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All Journal Medica Hospitalia Jurnal Penyakit Dalam Indonesia
Handy Kurnia
Mahasiswa Fakultas Kedokteran Universitas Diponegoro Semarang
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Oropharyngeal Dysphagia as The Presenting Symptom of Myasthenia Gravis with Diabetes Mellitus Kurnia, Handy; Seno, Heri Nugroho Hario; Bintoro, Aris Catur; Purnomo, Hery Djagat
Medica Hospitalia : Journal of Clinical Medicine Vol. 11 No. 3 (2024): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v11i3.1154

Abstract

Background: Oropharyngeal dysphagia may caused by a variety of causes. Myasthenia gravis is a common autoimmune disease affecting the neuromuscular junction. While ocular symptoms are common in myasthenia gravis, bulbar symptoms such as dysarthria and dysphagia are less common. Aim: To present the importance of recognizing atypical presentations of myasthenia gravis and utilizing electromyography in diagnosis when AChR antibody testing is unavailable. Case Presentation: A 57-year-old woman was referred because of progressive dysphagia for both solid and liquid food. She also experienced weight loss, heaviness of the right eyelid, drooling, and chewing difficulty. Medical history revealed diabetes. Vital signs were stable. Physical examination revealed right ptosis without any other neurological deficits. Wartenberg test and dysarthria counting test were positive. Laboratory examination revealed a blood glucose level of 270 mg/dL and an HbA1c level of 9.4%. The barium swallow study revealedno abnormalities. Esophagogastroduodenoscopy revealed esophageal candidiasis. Electromyography showed more than 20% decremental response of the orbicularis oculi muscle. This result is suggestive of neuromuscular junction disorder. Improvement of the condition was achieved after the administration of intravenous steroids and oral pyridostigmine combined with therapeutic plasma exchange. Discussion: Oropharyngeal dysphagia accompanied by ptosis and positive Wartenberg & dysarthria counting test is suggestive of myasthenia gravis. Although an AChR antibody test cannot be performed, significant electromyography alongside relevant clinical presentation is sufficient to diagnose myasthenia gravis. Conclusion: It is crucial to recognize the accompanying signs and symptoms of oropharyngeal dysphagia. EMG may be used to diagnose MG in the appropriate clinical context.
Pengaruh Ivabradin terhadap Variabilitas Detak Jantung pada Gagal Jantung dengan Fraksi Ejeksi Rendah Akibat Penyakit Jantung Koroner Kurnia, Handy; Limantoro, Charles; Silitonga, Friska Anggraini Helena; Setiawan, Andreas Arie
Jurnal Penyakit Dalam Indonesia
Publisher : UI Scholars Hub

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Introduction. Heart failure is one of the major challenges in global health due to its significant contribution to morbidity and mortality. One of the pathophysiological aspects is autonomic nervous system dysfunction which can be monitored through heart rate variability (HRV) parameters. Ivabradine is a pharmacological agent that potentially improves the balance of sympathetic and parasympathetic tone. This study was designed to evaluate the impact of ivabradine administration on HRV parameters in heart failure with reduced ejection fraction (≤40%) due to coronary heart disease in Indonesian population. Methods. This study used a quasi-experimental research type with a pretest and posttest method without control which was conducted at Dr. Kariadi Hospital from October 2024 to February 2025. Sixteen patients diagnosed with heart failure with reduced ejection fraction due to coronary heart disease underwent intervention in the form of ivabradine administration at a fixed dose of 5 mg twice a day for 30 days. Evaluation of HRV was carried out through 24 hours holter recording before and after therapy. The HRV parameters analyzed included SDNN, SDANN, RMSSD, pNN50, and LF/HF ratio. Data processing was carried out using a paired t-test for normal distribution and the Wilcoxon Signed-Rank test for non-normal data. P value <0.05 was considered statistically significant. Results. A total of 16 subjects participated in this study, consisting of 14 men (87.5%) and 2 women (12.5%), with a mean age of 57 years. There was a significant increase in SDNN of 14.71 (SD 24.15) milliseconds (p = 0.028), SDANN of 56.99 (SD 26.94) milliseconds (p < 0.001), RMSSD of 18.39 (SD 27.05) milliseconds (p = 0.007), and pNN50 of 6.96% (SD 7.87) (p < 0.001), as well as a decrease in the LF/HF ratio of 1.42 (SD 0.85) (p < 0.001) after 30 days of ivabradine therapy. Conclusions. The administration of ivabradine had a significant effect on improving heart rate variability parameters in both the time and frequency domains in patients with heart failure with reduced ejection fraction due to coronary heart disease. These findings indicate enhanced parasympathetic dominance and reduced sympathetic nervous system activity.
Co-Authors Andreas Arie Setiawan, Andreas Arie Aris Catur Bintoro Charles Limantoro Hery Djagat Purnomo K. Heri Nugroho HS, K. Heri Silitonga, Friska Anggraini Helena