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All Journal Acta Interna : The Journal of Internal Medicine Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Indonesian Journal of Rheumatology
Deddy Nur Wachid Achadiono
Division Of Rheumatology, Department Of Internal Medicine, Faculty Of Medicine, Public Health And Nursing, Universitas Gadjah Mada/ Dr. Sardjito General Hospital
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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Correlation Between Mex-Sledai and Mean Platelet Volume In Systemic Lupus Erythematosus Patients Ayu Paramaiswari; Dody Hendro Susilo; Deddy Nur Wachid Achadiono
Indonesian Journal of Rheumatology Vol. 12 No. 2 (2020): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ijr.v12i2.158

Abstract

A B S T R A C TBackground. Systemic lupus erythematosus (SLE) is a chronic autoimmunedisease which has a variety of clinical phenotypes with a complex clinical course.The clinical phenotypes are highly variable which can be characterized by acuteattacks, active periods, controllable or remission. Mean platelet volume (MPV) is astraightforward accessible indicator of platelet activity and is associated withsystemic inflammation. The routine usage of MPV as markers for disease activityin SLE remains problematic. Early detection of disease progression is pivotal in themanagement of SLE for obtaining better outcomes. Objective. The study aimed toconfirm that the measurement of the disease severity in patients with SLE usingMex-SLEDAI has a negative correlation with the decrease of MPV value. Methods.This cross-sectional analytic descriptive study was conducted using secondary datafrom the medical records of patients with SLE older than 18 years of age who werenot taking antiplatelets in the Internal Medicine policlinic of Dr. Sardjito GeneralHospital in 2018. Patients with a previous history of cardiovascular andcerebrovascular events, malignancies, receiving a treatment for infections,including sepsis, chronic infections (i.e. tuberculosis, cytomegalovirus, herpessimplex, herpes zoster), HIV, hepatitis B or hepatitis C, and incomplete data ofmedical record were excluded. The correlation between SLEDAI Mex and MPVvalues was evaluated using the Spearman's correlation test. Results. Sixty-sevensubjects (65 women, 2 men) aged 34 ± 11 years were recruited in the study. Themedian duration of diagnosis was 38,2 ± 45,7 months. Arthritis, skin rash andphotosensitivity were identified in 81,1%, 53,7%, and 46,3% of patients,respectively. The Mex-SLEDAI score ranged from 0 to 16. The average of MPV valueis 9.73 ± 1.21 fL. A significant correlation between MPV and SLEDAI Mex wasobserved (p = 0.03 (p <0.05), r = -0.255). Conclusion. The more severe SLE diseaseactivity (based on the Mex-SLEDAI scoring), the more negative correlation with theMPV value.
Indonesian Rheumatology Association (IRA) Recommendations for Diagnosis and Management of Sjogren’s Syndrome Deddy Nur Wachid Achadiono
Indonesian Journal of Rheumatology Vol. 15 No. 2 (2023): IJR VOL 15 No 2
Publisher : Indonesian Rheumatology Associantion

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/IJR.v15i2.245

Abstract

Background. Sjogren’s syndrome (SS) is a systemic autoimmune diseasethat affects exocrine glands. Dealing with SS is challenging due to the lowlevel of awareness and knowledge about SS, as well as the difficulty indiagnosing and treating the disease. Diagnosing SS requires manysupporting examinations from many medical specialties. Therefore, theserecommendations were developed to serve as a guide for health practitionersin diagnosing and treating SS. Methods. Six selected rheumatologists fromthe Indonesian Rheumatologist Association (IRA) formulated therecommendations based on key questions formed by a steering committeefrom IRA. These recommendation materials were taken from several onlinedatabases such as PubMed, Science Direct, and Google Scholar. Level of evidence and grades of recommendation were then assigned, and everymember of the panellist team will assign a score for level of agreement.Results. The panel generated a total of 19 recommendations discussing thediagnosis, pharmacological and non-pharmacological therapy, andprognosis for SS. Conclusion. These recommendations can be used to helpclinicians correctly diagnose and choose the most suitable therapy for SSpatients. All recommendation statements were created with theconsideration of Indonesia’s clinical setting, facility, and drug availability. 
Co-Authors Andika Ilham Rahmatullah Anggi Wahyu Nugroho Asdie, Achmad Husain Ayu Paramaiswari Ayu Paramaiswari Ayu Paramaiswari Bambang Setyohadi Bambang Setyohadi Bambang Udji Djoko Riyanto, Bambang Udji Djoko Dody Hendro Susilo Eko Nugroho Handono Kalim Handono Kalim Harry Isbagio Harry Isbagio I Dewa Putu Pramantara Joewono Soeroso Joewono Soeroso Muhipah Muhipah Nyoman Kertia Rachmat Gunadi Wachjudi Rengganis, Anggraeni Ayu Retnowulan, Heni Tiara Putri Utami Yulyani Werdhiningsih