral neuropathy is needed in patients with chemotherapy. This community service activity was conducted in the Oncology Building at West Nusa Tenggara Province General Hospital. Implementing activities regarding education on peripheral nerve disorders due to chemotherapy drugs is carried out by providing pretests, educational materials, post-tests and discussions. In the pretest activity, many participants were still unaware of peripheral nerve disorders due to chemoteraphy side effects. In the post-test, the knowledge score was above average (100%) regarding peripheral nerve disorders due to chemoterapy side effects. This shows an increase in the understanding of the side effects of chemotherapy in oncology outpatients clinic at West Nusa Tenggara Province General Hospital

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