Andreas Arie Setiawan, Andreas Arie
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GAMBARAN GANGGUAN IRAMA JANTUNG YANG DISEBABKAN KARENA HIPERTIROID Widjaja, Daniel Karen; Setiawan, Andreas Arie; Ariosta, Ariosta
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 6, No 2 (2017): JURNAL KEDOKTERAN DIPONEGORO
Publisher : DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (391.873 KB)

Abstract

Latar belakang :Aritmia adalah variasi – variasi di luar irama normal jantung berupa kelainan pada kecepatan, keteraturan, tempat asal impuls, atau urutan aktivasi, dengan atau tanpa adanya penyakit jantung struktural yang mendasari. Prevalensi penyakit jantung di Indonesia pada populasi usia 15 tahun ke atas adalah 9,2%, dimana 5,9 % diantaranya mengalami gejala aritmia.Hormon tiroid memiliki hubungan secara langsung dan tidak langsung terhadap miokardium dan mempengaruhi sistem saraf otonom pada jantung yang menyebabkan terjadinya gangguan irama jantung.Tujuan :Mendapatkan informasi tentang gambaran aritmia yang disebabkan oleh hipertiroid.Metode :Penelitian menggunakan metode deskriptif retrospektif. Data diambil dari catatan medik pasien dengan hipertiroid yang dirawat di RSUP Dr. Kariadi Semarang pada tahun 2013 dan telah menjalani pemeriksaan penunjang elektrokardiografi.Subjek penelitian berjumlah 21 orang dan didapatkan secara consecutive sampling.Hasil : Gambaran gangguan irama jantung pada pasien hipertiroid adalah 6 orang atrial fibrilasi respon cepat, 4 orang sinus takikardi, 3 orang atrial fibrilasi respon normal, 3 RBBB, 2 VES benigna, 1 SVES, 1 atrial flutter, dan 1 RBBB dengan sinus takikardi.Kesimpulan : Gambaran gangguan irama jantung pada pasien hipertiroid adalah atrial fibrilasi respon cepat, sinus takikardi, atrial fibrilasi respon normal, RBBB,VES Benigna, SVES, atrial flutter,RBBB dengan sinus takikardi  .
HUBUNGAN DERAJAT KEPARAHAN GAGAL GINJAL KRONIK DENGAN KEJADIAN PENYAKIT JANTUNG KORONER Sagita, Tiffany Christine; Setiawan, Andreas Arie; Hardian, Hardian
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 7, No 2 (2018): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (378.431 KB) | DOI: 10.14710/dmj.v7i2.20689

Abstract

Latar Belakang: Penyakit Jantung Koroner (PJK) adalah salah satu komplikasi gagal ginjal kronik (GGK). Beberapa penelitian sebelumnya telah meneliti hubungan antara gagal ginjal kronik (GGK) dengan kalsifikasi pada arteri koroner namun hubungan antara derajat keparahan gagal ginjal kronik (GGK) dan dampak terhadap atherosklerosis masih belum jelas.Tujuan: Menilai hubungan antara derajat keparahan gagal ginjal kronik dengan penyakit jantung koroner.Metode:  Penelitian ini adalah penelitian observasional analitik cross sectional di RSUP Dr. Kariadi Semarang pada periode 2013-2016. Subyek penelitian adalah 146 pasien GGK. Data yang dikumpulkan adalah usia, jenis kelamin, diganosis kerja, gula darah, profil lipid, tekanan darah, dan riwayat merokok.Hasil: Derajat keparahan GGK adalah derajat I 6 orang (4,11%), II 12 (8,22%), III 29 (19,86%), IV 21 (14,38%), dan V 78 orang (53,42%). Kejadian PJK dijumpai pada 72 orang (49,32%). Hasil uji korelasi terdapat hubungan yang bermakna antara kejadian PJK dengan derajat keparahan GGK (p<0,001). Rasio Prevalensi untuk kejadian PJK pada GGK II 1,2 (95% IK=0,1 s/d10,7), III 2,3 (95% IK= 0,3 s/d 15,5), IV 4,7 (95% IK =1,3 s/d 16,7), V 4,0 (95% IK =1,2 s/d 14,0).Kesimpulan:  Semakin berat derajat gagal ginjal kronik maka semakin tinggi kejadian penyakit jantung koroner.
Factors Affecting Glycemic Control in Diabetes Mellitus Patients Wireno, Eros Hanif; Setiawan, Andreas Arie; Hendrianingtiyas, Meita; Pramudo, Setyo Gundi
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 12, No 2 (2021): December 2021
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (653.192 KB) | DOI: 10.30659/sainsmed.v12i2.7620

Abstract

Introduction: Indonesia ranked seventh in the prevalence of diabetes mellitus in the world. Improved glycemic control has been proven to prevent the diabetes and its complications. Adherence to treatment, weight regulation with benchmarks for Body Mass Index (BMI) indicators, activity or exercise habits, diet, and smoking history play an important role in glycemic control. Objective: The aim  of  this study was to identify factors affecting glycemic control in outpatient with diabetes mellitus.Methods: A cross sectional study  among 32 diabetes mellitus patients.This study was conducted from April 2019 to September 2019 at Rumah Sakit Nasional Diponegoro (RSND), Semarang. The glycemic control status were assesed by HbA1c. Factors such medication adherence, diet adherence, smoking status, and physical activity were assesed with a structured questionnaire. Anthropometric measurement done to get the BMI status. Data were analyzed with bivariat analysis with chi square test (p<0.05).Result: The factors that were significantly have relationship with glycemic control status are diet adherence (p=0.046), and medication adherence (p=0.040). Physical activity, smoking status and BMI doesn’t have significant relationship with glycemic control status.Conclusion: Factors affecting glycemic control of diabetes mellitus patients in this study were diet adherence and medication adherence. History of smoking, BMI, and physical activity were not factors that influenced the control status in diabetes mellitus patients in this study.
Five-Year Survival in Patients with 3-Vessels Coronary ArteryDisease and Diabetes Mellitus Undergoing Coronary ArteryBypass Graft, Coronary Percutaneus Intervention, or ReceivingPharmacological Therapy in Cipto Mangunkusumo Hospital Setiawan, Andreas Arie; Panggabean, Marulam; Yamin, M; Setiati, Siti
Jurnal Penyakit Dalam Indonesia Vol. 3, No. 2
Publisher : UI Scholars Hub

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Abstract

Introduction. Revascularization results in patients with diabetes mellitus (DM) and coronary artery disease involving 3 vessels (CAD 3VD) undergo coronary artery bypass surgery (CABG) are better compared with those undergo percutaneous coronary intervention (PCI) or medical therapy. However, CABG is not always done despite being recommended in accordance with Syntax Score because some patients unwilling to undergo CABG or PCI . This trial determined whether the choice of revascularization affect 5-years survival. Methods. This was a retrospective cohort study with survival analysis to examine the 5-years survival rate of CAD 3VD DM patients undergoing CABG, PCI, or medical therapy. The study was conducted using secondary data of 126 CAD 3VD DM patients who underwent CABG, PCI, or medical therapy at Cipto Mangunkusumo Hospital in 2006-2007 and followed up to 2011-2012 if there any incident died. Results. Best survival was seen in the CABG group (93.5%). The largest proportion of death occured in the medical therapy group (36.1%). The CABG survival was significantly better than the IKP (p=0.01) and medical therapy (p=0.001). PCI group had better survival than medical therapy (69.5% vs. 63.9%). Although not statistically significant, but the proportion of complaints after revascularization in PCI group were found less than medical therapy group (52% vs. 38%). Syntax score that assesses the complexity of stenosis had a significant association with survival (p 0.039). Conclusions.5-years survival of CAD 3VD DM patients is best obtained in the group that underwent CABG. 5-year survival of CAD 3VD DM patients who underwent PCI better than medical therapy but was not statistically significant. Factor that affect the 5-years survival is the complexity stenosis viewed by the Syntax score.
Hafidh, THE LEVEL OF KNOWLEDGE OF HEALTH CARE WORKERS WITH THE LATENT TUBERCULOSIS Aji Prasetyo, Hafidh Bagus; Adji, Raden Mas Soerjo; Setiawan, Andreas Arie; Pramudo, Setyo Gundi
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 1 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (275.909 KB) | DOI: 10.36408/mhjcm.v8i1.453

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ABSTRACT Background : Pulmonary tuberculosis is a contagious infectious disease caused by the Mycobacterium tuberculosis. Health workers have an increased risk of contracting tuberculosis, because they are exposed to TB in their workplaces. The absence of hospital control measures against TB infection makes the risk factor becomes high. Health workers often make contact with TB sufferers. In a good body condition, although infected by TB germs, it does not manifest as a disease or called latent TB. However, latent TB sufferers still have the risk of being active in certain conditions, which then becomes a source of new TB transmission. Objective: This study aims to look at the level of knowledge of health workers towards the incidence of Latent TB in the Hospital. Method : The research method is cross-sectional using a sample of health workers who work in hospitals. The sample size of this study was 46 people using purposive sampling. This study has a variable Health worker knowledge about TB disease and Latent TB incidence. The method of data analysis using Chi Square Test. Result : The results were not significant between the level of knowledge and the incidence of Latent TB in health workers (p = 0.584). While the use of masks with the incidence of latent TB had a significant relationship (p=0,001). Conclusion : There is no significant relationship between the level of knowledge with the incidence of Latent TB in health workers. While the use of masks with the incidence of latent TB has a significant relationship. Keywords : Tuberculin Skin Test, Awareness, Incident, Workplaces.
Effects of Garcinia Mangostana Linn Pericarp Extract and Physical Exercise on Atheroembolic Histopathologic Features Kidney in Wistar Rats with Metabolic Syndrome Perdana, Evangga Yudha; Miranti, Ika Pawitra; Kholis, Fathur Nur; Wijayahadi, Noor; Setiawan, Andreas Arie
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 2 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i2.42578

Abstract

Background: Renal atheroembolism is an under-recognized cause of renal failure. Atheroembolism is caused by cholesterol crystals from ulcerated atherosclerotic plaques and is influenced by inflammation and endothelial dysfunction. The formation of complicated atherosclerotic lesions is a prerequisite for the development of cholesterol crystal emboli. The exact incidence of atheroembolism remains unclear due to frequent underdiagnosis. In a previous report, the rate of embolism in the kidney among patients dying after surgery for acute atherosclerosis of the aorta was 77%. Non-pharmacological therapeutic management (such as diet and physical exercise) is an important factor in preventing and reducing the risk of atherogenesis. Prior research suggests that controlling body weight, primarily through physical exercise, is a critical factor in preventing and reducing the risk of atherogenesis, in addition to medication adherence and other therapeutic management alternatives. Another study found that mice with metabolic syndrome given Garcinia mangostana pericarp can reduce inflammatory cell infiltration, thereby reducing physiological symptoms, metabolic syndrome, liver disorders, and cardiovascular symptoms. The combination of physical exercise and metabolic supplements in the treatment was even able to significantly reduce atheroma plaque area as well as the incidence of plaque rupture, and prolong survival time. Objective: To investigate the effect of Garcinia Mangostana Linn Pericarp administration along with Physical Exercise on the histopathologic features of renal atheroembolism in Wistar rats with metabolic syndrome. Methods: This study is a true experimental study with research subjects in the form of male Rattus norvegicus Wistar rats which were randomly divided into 3 groups. All groups were induced metabolic syndrome through the administration of a diet similar to the "Western" purified atherogenic diet patent Envigo® formulated as a high fat diet (20 - 23% BW; 40 - 45% kcal from fat), saturated fatty acids (SFA >60% of total fatty acids), and drinking tap water ad libitum. However, in group K (no additional treatment), P1 (garcinia pericarp extract 800 mg / kg / day with physical exercise), and P2 (nanoemulsion garcinia pericarp extract 50 mg / kg / time of administration with physical exercise). Results: In the group treated with garcinia pericarp extract 800 mg/kg bw/day with physical exercise and the group with nanoemulsion 50 mg/kg bw/day with physical exercise, there were no fatty streaks, inflammation, and impaired myocyte coherence. There was 0-5% fibrous connective tissue, one layer of foam cell layer and myocyte-lipid, no cholesterol crystal embolism was found. Conclusion: The administration of Garcinia Mangostana Linn pericarp extract and/or nanoemulsion with physical exercise can have an effect on the histopathological picture of the kidneys of Wistar rats with metabolic syndrome, although there was no difference in effect between the two treatments.
Effects of α-Mangostin-Loaded Self-Nanoemulsion (MG-SNE) and Physical Exercise on The Reduction of Waist Circumference in Wistar Rats Setiawan, Andreas Arie; Sugiri, Sugiri; Prasetyo, Awal; Kurniawan, Eirin Yovita; Putra, Dominikus Evano
Medica Hospitalia : Journal of Clinical Medicine Vol. 11 No. 3 (2024): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v11i3.1103

Abstract

BACKGROUND : Waist circumference (WC) is a marker of intra-abdominal adipose tissue and a risk factor for cardiometabolic disease. A higher risk of coronary heart disease was associated with an increased WC. Garcinia mangostana Linn's anti-inflammatory activity would reduce abdominal fat deposition and WC. Additionally, Garcinia mangostana Linn's potential would increase in nanotechnology. AIMS :  To demonstrate that WC in Wistar rats induced by an atherogenic diet can be decreased by α-Mangostin-loaded self-nanoemulsion (MG-SNE) treatment combined with physical activity. METHOD : Experimental research with Randomized Control Trial design using a total sample of 15 male white rats (Rattus novergicus strain Wistar) weighing 300 grams and aged between 6 and 8 weeks, split into 3 groups given physical exercise for 8 weeks along with 3 different doses of medication (group K received Atorvastatin 1.44 mg once; group P1 received Garcinia mangostana Linn pericarp extract, at a dose of 800 mg/kg, divided into 3 administrations; and group P2 received MG-SNE 50 mg/kg once). Waist circumference was measured using a metline, before and after treatment. RESULT :  WC decreased in Groups K, P1, and P2, with deltas of -5.00±21.21 mm, -12.50±24.75 mm, and -17.50±12.58 mm. The greatest decrease in WC was P2. There was no significant difference, according to the paired test between the pre-test and posttest in all groups. The p value >0.05 was determined to indicate that there were no significant differences between the groups. CONCLUSION : WC in Wistar rats induced by an atherogenic diet can be decreased by MG-SNE treatment combined with physical exercise.