Article Per Year (5 Year)
p-Index From 2020 - 2025
2.928
P-Index
This Author published in this journals
All Journal e-Journal Pustaka Kesehatan Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology Pharmacon Pharmascience JSFK (Jurnal Sains Farmasi & Klinis) JPSCR : Journal of Pharmaceutical Science and Clinical Research PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmu Kefarmasian Indonesia Abdimasku : Jurnal Pengabdian Masyarakat Jurnal farmasi UIN Alauddin Makassar Nusantara Science and Technology Proceedings
Bawon Triatmoko
Fakultas Farmasi Universitas Jember
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Economics, Econometrics & Finance Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

Published : 28 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 28 Documents
Search

 1   2   3 
Skrining Fitokimia dan Uji Aktivitas Antibakteri Ekstrak dan Fraksi Tumbuhan Anyang-Anyang (Elaeocarpus grandiflorus J. E. Smith.) terhadap Escherichia coli Savitri, Ganevi Resta; Triatmoko, Bawon; Nugraha, Ari Satia
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 5, No 1 (2020)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v5i1.32206

Abstract

Pada saat ini sudah banyak dilakukan penelitian terhadap khasiat antibakteri suatu tanaman. Salah satu sumber alternatif antibakteri dari bahan alam adalah tumbuhan anyang-anyang. Penelitian potensi antibakteri tumbuhan anyang-anyang bertujuan untuk mengetahui nilai IC50 esktrak dan fraksi dari tumbuhan anyang-anyang (Elaeocarpus grandiflorus J. E. Smith) dalam menghambat pertumbuhan Escherichia coli (E. coli). Ekstraksi dilakukan secara maserasi dan fraksinasi secara partisi cair-cair. Uji aktivitas antibakteri yang dilakukan adalah metode mikrodilusi dengan mengacu pada protokol yang ditetapkan oleh Clinical and Laboratory Standard Institute (CLSI) M07-A9. Skrining fitokimia dilakukan dengan metode Kromatografi Lapis Tipis (KLT) untuk mengetahui golongan senyawa yang terdapat dalam ekstrak dan fraksi daun anyang-anyang. Nilai IC50 diperoleh dengan melakukan analisis probit terhadap masing-masing nilai persen penghambatan setelah pemberian 5 seri konsentrasi sampel ekstrak dan fraksi daun anyang-anyang. Kontrol positif menggunakan injeksi gentamisin 40.000 µg/mL dan kontrol negatif menggunakan dimetilsulfoksida (DMSO) 1%. Ekstrak daun anyang-anyang memiliki IC50 yang paling rendah yakni sebesar 360,969±10,542 µg/mL. Hasil skrining fitokimia menunjukkan sampel dan fraksi positif mengandung polifenol. Kesimpulan dari penelitian  ini adalah ekstrak methanol kasar daun anyang-anyang mempunyai potensi menghambat pertumbuhan bakteri E. coli.
POTENSI EKSTRAK ETANOL DAN FRAKSI-FRAKSINYA DARI TIGA VARIETAS JAHE SEBAGAI AGEN ANTIBAKTERI TERHADAP STAPHYLOCOCCUS AUREUS Dianasari, Dewi; Puspitasari, Endah; Ningsih, Indah Yulia; Triatmoko, Bawon; Nasititi, Fauzia Ken
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.9226

Abstract

One of the natural ingredients that to be used to inhibit bacterial growth is the Zingiber officinale. In Indonesia, there are 3 types of ginger which are distinguished by morphology, namely ?emprit ginger (Zingiber officinale var. Amarum), ? gajah? ginger (Zingiber officinale var. Officinarum), and red ginger (Zingiber officinale var. Rubrum). This research was conducted to determine the activity of extracts and fractions of three ginger varieties in inhibiting the growth of Staphylococcus aureus using the disc diffusion method. The test group consisted of ethanol extract, n-hexane fraction, and ethyl acetate fraction from 3 ginger varieties, concentrations of 5, 10, 20% w / v, gentamicin 10 ?g (positive control) and 10% DMSO (negative control). The test results showed that ethanol extracts and fractions from the rhizomes of three varieties of ginger have the ability to inhibit S. aureus at concentrations of 5, 10, and 20% w / v, increasing the concentration will increase the diameter of the inhibition zone. At a concentration of 20% of all samples, the one with the greatest resistance was the n-hexane fraction (diameter of inhibitory zone of emprit ginger 9.80 mm, elephant ginger 9.78 mm, and red ginger 9.90 mm). The difference in ginger variety only affects the antibacterial activity of the ethanol extract, but not the n-hexane and ethyl acetate fractions.
Isolasi Fungi Tanah Muara dan Skrining Aktivitas Antibakteri Terhadap Staphylococcus aureus Afrian Rosyadi; Bawon Triatmoko; Ari Satia Nugraha
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No 1 (2022)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.28834

Abstract

Penyakit infeksi merupakan salah satu penyebab kematian di dunia. Antibiotika sering digunakan dalam pengobatan infeksi bakteri namun saat ini mengalami resistensi. Berdasarkan hal tersebut, penelusuran alternatif antibiotika dari bahan alam perlu dilakukan, salah satunya dari fungi. Fungi merupakan mikrobe eukariotik sebagai sumber utama antibiotika yang tersedia saat ini termasuk penisilin. Penelitian ini dilakukan untuk mengetahui potensi aktivitas antibakteri ekstrak etil asetat hasil fermentasi isolat fungi tanah muara terhadap bakteri gram positif Staphylococcus aureus. Penapisan fitokimia ekstrak menggunakan metode KLT sedangkan pengujian aktivitas antibakteri penelitian ini menggunakan metode mikrodilusi. Aktivitas antibakteri dilaporkan dalam persen penghambatan. Hasil uji antibakteri ketujuh ekstrak memiliki aktivitas dengan persen penghambatan tertinggi dari kode isolate IS-IB-T2 sebesar 66,5 ± 1,1 % dan terendah dari kode isolate IS-IB-B2 sebesar 12,2 ± 0,7 % pada konsentrasi 100 μg/mL. Adanya terpenoid dalam tiap ekstrak diduga memiliki kontribusi dalam mekanisme antibakteri. Maka dari itu, fungi yang berasal dari tanah muara berpotensi untuk dieksplorasi senyawa antibiotiknya lebih jauh lagi.
Uji Aktivitas Antibakteri Kombinasi Minyak Atsiri Biji Ketumbar (Coriandrum sativum L.) dan Gentamisin terhadap Staphylococcus epidermidis Bawon Triatmoko; Huda Almuttaqin; Dewi Dianasari
Pustaka Kesehatan Vol 6 No 3 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i3.9870

Abstract

Gentamicin is one of the antibiotics from the aminoglycoside group used for the treatment of infections. Gentamicin has side effect such as permanent ototoxicity and reversible nephrotoxicity. It was necessary to reduce these effects by combining antibiotic with natural ingredients, one of those is coriander seeds essential oil. Combination therapy is done to reduce the potential side effects, and increase antibacterial efficacy. Antibacterial activity test were conducted to measure the MIC values of gentamicin, essential oils of coriander seeds, and combination of both. Based on the antibacterial activity test, MIC value of gentamicin was 4 µg/mL, coriander seed essential oil was 50 µg/mL and MIC combination of gentamicin and essential oil of coriander seeds were 0.5 µg/mL and 50 µg/mL. The FIC Index value obtained was 1.125 meaning that the combination effect was indifferent. Indifferent combination effect means the use of a combination of coriander seeds essential oil and gentamicin as antibacterial was not better than the single use. Keywords: coriander, essential oil, antibacterial, FIC Index, S. epidermidis
Sitotoksisitas Minyak Mesoyi (Cryptocarya massoy) terhadap Sel Vero (Cytotoxicity of Mesoyi Oil (Cryptocarya massoy) on Vero Cell Lines) Bawon Triatmoko; Triana Hertiani; Agustinus Yuswanto
Pustaka Kesehatan Vol 4 No 2 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Mesoyi oil distilled from the bark of Cryptocarya massoy have been used for traditional treatment of various ethnicities. However, its safety use has not been widely studied. This study aimed to investigate the cytotoxicity of mesoyi oil on vero cells in vitro. The Inhibitory concentration 50% (IC50) of mesoyi oil is evaluated using MTT assay. The results indicated that the mesoyi oil exhibited cytotoxic effects on vero cells with IC50 value of 97.4 μg//mL. This call for further studies to evaluate the cytotoxic activity in vivo. Keywords: cytotoxicity, essential oil, cryptocarya massoy, vero cell
Uji Aktivitas Antibakteri Ekstrak Metanol dan Fraksi Daun Kenikir (Cosmos caudatus Kunth) terhadap Salmonella typhi Achmad Syarifudin Noor; Bawon Triatmoko; Nuri Nuri
Pustaka Kesehatan Vol 8 No 3 (2020): Volume 8 No. 3, 2020
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v8i3.13008

Abstract

The leaves of kenikir are known to have many benefits, one of which can be used as medicine. Kenikir leaves are reported to have antibacterial activity against the bacteria Salmonella typhi (S.typhi). S. typhi is a bacterium that causes typhoid fever. Typhoid fever is still an endemic disease in Asian countries, especially Indonesia. Typhoid fever became the third largest disease in Indonesia in 2010. The study related to the antibacterial activity of kenikir leaf fraction to S. typhi has never been reported. Therefore, it is necessary to conduct research related to the antibacterial activity of extracts and leaf fractions of kenikir to compare their potential against S. typhi. The study was conducted using the disk diffusion method using 5 series of concentrations namely 5%, 10%, 15%, 20%, and 30%. Tests were carried out on methanol extract, hexane, ethyl acetate, and methanol-water fraction. The results showed that highest inhibition zone diameter is 7,75 mm which is reached by methanol extract. The order of the highest inhibiting zone diameter are extract, hexane, ethyl acetate, and methanol-water fraction.
Uji Aktivitas Antibakteri Ekstrak Etanol Daun Waru Gunung (Hibiscus macrophyllus) dan Fraksinya terhadap Staphylococcus aureus Afif Rifqie Maulana; Bawon Triatmoko; Mochammad Amrun Hidayat
Pustaka Kesehatan Vol 9 No 1 (2021): Volume 9 No.1, 2021
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v9i1.16432

Abstract

Infection is one of the main causes of world health problems, especially in developing countries like Indonesia, one of which is an acute respiratory infection caused by bacteria such as Staphylococcus aureus. Therapeutics are used for the treatment of infections today with antibiotics. However, there are many cases of bacterial resistance to antibiotics that need to develop alternatives derived from plants. One of the plants that have antibacterial activity is the leaves of Waru Gunung (Hibiscus macrophyllus). The purpose of this study was to determine whether the ethanolic extract of H. macrophyllus leaves and their fractions have antibacterial activity against S. aureus. The method used in this antibacterial activity test is the disk diffusion method with a test concentration of 5%, 10%, 15%, 20%, and 25%. The results of this study indicate that all test samples have antibacterial activity except in the water fraction. The highest antibacterial activity was obtained in the ethyl acetate fraction which attracted semipolar compounds in the ethanolic extract of H. macrophyllus leaves. The antibacterial activity of the test samples in sequence from high to low includes ethyl acetate fraction, ethanolic extract, n-hexane fraction, and water fraction.
Potensi Ekstrak Etanol dan Fraksi-Fraksinya Dari Tiga Varietas Jahe Sebagai Agen Antibakteri Terhadap Staphylococcus aureus Dewi Dianasari; Endah Puspitasari; Indah Yulia Ningsih; Bawon Triatmoko; Fauzia Ken Nasititi
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.9226

Abstract

One of the natural ingredients that to be used to inhibit bacterial growth is the Zingiber officinale. In Indonesia, there are 3 types of ginger which are distinguished by morphology, namely ‘emprit ginger (Zingiber officinale var. Amarum), ‘ gajah’ ginger (Zingiber officinale var. Officinarum), and red ginger (Zingiber officinale var. Rubrum). This research was conducted to determine the activity of extracts and fractions of three ginger varieties in inhibiting the growth of Staphylococcus aureus using the disc diffusion method. The test group consisted of ethanol extract, n-hexane fraction, and ethyl acetate fraction from 3 ginger varieties, concentrations of 5, 10, 20% w / v, gentamicin 10 μg (positive control) and 10% DMSO (negative control). The test results showed that ethanol extracts and fractions from the rhizomes of three varieties of ginger have the ability to inhibit S. aureus at concentrations of 5, 10, and 20% w / v, increasing the concentration will increase the diameter of the inhibition zone. At a concentration of 20% of all samples, the one with the greatest resistance was the n-hexane fraction (diameter of inhibitory zone of emprit ginger 9.80 mm, elephant ginger 9.78 mm, and red ginger 9.90 mm). The difference in ginger variety only affects the antibacterial activity of the ethanol extract, but not the n-hexane and ethyl acetate fractions.
OPTIMASI ASAM TARTRAT DAN NATRIUM BIKARBONAT GRANUL EFFERVESCENT KOMBINASI EKSTRAK DAUN Guazuma ulmifolia Lam. DAN KELOPAK Hibiscus sabdariffa L. Dwi Nurahmanto; Dita Isnaini Prabawati; Bawon Triatmoko; Nuri Nuri
Jurnal Farmasi UIN Alauddin Makassar Vol 7 No 2 (2019): Jurnal Farmasi Volume 7 Nomor 2
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jurfar.v7i2.11573

Abstract

Guazuma ulmifolia Lam. dan Hibiscus sabdariffa L. secara empiris digunakan sebagai jamu untuk menurunkan kadar kolesterol dalam darah. Jamu yang mengandung ekstrak tersebut memiliki rasa yang pahit dan aroma yang tidak menyenangkan. Penelitian ini dibuat sediaan granul effervescent dari kombinasi ekstrak daun Guazuma ulmifolia Lam. dan ekstak Kelopak Bunga Hibiscus sabdariffa L. Formulasi dalam bentuk granul effervescent, terdiri dari sumber asam dan basa yaitu asam tartrat dan natrium bikarbonat. Granul effervescent dapat memperbaiki rasa dan aroma. Penelitian ini bertujuan untuk mengetahui formula optimum yang memiliki sifat fisik granul effervescent yang baik.  Penelitian ini dilakukan berdasarkan metode desain faktorial dengan dua faktor dan dua level yang menghasilkan empat formula yaitu formula (1), a, b, dan ab. Sifat fisik granul effervescent yang diuji adalah kelembaban dan waktu larut. Hasil menunjukkan bahwa peningkatan konsentrasi natrium bikarbonat dapat menurunkan kelembaban dan waktu larut. Sedangkan, peningkatan konsentrasi asam tartrat justru sebaliknya. Formula optimum yang diperoleh dalam penelitian ini mengandung asam tartrat 600 mg dan natrium bikarbonat 1209 mg. Formula tersebut memiliki komposisi yang sama seperti formula b.
Isolasi Fungi Tanah Kabupaten Situbondo serta Skrining Aktivitas Antibakteri Terhadap Pseudomonas Aeruginosa Fawwas Batio Putra Pamungkas; Bawon Triatmoko; Ari Satia Nugraha
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 1 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i1.750

Abstract

Bacterial resistance to antibiotics is a serious concern. The search for new antibacterial compoundsfrom medicinal plants can result in overexploitation of natural ingredients. Therefore, it is necessary to search for new alternative sources. This study was aimed to fi nd new antibacterial agents derived from soil fungi isolated from swampy soil in the Pasir Putih Beach area of Situbondo Regency in inhibiting Pseudomonas aeruginosa (P. aeruginosa). Isolation was carried out using Potato Dextrose Agar (PDA) dissolved in sea water. The isolation results showed that 5 isolates fungi. The fungi IS-STB-III-4 and IS-STB-III-5 have the potential to inhibit bacterial using antagonist tests. Potential soil fungi were fermented for 14 days and extracted with ethyl acetate as a solvent. The extraction results were dissolved in 10% DMSO with a concentration series of 1000 μg /mL, 2000 μg/mL, 4000 μg/mL, 6000 μg/mL, 8000 μg/mL which will be used for antibacterial activity test using the disc diff usion method. The extract activity test showed results that were directly proportional to the extract concentration. The analysis and profi ling of the extract using High Performance Liquid Chromatography (HPLC) instrument showed that the extract contained alkaloids which were then isolated and identifi ed by HPLC.
Co-Authors Achmad Syarifudin Noor Adinda Kusuma Pertiwi Afif Rifqie Maulana Afrian Rosyadi Agustinus Yuswanto Amrina Rosyada Fajriyanti Ari Satia Nugraha Arthur Hariyanto Prakoso Arthur Hariyanto Prakoso Arthur Hariyanto Prakoso Asia Asia Dewi Dianasari Dewi Dianasari Dianasari, Dewi Dinar Mutia Rani Dita Isnaini Prabawati Dwi Nurahmanto Dwi Nurahmanto Endah Puspitasari Fauzia Ken Nasititi Fawwas Batio Putra Pamungkas Gani Asri Muharam Huda Almuttaqin Ifan Arif Maulana Indah Yulia Ningsih Ita Husnul Chotimah Mariatul Kibthiyyah Marsalita Irine Prabandari Mochammad Amrun Hidayat Muhammad Habiburrohman Muhammad Habiburrohman Muhammad Habiburrohman Muhammad Zainul Arifin Nafa Rosyida Zanuba Nasititi, Fauzia Ken Naura Bathari Winarto Nimas Ayu Amanda Putri Nuri Nuri Nuri Nuri Nuri Nuri Saeful Akhmad Tauladani Savitri, Ganevi Resta Triana Hertiani Wilda Nur Rohmatilah Wilda Nur Rohmatillah Wilda Nur Rohmatillah Yoshinta Debby Ziyan Nihlatul Millah