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All Journal Jurnal Biologi Udayana Jurnal Ilmu Dasar BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) BIOEDUSCIENCE Biota Bioscientist : Jurnal Ilmiah Biologi BIOTROPIC

Susantin Fajariyah

Jurusan Biologi, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Jember

Author-ID : 2976175

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Control & Systems Engineering Education Environmental Science Immunology & microbiology Mathematics Medicine & Pharmacology Social Sciences

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DIURETICS EFFECT OF AVOCADO LEAF (Persea americana Mill.) ETHANOL EXTRACT ON THE GASTRIC HISTOLOGY OF WISTAR MALE RATS (Rattus norvegicus) Dwi Erlinda; Mahriani Mahriani; Susantin Fajariyah
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol 7, No 1 (2020): August 2020
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/biolink.v7i1.3007

Irregular urine output triggers kidney stone disease. One way to cure it is by using synthetic diuretic compounds. The use of synthetic diuretic drugs for a long time can cause side effects, namely gastric damage. Therefore, research is needed to determine the diuretic effect of ethanol extract of avocado leaves (Persea americana) and its effect on the histological structure of the gastric of male rats. Avocado leaf extract is made by maceration method, using 70% ethanol and then evaporated. Wistar male rats were divided into 5 treatment groups namely negative control (aquadest), positive control (furosemide), avocado leaf extract dose of 50 mg / kg body weight, 100 mg / kg body weight, and 150 mg / kg body weight with oral administration for 15 days. The volume of urine was measured for 24 hours, then the mice were sacrified on the 16th day. Gastric organs were taken for histological observation by the paraffin method and Hematoxylin and Eosin (H&E) staining. The results showed that the optimum avocado leaf ethanol extract was a dose of 100 mg/kg showed a diuretic effect but did not affect the histological structure of the gastric.

EFFECT OF PERIWINKLE (CATHARANTHUS ROSEUS) LEAF EXTRACT ON LIVER HISTOLOGY OF MICE (MUS MUSCULUS L) AFTER ASPARTAME INDUCE Mahriani Mahriani; Rosita Dewi Wulandari; Susantin Fajariyah
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol 8, No 2 (2022): Februari 2022
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/biolink.v8i2.5161

Aspartame is an artificial sweetener in foods and beverages. Continuous use of aspartame will result in oxidative stress in the liver. So we need antioxidants from outside the body such as periwinkle leaves.This study aims to determine the effect of periwinkle leaves (Catharanthus roseus L) on aspartame-induced liver histology. This study used 24 male mice divided into 4 groups, namely negative control (K-) without treatment; Positive control (K +) treatment of aspartame; D1: treatment of aspartame and periwinkle extract doses of 0.42 mg/kg. D2: aspartame and periwinkle extract doses of 0.84 mg/kgbb. Administration of aspartame dose of 0.2 mg /kgbb by intraperitoneal for 14 days followed by gavage administration of periwinkle leaf extract for 12 days. The liver was taken on the 27th day by surgery, then made slide histology with Hematoxylin-Eosin staining. The results show that the administration of Catharanthus roseus leaf extract at a dose of 0.84 mg/kgbw in aspartame-induced mice was effective in reducing hepatocyte damage, namely hydrophilic degeneration and necrosis.

Efek ekstrak etanol kedelai hitam (Glycine soja) terhadap ketebalan dermis mencit (Mus musculus L.) pasca unilateral ovariektomi Isna Kurotul Akyun; Susantin Fajariyah; Mahriani Mahriani
Jurnal Biologi Udayana Vol 23 No 2 (2019): JURNAL BIOLOGI UDAYANA
Publisher : Program Studi Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Udayana

Estrogen is a steroid hormone produced by the ovaries. Estrogen is a hormone that triggers collagensynthesis by fibroblast.Collagen has affects for thickness of dermis.Estrogen deficiency can lead disruptioncollagen synthesis, so has an impact on decline dermis thickness. Unilateral ovariectomy is the act ofremoval of one ovary in the female reproductive system and is a model for estrogen deficiency. Thecondition of estrogen deficiency can be overcome by giving phytoestrogens. Black soybean seed is one ofphytoestrogens source. The purpose of this study was to determine the effect of black soybean extract afterovariectomy on increasing on dermis thickness (Mus musculus L.). The dosage of black soybean ethanolextract used was 0.31 g / ml / day and 0.63 g / ml / day administered orally (gavage) for 20 days. The resultsshowed a dose of 0.31 g / ml / day may and 0.63 g / ml / day increase dermis thickness of mice.

The Diversity of Holothurioidea in the Intertidal Zone of the Pancur Shore of the Alas Purwo National Park Riya Wulan Afrely; Moh. Imron Rosyidi; Susantin Fajariyah
Jurnal ILMU DASAR Vol 16 No 1 (2015)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

Holothurioidea well known as Sea Cucumber is one of the classes from the Echinodermata phylum. Sea cucumbers are benthic animals that move slowly. Currently they already identified about 1135 species. Their existence usually associated with abiotic factors such as water salinity, temperature, pH, wave motion, light intensity and the substrate. The ability of the Holothurioidea to adapt to the abiotic factors will affect species diversity. The research aims is to determine the species diversity in the intertidal zone at Pancur Shore of the Alas Purwo National Park. It includes the species composition, species diversity index and the index of equality The study was conducted on 14th-21st of June 2014, by using systematic plotting transect method. The results found: one order, one family, two generas and eight species. The Species diversity index of Holothurioidea at Pancur Shore is low (0.930) and the equality index classified uneven (0.447).Keywords: Holothurioidea, intertidal, diversity, evennes

The Effect of Cinnamon (Cinnamomum burmanii) Aqueous Extract on Pancreas Structure of Diabetic Mice (Mus musculus) Strain Balb-C Ika Dewi Kusumaningtyas; Susantin Fajariyah; Eva Tyas Utami
Jurnal ILMU DASAR Vol 15 No 2 (2014)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

The objectives of this study were to observe effect and the effective dose of cinnamon (Cinnamomum burmanii) aqueous extract on pancreas structure of strain Balb-C mice (Mus musculus) diabetic after alloxan exposure. A total of 30 strains Balb-C mice (Mus musculus L.) were divided into 5 groups. Negative control group was not induced by alloxan and a positive control group was induced alloxan 0,15 mg/g bw intraperitoneally for 9 days. The treatment group was divided into 3 groups was induced alloxan 0,15 mg/g bw and given an aqueous extract of cinnamon at a dose of 0,73 mg/g bw; 1,09 mg/g bw and 1,45 mg/g bw orally for 7 days. Mice were dissected pancreas histhological taken using paraffin method and Haematoxylin-eosin (HE) stain. The result showed giving aqueous extract of cinnamon gave a strong effect in the repairing of pancreas structure after giving the alloxsan and the most effective aqueouse xtract of cinnamon with dose of 0,73 mg/g bb was able to repair the structure of mice's pancreas after giving the alloxan. Keywords: Cinnamon, pancreas structur,diabetic mice

The Effect of Synthetic Estrogen on Hepar Stucture And Level of SGOT and SGPT of Balb’C Female Mice (UMus musculus) Susantin Fajariyah; Eva Tyas Utami; Yunita Arisandi
Jurnal ILMU DASAR Vol 11 No 1 (2010)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (255.087 KB)

The objectives of this study were to observe the effect of synthetic estrogen (diethylstilbestrol/DES) on hepar structure and level of SGOT as well as SGPT of female mice (Mus musculus). Mice were gavage by DES dose 0.084 μg/g bb, 0.168 μg/g bb, 0.336 μg/g body weight, sesame oil and control. DES was treated by gavage for 15 days. Observation were performed liver structure contain of number of normal hepatocyte, and hepatocyte disruption (picnosis, vacuole cell, and necrosis), also SGOT-SGPT level. The result showed that DES effected to the disruption of hepatocyte particularly necrosis was relativity high in 0,168 μg/g bb DES treatment. SGOT and SGPT level on blood increased after DES treatment.

Curcumin Effectivity on Hepar and Reproductive Organ Recovery Male Mice (Mus musculus L) after Methoxychlor Exposure Mahriani Mahriani; Susantin Fajariyah; Eva Tyas Utami
Biota Vol 13 No 1 (2020)
Publisher : Universitas Islam Negeri Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20414/jb.v13i1.196

Methoxychlor (MXC) is an insecticide (DDT derivates) that has the potential for bioaccumulation in mammal and causes a disruptive effect on the hepar and reproductive system. This study was done to find out the benefits of curcumin as a natural ingredient to overcome the negative impact of Methoxychlor (MXC) on hepar and male reproductive organ of Balb’C mice (Mus musculus L). The study was carried out in a Completely Randomized Design (CRD) Posttest Only Control Group Design used four treatments and six replications. The curcumin treatment after administration of MXC was carried out by gavage with curcumin doses: 0.05; 0,1; and 0.2 mg/g body weight, every day for two weeks, respectively. Histological observations of the liver, and testis was performed using the paraffin method and Hematoxylin Eosin stained. The results showed that MXC exposure caused liver disruption by increasing the number of pycnotic necrotic hepatocytes and hydrophic degeneration hepatocytes. On the male reproductive organ, MXC caused testis impairment by reducing the number of Sertoli cells and Leydig cells, spermatogenic cell counts, and the diameter of seminiferous tubules. The administration of curcumin at doses of 0.1 mg/g bw in mice exposed to methoxychlor can reduce the number of hydrophic degeneration hepatocytes and tend to reduce the number of pycnotic hepatocytes; and also increase the number of Sertoli cells, the number of spermatogenic cells, and the diameter of the seminiferous tubules, and tend to reduce the amount of Leydig cells. Curcumin treatment tends to recover hepar dan testis disruption of mice that were exposed by MXC.

Pengaruh Paparan Asap Rokok Elektrik terhadap Histologi Paru Mencit (Mus musculus L.) Strain Balb/c Jantan Eva Tyas Utami; Bella Dwi Arifianti; Mahriani; Susantin Fajariyah
BIOEDUSCIENCE Vol 4 No 2 (2020): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Background: Electric cigarette is a type of cigarette that change the liquid containing nicotine and other ingredients in the form of steam. This research aimed to identify the effect of exposure to e-cigarette smoke towards the thickness of bronchioles mucosa and the alveolar septa on male Balb'C mice (M. musculus). Methods: This research was an experimental design used 24 male divided into four groups, i.e., control dan three treatment groups. Treatment groups were given different volume of e-cigarettes liquid, i.e., 1 ml; 2 ml; and 4 ml. The exposure of e-cigarette was done in 4 weeks, respectively. Results: Electric cigarette exposure with different fluid volumes leads to an increase in the bronchioles mucosa's thickness and the alveoli septa. Increasing the volume of fluid used results in an increase in bronchioles mucosal thickness, but decreases the alveoli septa's thickness, resulting in destruction and dilatation of the alveoli. Conclusion: Exposure to e-cigarette smoke with a liquid volume of 1 ml affects the increase in the average thickness of the bronchial mucosa and alveoli septa. An increase in the average thickness of the bronchioles mucosa occurs along with increased fluid volume in exposure to e-cigarette smoke.

EFFECT OF PERIWINKLE (CATHARANTHUS ROSEUS) LEAF EXTRACT ON LIVER HISTOLOGY OF MICE (MUS MUSCULUS L) AFTER ASPARTAME INDUCE Mahriani Mahriani; Rosita Dewi Wulandari; Susantin Fajariyah
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol. 8 No. 2 (2022): February 2022
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/biolink.v8i2.5161

Aspartame is an artificial sweetener in foods and beverages. Continuous use of aspartame will result in oxidative stress in the liver. So we need antioxidants from outside the body such as periwinkle leaves.This study aims to determine the effect of periwinkle leaves (Catharanthus roseus L) on aspartame-induced liver histology. This study used 24 male mice divided into 4 groups, namely negative control (K-) without treatment; Positive control (K +) treatment of aspartame; D1: treatment of aspartame and periwinkle extract doses of 0.42 mg/kg. D2: aspartame and periwinkleÂ extract doses of 0.84 mg/kgbb. Administration of aspartame dose of 0.2 mg /kgbb by intraperitoneal Â for 14 days followed by gavage administration of periwinkle leaf extract for 12 days. The liver was taken on the 27th day by surgery, then made slide histology with Hematoxylin-Eosin staining. The results show that the administration of Catharanthus roseus leaf extract at a dose of 0.84 mg/kgbw in aspartame-induced mice was effective in reducing hepatocyte damage, namely hydrophilic degeneration and necrosis.

Pengaruh Pemberian Ekstrak Rimpang Kunyit (Curcuma longa L.) terhadap Histologi Hepar Tikus Pasca Diinduksi Thioacetamide (TAA) Eva Tyas Utami; Dewi Syaibatul Aqlina; Susantin Fajariyah; Mahriani Mahriani
Bioscientist : Jurnal Ilmiah Biologi Vol 10, No 2 (2022): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v10i2.6011

Turmeric (Curcuma longa L.) rhizome contains antioxidant compounds that can prevent damage to the liver. Thioacetamide (TAA) is an organosulfur compound in the form of crystals and is widely used as a fungicide and organic solvent in the textile, leather and paper industries, as well as being used as a motor fuel stabilizer. Continuous exposure to TAA compounds can cause hepatocyte damage in the form of parenchymatous degeneration and necrosis. The purpose of this study was to determine the effect of turmeric (Curcuma longa L.) rhizome extract on the histological appearance of the rat (Rattus norvegicus) liver after being induced by TAA. This study used a completely randomized design (CRD) with 24 Wistar rats (Rattus norvegicus) which were divided into 4 groups, namely: K- (no treatment), K+ (TAA induced 200 mg/kg BW), D1 (TAA induced 200 mg/kg BW + administration of turmeric rhizome extract at a dose of 200 mg/kg BW), and D2 (TAA induction of 200 mg/kg BW + turmeric rhizome extract at a dose of 400 mg/kg BW). TAA induction was carried out intraperitoneally, while administration of turmeric rhizome extract was carried out by gavage. Preparation of liver histology preparations using the paraffin method and Hematoxylin Eosin (HE) staining to see liver damage including parenchymatous degeneration and necrosis. The results showed that administration of turmeric rhizome extract doses of 200 mg/kg BW and 400 mg/kg BW had a significant effect on decreasing the average number of hepatocytes undergoing parenchymatous degeneration and necrosis after being induced by TAA at a dose of 200 mg/kg BW.

Co-Authors Bella Dwi Arifianti Dewi Syaibatul Aqlina Dwi Erlinda Eva Tyas Utami Firna Putri Mandasari Ika Dewi Kusumaningtyas Isna Kurotul Akyun Mahriani Mahriani Mahriani Mahriani Mahriani Mahriani Moh. Imron Rosyidi Purwatiningsih Purwatiningsih Riya Wulan Afrely Rosita Dewi Yunita Arisandi

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