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All Journal Jurnal Kedokteran Diponegoro Journal of Biomedicine and Translational Research Media Medika Muda Medica Hospitalia
Charles Limantoro
Division Of Cardiology, Department Of Internal Medicine, Diponegoro University, Kariadi Hospital, Semarang
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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PERBANDINGAN KUALITAS HIDUP PASIEN PASCA PENATALAKSANAAN STENOSIS MITRAL DENGAN METODE PERCUTANEOUS BALLOON VALVOTOMY DAN METODE MITRAL VALVE REPLACEMENT Permatasari, Pratiwi Nurvita; Limantoro, Charles; Purwoko, Yosef
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 6, No 2 (2017): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (367.429 KB) | DOI: 10.14710/dmj.v6i2.18618

Abstract

Latar Belakang Metode yang dapat digunakan untuk penatalaksanaan stenosis mitral adalah percutaneous balloon valvotomy dan MVR. Kedua metode tersebut dapat meningkatkan kualitas hidup. Namun, perbandingan kualitas hidup pasca penatalaksanaan dengan kedua metode masih belum banyak diketahui.Tujuan Membandingkan kualitas hidup pasien pasca penatalaksanaan stenosis mitral dengan metode percutaneous balloon valvotomy dan MVR.Metode Penelitian deskriptif analitik dengan desain belah lintang. Sebanyak 14 orang pasca percutaneous balloon valvotomy dan 16 orang pasca MVR. Kuesioner SF-36 digunakan untuk mengukur kualitas hidup dan kuesioner KCCQ-12 digunakan untuk mengetahui NYHA. Uji statistik menggunakan Uji T-tidak berpasangan dan uji Mann Whitney.Hasil Pada kelompok percutaneous balloon valvotomy terdapat 5 orang dengan NYHA I, 6 orang dengan NYHA II dan 3 orang dengan NYHA III. Pada kelompok MVR terdapat 8 orang dengan NYHA I, 7 orang dengan NYHA II dan 1 orang dengan NYHA III. Baik pada kelompok percutaneous balloon valvotomy maupun MVR tidak terdapat pasien dengan NYHA IV. Tidak terdapat perbedaan kualitas hidup antara kedua kelompok (70,6049 ± 18,07602 dibanding 78,6099 ± 13,28219, p=0,174), kecuali pada domain keterbatasan akibat masalah emosional (p=0,041).Kesimpulan Tidak terdapat perbedaan kualitas hidup secara keseluruhan antara pasien pasca penatalaksanaan stenosis mitral dengan metode percutaneous balloon valvotomy dan MVR.
THE DIFFERENCES IN TROPONIN I AND CK-MB VALUES IN ACUTE MYOCARDIAL INFARCTION PATIENTS WITH ST ELEVATION AND WITHOUT ST ELEVATION Paulus Rio Kurniawan; Andreas Arie Setiawan; Charles Limantoro; Ariosta Ariosta
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 2 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i2.29601

Abstract

Background: Acute myocardial infarction includes STEMI and NSTEMI. In STEMI and NSTEMI, an increase in cardiac biomarkers especially troponin I and CK-MB are affected by the ischemic process. In STEMI thrombus blocks the entire artery lumen while in NSTEMI thrombus does not block the entire artery lumen. This can lead to different ischemic processes. Aim: To prove the differences in troponin I and CK-MB values in acute myocardial infarction patients with ST-elevation and without ST- elevation. Methods: An observational analytic study using a cross-sectional design was conducted between April and September 2020. The total sample of the study was 48 samples, consists of 25 samples with STEMI and 23 samples with NSTEMI. The normality test was analyzed using  Shapiro-Wilk test. The difference test was analyzed using Mann-Whitney test. Results: Mean troponin I values of STEMI and NSTEMI patients were 30.40 ± 20.79 ng/mL; 1.38 ± 1.76 ng/mL, respectively. Mean CK-MB values in STEMI and NSTEMI patients were 386.12 ± 319.70 U/L; 42.39 ± 27.54 U/L, respectively. There were statistically significant differences in troponin I and CK-MB values (p respectively 0.00; 0.00) in STEMI patients compared to NSTEMI patients. Conclusion: There were differences in troponin I and CK-MB values between STEMI and NSTEMI patients. The troponin I and CK-MB values in STEMI patients were higher than in NSTEMI patients.
Acute COVID-19 cardiovascular syndrome: A case report Agus Layanto; Sofyan Rais Addin; Friska Anggraini Helena Silitonga; Ayudyah Nurani; Rakhma Yanti Hellmi; Charles Limantoro; K Heri Nugroho Hario Seno; Fathur Nur Kholis
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 6 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i6.30323

Abstract

A man 44 years old with metabolic syndrome and chronic kidney disease was presenting acute COVID-19 cardiovascular syndrome. The condition was aggravated by presence of ureterolithiasis and gout. After treatment, hemodialysis and ureteroscopic lithotripsy-double J ureteral stent, the patient was recovered from his condition
Difference in Profiles of Oxidative Stress Marker (MDA) in STEMI and NSTEMI Kaninta Nuga Sekunda; Ariosta Ariosta; Charles Limantoro; Andreas Arie Setiawan
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 2 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i2.29673

Abstract

ABSTRACT Introduction: Acute Myocardial Infarction (AMI) results in necrosis of the myocardium due to blockage in the coronary artery. AMI is classified into two categories, STEMI and NSTEMI. AMI is a multifactorial condition closely related to the increase in production of reactive oxygen species (ROS). As the end product of lipid peroxidase, Malondialdehyde (MDA) is often used as a biomarker for oxidative stress. Purpose: To prove the difference between profiles of oxidative stress marker (MDA) in STEMI and NSTEMI. Methods: An observational analytic study with a cross-sectional study approach done in Dr. Kariadi Central Public Hospital and Diponegoro National Hospital, Semarang, Central Java, between April and September 2020. Subjects were diagnosed by the presence of chest pains and an increase in CKMB and troponin levels. The study was conducted on 47 subjects consisting of 20 STEMI samples and 27 NSTEMI samples. Serum MDA was examined using the TBARS method. Data were analyzed by a computer program. Results: Mean serum MDA in STEMI and NSTEMI was 0,22 ± 0,12 μmol/L and 0,82 ± 0,92 μmol/L respectively. From the statistical analysis, results showed that the difference in serum MDA concentrations between STEMI and NSTEMI were significant (p = 0,007). Conclusion: Malondialdehyde concentration in NSTEMI was significantly higher than in STEMI. It is suggested that further research be done to know which type of MDA is more accurate, to understand the effect of lipid profile towards STEMI and NSTEMI, and to put patient’s medical history into consideration. Key Words: Acute Myocardial Infarction, Reactive Oxygen Species, Oxidative Stress, Malondialdehyde
THE DIFFERENCE OF MEAN PLATELET VOLUME AND PLATELET COUNT IN CORONARY HEART DISEASE PATIENTS WITH ACUTE CORONARY SYNDROME AND NON ACUTE CORONARY SYNDROME Aditya Paelo Rizki Sikumbang; Indranila Kustarini Samsuria; Novi Anggriyani; Charles Limantoro
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 2 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i2.29460

Abstract

Background: Coronary Heart Disease (CHD) is currently one of main causes and the first death in developed and developing countries, including Indonesia. CHD appeared with the clinical appearance of asymptomatic, stable angina pectoris until acute coronary syndrome. ACS is a progressively CHD and takes parameters that describe the process pathogenesis. MPV and platelet count are two parameters in the complete blood count which reflect the activity of platelets in CHD.Objective: This study is to investigate the differences Mean Platelet Volume and Platelet Count in CHD with ACS compared to non ACS.Methods: A cross-sectional study was conducted with collecting data from the medical records of patients with CHD who underwent treatment in the dr. Kariadi General Hospital Medical Center Semarang, the period of January - December 2019. Eighty subjects of 20 non-ACS patients and 60 ACS patients were included in this study which is Mean Platelet Volume and Platelet Count in hematology laboratory were analyzed. The Independent T-test were used for comparing the group means.Results: MPV was found to be higher significantly among ACS patients as compared to non ACS, 9,43 ± 0,3868 fl vs 9,43 ± 0,3868 fl (p-value<0.01) while Platelet Count was lower significantly among ACS patients as compared to non ACS, 282,63 ± 75,084 109/L  vs 322,30 ± 41,980 109/L.Conclusion: There were significantly differences in Mean Platelet Volume and Platelet count between patients with ACS and non ACS.
Correlation between Non-Alcoholic Fatty Liver Disease (NAFLD) fibrosis score (NFS) with Left Ventricular Mass Index (LVMI) in patients with NAFLD Tri Ferry Rachmatullah; Cecilia Oktaria Permatadewi; Hesti Triwahyu Hutami; Charles Limantoro; Hery Djagat Purnomo, MD, PhD
Journal of Biomedicine and Translational Research Vol 7, No 2 (2021): August 2021
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v7i2.11624

Abstract

Background: Cardiovascular-related mortality is a major concern in NAFLD. Advanced fibrosis was known to be associated with cardiovascular diseases. NAFLD Fibrosis Score (NFS) is used to identify the development of liver fibrosis in NAFLD patients. Left ventricular mass index (LVMI) is a sign of subclinical cardiovascular complications in NAFLD. The correlation between NAFLD fibrosis score with LVMI in NAFLD patients is not fully established.Objective: To analyze the correlation between NAFLD fibrosis score with LVMI  in NAFLD patients.Methods: A cross-sectional study of NAFLD patients in Kariadi Hospital Indonesia. NFS was done using a formula based on clinical and biochemical parameters. LVMI was measured with echocardiography. Pearson’s, Mann-Whitney, and logistic regression were used for analysis.Results: A total of 64 patients with primary NAFLD were enrolled, 54.7% males and 45.3% females. Mean age was 52,8 ± 10,5 years (30-77 years). Based on NFS criteria, high probability group was the highest (50%), followed by intermediate probability group (34,4%) and low probability group (15,6%). Highest increase in LVMI was obtained in the high probability group (93,8%), followed by intermediate probability (59,1%), and low probability group (10%) respectively. There was significant correlation between NFS and LVMI (P 0,002). Logistic regression showed that NFS has a more significant correlation with LVMI compared to gender (P=0,002).Conclusion: NFS is a non‐invasive liver fibrosis scores which independently corelated with Left ventricular mass index (LVMI), a marker of cardiovascular abnormality.
KORELASI ANTARA KADAR TNF-α PLASMA DENGAN NILAI KETEBALAN INTIMA MEDIA (KIM) ARTERI KAROTIS PADA PASIEN LUPUS ERITEMATOSUS SISTEMIK (LES) Hesti Triwahyu Hutami; Rahmayanti Hellmi; Bantar Suntoko; Suyanto Hadi; Charles Limantoro
Media Medika Muda Vol 3, No 3 (2018)
Publisher : Faculty of Medicine Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (307.452 KB)

Abstract

Latar belakang: Komplikasi dan mortalitas jangka panjang Lupus Eritematosus Sistemik (LES) berkaitan dengan penyakit vaskular dan aterosklerosis. Aterosklerosis secara klinis didahului dengan perubahan dinding arteri, yang disebut sebagai ketebalan intima media (KIM) dan pembentukan plak. KIM dapat diukur dengan menggunakan B-mode ultrasonography arteri karotis. Aterosklerosis merupakan prosen inflamasi yang dipengaruhi oleh sitokin inflamasi diantaranya TNF-α. Peran TNF-α cukup penting dalam penyakit LES, sehingga perlu dicari korelasi antara kadar TNF-α plasma dengan KIM arteri karotis pasien LES. Penelitian ini bertujuan untuk mengetahui adanya korelasi antara kadar TNF-α plasma dengan KIM arteri karotis pasien LES di RSUP Dr. Kariadi Semarang.Metode: Penelitian ini merupakan penelitian cross sectional. Subyek penelitian sebesar 32 orang, terdiri dari perempuan usia ≥18 tahun.Uji statistik dengan menggunakan uji beda t-test tidak berpasangan dan uji korelasi Rank Spearman. Selanjutnya ditentukan cut-of point kadar TNF-α plasma terhadap nilai KIM arteri karotis pasien LES.Hasil: Dari semua subyek penelitian, didapatkan 20 orang (62,50%) mempunyai nilai KIM tebal. Tidak terdapat perbedaan kadar TNF- α plasma pada subjek pasien LES dengan nilai KIM tebal dan tidak tebal (p=0,405, 95%CI -2,34 s.d. .5,64). Tidak didapatkan korelasi bermakna antara kadar TNF-α plasma dengan nilai KIM arteri karotis pasien LES (p=0,075 ; r = -0,319). Subjek dengan kadar TNF-α plasma tinggi, didapatkan nilai KIM yang tebal sebanding dengan subjek dengan kadar TNF-α yang tidak tinggi (31,25% vs 31,25%). Tidak didapatkan nilai cut-of point kadar TNF-α plasma terhadap nilai KIM arteri karotis pasien LES.Simpulan: Tidak terdapat perbedaan kadar TNF-α plasma pada subjek pasien LES dengan nilai KIM tebal dan tidak tebal Tidak didapatkan korelasi bermakna antara kadar TNF-α plasma dengan KIM arteri karotis pasien LES. Tidak didapatkan nilai cut-of point kadar TNF-α plasma terhadap nilai KIM arteri karotis pasien LES.
Nilai Rerata Volume Trombosit, Rasio Trombosit Limfosit, Rasio Rerata Volume Trombosit-Limfosit sebagai Prediktor Tingkat Keparahan Sindrom Koroner Kronik Wijaya, Friska; Limantoro, Charles; Fitria, Indah; Suharti, Catharina; Nugroho, Trilaksana
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 1 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i1.813

Abstract

BACKGROUND: The increase in platelet aggregation and inflammation play an essential role in atherosclerosis. Furthermore, the level of activity depends on their size, with larger platelets facilitating the thrombosis process. Severe Coronary Artery Disease (CAD) is associated with low lymphocyte count. It is also linked with Mean platelet volume [MPV], Platelet Lymphocyte Ratio [PLR], and Mean Platelet Volume to Lymphocyte Ratio [MPVLR]. OBJECTIVE:  This study aims to investigate MPV, PLR, and MPVLR as predictors of the severity of Coronary Artery Lesion in Chronic Coronary Syndrome (CCS) using the Gensini score. METHOD: This is a cross sectional study conducted in Dr. Kariadi General Hospital, involving a total sample of 68 respondents. Furthermore, CCS were evaluated before conducting coronary angiography. The study comprises of two group of patients divided according to their Gensini scores, namely mild and severe, for ≤ 20 and > 20, respectively. MPV, PLR, and MPVLR were then compared between the two groups. RESULT: At a cut-off level of 3.4, MPVLR predicted the coronary artery severity with a sensitivity, specificity, positive predictive value (PPV), and negative predictive value of 80%, 50%, 82%, and 47% (area under the curve [AUC] 0.67; 95% confidence interval [CI], 0.52-0.82; p 0.029). Meanwhile, its value ≥3.4 has OR 1.55; 95% CI, 0.99-2.43; p 0.034. CONCLUSION: This study conclude that MPVLR ≥3.4 can be used as a predictor of Coronary Artery Lesion Severity based on the Gensini score in CCS cases.
Co-Authors Aditya Paelo Rizki Sikumbang Agus Layanto Andreas Arie Setiawan Ariosta Ariosta Ayudyah Nurani Bantar Suntoko Catharina Suharti Cecilia Oktaria Permatadewi Fathur Nur Kholis Friska Anggraini Helena Silitonga Hery Djagat Purnomo, MD, PhD Hesti Triwahyu Hutami Hesti Triwahyu Hutami Indah Fitria, Indah Indranila Kustarini Samsuria K. Heri Nugroho HS, K. Heri Kaninta Nuga Sekunda Novi Anggriyani Nugroho, Trilaksana Paulus Rio Kurniawan Permatasari, Pratiwi Nurvita Rahmayanti Hellmi Rakhma Yanti Hellmi Sofyan Rais Addin Suyanto Hadi Tri Ferry Rachmatullah Wijaya, Friska Yosef Purwoko