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All Journal Narra J The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy The Journal of Society Medicine (JSOCMED) Jurnal Penyakit Dalam Indonesia
Imelda Rey
Division of Gastroentero-hepatology, Department of Internal Medicine, Faculty of Medicine, University of Sumatera Utara/Pirngadi Hospital, Medan.
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Effect of Glycemic Parameters on Mortality of Type 2 Diabetes Mellitus Patients with COVID-19 Infection in Haji Adam Malik Hospital Medan Pangaribuan, Jessica Patricia; Syafril, Santi; Lubis, Dian Anindita; Isnanta, Rahmad; Rey, Imelda
Journal of Society Medicine Vol. 2 No. 8 (2023): August
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v2i8.81

Abstract

Introduction: Diabetes Mellitus Type 2 (DM T2) is a major health problem, especially in people in developing countries. DM T2 is the most frequently reported comorbid disease in patients with COVID-19. The relationship between DM T2 and poorer outcome in COVID-19 infection is thought to be because hyperglycemia and chronic inflammation impair control of viremia and inflammation by weakening the immune response. This research aim to determine the effect of glycemic parameters on the mortality of DM T2 patients with COVID-19. Method: This research is a descriptive analytic study with a retrospective design which was carried out at the H. Adam Malik General Hospital in Medan. The data obtained was analyzed statistically and said to be statistically significant if p <0.05. Results: Based on the results of the study, there were significant differences in the values of inflammatory markers such as leukocytes, neutrophils, NLR, PCT, LDH, D-dimer, ferritin, SGOT, urea and creatinine in the severity of COVID-19 patients and there were significant differences in the mean fasting blood sugar, blood sugar 2PP, in moderate, severe and critical COVID-19 patients. Conclusion: Glycemic parameters in patients who died were worse than patients who recovered, although the statistical results were not significantly different.
The Relationship Between Stress and Anxiety with the Occurrence of Functional Dyspepsia among Medical Students of Sumatera Utara University Aries, Tri Mulyani; Rey, Imelda
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 25, No 3 (2024): VOLUME 25, NUMBER 3, December, 2024
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/253202439-44

Abstract

Background: Functional dyspepsia is characterized by upper gastrointestinal symptoms like epigastric bloating, pain, and early satiation without structural disease evidence, including negative findings on endoscopy. Psychological triggers, such as stress and anxiety, may influence its occurrence. Previous research in Indonesia, including studies at Tarumanegara University, Mulawarman University, and the Islamic University of North Sumatra, has found associations between psychological factors and functional dyspepsia symptoms. Most respondents experienced dyspepsia linked to stress and anxiety. A study on patients at Dr. M. Jamil Hospital also confirmed this relationship. Building on the data mentioned, this study aims to explore and confirm the relationship between stress, anxiety, and the occurrence of functional dyspepsia in medical students at Sumatera Utara University.Methods: This research utilized a cross-sectional analytical approach with a sample of 261 medical students from Sumatera Utara University, selected via quota sampling, and applied the Rome IV and DASS-21 criteria questionnaires. Data were collected from September 2022 until October 2022.  Results: This study showed a 47.9% prevalence of functional dyspepsia among respondents, with 44.1% experiencing moderate stress and 72.4% having very severe anxiety. The Chi-square test revealed significant relationships between stress (p=0.026) and anxiety (p=0.038) with functional dyspepsia incidence. Spearman correlation tests further confirmed significant relationships between stress levels (p=0.049) and anxiety levels (p=0.030) and functional dyspepsia. Conclusion: There is a relationship between stress and anxiety with the incidence of functional dyspepsia in medical students of Sumatera Utara University. 
CTLA-4 +6230G>A polymorphism and its impact on CTLA-4 level and risk of hepatocellular carcinoma: A case-control study in Batak patients with chronic hepatitis B Darmadi, Darmadi; Rey, Imelda; Lubis, Masrul; Lindarto, Dharma; Muzasti, Riri A.
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1959

Abstract

Genetic polymorphisms in cytotoxic T-lymphocyte-associated protein 4 gene (CTLA-4) vary by ethnic background, necessitating population-specific studies. The aim of this study was to assess the association between the CTLA-4 +6230G>A polymorphism, serum CTLA-4 level, and hepatocellular carcinoma (HCC) in Batak patients with chronic hepatitis B, a group with high hepatitis B virus (HBV) endemicity. A case-control study was conducted among cases (Batak patients with chronic hepatitis B and HCC) and controls (chronic hepatitis B without HCC). Genotyping of the CTLA-4 +6230G>A polymorphism was performed using the TaqMan SNP Genotyping Assay. Serum CTLA-4 level was quantified using enzyme-linked immunosorbent assay (ELISA). Patient’s demographic, clinical and laboratory data were recorded and assessed including age, sex, body mass index (BMI), smoking history, cirrhosis status, HBV DNA level, liver function markers (aspartate aminotransferase (AST) and alanine aminotransferase (ALT)), hepatitis B e-antigen (HBeAg) status, smoking history, and alcohol consumption. This study found that G allele was significantly associated with an increased risk of HCC (OR: 2.69; 95%CI: 1.21–6.00; p=0.013). Individuals with GG/AG genotypes had a 2.89-fold higher risk of developing HCC compared to those with the AA genotype (p=0.032). Serum CTLA-4 level was significantly elevated in G allele carriers (GG: 159.9±57.1 pg/mL vs AA: 83.7±44.7 pg/mL; p<0.001). Multivariate analysis identified cirrhosis as the strongest predictor of HCC (OR: 7.60; p<0.001), followed by elevated ALT (OR: 3.42; p=0.018) and high HBV DNA levels (OR: 2.31; p=0.024). In conclusion, the CTLA-4 +6230G>A GG/AG genotype and elevated serum CTLA-4 level were significantly associated with an increased risk of HCC in Batak individuals with chronic HBV infection. Further research is needed to explore additional CTLA-4 polymorphisms and immune regulatory mechanisms in HBV-related HCC to improve risk stratification and therapeutic strategies.
Hubungan Aktivitas Fisik dengan Kualitas Hidup Pasien Hemodialisis Reguler Br Manurung, Shofi 'Ainun Azzahra; Nasution, Bayu Rusfandi; Rey, Imelda
Jurnal Penyakit Dalam Indonesia
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction. Hemodialysis (HD) is one of the renal replacement therapies commonly used in patients with end-stage renal disease. Patients undergoing hemodialysis typically exhibit lower levels of physical activity compared to inactive yet healthy individuals. A decline in physical function and muscular strength may impair the ability to perform daily activities, ultimately affecting patients’ quality of life (QoL). This study aimed to examine the relationship between physical activity and quality of life among hemodialysis patients at Rumah Sakit Khusus Ginjal Rasyida Medan. Methods. This was an analytical observational study with a cross-sectional design involving 50 respondents undergoing hemodialysis therapy at Rumah Sakit Khusus Ginjal Rasyida Medan between July and November 2022. Participants were selected based on predetermined inclusion and exclusion criteria. The association between variables was analyzed using the Chi-square test. Results. Among the respondents, 72.0% were categorized as having a good quality of life, while 28.0% had a poor quality of life. Regarding physical activity levels, 48.0% of patients had moderate activity, 26.0% had high activity, and 26.0% had low activity. Bivariate analysis revealed significant associations between quality of life and physical activity (p = 0.007), as well as between quality of life and comorbidities (p = 0.024). Multivariate analysis indicated that physical activity was a significant predictor of quality of life, with a prevalence ratio (PR) of 4.429 (95% CI: 1.383–14.191). Conclusion. There is a significant association between physical activity and quality of life among hemodialysis patients at Rumah Sakit Khusus Ginjal Rasyida Medan.
Co-Authors -, Suhelmi - Aries, Tri Mulyani Br Manurung, Shofi 'Ainun Azzahra Darmadi Darmadi dharma Lindarto, dharma Effendi-YS, Rustam Khadafi, M Lubis, Dian Anindita Lukman Hakim Zain Masrul Lubis Muzasti, Riri A. Nasution, Bayu Rusfandi Pangaribuan, Jessica Patricia Rahmad Isnanta, Rahmad Restuti Hidayani Saragih Rustam Effendi YS, Rustam Effendi Santi Syafril, Santi Siregar, Erina Taufik Sungkar, Taufik W, Andrie Zulkhairi Sofyan