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All Journal Jurnal Biologi Udayana Jurnal Ilmu Dasar BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) BIOTROPIC The Journal of Tropical Biology BIOEDUSCIENCE Biota Bioscientist : Jurnal Ilmiah Biologi
Susantin Fajariyah
Jurusan Biologi, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Jember
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Control & Systems Engineering Education Environmental Science Immunology & microbiology Mathematics Medicine & Pharmacology Social Sciences

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Pengaruh Pemberian Ekstrak Rimpang Kunyit (Curcuma longa L.) terhadap Histologi Hepar Tikus Pasca Diinduksi Thioacetamide (TAA) Eva Tyas Utami; Dewi Syaibatul Aqlina; Susantin Fajariyah; Mahriani Mahriani
Bioscientist : Jurnal Ilmiah Biologi Vol 10, No 2 (2022): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v10i2.6011

Abstract

Turmeric (Curcuma longa L.) rhizome contains antioxidant compounds that can prevent damage to the liver. Thioacetamide (TAA) is an organosulfur compound in the form of crystals and is widely used as a fungicide and organic solvent in the textile, leather and paper industries, as well as being used as a motor fuel stabilizer. Continuous exposure to TAA compounds can cause hepatocyte damage in the form of parenchymatous degeneration and necrosis. The purpose of this study was to determine the effect of turmeric (Curcuma longa L.) rhizome extract on the histological appearance of the rat (Rattus norvegicus) liver after being induced by TAA. This study used a completely randomized design (CRD) with 24 Wistar rats (Rattus norvegicus) which were divided into 4 groups, namely: K- (no treatment), K+ (TAA induced 200 mg/kg BW), D1 (TAA induced 200 mg/kg BW + administration of turmeric rhizome extract at a dose of 200 mg/kg BW), and D2 (TAA induction of 200 mg/kg BW + turmeric rhizome extract at a dose of 400 mg/kg BW). TAA induction was carried out intraperitoneally, while administration of turmeric rhizome extract was carried out by gavage. Preparation of liver histology preparations using the paraffin method and Hematoxylin Eosin (HE) staining to see liver damage including parenchymatous degeneration and necrosis. The results showed that administration of turmeric rhizome extract doses of 200 mg/kg BW and 400 mg/kg BW had a significant effect on decreasing the average number of hepatocytes undergoing parenchymatous degeneration and necrosis after being induced by TAA at a dose of 200 mg/kg BW.
Pengaruh Paparan Asap Rokok Elektrik terhadap Histologi Paru Mencit (Mus musculus L.) Strain Balb/c Jantan Eva Tyas Utami; Bella Dwi Arifianti; Mahriani Mahriani; Susantin Fajariyah
BIOEDUSCIENCE Vol 4 No 2 (2020): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/j.bes/425319

Abstract

Background: Electric cigarette is a type of cigarette that change the liquid containing nicotine and other ingredients in the form of steam. This research aimed to identify the effect of exposure to e-cigarette smoke towards the thickness of bronchioles mucosa and the alveolar septa on male Balb'C mice (M. musculus). Methods: This research was an experimental design used 24 male divided into four groups, i.e., control dan three treatment groups. Treatment groups were given different volume of e-cigarettes liquid, i.e., 1 ml; 2 ml; and 4 ml. The exposure of e-cigarette was done in 4 weeks, respectively. Results: Electric cigarette exposure with different fluid volumes leads to an increase in the bronchioles mucosa's thickness and the alveoli septa. Increasing the volume of fluid used results in an increase in bronchioles mucosal thickness, but decreases the alveoli septa's thickness, resulting in destruction and dilatation of the alveoli. Conclusion: Exposure to e-cigarette smoke with a liquid volume of 1 ml affects the increase in the average thickness of the bronchial mucosa and alveoli septa. An increase in the average thickness of the bronchioles mucosa occurs along with increased fluid volume in exposure to e-cigarette smoke.
Pengaruh Paparan Asap Rokok Elektrik terhadap Histologi Paru Mencit (Mus musculus L.) Strain Balb/c Jantan Eva Tyas Utami; Bella Dwi Arifianti; Mahriani Mahriani; Susantin Fajariyah
BIOEDUSCIENCE Vol 4 No 2 (2020): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/j.bes/425319

Abstract

Background: Electric cigarette is a type of cigarette that change the liquid containing nicotine and other ingredients in the form of steam. This research aimed to identify the effect of exposure to e-cigarette smoke towards the thickness of bronchioles mucosa and the alveolar septa on male Balb'C mice (M. musculus). Methods: This research was an experimental design used 24 male divided into four groups, i.e., control dan three treatment groups. Treatment groups were given different volume of e-cigarettes liquid, i.e., 1 ml; 2 ml; and 4 ml. The exposure of e-cigarette was done in 4 weeks, respectively. Results: Electric cigarette exposure with different fluid volumes leads to an increase in the bronchioles mucosa's thickness and the alveoli septa. Increasing the volume of fluid used results in an increase in bronchioles mucosal thickness, but decreases the alveoli septa's thickness, resulting in destruction and dilatation of the alveoli. Conclusion: Exposure to e-cigarette smoke with a liquid volume of 1 ml affects the increase in the average thickness of the bronchial mucosa and alveoli septa. An increase in the average thickness of the bronchioles mucosa occurs along with increased fluid volume in exposure to e-cigarette smoke.
Co-Authors Bella Dwi Arifianti Dewi Syaibatul Aqlina Dwi Erlinda Eva Tyas Utami Firna Putri Mandasari Ika Dewi Kusumaningtyas Isna Kurotul Akyun Mahriani Mahriani Mahriani Mahriani Mahriani Mahriani Moh. Imron Rosyidi Purwatiningsih Purwatiningsih Riya Wulan Afrely Rosita Dewi Yunita Arisandi