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All Journal e-Journal Pustaka Kesehatan Jurnal Pangan dan Agroindustri UNEJ e-Proceeding Dental Journal (Majalah Kedokteran Gigi) Jurnal Kedokteran Gigi Universitas Padjadjaran Health Notions Dental Agromedis
Dyah Indartin Setyowati
Faculty Of Dentistry, Universitas Jember, Jember
Agriculture, Biological Sciences & Forestry Dentistry Education Health Professions Library & Information Science Medicine & Pharmacology Nursing Public Health

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Journal : UNEJ e-Proceeding

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ROLE OF CHEMOATTRACTANT CHEMOKINE (SDF-1/CXCR4) IN BONE MARROW NICHE Dyah Indartin Setyowati; Zahreni Hamzah
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Bone marrow is the pioneer for studying stem cells.The basic concept of stem cells obtained by studyinghematopoietic stem cells. Although how theinteraction of HSCs with the local environmentnecessary for the maintenance of stem cells can notbe fully explained ( Compston, 2002; Iwasaki andSuda., 2010). Studies of HSCs aims to study thehabits of these cells in a population of cellscontained in bone marrow . So far little is knownabout the interaction of the bone marrow niche. Thestudy was conducted using a culture system thatlimited done in a sustainable way to prove theinteraction of the bone marrow niche. From theseresults can then be identified subset of osteoblasts (N-Cadherin + CD 45-) that physically attaches to theHSCs in the BM . ( Tong Yin , 2006)Bone marrow consist of hematopoietic cells arewrapped by the bone structure. Hematopoietic cellsdevelop in the bone cavity and retained in the bonemarrow until they have matured, then released intothe vascular system ( Yin and Li , 2006). Most cells ofhaemopoietic can be found next to the endostealsurface of the bone, which layer is primarilyosteoblasts. Osteoblasts is one type of bone cell thatserves to reform or bone formation. HSCs are stemcells that are known to differentiate into osteoclasts.Osteoclasts are the cells of bone that serves to boneresorption. Their physical proximity betweenosteoblasts and which HSCs are parent cellsosteoclasts, as well as the identification of N -Cadherin / β - Catenin adherent complex betweenthe two prove their relationship or communicationbetween these cells. Osteoblast cells not only play arole in bone formation, but as osteoblast niche inthe bone marrow also, contribute to themaintenance of HSCs that are stem cells osteoclasts(Yin and Li , 2006 ; Tong Yin , 2006 ).There are two main types of stem cells areembryonic and adult stem cells . Pluripotentembryonic stem cells derived from the inner cellmass of blastocysts and has the ability to be a threeembryonic germ layers , namely ectoderm ,endoderm , and mesoderm (Li and Xie , 2005). Atbirth, adult stem cells including GSCs and SSCs willoccupy and live in a special microenvironment,called a niche (Li and Sie., 2005)Niche is different depending on the type of tissue ororgan. Structurally niche supported by the cells andtheir interactions molecular signals that preparedand provided to form a microenvironment for stemcells. Niche hypothesis has actually been describedby Scofield in 1978 ( Li and Sie , 2005; Yin and Li ,2006) . Stem cell niche is supported by manysignaling and adhesion molecules involved in theinteraction of the stem cell niche, accounted diversecharacteristics for each niche function ( figure 1 )that is; SDF -1/CXCR4 , SCF/c - Kit, Jagged/Notch,angiopoietin-1/ Tie2 ( Ang-1/Tie2 ), and Ca2 + -sensing receptor ( Yin and Li, 2006). Most studiesconducted to know and understand the molecularmechanisms of interaction and behavior of stemcells. Understanding the interaction and behavior ofstem cells in the bone marrow niche is veryimportant to understand the eventsosteoclastogenesis, especially how osteoclastprecursor cells can be recruited from niche thenmobile until homing (Kollet et al , 2007). Research isusually conducted in diseases associated with theaccumulation of osteoclasts or osteoclast progenitorcells that causes pathological osteolysis , such as ;benign bone tumors and bone metastases cancer (Kollet et al , 2007; Jennifer , 2009).
ROLE OF REACTIVE OXYGEN SPECIES ON DEVELOPMENTS OF OSTEOCLASTOGENESIS IN AGING Dyah Indartin Setyowati; Zahreni Hamzah; Zahara Meilawaty
UNEJ e-Proceeding 2016: Proceeding The 1st International Basic Science Conference
Publisher : UPT Penerbitan Universitas Jember

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Osteogenesis is a process of development which is perfectly controlled by a number of extrinsic and instrinsic factors that consists of hormones, growth factors, cytokines produced in the bone marrow micro environment, due to process of molecules adhesion that mediate by the interaction of cells and cell-matrix, osteoblasts-specific signaling proteins and transcription factors (TFs). Recently, research explained that adherence osteoclasts on the bone surface and secretion of protons into an extracellular compartment between osteoclasts and bone surface together with the production of Reactive Oxygen Species (ROS) involved in the complex process of bone resorption. Superoxide role in the activation and transcription NF-κB factor is to increase osteoclastogenesis. Furthermore, it is alleged that ROS is involved in both differentiation of osteoclasts and osteoblast cell. Aging and diseases which associated with aging is a result of ROS that cause damage was reported increase with age. This review, which is dedicated to geriatric physicians, geriatric dentistry or gerodontology reviews ROS-related osteoclastogenesis in aging and as the basic of the research to determine benefit of ROS through NADPH oxidase activation in the osteopetrotic case.
MANAGEMENT OF RECURRENT APHTHOUS STOMATITIS WITH PSYCHOLOGICAL STRESS (Case Report) Ayu Mashartini Prihanti; Dyah Indartin Setyowati; Leni Rokhma Dewi
UNEJ e-Proceeding 2022: E-Prosiding Kolokium Hasil Penelitian dan Pengabdian kepada Masyarakat
Publisher : UPT Penerbitan Universitas Jember

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Recurrent aphthous stomatitis (RAS) is an inflammation of the soft tissues of the mouth characterized by recurrent ulcers in the absence of other underlying diseases. Pain and discomfort in the area around the ulcer can be caused by mastication, or during speech. The characteristics of RAS are in the form of recurrent ulcers in the oral cavity with a round or oval shape and edges surrounded by erythema with a gray-yellow base of the lesion. RAS occurs starting at a young age, namely children and puberty, and can occur in adults. RAS is clinically divided into 3 types, namely major, minor, and herpetiform. A 21-year-old female patient came to the RSGM Universitas Jember with complaints of stomatitis in the mouth. Canker sores recur at least 1 year 3-5 times, and usually heal on their own in about 10 days. Intra-oral examination of the lower and lateral labial mucosa of the right tongue found ulcers, round, 2-3mm in diameter, white center, erythematous edges, clear boundaries. Based on the examination, the patient was diagnosed with Minor Recurrent Aphthous Stomatitis with a predisposition to psychological stress. The patient was given topical anti-inflammatory aloe vera therapy with multivitamin becomzet (vitamin B complex, A, C, E, and Zinc). The patient showed a positive response to the therapy.
Co-Authors Alvin Ananda Susetyo Amandia Dewi Permana Shita Ari Tri Wanodyo Handayani Ayu Mashartini Prihanti Debi Suntari Dominica Diana Siswadi Iin Eliana Triwahyuni Inaayatul Maula Leni Rokhma Dewi Masniari Novita Ni Made Widia Sasmita Indraswari Ratih Iswari Ningtias Ristya Widi Endah Yani Safira Zahra Marari Sofira Nadia Sri Hernawati Tecky Indriana Zahara Meilawaty Zahreni Hamzah