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All Journal Pharmaciana: Jurnal Kefarmasian Ahmad Dahlan Medical Journal Jurnal Farmasi Sains dan Praktis
Isabella Meliawati Sikumbang
Universitas Muhammadiyah Magelang
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Wound healing activity of aloe vera extract spray on acute wound in male balb/c mice Isabella Meliawati Sikumbang; Ratih Arum Astuti; Eka Sakti Wahyuningtyas; Heni Lutfiyati; Ratna Wijayatri; Nasruddin Nasruddin
Pharmaciana Vol 10, No 3 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2540.844 KB) | DOI: 10.12928/pharmaciana.v10i3.16640

Abstract

Acute wounds are tissue injuries that are at risk of infection so they require good treatment and care. Aloe vera (Aloe vera L) contains glukomanan compound that are thought to be beneficial in the wound healing process. Spray preparations in the treatment of wounds can provide concentrared content, dry quickly, and easy to use. The purpose of this study was to examine the spray activity of Aloe extract as an acute wound healer in male balb/c mice. This research method is experimental research. The steps that have been carried out include maceration extraction from Aloe vera simplicia powder with 70% ethanol which is then thick extracted in freeze drying to powder extract. Aloe vera spray preparations are made with concentrations of 1%, 3% and 5%. Balb / C mice that had made full thickness acute wounds were divided into 5 treatment groups namely positive control (PC), negative control (NC), F1, F2, and F3. Mice were treated for 14 days then the wound ratio was calculated and analyzed with one way anova test followed by post hoc tukey cramer test. The results showed that the higher of the percentage of Aloe vera extract is the higher of the wound healing activity. 
Wuluh Starfruit (Averrhoa Bilimbi) Extract Gel For Recurrent Aftosa Stomatitis Umaimatun Nakhil; Isabella Meliawati Sikumbang; Nugrahani Hendra Putri; Heni Lutfiyati
Jurnal Farmasi Sains dan Praktis Vol 5 No 2 (2019)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v5i2.2713

Abstract

The purpose of this study was to test the antibacterial activity of the gel extract of Wuluh starfruit (Averrhoa bilimbi L.). So that it can provide a representation of the use of starfruit in medicine and as an enrichment of insight. Averrhoa bilimbi L contains flavonoids, tannins and saponins which have antibacterial properties. The stages that have been carried out include identification and determination of the starfruit fruit plant, then the simplicia powder of starfruit is extracted using 70% ethanol by maceration which is then carried out evaporation on the waterbath to obtain thick extract. Then made the gel preparation with a concentration of b / v 40%, 45% and 50%. Evaluation of stability physical gel includes organoleptic test, homogeneity, pH, viscosity and spreading ability. The result showed that the three formulas were thick, brown with a characteristics smell of starfruit, homogeny, pH 5, viscosity 190-260 dPas and the spreadability test was 2,5-4,2 cm. Then a bacterial suspension was made by being immersed for 24 hours at 37 ℃. Then tested by dividing into 5 treatment groups, with positive controls Amoxicillin and negative control gel basis. The results showed that the average inhibition zone for each treatment was positive control 4.66 cm, negative control 0 cm, gel 40% 1.77 cm, gel 45% 1.93 cm, and gel 50% 2.67 cm. From the average inhibitory zone it can be seen that gel wuluh starfruit extract has antibacterial activity.
Early Detection of Mental Health of Doctoral Students UAD due to the Covid-19 Pandemic through the Questionnaire Method Muhammad Agita Hutomo; Laela Hayu Nurani; Widea Rossi Desvita; Isabella Meliawati Sikumbang
Ahmad Dahlan Medical Journal Vol. 3 No. 2 (2022): November 2022
Publisher : Universitas Ahmad Dahlan

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Abstract

Stress and a decrease in student learning achievement can be triggered by the mal-adaptive coping experienced, especially during the COVID-19 pandemic which requires students to adjust physically and psychologically in the learning process on campus which is now done online and is more independent in learning. So, psychological support for students, especially UAD doctoral students, needs to be done, one of which is mental health screening. The purpose of this study was to determine the mental health condition and social support of students. In the end, this will be the basis for providing psychological support and improving educational and learning activities for UAD Doctoral program students. The research method used was the adjustment and validation of the Self-Report Questionnaire (SRQ) 29, covering aspects of mental health, namely anxiety, depression, stress, use of psychostimulants/substances, symptoms of psychosis (reality rating disorder) and post-traumatic stress disorder (PTSD); Customize and validate social support questionnaires; Submission of ethical review; and Conducting an online survey of mental health, anxiety, depression and social support for Doctoral students. The results obtained from SRQ29 showed that as many as 30% of students experienced PTSD and 10% experienced depression. However, the results of the high religiosity test and quality of life were not compromised. The conclusion of this study is that the existence of religiosity and spirituality can provide positive coping to reduce mental disorders and improve the quality of life for students during the COVID-19 pandemic.
Co-Authors Astuti, Ratih Arum Eka Sakti Wahyuningtyas Heni Lutfiyati Heni Lutfiyati Laela Hayu Nurani Muhammad Agita Hutomo Nasruddin Nasruddin Nugrahani Hendra Putri Ratna Wijayatri Umaimatun Nakhil Widea Rossi Desvita