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All Journal Pharmaciana: Jurnal Kefarmasian Journal of Medicine and Health
Sijani Prahastuti
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Medicine & Pharmacology Public Health

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The ethanol extract of the bastard cedar (Guazuma ulmifolia L.) as antioxidants Sijani Prahastuti; Meilinah Hidayat; Stella Tinia Hasiana; Wahyu Widowati; Wahyu Setia Widodo; Rr. Anisa Siwianti Handayani; Rizal Rizal; Hanna Sari Widya Kusuma
Pharmaciana Vol 10, No 1 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (29.278 KB) | DOI: 10.12928/pharmaciana.v10i1.13636

Abstract

Guazuma ulmifolia, or commonly known as the bastard cedar, has many pharmaceutical activities and is, therefore, claimed as a source of various plant-based medicines. This reserach was purposed to identify the antioxidant activities of the ethanolic extract of G. ulmifolia (EEGU) by phytochemical screening assay, total flavonoid and total phenolic testing, and comparative analysis between the antioxidant activities of EEGU and epicatechin. The qualitative phytochemical screening assay of EEGU detected the availability of phenols, flavonoids, alkaloids, tannins, and terpenoids, but not saponins and triterpenoids. Meanwhile, the total phenolic content was 32.24 µg GAE/mg extract, and the total flavonoid content decided using aluminum chloride reagent with quercetin standard, was 6.48 µg QE/mg extract. The role of antioxidants examined by FRAP, DPPH, H2O2, and ABTS assays. These assay are proved that the IC50 values of EEGU are higher than those of epicatechin. For DPPH scavenging, H2O2 scavenging, and ABTS reduction activities, EEGU resulted IC50 45.70 μg/mL, 162.93 μg/mL, and 35.96 μg/mL, while epicatechin only yielded IC50 0.56 μg/mL, 57.91 μg/mL, and 16.74 μg/mL respectively. Otherwise, the highest reduction in FRAP activities were shown at  50 μg/mL concentration  of epicatechin and EEGU were 236.33 and 202.71 µM Fe (II)/µg respectively. Based on these results, EEGU is concluded as an active natural product because it exhibit antioxidant activities.
Potency of Black Soybean (Glycine max L. Merr) and Jati Belanda Leaves (Guazuma ulmifolia Lamk) for Dyslipidemia Treatment In Vivo Sijani Prahastuti; Meilinah Hidayat; Michael W. Kurniadi; Selvina Christiany
Journal of Medicine and Health Vol 1 No 3 (2016)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v1i3.515

Abstract

Soybean Detam 1 and Jati Belanda leaves are potential alternative medicines for treating dyslipidemia. The purpose of this study is to explore  the potential of the combination of Ethanolic Extract Soybean Detam 1 (EEKD) and Jati Belanda (EEJB) in lowering LDL cholesterol and triglycerides compared to single extract and Simvastatin. Using a real laboratory experimental method with CRD, a total of 36 male Wistar rats were divided into 6 groups and administrated for treatment of 28 days. The results showed a significant decrease of LDL cholesterol as well as triglyceride in NC  as compared to P1, P2, P3 (p <0.05) and no significant difference with PC (p> 0.05). The highest suppression of LDL cholesterol between P1 with P2 and P3 is (p <0.05) while the triglyceride is between P1 and P2 (p <0.05). This study concludes that the combination of EEKD 10 mg, 20 mg EEJB, EEKD 30 mg and EEJB 30 mg is significantly lowering LDL cholesterol and triglyceride. The combination of EEKD 10 mg, 20 mg EEJB is the highest compression of LDL cholesterol and triglyceride, and has an equivalent effect with simvastatin in lowering LDL cholesterol and triglycerides in male Wistar rats induced with high fat diet. Keywords: LDL cholesterol, triglycerides
Subchronic Treatment of Combination Extract Detam 1 Soybean and Jati Belanda Leaves has No Toxic Effect on Function, Weight, and Histopathological of Wistar Rat Kidney Meilinah Hidayat; Sijani Prahastuti; Vibiola Chikita; Dewi Safitri; Siti F. Rahmawati; Andreanus A. Soemardji
Journal of Medicine and Health Vol 1 No 4 (2016)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v1i4.530

Abstract

The combination of Detam 1 soybean and Jati Belanda leaves proved to have effect of weight loss. Since it will become longterm using, toxicity effectvresearch is needed.  This study was conducted to determine the effect of subchronic combination of ethanol extract of soybean Detam 1 (EEDS) and Jati belanda (EEJB) on kidney function, with parameters: urea and creatinine, macroscopic and histopathological of kidney. This study were conducted on 120 Wistar rats (60 males, 60 females), 90 days (treatment group) and 120 days (satellite group). Rats were divided into six treatment groups. Test results of urea and creatinine levels of all treatment groups was lower than control group (p <0.05). The treatment turned out to have a good effect on kidney function. Kidney weight of all groups showed no significant difference with the control group (p> 0.05). Histopathological score interpretation’s result of low dose group male and female kidney rats were not disturbed. In conclusion, the combination of EEDS and EEJB  have a good effect on kidney function, did  not lead to changes in organ weight and at low doses did not cause disturbance of  renal histopathology. Key words: combination of soybean jati Belanda, subchronic treatment, kidney function, kidney’s  weight, kidney’s histopathology
Hypolipidemic Effects of Pea Protein Hydrolysates on Lipid Profile and Uric Acid in Cisplatin-Induced Nephropathy Rats Meilinah Hidayat; Sijani Prahastuti; Andreas A Soemardji; Khomaini Hasan; Gabriella Audrey; Janifer Gabriella; Petrisia Luvina; Cicilia Liempapas; et al
Journal of Medicine and Health Vol 2 No 3 (2019)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v2i3.1234

Abstract

The usage of Cisplatin (CP) can cause side effects such as toxicity and impaired kidneyfunction. Poor kidney function causes dyslipidemia and hyperuricemia. Researchers in Canadastate that pea protein hydrolysates can improve kidney function. The aim was to examine thehypolipidemic effect of 8 types of pea protein hydrolysate on lipid profiles and uric acid in CPinduced rats in purpose to find protein sources origin of Indonesia for kidney therapy. This is atrue experimental study using fifty female Wistar rats divided into 10 treatment groups.Weadministered 8 types of pea protein hydrolysate for 30 days. On day 7 all rats (except negativecontrol) were induced CP intraperitoneally. Study parameters was evaluated on days 12 and30. In general, all treatments showed good hypolipidemic effects, and differed significantly fromCP group (p <0.01). The group that showed lowest total cholesterol, LDL and triglycerideresults is yellow pea protein hydrolysate Neutrase; HDL: green peas protein hydrolysatebromelain, uric acid: protein hydrolysate of pea protein isolate bromelain. As conclusion,protein hydrolysates of pea has good hypolipidemic effects on Lipid profile and Uric Acid inCP-induced nephropathy Rats. Keywords: protein hydrolysates, green peas, neutrase, bromelain, lipid profiles
Co-Authors Andreanus A. Soemardji Andreas A Soemardji Cicilia Liempapas Dewi Safitri et al Gabriella Audrey Hanna Sari Widya Kusuma Janifer Gabriella KHOMAINI HASAN Meilinah Hidayat Michael W. Kurniadi Petrisia Luvina Rizal Rizal Rr. Anisa Siwianti Handayani Selvina Christiany Siti F. Rahmawati Stella Tinia Hasiana Vibiola Chikita Wahyu Setia Widodo Wahyu Widowati