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Lily Loho
Universitas Sam Ratulangi
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology

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Journal : JURNAL BIOMEDIK

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SEMINOMA ANAPLASTIK DENGAN YOLK SAC TUMOR TESTIS (MIXED GERM CELL TUMOR TESTIS) Loho, Lily
Jurnal Biomedik : JBM Vol 4, No 3 (2012): JURNAL BIOMEDIK : JBM Suplemen
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.4.3.2012.1214

Abstract

Abstract: Testicular cancer is relatively rare, accounting for less than 1% of malignant tumors affecting men. More than 90% of these tumors are of germ cell origin and most of them are found in young men between the ages of 15-34 years. Germ cell tumors are divided into seminoma and nonseminoma tumors. The seminoma makes up 30-40% of all testicular tumors. An anaplastic seminoma is a classic type of seminoma that has three or more mitosis under the high power microscopic field, combined with other morphologic criteria such as nuclear hyperchromasia, greater nucleolar sizes, pleomorphism, and an amount of necrosis. We reported a case of a 38-year-old male that was clinically diagnosed with a left testicular tumor and with an elevated alpha fetoprotein (AFP) and β human chorionic gonadotropin (β HCG) serum. The histopathological diagnosis was an anaplastic seminoma with a yolk sac tumor (YCT), i.e. a mixed germ cell tumor. Keywords: seminoma, testicular tumor, yolk sac tumor.   Abstrak: Kanker testis relatif jarang,  <1% dari semua kanker ganas pada laki-laki. Lebih dari 90 persen jenis tumor ini berasal dari sel germinal dan umumnya menyerang laki-laki muda berusia 15-34 tahun. Tumor sel germinal dibagi atas dua jenis: seminoma dan non seminoma. Jenis seminoma terdapat pada 30-40% dari seluruh tumor testis. Seminoma anaplastik adalah seminoma dengan ciri klasik mikroskopik berupa adanya tiga atau lebih sel-sel mitosis per lapangan pandang besar, disertai terdapatnya kriteria morfologik lain seperti inti sel hiperkromatik, anak inti berukuran besar, pleomorfik, dan terdapatnya sejumlah nekrosis. Kami melaporkan kasus seorang laki-laki berusia 38 tahun dengan diagnosis klinis tumor testis kiri disertai peningkatan kadar alfa feto protein (AFP) dan β human chorionic gonadotropin (β HCG) serum. Diagnosis histopatologik ialah  seminoma anaplastik dengan tumor yolk sac (YCT), yaitu tumor sel germinal campuran. Kata kunci: seminoma, tumor testis, tumor yolk sac.
KARSINOMA ADENOSKUAMOSA ENDOMETRIUM Loho, Lily
Jurnal Biomedik : JBM Vol 1, No 1 (2009): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.1.1.2009.812

Abstract

Abstrak: Karsinoma endometrium (KE) sering mengandung fokus-fokus metaplasia skuamosa. Bila komponen skuamosa jinak disebut adenoakantoma, yang prognosisnya tidak berbeda bermakna dengan bentuk murni adenokarsinoma. Bila komponen tersebut ganas disebut karsinoma adenoskuamosa, dengan pertumbuhan yang lebih agresif. Di Amerika Serikat insiden KE adenoskuamosa masih tinggi, sedangkan di Laboratorium Patologi Fakultas Kedokteran Universitas Sam Ratulangi Manado jenis ini sangat jarang ditemukan. Kami melaporkan sebuah kasus KE adenoskuamosa seorang perempuan berusia 53 tahun yang telah dilakukan histerektomi radikal dengan diagnosis klinis mioma uteri dan diagnosis patologik karsinoma sel skuamosa tanpa keratinisasi dari hasil kerokan endometrium tiga minggu sebelumnya. Diagnosis akhir kasus ini adalah KE adenoskuamosa tipe I, derajat dua, dengan invasi ke lapisan dalam miometrium. Tidak ditemukan invasi ke jaringan lain atau metastasis ke kelenjar getah bening. Prognosis kasus ini cukup baik. Kata kunci: karsinoma endometrium, adenoskuamosa, klasifikasi.     Abstract: Adenocarcinoma of the endometrium frequently contains foci of squamous metaplasia. If the squamous component is benign, it is called adenoacanthoma. On the other hand, if the squamous component is malignant, it is called adenosquamous carcinoma, which grows much more aggressively. The prognosis of adenoacanthoma does not differ significantly from that of pure adenocarcinoma. In the United States the incidence of adenosquamous carcinoma of the endometrium is still high, while in the Pathology Laboratory of the Medical Faculty, University of Sam Ratulangi, Manado this type is very rarely identified. We reported a case of adenosquamous carcinoma of the endometrium in a 53-year-old female that had undergone a radical hysterectomy due to a clinical diagnosis of uterine myoma and a pathologic diagnosis of nonkeratinizing squamous cell carcinoma for which she underwent an endometrial curettage three weeks before. After the operation, the final diagnosis of this case was adenosquamous carcinoma of the endometrium type I, grade two, with deep invasion into myometrium. There was no invasion into other tissues and no metastasis to lymph nodes. The prognosis of this case was good. Key words: endometrial carcinoma, adenosquamous, clasificassion.
Co-Authors Bawulele, Abel T. Carla F. Kairupan Chelyne F. Sundalangi, Chelyne F. Dewi Febry Kololu Eka Sari Tappi Indah S. Mappa Janet Walangitan Juita Pasaribu Limpo, Jessica P. Meilany Durry Patricia Tatukude Philip Teng Poppy Lintong Poppy M. Lintong Rajak, Zularsil F.W. Rico Lukas Tatukude Satriani Syahrin, Satriani Setiani, Ni Nyoman G. Wowor, Maurin