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All Journal Pharmacon PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmu Kefarmasian Indonesia Journal of Pharmacy Science and Technology Journal of Tropical Pharmacy and Chemistry
Angelica Kresnamurti
Program Studi Farmasi, Universitas Hang Tuah, Surabaya
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Aktivitas Antiinflamasi Ekstrak Etanol Echinometra mathaei pada Tikus Putih Jantan dengan Induksi Karaginan Angelica Kresnamurti; Hardiyono Hardiyono; Febriana Siswulandari; Iwan Sahrial Hamid
Pharmacon: Jurnal Farmasi Indonesia Vol 18, No 2 (2021)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v0i0.15021

Abstract

Sea urchin (Echinometra mathaei) is one of the marine biota that contains high flavonoid and phenolic compounds that are potent as anti-inflammatory and antioxidant. This study aimed to measure the anti-inflammatory activity of the 70% ethanol extract of sea urchins in male white rats induced by carrageenan. Anti-inflammatory activity test using 5 groups of rats selected randomly, each group consists of 5 rats. Negative control group, positive control group, and 3 groups of extracts (doses of 100, 200, and 400mg/kgBW). Each group was induced using 1% carrageenan subplantarly and the volume of edema was measured using a mercury plethysmometer every 30 minutes for 3 hours. The data were statistically analyzed using one-way Anova. The results showed that the percentage of inflammatory inhibition in the positive control group, and the Echinometra mathaei ethanol extract group (dose of 100, 200, and 400 mg/KgBW) showed a significant difference (P0.05) with the negative control group with a percentage value of Inflammation inhibition was 61.11%, 85.19%, 85.19%, and 74.07%, respectively. The administration of sea urchin ethanol extract at all doses had a higher percentage of anti-inflammatory than diclofenac sodium, but increasing the extract dose did not significant increase inflammatory inhibition. This research concluded that 70% ethanol extract of Echinometra mathaei at doses of 100, 200, 400 mg/KgBW has strong anti-inflammatory activity potential.
Tingkat Kepuasan Pasien Swamedikasi Terhadap Pelayanan Informasi Obat di Apotek Pesisir Surabaya Timur Oki Nugraha Putra; Angelica Kresnamurti; Akalili Yunita
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 2 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v18i2.727

Abstract

Pharmacy is a facility for pharmaceutical services conducted by pharmacists. One of pharmaceuticalservices performed at a pharmacy is swamedication services. The purpose of this study was to determine thelevel of satisfaction of swamedication patients in drug information services in several pharmacies in the EastSurabaya Coastal Area, based on fi ve dimensions of service quality, namely reliability, responsiveness, assurance, empathy and tangibles. This cross sectional study using a validated questionnaire instrument. The research sample is swamedication patients who meet the inclusion criteria. Swamedication patients were selected nonrandomly by consecutive sampling method. Data retrieval was carried out in October-December 2018. Data from the fi ve dimensions of service quality were analyzed by the SERVQUAL method. There were 100 patients who performed swamedication services that met the inclusion criteria. The results showed that the average gap between expectation and performance is -0.36 with the largest gap value indicated on the reliability dimension of -0.51. At overall satisfaction level, the results are 89%. The conclusion is that the level of expectations of swamedication patients is higher than the level of performance of drug information services provided by the pharmacy with a good level of patient satisfaction.
Uji Aktivitas Analgesik Minyak Ikan pada Mencit Putih (Mus musculus) Jantan Galur BALB/c dengan Metode Writhing Test Risca Amilia; Angelica Kresnamurti; Ana Khusnul Faizah
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 17 No. 01 Juli 2020
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (913.086 KB) | DOI: 10.30595/pharmacy.v17i1.5049

Abstract

Minyak ikan merupakan sumber EPA dan DHA yang berasal dari sumber daya laut. Kapsul minyak ikan merupakan salah satu nutraseutikal untuk memenuhi kebutuhan omega-3 dan omega-6. Penelitian telah dilakukan menggunakan minyak ikan salmon yang mengandung EPA dan DHA. Tujuan dari penelitian ini adalah untuk menentukan aktivitas analgesik pada tikus putih jantan (Mus musculus) strain BALB/c. Sejumlah 25 ekor tikus putih jantan dibagi menjadi 5 kelompok, masing-masing kelompok terdiri dari 5 ekor tikus putih jantan. Kelompok kontrol negatif diberi kombinasi emulsi Tween 80 dan Span 80, kelompok kontrol positif diberi aspirin, dan kelompok perlakuan diberi emulsi minyak ikan salmon dengan dosis 20, 30, dan 40 mg/kg BB. Metode yang digunakan pada penelitian ini adalah writhing test dengan menginduksi tikus putih jantan dengan asam asetat 0,6%. Hasil penelitian menunjukkan bahwa emulsi minyak ikan salmon dengan dosis 20, 30, dan 40 mg/kg BB memiliki persentase hambatan nyeri masing-masing sebesar 29,44; 42,64; dan 52,59%. Dapat disimpulkan bahwa emulsi minyak ikan salmon memiliki aktivitas analgesik.  
STUDI KEPATUHAN PASIEN DIABETES MELLITUS RAWAT JALAN di RSUD KABUPATEN SIDOARJO Efer Memento Yotlely Romera; Angelica Kresnamurti; Dyah Ayu Febiyanti
JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY Voume 1 Nomor 1
Publisher : Prodi Farmasi Fakultas Kedokteran Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Diabetes mellitus is a metabolic disease that has symptoms due to elevated blood glucose levels above normal values and requires regular treatment. Patient adherence is very important to reduce the risk of complications in diabetes mellitus patient. This research aims to determine correlation the patient adherence in taking antidiabetic drugs with two different methods, Pill count and MMAS-8 method. This research used cross-sectional with non-probability sampling methods. There were 21 outpatients in Sidoarjo Hospital included in this research. Based on the result by pill count, obtained 14 respondents adherent (66.67%) and non-adherent respondents was 7 (33.33%), while the result of MMAS-8 method was 8 respondents (38.10%) with high adherence, 10 respondents (47.62%) with moderate adherence and 3 respondents (14.29%) with low adherence. Comparison between pill count and MMAS-8 was carried out using the SPSS statistical program, and 50% result had expected count value less than 5, so did not qualify for chi-square (χ2). Therefore, the Fisher exact test was done as the alternative way by viewing the exact-sig value in the column Fisher exact-test and obtained the value of 0.247 with a significance value of 0.05. So it shows there is no correlation between the measurements result of adherence with the method MMAS-8 and pill count.
The Effectiveness of Sea Urchin Extract (Echinometra matthaei) for Wound Healing on Deep Second-Degree in White Rats (Rattus norvegicus) Wistar Angelica Kresnamurti; Dita Nurlita R; Fitri Budiarti
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 3 (2021): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i3.281

Abstract

Background: Burns is a form of tissue damage caused by high temperatures. Echinometra matthaei sea urchins have several secondary metabolites that can potentially help in the healing process of burns. In this study, 70% E. matthaei ethanol extract was formulated in the form of O / W (oil in water) type cream preparations which were applied topically. Objective: This study aims to determine the effectiveness of E. matthaei ethanol extract cream preparations on the healing of second-degree burns in Wistar strain rats. In this study preparations were made in 3 formulations, namely Formulation 1 (extract concentration of 1%), Formulation 2 (extract concentration of 3%), and Formulation 3 (extract concentration of 5%). This research was conducted for 7 days with the method used is the post-test only control group design. Experiments were given induction of burns using a hot plate with a diameter of 20 mm at a temperature of ± 200ºC for 15 seconds. Wound healing is observed periodically by observing macroscopically healing inflammation of the inflammatory phase and observing tissue growth in the proliferation phase. Results: The average percentage of inflammation healing showed improvement in the F2: 100%, F1: 80%, F3: 71% results were better than the wound group: 50% as evidenced by the value ? = 0.012 (
Co-Authors Akalili Yunita Ana Khusnul Faizah Dita Nurlita R Dyah Ayu Febiyanti Efer Memento Yotlely Romera Febriana Siswulandari Fitri Budiarti Hardiyono Hardiyono Iwan Sahrial Hamid Oki Nugraha Putra Risca Amilia