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All Journal JURNAL SAINS DAN TEKNOLOGI INDONESIA Pharmaceutical Sciences and Research (PSR) Makara Journal of Science
Dadang Kusmana
Departemen Biologi FMIPA Universitas Indonesia
Computer Science & IT Education

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Journal : Makara Journal of Science

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EFEK ESTROGENIK EKSTRAK ETANOL 70% KUNYIT (Curcuma domestica VAL.) TERHADAP MENCIT (Mus musculus L.) BETINA YANG DIOVARIEKTOMI Kusmana, Dadang; Lestari, R; Dewi, A. N.; Ratri, P. R.
Makara Journal of Science Vol. 11, No. 2
Publisher : UI Scholars Hub

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Estrogenic Effect of 70% Ethanol Turmeric (Curcuma domestica Val.) extract on ovariectomized Female Mice (Mus musculus L.). The influence of extract turmeric (Curcuma domestica Val.) on endometrium thickness, vaginal epithelium, mammary gland, and protein of estrogen receptor of ovariectomized mice was examined. Twenty five ovariectomized mice which were divided into five groups, were treated by ethynilestradiol (8,4 x 10-3 g), aquades (10 ml), and turmeric extract at doses 230 mg/kg b.w.; 310 mg/kg b.w.; and 390 mg/kg b.w. for eight days. At the end of experiments the mice were killed, then the uterus, vagina, and mammae were removed and the wet weight of uterus was recorded. Uterus, vagina, and mammae were examined histologically. Estrogen receptor protein from uterus were analized by using SDS-PAGE. One way anava test showed that turmeric extract at doses 310 mg/kg b.w. and 390 mg/kg b.w give estrogenic effect on vaginal ephitelium, endometrium thickness, and diametre of mammary glands. SDS-PAGE analysis showed there were differences in protein concentration between control and treatment groups which were seen in the thickness of the bands. Estrogen receptor band could be detected in sampel of treatment groups at molecular weight 45 kDa
KUALITAS SPERMATOZOA DARI TANAMAN Polyscias guilfoylei Elya, Berna; Kusmana, Dadang; Krinalawaty, Nevy
Makara Journal of Science Vol. 14, No. 1
Publisher : UI Scholars Hub

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Spermatozoa Quality from Polyscias guilfoylei. In our study, we investigated the effect of extract Polyscias guilfoylei L.H. Bailey leaves on spermatozoa quality in rabbits. The experiment used 18 male rabbits from New Zealand white strain which were devided randomly into three groups. Group I was normal control group, Group II and III were given the extract of Polyscias guilfoylei leaves in these following doses: 327.56 mg/1.5 kg body weight and 655.2 mg/1.5 kg bw. The extract was given orally once a day, continuously for 8 weeks. Semens from the rabbit was taken every two weeks and were observed over the quality and consentration of spermatozoa. The result of the research showed that the extract of Polyscias guilfoylei leaves with dosage of 327.56 mg/1.5 kg bw and 655.2 mg/1.5 kg bw could decrease the consentration and the quality of spermatozoa of the male rabbits
Co-Authors Berna Elya Dewi, A. N. Indah Widyaningsih J. Supriatna Krinalawaty, Nevy kurnia agustini Lestari, R MARIA BINTANG N. Moeloek N. Suhana O. Soeradi Ratri, P. R. Rianti Adi Cahyaningsih, Rianti Adi S. S. Sukmaniah Sumali Wiryowidagdo Yahdiana Harahap