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All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Sains dan Praktis
Ibnu Gholib Gandjar
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Immunology & microbiology Medicine & Pharmacology Public Health

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Cytotoxic Potential of Arthrospira platensis Extract on Cervical Cancer Cells Line Hela: Study on Antiproliferative, Cell Cycle, Apoptosis Induction and Anti Metastasis Laela Hayu Nurani; Nurkhasanah Mahfudh; Ibnu Gholib Gandjar; Intan Rahayu
Indonesian Journal of Pharmacy Vol 31 No 1, 2020
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjpharm31iss1pp19

Abstract

Cervical cancer can be treated conventionally with chemotherapy agents, but its use has side effects and complications in the form of damage to normal cells. This study aims to determine the potential of A. platensis as an alternative anticancer agent that is selective towards normal cells. Based on TLC analysis, A. platensis contains antioxidant compounds such as β-carotene, flavonoids, and terpenoids which are able to inhibit proliferation and trigger apoptosis of cancer cells. The study was conducted using cervical cancer cells HeLa and normal cells HDFa. A. platensis macerated with 96% ethanol at a ratio of 1:4. Based on probit analysis, it is known that ethanol extract of A. platensis has a cytotoxic effect on HeLa cells with IC50 values of 260.444μg/mL and index selectivity towards HDFa cells of 7.931. The mechanism of cytotoxic activity of ethanol extract of A. platensis is related to its ability to extend the doubling time, increase the induction of apoptosis, and reduce the rate of cells migration. Ethanol extract of A. platensis can also increase cells accumulation in the S phase to prevent cells from entering the G2/M phase.
OPTIMASI FASE GERAK PADA ANALISIS CAMPURAN CIPROFLOXACIN HCL DAN METRONIDAZOL MENGGUNAKAN KROMATOGRAFI CAIR KINERJA TINGGI Aqnes Budiarti; Ibnu Gholib Gandjar
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peranan dan Kontribusi Herbal dalam Terapi Penyakit Degeneratif"
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (127.383 KB) | DOI: 10.31942/jiffk.v0i0.377

Abstract

Penggunaan ciprofloxacin (CIP) untuk terapi penyakit infeksi saat ini sering dikombinasi dengan obat anti bakteri lain karena keterbatasannya melawan bakteri anaerob, salah satunya dengan metronidazol (MDZ). CIP berada dalam bentuk kationik pada kondisi asam (pH kurang dari 4,68) sehingga akan berikatan dengan residu silanol yang bermuatan negatif pada pH di atas 3,0, akibatnya dapat menyebabkan tailing. Hal ini dapat dicegah dengan penambahan reagen pasangan ion yang akan berikatan dengan residu silanol. Reagen pasangan ion yang sering digunakan dalam analisis senyawa kationik adalah amin tersier, seperti trietilamin (Anonim, 2010). Penelitian ini bertujuan untuk mengoptimasi fase gerak pada analisis campuran CIP.HCl dan MDZ menggunakan KCKT dengan penambahan trietilamin sebagai reagen pasangan ion. Fase diam yang digunakan adalah C18 dan fase gerak berupa campuran dapar fosfat 0,05 M dan asetonitril dengan perbandingan sesuai dengan hasil optimasi. Hasil penelitian menunjukkan bahwa pemisahan optimum diperoleh pada fase gerak berupa campuran dapar fosfat 0,05 M pH 3,5 dan asetonitril (80: 20, v/v) dengan kecepatan laju alir 1,2 mL/menit dan kadar trietilamin 0,05 Molar.   Kata kunci : Optimasi fase gerak, ciprofloxacin HCl,metronidazol,Kromatografi     Cair Kinerja Tinggi
AUTHENTICATION OF PATCHOULI OIL FROM VARIOUS GROWING REGIONS USING GC-MS METHOD WITH CHEMOMETRIC COMBINATION ON THE PRODUCTS IN THE MARKET Nurani, Laela Hayu; Guntarti, Any; Milanie, Rida Dwi; Gandjar, Ibnu Gholib; Rais, Ichwan Ridwan; Prasasti, Dian; Edityaningrum, Citra Ariani
Jurnal Farmasi Sains dan Praktis Vol 10 No 1 (January-April 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i1.10523

Abstract

Adulteration in patchouli oil trade is an ancient practice, where additional substances like turpentine oil are added to increase volume and odor. Therefore, this research aimed to determine the composition of patchouli oil, considering variations in growing regions and potential adulteration in the products available in the market. The analysis was carried out using the Gas Chromatography-Mass Spectrormetry (GC-MS) method with a Principal Component Analysis (PCA) chemometric combination for authentication. The sample obtained from Bantul, Kulon Progo, and Purworejo was isolated through steam and water distillation. Subsequently, it was tested in accordance with SNI standard 06-2385-2006 and analyzed using GC-MS. The results were compared to the products on the market and processed using multivariate chemometric, namely PCA with Minitab 19 software. GC-MS analysis showed the presence of various compounds contained in the oil, including alcohol, alpha-guaiene, beta-humulene, seychellene, trans-caryophyllene, neoalloocimene, and beta-patchoulene. The combination of GC-MS and PCA chemometrics was able to distinguish patchouli oil from others and the products available on the market. PCA chemometric analysis showed that the patchouli oil from various growing regions had the same chemical components as essential oil. Furthermore, PCA chemometric analysis of market products also showed similar results but varied significantly from turpentine oil. This showed that the patchouli oil product available on the market did not contain turpentine oil.
Co-Authors Achmad Purnomo Any Guntarti Apriyanti, Anna Aqnes Budiarti Atmini, Kuswardani Dwi Citra Ariani Edityaningrum, Citra Dian Prasasti Ichwan Ridwan Rais Intan Rahayu Laela Hayu Nurani Mala, Cindhany Darmaria Faridhah Utami Malasari, Yenita Milanie, Rida Dwi Nurkhasanah Mahfudh Satibi Satibi Sumarni Sumarni Wakhid Slamet Ciptono