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All Journal Jurnal Kedokteran MNJ (Malang Neurology Journal) Jurnal Biologi Tropis Jurnal Abdi Insani Jurnal Kesehatan Tambusai
Anggoro, Joko
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Korioretinitis Toksoplasmosis pada Penderita Imunokompeten Anggoro, Joko
Jurnal Kedokteran Vol 5 No 4 (2016)
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Toksoplasmosis merupakan penyakit sistemik yang disebabkan parasit protozoa koksidia Toxoplasma gondii, infeksi biasanya tanpa gejala atau muncul dalam bentuk akut dengan gejala limfadenopati atau dengan gejala menyerupai flu (flu-like symptoms). Pada infeksi primer, penderita biasanya asimtomatik dan kadang hanya bergejala seperti demam, limfadenopati dan limfositosis yang berlangsung sampai berhari-hari atau beberapa minggu. Kami akan membahas lebih dalam sebuah kasus chorioretinitis toksoplasmosis pada penderita imunokompeten baik dari gejala klinis dan terapinya
HYPERTENSION AS DETERMINANT OF COGNITIVE DYSFUNCTION AMONG ELDERLY SUB-POPULATION Darmaningrat, Cokorda Istri Agung Asvini; Harahap, Herpan Syafii; Anggoro, Joko; Rianawati, Sri Budhi
MNJ (Malang Neurology Journal) Vol. 10 No. 2 (2024): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.02.07

Abstract

Background: Cognitive dysfunction is one of the main impacts of hypertension in the elderly population. Early detection and adequate management of early-stage cognitive dysfunction in hypertensive elderly is expected to improve their cognitive status and quality of life. Objective: This study aimed to determine the association between hypertension and cognitive dysfunction in a sub-population of the elderly in Mataram, Indonesia. Methods: This cross-sectional study involved elderly sub-population recruited consecutively in three public health centers in Mataram, Indonesia. Data included in this study were age, gender, occupation, educational level, hypertension, diabetes mellitus, and cognitive status. Cognitive status was assessed using the Indonesia version of Montreal Cognitive Assessment instrument. Multiple logistic regression analysis was performed to test whether hypertension was a determinant of cognitive dysfunction in participants taking into account the presence of socio-demographic status and diabetes mellitus as another vascular risk factor. Results: This study included 88 elderly as eligible participants. The frequency of cognitive dysfunction among participants was 61.4%. Multiple logistic regression analysis revealed that hypertension was the single variable significantly associated with a high frequency of cognitive dysfunction in elderly sub-population (odds ratio = 3.7; 95% confidence intervals = 1.3 – 10.4; p = 0.014). Conclusion: The frequency of cognitive dysfunction in the elderly sub-population in Mataram was high, amounting to 61.4%. Hypertension was the determinant of this high frequency of cognitive dysfunction in the sub-population studied.
Chronic Lymphocytic Leukemia: A Literature Review Maulana, Muhammad Rafi; Nurmawaddah, Intan; Ilmiah, Janiya Abdila; Damayanti, Ida Ayu Andara; Wiguna, I Made Danuarta; Anggoro, Joko; Maulana, Akhada
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10078

Abstract

Chronic Lymphocytic Leukemia (CLL) is a slowly progressing hematological cancer characterized by the accumulation of abnormal B lymphocytes in the blood, bone marrow, and lymphatic tissue, commonly affecting the elderly. This review aims to comprehensively review the epidemiology, molecular basis of the disease, clinical symptoms, diagnosis, and therapeutic advances of CLL, emphasizing the importance of shifting treatment approaches towards more precision therapy. A literature search was conducted through PubMed, Scopus, and Web of Science using the keywords "Chronic Lymphocytic Leukemia", "epidemiology", "molecular basis of the disease", and "targeted therapy", with publication criteria between 2018–2025, full text, and topic relevance. Analysis was conducted using a narrative review and thematic synthesis approach to identify epidemiological trends, therapeutic effectiveness, and clinical implications. The results showed that the incidence of CLL is higher in Western countries compared to Asia, with a higher prevalence in elderly men. The main genetic factors that play a role include del(13q), del(17p), and TP53 mutations. Over the past decade, targeted therapies such as second-generation Bruton's tyrosine kinase inhibitors (acalabrutinib, zanubrutinib) and the venetoclax-obinutuzumab combination have been shown to improve remission rates with fewer side effects compared to chemoimmunotherapy. Minimal Residual Disease (MRD) status has become an important marker for determining when therapy can be stopped early. In conclusion, this review underscores the crucial role of biomarkers and MRD in modern CLL management. Future developments include the integration of personalized therapy approaches and translational research to develop more effective and safe treatment strategies.
Literature Study: Acute Myeloid Leukimia (AML) Pramesti, Evane Dyahayu; Dhevi, Ni Made Saithanya Gitanjali; Hudhori, Syalsa; Salsabila, Ericha Zabrina; Asriantin, Isna; Anggoro, Joko
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10082

Abstract

Leukemia is a cancer that originates from cells that initially develop into blood cells. Leukemia can be classified as acute or chronic, depending on how quickly the disease appears and how it progresses in the body. This literature review aims to determine the treatment for patients with AML depending on the subtype. This literature review used journal review methods and data searches through various sources. The results of the literature study found that Acute Myeloid Leukemia (AML) is divided into six subtypes. AML is caused by clonal transformation of hematopoietic cells through chromosomal abnormalities and gene mutations, with risk factors including exposure to radiation, benzene, smoking, chemotherapy therapy, the development of chronic myeloid neoplasms, aging, and predisposing diseases. Diagnosis of AML involves peripheral blood and bone marrow analysis, immunophenotyping, cytogenetics, molecular cytogenetics, and imaging to detect the presence and characteristics of leukemic cells. Treatment of AML includes induction therapy, consolidation therapy, and response monitoring, with special considerations for the selection of chemotherapy regimens, stem cell transplantation, and transfusion support to manage associated complications. In conclusion, Acute Myeloid Leukemia (AML) is a condition in which myeloblasts undergo excessive proliferation and fail to differentiate into granulocytes. This condition causes the bone marrow to fill with myeloblasts.
PELATIHAN DETEKSI DINI NEUROPATI AKIBAT KEMOTERAPI Hunaifi, Ilsa; Primayanti, Ika; Sapta Wardhani, Indah; Briliansy, Briliansy; Anggoro, Joko; Setyawati, Indri; Fesmia, Herodya Lajunee; Ismiana, Baiq Holisatul; Wiracakra, I Gusti Lanang Krisna; Gea, Endah Irnanda Ulfa; Jacob, Lusye Diana; Putri, Siti Noururrifqiyati Juna; Wardi, Bq. Prita Riantiani; Suryani, ⁠Dini; Andiyani, Dinda Zahra Putri
Jurnal Abdi Insani Vol 12 No 9 (2025): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v12i9.2843

Abstract

Cancer is currently a disease that is experiencing significant growth. This has resulted in the number of chemotherapy administrations reaching 9.8 million to 15 million people and increasing by 53%. One of the side effects that can be caused is peripheral nerve disorders called Chemotherapy-Induced Peripheral Neuropathy (CIPN). In connection with the increasing number of cancer patients undergoing chemotherapy and the severe impact on peripheral nerves due to chemotherapy, early detection is very important to prevent severe complications. This training aims to improve the knowledge and skills of medical personnel in the early detection of chemotherapy-induced neuropathy in order to improve the quality of life of patients and reduce complications and disabilities due to neuropathy. This training was carried out in collaboration with the West Nusa Tenggara Province General Hospital and was attended by 62 nurses. The series of training activities included delivering materials and direct practice to patients. Evaluation of participant knowledge was through a pre-test using the Kahoot application and a post-test using the Plataran Sehat application with a pre-test completion time of 5 minutes. The average pre-test score was 59.35, while the average post-test score was 79.35. The simulation sessions are conducted directly with patients using a neuropathy screening questionnaire, accompanied by a physician. The presentation of the material and the simulation sessions are highly beneficial in neuropathy screening, allowing early detection of neuropathy symptoms and prompt treatment.
CHRONIC MYELOID LEUKEMIA Akbar, Nugraha Malik; Pratiwi, Rukmanggana Satya; Azmi, Naurah Arika; Supriantarini, Dita; Amatullah, Tazkiyah Arafah; Anggoro, Joko
Jurnal Kesehatan Tambusai Vol. 5 No. 4 (2024): DESEMBER 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i4.38268

Abstract

Chronic Myelogenous Leukemia  (CML) merupakan suatu jenis kanker yang disebabkan oleh gangguan pada hematopoietic stem cell. CML adalah bentuk leukemia yang ditandai dengan peningkatan dan pertumbuhan yang tak terkendali dari sel myeloid pada sumsum tulang. CML merupakan gangguan stem sel sumsum tulang klonal, dimana ditemukan proliferasi dari granulosit matang (neutrofil, eosinofil, dan basofil) dan prekursor nya.Metode yang digunakan dalam penulisan tinjauan pustaka ini adalah studi literatur dari berbagai referensi. Pencarian literatur ini menggunakan basis data online yaitu, PubMed, Google Scholar, ProQuest dan Mendeley Search. CML pada umumnya lebih cenderung terjadi pada usia 53-60 tahun, namun usia rata-rata dianggap sebagai usia 40 tahun, walaupun dapat ditemukan pada usia muda dan biasanya lebih progresif. Penyebab dari CML adalah tidak jelas dengan peran penting dari faktor genetic dan lingkungan, seperti paparan terhadap radiasi dan sebagainya. Dalam perjalanan penyakitnya, CML dapat dibagi kepada biphasic dan triphasic course. Proses awalnya adalah kronik dan berlanjut ke fase blastik terminal. Leukemia mielositik kronik dibagi menjadi 3 fase, yaitu: fase kronik, fase akselerasi, dan fase krisis blast. Terapi yang digunakan dalam tatalaksana CML busulfan, Hidroxiurea, Imatinib (Gleevec), nilotinib (Tasigna), dasatinib (Sprycel), Interferon, Transplantasi sumsum tulang alogenik (stem cell transplantation, SCT).CML yang tidak diobati dan berlangsung lama akan menimbulkan komplikasi berupa hepatomegali, splenomegali, anemia yang memburuk.
EDUKASI GANGGUAN SARAF TEPI AKIBAT OBAT KEMOTERAPI PADA PASIEN POLI ONKOLOGI RUMAH SAKIT UMUM DAERAH (RSUD) PROVINSI NUSA TENGGARA BARAT Hunaifi, Ilsa; Briliansy, Briliansy; Anggoro, Joko; Bharata, Irsyadina Hasana; Adhima, Daffa Aulia Faza; Karima, Khaula; Kuta, Putu Cicilia Rarasati; Fitroningtyas, Elvika Aulia; Hidayati, Eriska; Moestafa, Rizka Febriya; Maharani, Baiq Nadya Putri
Jurnal Abdi Insani Vol 11 No 2 (2024): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v11i2.1522

Abstract

Peripheral neuropathy is a disorder of peripheral nerve fibres secondary to various pathological processes such as diabetes mellitus, vitamin deficiencies or drugs such as chemotherapy regimen. Clinical symptoms include motor, sensory and autonomic disorders. Cancer patients undergoing chemotherapy are susceptible to experiencing symptoms of peripheral neuropathy caused by anatomical changes (such as distal axonal degeneration) or physiological changes. So, the education of regarding peripheral neuropathy is needed in patients with chemotherapy. This community service activity was conducted in the Oncology Building at West Nusa Tenggara Province General Hospital. Implementing activities regarding education on peripheral nerve disorders due to chemotherapy drugs is carried out by providing pretests, educational materials, post-tests and discussions. In the pretest activity, many participants were still unaware of peripheral nerve disorders due to chemoteraphy side effects. In the post-test, the knowledge score was above average (100%) regarding peripheral nerve disorders due to chemoterapy side effects. This shows an increase in the understanding of the side effects of chemotherapy in oncology outpatients clinic at West Nusa Tenggara Province General Hospital
Co-Authors Adhima, Daffa Aulia Faza Akbar, Nugraha Malik Akhada Maulana, Akhada Amatullah, Tazkiyah Arafah Andiyani, Dinda Zahra Putri Asriantin, Isna Azmi, Naurah Arika Bharata, Irsyadina Hasana Briliansy, Briliansy Damayanti, Ida Ayu Andara Darmaningrat, Cokorda Istri Agung Asvini Dhevi, Ni Made Saithanya Gitanjali Fesmia, Herodya Lajunee Fitroningtyas, Elvika Aulia Gea, Endah Irnanda Ulfa Herpan Syafii Harahap Hidayati, Eriska Hudhori, Syalsa Ilmiah, Janiya Abdila Ilsa Hunaifi, Ilsa Ismiana, Baiq Holisatul Jacob, Lusye Diana Khaula Karima Kuta, Putu Cicilia Rarasati Maharani, Baiq Nadya Putri Maulana, Muhammad Rafi Moestafa, Rizka Febriya Nurmawaddah, Intan Pramesti, Evane Dyahayu Pratiwi, Rukmanggana Satya Primayanti, Ika Putri, Siti Noururrifqiyati Juna Salsabila, Ericha Zabrina Sapta Wardhani, Indah Setyawati, Indri Sri Budhi Rianawati, Sri Budhi Supriantarini, Dita Suryani, ⁠Dini Wardi, Bq. Prita Riantiani Wiguna, I Made Danuarta Wiracakra, I Gusti Lanang Krisna