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Endang Listyaningsih S
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Pengaruh Pemberian Ekstrak Daun Sambiloto (Andrographis paniculata [Burm.F.] Ness) terhadap Kerusakan Struktur Histologis Sel Hepar Mencit yang Diinduksi Parasetamol Putri, Heigy Mutiha; Listyaningsih S, Endang; Riyadi, Slamet
Nexus Biomedika Vol 2, No 3 (2013): Nexus Biomedika
Publisher : Nexus Biomedika

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Background: Green chiretta contains andrographolide as active substances, flavonoids, saponins, and tannins which were thought to protect the liver’s cell  from free radicals. In present study, Green chiretta leaves extract was evaluated for its protective effect on heksaklorosiklon-induced liver cell damage in mice. Methods: To evaluate the hepatoprotective effect of Green chiretta leaves extract, 28 male, Swiss Webster mice (Mus musculus) were equally divided into four groups. The group I (KK) were administered aquadest and group II (KP1) were not only administered aquadest but also a toxic dose of paracetamol on the day 12, 13 and 14. Grup III–IV (KP2-KP3) were administered Green chiretta leaves extract (0.2 ml and 0.4 ml, successively) for 14 days and a toxic dose of paracetamol on the day 12, 13 and 14. Mice were sacrificed on the 15th day with neck dislocation and their livers were prepared for microscopy study to evaluate their cell damages. The  damages were assessed  by  counting  the  number  of hepatocyte on centrolobuler zone undergoing pyknosis, karyorhexis, and karyolysis. The data were analyzed using the One Way ANOVA test (α = 0.05) and the Post Hoc Multiple Comparisons (LSD) test (α = 0.05). Results: The mean liver cell damage score of  the KP1 group was significantly higher  (61.80 ± 7.991) than the KK group (33.00 ± 5.225). The KP2 group showed fewer numbers of liver cell damage (37.81 ± 5.653) compared to the KP1 group (61.80 ± 7.991) and the KP3 group (60.81 ± 8.268). The One Way ANOVA test showed the significant difference between the four groups (p=0.000) while the  LSD test showed the significant differences between each other group (p<0.005), except the group of KP1-KP3 (p> 0.005). Conclusions: The treatment of Green chiretta leaves extract was able to decrease the liver cell damage of mice. The increase dose of Green chiretta leaves extract was not followed by the increase of protection effect to the liver cell damage of mice induced by paracetamol. Keywords: Green chiretta leaves extract, paracetamol, liver cell histological damage.  
Pengaruh Pemberian Ekstrak Daun Sambiloto (Andrographis paniculata [Burm.F.] Ness) terhadap Kerusakan Struktur Histologis Sel Hepar Mencit yang Diinduksi Parasetamol Heigy Mutiha Putri; Endang Listyaningsih S; Slamet Riyadi
Nexus Biomedika Vol 2, No 3 (2013): Nexus Biomedika
Publisher : Nexus Biomedika

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (13.862 KB)

Abstract

Background: Green chiretta contains andrographolide as active substances, flavonoids, saponins, and tannins which were thought to protect the livers cell from free radicals. In present study, Green chiretta leaves extract was evaluated for its protective effect on heksaklorosiklon-induced liver cell damage in mice. Methods: To evaluate the hepatoprotective effect of Green chiretta leaves extract, 28 male, Swiss Webster mice (Mus musculus) were equally divided into four groups. The group I (KK) were administered aquadest and group II (KP1) were not only administered aquadest but also a toxic dose of paracetamol on the day 12, 13 and 14. Grup IIIIV (KP2-KP3) were administered Green chiretta leaves extract (0.2 ml and 0.4 ml, successively) for 14 days and a toxic dose of paracetamol on the day 12, 13 and 14. Mice were sacrificed on the 15th day with neck dislocation and their livers were prepared for microscopy study to evaluate their cell damages. The damages were assessed by counting the number of hepatocyte on centrolobuler zone undergoing pyknosis, karyorhexis, and karyolysis. The data were analyzed using the One Way ANOVA test (? = 0.05) and the Post Hoc Multiple Comparisons (LSD) test (? = 0.05). Results: The mean liver cell damage score of the KP1 group was significantly higher (61.80 7.991) than the KK group (33.00 5.225). The KP2 group showed fewer numbers of liver cell damage (37.81 5.653) compared to the KP1 group (61.80 7.991) and the KP3 group (60.81 8.268). The One Way ANOVA test showed the significant difference between the four groups (p=0.000) while the LSD test showed the significant differences between each other group (p<0.005), except the group of KP1-KP3 (p> 0.005). Conclusions: The treatment of Green chiretta leaves extract was able to decrease the liver cell damage of mice. The increase dose of Green chiretta leaves extract was not followed by the increase of protection effect to the liver cell damage of mice induced by paracetamol. Keywords: Green chiretta leaves extract, paracetamol, liver cell histological damage.
Pengaruh Pemberian Ekstrak Buah Naga Putih (Hylocereus undatus)Terhadap Struktur Histologis Paru Mencit (Mus musculus) Yang Dipapar Asap Rokok Nurul Wahda Aulia; endang listyaningsih s; yulia sari .
Nexus Biomedika Vol 2, No 3 (2013): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background: White Dragon fruit contains substances like vitamin A, E, C and polyphenolic compound that can counteract free radical. Cigarette smoke is a type of oxidant compound that causes oxidative stress and lung damage. The purpose of this study was to determine the effect of White Dragon fruit extract on histological of the alveolar lung of mice exposed by cigarette smoke, and to find out whether the increase in dose enhanced the protective effect against histological of the alveolar lung exposed by cigarette smoke. Methods: This study was a laboratory experimental research with the post-test only control group design. The subjects used in this experiment was male Swiss Webster mice (Mus musculus), 2-3 months old and 20g of body weight. Sampling technique was incidental sampling. Twenty eight mice were divided into 4 groups, each group consisted of 7 mice. Negative control group / KK(-) was administered distilled water. Positive Control Group/ KK(+) was administered distilled water, then, 2 hours later was treated with cigarette smoke. Treatment group 1 (KP1) and 2 (KP2) were administered white dragon fruit extract with dose 70 mg/20 g and 140 mg/20 g, successively, then, 2 hours later were treated with cigarette smoke. These treatments were performed for 14 days. On the day 15, all lungs of subjects were prepared for histological study. Lung damage was assessed by looking at the destruction of the alveolar septum, pulmonary edema, and infiltration of inflammatory cells. Observation result were classified into normal category, moderate and serious. Then, the data were analyzed using the Kruskal-Wallis test and Mann Whitney test with ? = 0.05. Results: The Kruskal-Wallis test showed that at least one group had significantly greater effect than other groups with p = 0.004 (p <0.050). The Mann Whitney test showed significant difference between KK(-) KK(+), KK(-) - KK2, KK(+) - KK1 groups and no significant difference between KK(-) KK, KK(+) - KK2, KK1 KK2 groups. Conclusions: White Dragon fruit extract provided protective effect against mices lung histological damage from cigarette smoke. The increasing dose of White Dragon fruit extract did not enhance the protective effect of histological lung structure of the mice against cigarette smoke. Keywords:White Dragon fruit, cigarette smoke, histological damage of lung.
The Nefroprotector Effect of Salam Leaf Extract (Syzygium polyanthum) in Mices Renal Cell which is Induced by Paracetamol Asaduddien Faras; Endang Listyaningsih S; Sigit Setyawan
Nexus Kedokteran Translasional Vol 2, No 2 (2013): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background : Salam Leaf (Syzygium polyanthum) contains antioxidants such as flavonoids, selenium, vitamin A, vitamin C, vitamin E, triterpenes, tannins, saponins, niacin, and essential oils as an antioxidant compounds. In present study, Syzygium polyanthum leaves extract was evaluated for its protective effect on paracetamol- induced renal damage in mice. Methods: This study was laboratory experimental research with Randomized Controlled Trial design. A total of 28 Swiss Webster mices were equally divided into 4 groups. Mices for control group (KK) and the first group (KP1) will be given aquades for 14 day. The second(KP2) and third (KP3) group will be given Salam leaf extract with dose 7 mg/20 g and 14 mg/20 g weight of mice for 14 days. While paracetamol in toxic dose was given on to KP1, KP2, KP3, with dose 0,1 ml/ 20 g weight of mice on day 12, 13 and 14. Mice were sacrificed with neck dislocation on the 15th day and histological preparation was made to evaluate histological damage on proximal tubular renal cells stained by Hematoxillin Eosin (HE). Renal histological features were assesed by counting the number of proximal tubular renal cells histogical damage. Data were analyzed by One-Way ANOVA test (? = 0,05) continued by Post Hoc Multiple Comparisons test (LSD)(? = 0,05). Results: The results of One-Way ANOVA test showed p < 0.05 that there was significant difference between four-groups. LSD test results showed p < 0,05 there was significant difference between grups. Conclusion: Salam leaf extract can prevent the renal cell damage of mice. The difference dose of salam leaf extract give different effects nefroprotector in mices renal cell. Keywords : salam leaf extract, paracetamol, renal histologic structure damage
Pendampingan Pola Hidup Bersih Dan Sehat (PHBS) Untuk Menekan Angka Kejadian Covid-19 Pada Kader Wilayah Puskesmas Nguter Sukoharjo. Siti Marufah; Lilik Wijayanti; Yulia Sari; Widia Susanti; Sigit Setyawan; Sri Haryati; Endang Listyaningsih S; Sugeng Purnomo
Smart Society Empowerment Journal Vol 1, No 2 (2021): Smart Society Empowerment Journal
Publisher : Fakultas Kedokteran UNS

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (936.688 KB) | DOI: 10.20961/ssej.v1i2.52867

Abstract

Pendahuluan :Sejak wabah pertama dilaporkan di Wuhan, Cina pada Desember 20191 virus corona (COVID-19) dengan cepat menjadi perhatian global. WHO menyatakan wabah virus sebagai pandemi pada 11 Maret 2020. Saat ini lebih dari 100 juta orang telah terinfeksi COVID-19, dengan lebih dari dua juta kematian di seluruh dunia2. Data covid-19 di Indonesia lebih dari 1 juta ditahun 2021 dengan angka kematian diangka 25.000 orang . Kabupaten sukoharjo, merupakan salah satu kabupaten yang menyumbangkan pasien covid-19 dengan jumlah saat ini mencapai lebih dari 4300 orang (corona kab sukoharjo, 2021).  Dalam upaya untuk memperlambat laju infeksi dan kematian, pemerintah di kabupaten sukoharjo telah membentuk tim “Sukoharjo tanggap COVID-19” yang bertugas untuk membagikan 34.500 masker ke masyarakat, penutupan tempat makan, fasilitasi tempat cuci tangan di pasar, Pengadaan rumah sehat Covid-19, tim posko covid-19 siaga 24 jam, penundaan pelayanan langsung pemerintahan dan pembatalan hajatan masyarakat. Walaupun pemerintah sangat tanggap dalam upaya pencegahan covid-19 ini, tapi untuk sosialisasi dan pendampingan langsung kepada keluarga belum maksimal, yaitu pada kepatuhan berperilaku hidup bersih dan sehat (PHBS), juga termasuk protocol kesehatan pencegahan covid. Kita ketahui bahwa keluarga merupakan faktor terdekat dalam penularan covid, sehingga menunjukan pentingnya keluarga sebagai fokus dalam pencegahan penyebaran Covid-19.Metode: Pengabdian ini akan dilakukan dengan memberikan intervensi berupa pemdampingan dengan pemberian edukasi dan monitoring tentang perilaku hidup bersih dan sehat (PHBS) guna pencegahan Covids-19 di wilayah puskesmas Bendosari, Sukoharjo. Perilaku hidup sehat ini juga meliputi kepatuhan penggunaan menggunakan masker, jaga jarak dan mencuci tangan.Hasil dan pembahasan: Kegiatan pengabdian masyarakat ini dihadiri oleh 47 kader dengan protokol kesehatan yang ketat. Selama kegiatan berlangsung, kader sangat antusias dalam menyimak edukasi yang  ditampilkan  dalam  bentuk  presentasi power  point, mereka  juga  interaktif  dalam berdiskusi. Berdasarkan hasil pengabdian, terjadi peningkatan pengetahuan menjadi 63, dengan terlihat hampir 85% peserta pada materi PHBS dan Protokol kesehatan memiliki pengetahuan yang sangat baik. Hal ini mengindikasikan bahwa pengabdian yang dilaksanakan efektif dan sesuai dengan data sebelumnya bahwa Promosi kesehatan dalam bentuk penyuluhan secara terus menerus dapat memberikan pengaruh terhadap pengetahuan dan sikap PHBS.Kesimpulan: Pelaksanaan pengabdian berjalan dengan efektif dengan peningkatan pengetahuan tentang Covid-19, PHBS dan Protokol kesehatan dalam rangka menekan angka penyebaran covid-19.Kata kunci : Pendampingan, covid-19, PHBS.
Co-Authors Asaduddien Faras Heigy Mutiha Putri Lilik Wijayanti Nurul Wahda Aulia Sigit Setyawan Siti Marufah Slamet Riyadi Slamet Riyadi Sri Haryati Sugeng Purnomo Widia Susanti Yulia Sari yulia sari .