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All Journal Narra J Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Masrul Lubis
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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 1 
Etiology Profile of Lower Gastrointestinal Bleeding Masrul Lubis; Lukman Hakim Zain
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 13, NUMBER 2, August 2012
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (586.764 KB) | DOI: 10.24871/132201294-96

Abstract

Background: Lower gastrointestinal bleeding (LGIB) is still a significant health problem since the unknown etiology had not existed until now. Similar condition occurs at Adam Malik Hospital. No data about the etiology of LGIB has been defined. Therefore, this study was aimed to recognize the etiology profile of LGIB at Adam Malik Hospital, Medan. Method: A retrospective descriptive study was conducted on medical records of patients who had undergone lower gastrointestinal tract endoscopy (colonoscopy) at Adam Malik Hospital, Medan between January 2009 and December 2010 based on their complaint of hematochezia. Data was analyzed using SPSS version 19. The data was categorized based on subjects’ age, sex and etiology of their hematochezia. Results: There were 116 patients consisted of 61 (52.6%) males and 55 (47.4%) females with mean age of 50.52 (17-84) years. The colonoscopy revealed 52 (44.7%) cases of hemorrhoidal varices, 17 (14.7%) cases of rectal carcinoma, 17 (14.7%) normal endoscopic results, 8 (6.9%) cases of sigmoid carcinoma, 8 (6.9%) of proctitis, 6 (5.1%) cases of colitis, 4 (3.5%) cases of colon carcinoma, and 4 (3.5%) cases of rectosigmoid carcinoma. Conclusion: This study found that hemorrhoidal varices is the most common etiology of LGIB. Keywords: LGIB, colonoscopy, hemorrhoids
Differences in Inflammatory Parameters of Child-Pugh B and Child-Pugh C Scores of Liver Cirrhosis with Hepatorenal Syndrome Panggabean, Lider Olmen; Siregar, Gontar Alamsyah; Lubis, Masrul
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 3 No. 1 (2021): Journal of Endocrinology, Tropical Medicine, and Infectiouse Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (718.637 KB) | DOI: 10.32734/jetromi.v3i1.5507

Abstract

Background: Child-Pugh score is used to predict the poor prognosis of liver cirrhosis patients. The study objectives analyzed differences in inflammatory parameters of Child-Pugh B and Child-Pugh C of liver cirrhosis with hepatorenal syndrome. Method: Desain's study is cross-sectional in liver cirrhosis patients with hepatorenal syndrome.  This research was approved by the Health Research Ethics Commission FK USU / RSUP H. Adam Malik Medan and meets the criteria of inclusion or exclusion. Diagnosis of Liver cirrhosis Child-Pugh B and Child-Pugh C score is done by clinical examination, laboratory, and ultrasound, CT scan, MRI. The hepatorenal syndrome was diagnosed using Criteria International Ascites Club, 2007. Results: The sample number of this study was 26 liver cirrhosis with hepatorenal syndrome patients consisting of Child-Pugh B patients 9 patients and Child-Pugh C patients 17  patients. The comparison between Child-Pugh B and Child-Pugh C has significant differences in leukocyte, Na, Cl, SGOT, and CTP. There is a significant correlation between CTP and leukocytes, platelets, Cl, creatinine, GFR, albumin, total bilirubin, and glued bilirubin. Conclusion: There is no clear difference in the inflammatory parameters of the Child-Pug B and Child-Pug C scores in liver cirrhosis with hepatorenal syndrome.
Incidence and Characteristic of Gastroesophageal Reflux Disease (GERD): Before and During Covid-19 Pandemic Lubis, Masrul; Sianturi, Yolanda Anastasia
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 2 (2023): VOLUME 24, NUMBER 2, August, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2422023116-121

Abstract

Background: The incident numbers of gastroesophageal reflux disease (GERD) in Asia is increasing gradually from year to year. Activity restriction (lockdown) that happened during COVID-19 pandemic affects society’s eating habit and life style which are risk factors of GERD and the incidence of gastroesophageal reflux. This study was conducted to find the incidence and characteristics of GERD during COVID-19 pandemic and compared with the previous situation in patients who met the diagnostic criteria at H. Adam Malik General Hospital. Method: This research is a descriptive research study with a cross sectional design study where data were taken based on data from medical records at H. Adam Malik General Hospital in 2017–2022 with the sampling technique used is total sampling, where the research subjects were all patients diagnosed GERD that met the inclusion criteria.Results: The incidence of GERD before (2017–2019) and during the COVID-19 pandemic (2020–2022) were 21 and 37 patients respectively (there was a 76% escalation in the incidence of GERD during the COVID-19 pandemic compared to before the COVID-19 pandemic). The similar characteristics of GERD patients before and during the COVID-19 pandemic are age 40 years, work as an employee, high school graduate, and overweight body mass index (BMI).Conclusion: The incidence of GERD has increased during the COVID-19 pandemic compared to before the pandemic.
CTLA-4 +6230G>A polymorphism and its impact on CTLA-4 level and risk of hepatocellular carcinoma: A case-control study in Batak patients with chronic hepatitis B Darmadi, Darmadi; Rey, Imelda; Lubis, Masrul; Lindarto, Dharma; Muzasti, Riri A.
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1959

Abstract

Genetic polymorphisms in cytotoxic T-lymphocyte-associated protein 4 gene (CTLA-4) vary by ethnic background, necessitating population-specific studies. The aim of this study was to assess the association between the CTLA-4 +6230G>A polymorphism, serum CTLA-4 level, and hepatocellular carcinoma (HCC) in Batak patients with chronic hepatitis B, a group with high hepatitis B virus (HBV) endemicity. A case-control study was conducted among cases (Batak patients with chronic hepatitis B and HCC) and controls (chronic hepatitis B without HCC). Genotyping of the CTLA-4 +6230G>A polymorphism was performed using the TaqMan SNP Genotyping Assay. Serum CTLA-4 level was quantified using enzyme-linked immunosorbent assay (ELISA). Patient’s demographic, clinical and laboratory data were recorded and assessed including age, sex, body mass index (BMI), smoking history, cirrhosis status, HBV DNA level, liver function markers (aspartate aminotransferase (AST) and alanine aminotransferase (ALT)), hepatitis B e-antigen (HBeAg) status, smoking history, and alcohol consumption. This study found that G allele was significantly associated with an increased risk of HCC (OR: 2.69; 95%CI: 1.21–6.00; p=0.013). Individuals with GG/AG genotypes had a 2.89-fold higher risk of developing HCC compared to those with the AA genotype (p=0.032). Serum CTLA-4 level was significantly elevated in G allele carriers (GG: 159.9±57.1 pg/mL vs AA: 83.7±44.7 pg/mL; p<0.001). Multivariate analysis identified cirrhosis as the strongest predictor of HCC (OR: 7.60; p<0.001), followed by elevated ALT (OR: 3.42; p=0.018) and high HBV DNA levels (OR: 2.31; p=0.024). In conclusion, the CTLA-4 +6230G>A GG/AG genotype and elevated serum CTLA-4 level were significantly associated with an increased risk of HCC in Batak individuals with chronic HBV infection. Further research is needed to explore additional CTLA-4 polymorphisms and immune regulatory mechanisms in HBV-related HCC to improve risk stratification and therapeutic strategies.
RELATIONSHIP BETWEEN C-REACTIVE PROTEIN AND IL-6 LEVELS AND EJECTION FRACTION IN HEART FAILURE PATIENTS AT ADAM MALIK HOSPITAL Pratiwi, Harvinda Arya; Refli Hasan; Lubis, Masrul; Mardianto
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 7 No. 3 (2025): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v7i3.20467

Abstract

Background: Heart failure (HF) is a progressive condition markedby anatomical and functional cardiac defects. Inflammation is amajor factor in HF development. While some research implies a linkbetween elevated CRP and IL-6 levels and lower ejection fraction(EF), the results are inconsistent. This study aims to evaluate therelationship between C-reactive protein, IL-6 levels, and EF in heartfailure patients.Method: This cross-sectional analytic observational study wasconducted at Adam Malik Hospital to assess the relationshipbetween CRP and IL-6 levels and left ventricular EF (LVEF) in HFpatients. Result: The findings showed no significant connection betweenCRP and LVEF (p=0.391), implying that CRP does not directlyreflect systolic dysfunction. Conversely, IL-6 levels have asubstantial inverse connection with LVEF (p=0.001), indicating agreater link between systemic inflammation and cardiacperformance. Conclusion: These findings underline the importance of amultimodal approach to HF care, including the use of inflammatorymarkers for risk classification in this population. While CRP maynot be as accurate a predictor of systolic dysfunction, IL-6 appearsto be more closely related to heart failure severity. Keywords: CRP, Ejection fraction, Heart failure, IL-6.
Co-Authors Darmadi Darmadi dharma Lindarto, dharma Gontar Alamsyah Siregar Hasan, Refli Imelda Rey Lukman Hakim Zain Mardianto Muzasti, Riri A. Panggabean, Lider Olmen Pratiwi, Harvinda Arya Sianturi, Yolanda Anastasia