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All Journal e-Journal Pustaka Kesehatan Journal of Agromedicine and Medical Sciences Journal of Innovation Research and Knowledge
Dewi Dianasari
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Humanities Economics, Econometrics & Finance Education Health Professions Law, Crime, Criminology & Criminal Justice Library & Information Science Social Sciences

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Uji Aktivitas Antibakteri Kombinasi Minyak Atsiri Biji Ketumbar (Coriandrum sativum L.) dan Gentamisin terhadap Staphylococcus epidermidis Bawon Triatmoko; Huda Almuttaqin; Dewi Dianasari
Pustaka Kesehatan Vol 6 No 3 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i3.9870

Abstract

Gentamicin is one of the antibiotics from the aminoglycoside group used for the treatment of infections. Gentamicin has side effect such as permanent ototoxicity and reversible nephrotoxicity. It was necessary to reduce these effects by combining antibiotic with natural ingredients, one of those is coriander seeds essential oil. Combination therapy is done to reduce the potential side effects, and increase antibacterial efficacy. Antibacterial activity test were conducted to measure the MIC values of gentamicin, essential oils of coriander seeds, and combination of both. Based on the antibacterial activity test, MIC value of gentamicin was 4 µg/mL, coriander seed essential oil was 50 µg/mL and MIC combination of gentamicin and essential oil of coriander seeds were 0.5 µg/mL and 50 µg/mL. The FIC Index value obtained was 1.125 meaning that the combination effect was indifferent. Indifferent combination effect means the use of a combination of coriander seeds essential oil and gentamicin as antibacterial was not better than the single use. Keywords: coriander, essential oil, antibacterial, FIC Index, S. epidermidis
Anti-lipase Activity of Kemuning (Murraya paniculata) Leaves Extract and Its Fractions Nuri Nuri; Tazkiyatul Fitriyah; Endah Puspitasari; Bawon Triatmoko; Dewi Dianasari
Journal of Agromedicine and Medical Sciences Vol 10 No 1 (2024)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v10i1.44240

Abstract

Kemuning (Murraya paniculata) belongs to the Rutaceae family, it grows a lot in tropical areas such as Indonesia. Traditionally, Kemuning leaves are used for weight loss preparations and are believed to contain compounds that can inhibit pancreatic lipase, including flavonoids. This study aimed to reveal the antilipase activity of Kemuning leaves extract and its fractions. The extraction of Kemuning leaves was carried out by maceration with 70% ethanol as solvent. The vacuum liquid chromatography method was used to separate the secondary metabolites in the extract with the stationary phase of silica gel and the eluent mixture of n-hexane, ethyl acetate, and methanol in a gradient manner. Meanwhile, the antilipase activity was tested by colorimetric method, with p-nitrophenyl butyrate as a substrate and orlistat as a positive control. The extract obtained was 19.94% of the weight of the simplicia. The separated extract was collected in 20 flasks and then combined based on the Rf value of the spots observed on thin layer chromatography (TLC) producing 8 fractions (fractions A-H). The percentage yields of fractions A-H were 1.20, 1.33, 1.80, 3.92, 3.57, 4.20, 16.85, and 14.47%, respectively. Antilipase activity was indicated by IC50 values, which were 17.603 ± 1.660 and 108.554 ± 1.660 µg/mL for orlistat and extract, respectively. The antilipase activities of fractions A-H were 130.19 ± 2.90, 119.52 ± 1.95, 96.95 ± 1.81, 91.65 ± 0.78, 95.30 ± 1.46, 114.76 ± 2.87, 127.07 ± 3.56, and 134,04 ± 3.16 µg/mL, respectively. Based on these results, it can be concluded that the extract and its fractions exhibit very strong antilipase activity. Keywords: Murraya paniculata; extract; fraction; antilipase
ANALISIS REQUIREMENTS APLIKASI PEMESANAN JAMU BERBASIS MOBILE DENGAN PENDEKATAN HTO (HUMAN TECHNOLOGY ORGANIZATION) Tri Agustina Nugrahani; Dewi Dianasari; Karina Nine Amalia
Journal of Innovation Research and Knowledge Vol. 4 No. 7: Desember 2024
Publisher : Bajang Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53625/jirk.v4i7.9083

Abstract

Aplikasi Pemesanan Jamu berbasis mobile merupakan aplikasi yang digunakan untuk membantu pemasaran sekaligus penjualan jamu secara online. Pada penggalian kebutuhan yang dibutuhkan oleh system, maka digunakanlah pendekatan HTO(Human Technology Organization) analysis. Dengan menggunakan pendekatan HTO maka pemodelan kebutuhan menjadi rinci dan seluruh user dan stakeholder dikutsertakan berdasarkan kebutuhan yang relevan dengan sistem. Teori HTO merupakan analisis yang menempatkan komponen penting dalam sebuah sistem informasi yaitu manusia (human), teknologi (technology), organisasi(organization), dan kesesuaian hubungan diantaranya. Sehingga terdapat beberapa trend, ketidakpastian, scenario, dan analisis strategi yang dapat menjadi bahan untuk identifikasi potensi. Dengan hasil akhir yaitu beberapa fitur yang dapat diprioritaskan dalam pengembangan aplikasi berbasis mobile tersebut. Fitur tersebut yaitu fitur untuk melakukan pemesanan jamu secara online, fitur untuk melakukan pembayaran secara digital, fitur untuk melakukan pengantaran, dan fitur untuk memerikan rekomendasi jamu yang sesuai dengan kondisi kesehatan.
Co-Authors Amalia, Karina Nine Bawon Triatmoko Bawon Triatmoko Endah Puspitasari Huda Almuttaqin Nuri Nuri Tazkiyatul Fitriyah Tri Agustina Nugrahani