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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences INDONESIAN JOURNAL OF PHARMACY
Nurkhasanah Mahfudh
Faculty of Pharmacy, Universitas Ahmad Dahlan
Agriculture, Biological Sciences & Forestry Environmental Science Medicine & Pharmacology

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Immunomodulatory Activity of Yogurt Fortified with Honey and Rosella (Hibiscus sabdariffa L.) on Reactive Oxygen Intermediate (ROI) and Nitric Oxide (NO) Secretion Nurkhasanah Mahfudh; Rina Novitasari
Indonesian Journal of Pharmacy Vol 30 No 2, 2019
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (943.402 KB) | DOI: 10.14499/indonesianjpharm30iss2pp141-146

Abstract

Raise the body's immune system. Rosella (Hibiscus sabdariffa Linn.) is known to have anthocyanin compounds that have antioxidant and immunomodulatory effects. The aim of this research is to know the effect of immunomodulator yogurt which fortified by rosella (Hibiscus sabdariffa L.) extract to increase the secretion of Reactive Oxygen Intermediate (ROI) and Nitric Oxide (NO). This research was conducted in vivo using 25 male mices with Balb/C strain divided into 5 groups: normal group, plain yogurt treated group and 2%, 4%, 8% rosella yogurt treated group. Treatment was given for 21 days orally. On the 22nd day the mice were sacrificed by taking peritoneum macrophage cells and then tested the secretion of Reactive Oxygen Intermediate (ROI) and Nitrite Oxide (NO). The results showed that there was an increase of ROI and NO secretion in 2%, 4%, and 8% rosella yoghurt treated groups compare to plain yoghurt. The fortification of yoghurt with rosella extract and honey increase the potency of yoghurt in increasing the immunomodulatory activity
Cytotoxic Potential of Arthrospira platensis Extract on Cervical Cancer Cells Line Hela: Study on Antiproliferative, Cell Cycle, Apoptosis Induction and Anti Metastasis Laela Hayu Nurani; Nurkhasanah Mahfudh; Ibnu Gholib Gandjar; Intan Rahayu
Indonesian Journal of Pharmacy Vol 31 No 1, 2020
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjpharm31iss1pp19

Abstract

Cervical cancer can be treated conventionally with chemotherapy agents, but its use has side effects and complications in the form of damage to normal cells. This study aims to determine the potential of A. platensis as an alternative anticancer agent that is selective towards normal cells. Based on TLC analysis, A. platensis contains antioxidant compounds such as β-carotene, flavonoids, and terpenoids which are able to inhibit proliferation and trigger apoptosis of cancer cells. The study was conducted using cervical cancer cells HeLa and normal cells HDFa. A. platensis macerated with 96% ethanol at a ratio of 1:4. Based on probit analysis, it is known that ethanol extract of A. platensis has a cytotoxic effect on HeLa cells with IC50 values of 260.444μg/mL and index selectivity towards HDFa cells of 7.931. The mechanism of cytotoxic activity of ethanol extract of A. platensis is related to its ability to extend the doubling time, increase the induction of apoptosis, and reduce the rate of cells migration. Ethanol extract of A. platensis can also increase cells accumulation in the S phase to prevent cells from entering the G2/M phase.
Development of Bangle Rhizome and Purple Sweet Potato Flour Biscuit and Its in vivo Antioxidant Activity in High-Fat Diet-Induced Rats: Biscuit, hiperlipid and antioxidant Nanik Sulistyani; Nurkhasanah Mahfudh; Rofidah Nur Umar; Muhammad Fathurrachman Mantali
Journal of Tropical Life Science Vol. 13 No. 1 (2023)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.13.01.05

Abstract

Bangle rhizome and purple sweet potato could be used as functional food to overcome health problems such as hyperlipidemia. The anti-hyperlipidemic, nutritional properties of the above-said root vegetables could be formulated into a more community-preferred food in the form of biscuits. For this reason, this study aims to formulate biscuits from the mixed flour of bangle rhizome and purple sweet potato. Next, the prepared product's antioxidant activity and lipid-lowering properties are tested in vivo in high-fat diet-induced Wistar rats. In this study, bangle rhizome and purple sweet potato were turned into flour and formulated into three types of biscuits comprising different ratios of bangle rhizome and purple sweet potato flour (5:39 % w/w (F1), 3:41 % w/w (F2), and 2:42 % w/w (F3)). The study found that the baked products showed good organoleptic and physical properties, yielding golden- to brown-colored biscuits with a distinctive aroma and vaguely bitter after-taste, with F3 showing the highest hardness (8.94 0.18). The proximate analysis test showed that the biscuits achieved three of the six SNI 01-2973-2011 quality requirements. The best formula (F3) exhibited acceptable in vivo antioxidant catalase (5.12 0.16 U/mL) and glutathione peroxidase activity (64.44 2.11 U/mg) in high-fat diet Wistar rats tested for 28 days. The F3 formula was deemed the best, yielding biscuits with low moisture content and good crispiness. The formulated biscuits increased catalase's antioxidant activity (285.47%) and glutathione peroxidase (265.08%) more than the negative control. Hence, the study demonstrated that bangle rhizome and purple sweet potato-containing biscuits were potentially useful functional foods for improving antioxidant activity in high-fat diet-induced Wistar rats.
Co-Authors Ibnu Gholib Gandjar Intan Rahayu Laela Hayu Nurani Muhammad Fathurrachman Mantali Nanik Sulistyani Rina Novitasari Rofidah Nur Umar