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Pengaruh jenis zat dan teman sebaya dengan kejadian relaps pada penyalahgunaan narkotika di Rehabilitasi IPWL RSErnaldi Bahar Provinsi Sumatera Selatan Zuhro Haris; MT Kamaluddin; Rico J. Sitorus
JURNAL KEDOKTERAN DAN KESEHATAN Vol 6, No 1 (2019)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.v6i1.7237

Data BNN Provinsi Sumatera Selatan Desember 2015 menyatakan 80% dari 98.000 pecandu narkotika menggunakan narkotika golongan Stimulansia Amfet/ Metamfetamin. Sebagian dari mereka mengalami relaps setelah menjalani program terapi dan rehabilitasi, oleh karena itu penelitian ini bertujuan menganalisis pengaruh jenis zat narkotika dan teman sebaya dengan kejadian relaps pada penyalaguna narkotika. Desain penelitian adalah cross sectional dengan menggunakan kuisioner untuk 165 pasien yang kontrol ulang di Poli IPWL RS Ernaldi Bahar pada Bulan Maret sampai April 2017. Hasil temuan diperoleh data bahwa faktor dominan penentu relaps disebabkan pengaruh jenis zat narkotika golongan stimulansia (met/amphetamin/Shabu) sebesar 93,7% dan pengaruh teman sebaya sebesar 93,2%. Analisis statistik (Pvalue 0.008, 95% Confidence 1nterval 1.483 – 13.689), risiko relaps penyalahguna jenis narkotika stimulansia 4,5 kali dibanding penyalahguna yang menggunakan jenis zat halusinogen. Pengaruh teman sebaya(teman yang paling sering interaksi) dengan kejadian relaps (Pvalue 0.010,tingkat kepercayaan 95% Confident Interval 1.388 – 10.839) risiko relaps sebesar 3.8 kali bila penyalahguna berinteraksi dengan teman penyalahguna narkotika. Kesimpulan bahwa jenis zat dan teman sebaya berpengaruh terhadap kejadian relaps. Hasil penelitian ini diharapkan dapat menjadi informasi bagi Dinas Kesehatan dan Rumah Sakit Ernaldi Bahar dalam penyusunan program terapi rehabilitasi pengendalian efek euforia (efek yang sangat menyenangkan) dan program pasca rehabilitasi untuk pencegahan relaps penyalaguna narkotika.

The Efficacy of Cinnamomum burmanii Extract on the Protection of Neuronal Cell Death in Haloperidol Induced Male Wistar Rats Nita Parisa; MT Kamaluddin; Theodorus Theodorus
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 2 No. 4 (2018): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v2i4.62

Background Haloperidol is categorized as the first class antipsychotic drug. Long-term use of haloperidol may convey to increased Reactive Oxygen Species (ROS) that will yield oxidative damage which further leads to cell death. Several studies had identified the effects of cinnamon extract on cell death. This study aimed to determine the efficacy of cinnamon extract (Cinnamomum burmanii) on the protection of neuronal cell death in haloperidol-induced male Wistar white rats. Methods This study was experimental with pre and post-test design. Thirty male Wistar rats were divided into 5 groups, induced with haloperidol and followed by treatment. Caspase-3 and dopamine were assayed by ELISA sandwich method using ELISA kit. Mean difference of caspase expression and dopamine levels before and after induction were shown (p<0.05). Results There were mean differences of caspase-3 expression level in the positive control group, cinnamon extract of 100 and 200mg/kgBW before and after treatment (p<0.05). Whereas for dopamine levels, there were mean differences in positive control group, cinnamon extract of 50, 100 and 200mg/kgBW before and after treatment (p<0.05). With Post Hoc test, it was found that there were no mean differences of caspase-3 expression level between positive group with cinnamon extract group of 100 and 200mg/kgBW (p>0,05) and there were also no mean differences of positive group dopamine level with group of cinnamon extract of 100 and 200mg/kgBW (p>0.05). Conclussion Cinnamomum burmanii extract at dose of 100 and 200mg/kgBW were effective in the protection against neuronal cell death in haloperidol induced male Wistar white rats.

The Efficacy of Cinnamomum burmanii Extract on the Protection of Neuronal Cell Death in Haloperidol Induced Male Wistar Rats Nita Parisa; MT Kamaluddin; Theodorus Theodorus
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 2 No. 4 (2018): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v2i4.62

Background Haloperidol is categorized as the first class antipsychotic drug. Long-term use of haloperidol may convey to increased Reactive Oxygen Species (ROS) that will yield oxidative damage which further leads to cell death. Several studies had identified the effects of cinnamon extract on cell death. This study aimed to determine the efficacy of cinnamon extract (Cinnamomum burmanii) on the protection of neuronal cell death in haloperidol-induced male Wistar white rats. Methods This study was experimental with pre and post-test design. Thirty male Wistar rats were divided into 5 groups, induced with haloperidol and followed by treatment. Caspase-3 and dopamine were assayed by ELISA sandwich method using ELISA kit. Mean difference of caspase expression and dopamine levels before and after induction were shown (p<0.05). Results There were mean differences of caspase-3 expression level in the positive control group, cinnamon extract of 100 and 200mg/kgBW before and after treatment (p<0.05). Whereas for dopamine levels, there were mean differences in positive control group, cinnamon extract of 50, 100 and 200mg/kgBW before and after treatment (p<0.05). With Post Hoc test, it was found that there were no mean differences of caspase-3 expression level between positive group with cinnamon extract group of 100 and 200mg/kgBW (p>0,05) and there were also no mean differences of positive group dopamine level with group of cinnamon extract of 100 and 200mg/kgBW (p>0.05). Conclussion Cinnamomum burmanii extract at dose of 100 and 200mg/kgBW were effective in the protection against neuronal cell death in haloperidol induced male Wistar white rats.

The Effect of Health Community Behavior (PHBS), Health Service Quality to Diare’s Disease in Sub-Division Karang Jaya Palembang Sub-District Iman Suwono; MT Kamaluddin; Sriati Sriati; Dwi Putro Priadi
Sriwijaya Journal of Environment Vol 3, No 1 (2018): Mining Activities
Publisher : Program Pascasarjana Universitas Sriwijaya

AbstractThe aims of this study were to analyze the Effect of Healthy Living Community Behavior (PHBS), Quality of Health Service against Overcoming Diarrhea Disease in Sub-division Karang Jaya Palembang. The type of research used in this study was analytical research. This research was conducted in Palembang City selected area of Karang Jaya Sub-district Gandus District. The study was conducted in May 2016 to June 2017. The samples of research were people affected by diarrhea in 2017 as many as 95 people. Method’s of data analysis using logistic regression. Result showed that the PHBS coefficient with odds ratio-0.760 (1.561-0.370) with significance of 0.045 less than the 0.05 significance level (α). This means that hypothesis one (H1) was accepted if the variable quality of health service, constant then every increase PHBS effect on the occurrence of diarrhea. The better PHBS will decrease the incidences of diarrhea. Coefficient of health service quality with odds ratio 1.598 (3.217-0.74) with significant equal to 0.009 less than level of significant (α) 0.05. This means that hypothesis two (H2) is accepted if the variable PHBS, constant then the quality of health services affect the occurrence of diarrhea. The better quality of health care will reduce the incidence of diarrhea Keywords: PHBS, quality of service, health, diarrhea

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