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All Journal e-Journal Pustaka Kesehatan Jurnal Pangan dan Agroindustri UNEJ e-Proceeding Dental Journal (Majalah Kedokteran Gigi) Jurnal Kedokteran Gigi Universitas Padjadjaran Health Notions Dental Agromedis
Dyah Indartin Setyowati
Faculty Of Dentistry, Universitas Jember, Jember
Agriculture, Biological Sciences & Forestry Dentistry Education Health Professions Library & Information Science Medicine & Pharmacology Nursing Public Health

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Journal : e-Journal Pustaka Kesehatan

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Efektivitas Ekstrak Black Garlic dalam Menghambat Pertumbuhan Candida albicans Ratih Iswari Ningtias; Dyah Indartin Setyowati; Ari Tri Wanodyo Handayani
Pustaka Kesehatan Vol 8 No 3 (2020): Volume 8 No. 3, 2020
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v8i3.12990

Abstract

Black garlic has many properties naturally can be used as an antifungi. This study aims to determine the effectiveness of Black garlic extract in inhibiting the growth of Candida albicans and knowing the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC) of Black garlic extract against Candida albicans. This study used 5 groups of Black garlic extract concentration, namely 75%, 50%, 25%, 12.5%, and positive controls, with 5 replications. Extraction was carried out using maceration method with 96% ethanol solvent, while the antifungal test was carried out by liquid dilution method. MIC was determined by observing the turbidity and clarity of each test solution and compared to the control solution. MFC was determined by observing the presence or absence of fungi colonies growing on Sabouraud Dextrosa Agar (SDA) media after incubation for 24 hours. The results of the study carried out the Kruskall-Wallis test showed a significance value (p <0.05) which means that there were significant differences in all groups. In the Mann-Whitney test showed a significance value (p <0.05) which means there are differences between treatment groups. The conclusion is that Black garlic extract has the ability to antifungal with MIC at a concentration of 50% and MFC at a concentration of 75%.
Daya Hambat Ekstrak Buah Delima Merah (Punica granatum Linn) Terhadap Pertumbuhan Porphyromonas gingivalis (The Inhibition of Red Pomegranate Fruit Extract (Punica granatum Linn) on The Growth Porphyromonas gingivalis) Alvin Ananda Susetyo; Sri Hernawati; Dyah Indartin
Pustaka Kesehatan Vol 5 No 2 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Background : Halitosis is a common complaint among general population. Porphyromonasgingivalis 33277 is the most frequent bacteria that cause halitosis. Pomegranate (Punicagranatum Linn) extract is used to control the number of Porphyromonas gingivalis population.Bioactive compound of pomegranate is polyphenol (Flavonoids and its derivate, tanins,ellagitanins) and Alkaloids. Objective : To Analyze the effectiveness of pomegranate againstInhibition of Porphyromonas gingivalis Materials and Metdhods :The research used discdiffusion method (Kirby-Bauer) with 7 treatment group (n=6). Petridish was filled with Agar andinoculated by Porphyromonas gingivalis. after 5 minutes, set up disk that previously immersed in100%, 50%, 25%, 12,5%, 6,25% pomegranate extract, distilled water (negative control) andClorhexidine 0,2% (positive control) on top. The Petridish were then placed in the desiccator andincubator at 37oC for 24 hours. Zone of Inhibition were measured using digital caliper by threeindependent observer and recorded in millimeter. The result of this study showed that there wereInhibition zone in all treatment group (except negative control). Results and Conclusions :Pomegranate extract had antibacterial activity against Porphyromonas gingivalis at 6,25 minimuminhibitory concentration.Keywords: Antibacterial activity, Punica granatum Linn extract, Porphyromonas gingivalis, Kirby-Bauer disk diffusion method.
Efektivitas Ekstrak Bawang Putih dan Bawang Hitam dalam Menghambat Pertumbuhan Candida albicans Ni Made Widia Sasmita Indraswari; Dyah Indartin Setyowati; Zahreni Hamzah
Pustaka Kesehatan Vol 10 No 2 (2022): Volume 10 No.2, 2022
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v10i2.14625

Abstract

Antifungal drugs that already exist have several side effects, so it needs to be developed a new drug from natural ingredients. Garlic and black garlic are known to have organosulfur compounds that can be used as an antifungal. This study aimed to determine the effectiveness of garlic (A. sativum) and black garlic extract in inhibiting the growth of Candida albicans. This study used 3 groups, namely control group, the garlic (A. sativum) extract group and the black garlic extract group by using concentration 100%, 75%, 50%, and 25% with 3 times replication. Extraction using maceration method with 96% ethanol solvent, while the antifungal test using disk diffusion method. antifungal effect is determined by calculating the inhibition zone formed on Sabouraud Dextrosa Agar (SDA) media after incubating for 24 hours. The results of Kruskall-Wallis test showed a significance value (p <0.05) which means there were differences in all groups. In the Mann-Whitney test showed a significance value (p >0.05) which means there are no significant differences between treatment groups. In conclusion, garlic extract is more effective compared to black garlic extract but the difference is not significant.
Co-Authors Alvin Ananda Susetyo Amandia Dewi Permana Shita Ari Tri Wanodyo Handayani Ayu Mashartini Prihanti Debi Suntari Dominica Diana Siswadi Iin Eliana Triwahyuni Inaayatul Maula Leni Rokhma Dewi Masniari Novita Ni Made Widia Sasmita Indraswari Ratih Iswari Ningtias Ristya Widi Endah Yani Safira Zahra Marari Sofira Nadia Sri Hernawati Tecky Indriana Zahara Meilawaty Zahreni Hamzah