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All Journal Jurnal Kesehatan Andalas INDONESIAN JOURNAL OF PHARMACY Universa Medicina Acta Biochimica Indonesiana Majalah Kedokteran Andalas Sumatera Medical Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Scientific Journal Jurnal Ilmu Kesehatan Indonesia (JIKSI) Jurnal Pengabdian Masyarakat Kesehatan (JURABDIKES) Indonesian Journal of Endocrinology Metabolism and Diabetes (InaJEMD)

Dinda Aprilia

Fakultas Kedokteran Universitas Andalas

Author-ID : 3097475

Humanities Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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The Effect of Thionamide to TRH, TSH, IL-4, T-REG, and Anti-TPO in Graves’ Disease Eva Decroli; Dwitya Elvira; Dinda Aprilia
Indonesian Journal of Pharmacy Vol 30 No 2, 2019
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The most common cause of hyperthyroidism is Graves' disease. TRH and TSH are hormonal factors that modulate and control thyroid function in Graves' disease. In the immunological aspect, Graves' disease is played by the role of T-reg, IL-4, and anti-TPO. Graves' disease treatment goal is to inhibit thyroid hormone secretion by administering thionamide. The evaluation of this treatment is its hormonal and immunological aspects. To describe the effect of thionamide on serum TRH, TSH, IL-4, T-reg, and anti-TPO levels in Graves' disease. This study is a clinical trial study in 25 study participants. All study participants were given thionamide, namely PTU 300mg for three months and blood samples were taken for laboratory tests. Serum TRH, TSH, IL-4, T-reg FOXP3, and anti-TPO levels were examined by ELISA. The mean levels at the beginning and after three months of therapy are: serum TRH 92.589pg/mL and 115.944pg/mL; serum TSH 0.041mU/L and 0.223mU/L; serum IL-4 19.759pg/mL and 23.040pg/mL; T-reg FOXP3 gene polymorphism 0.621ng/mL and 0.518 ng/mL; serum anti-TPO 2697.539pg/mL and 2604.710pg/mL. Increased levels of serum TRH and TSH levels were statistically significant. The change in serum IL-4, T-reg FOXP3 gene polymorphism, and anti-TPO levels were not statistically significant. The administration of thionamide in Graves' disease for three months will significantly decrease Wayne index and serum FT4 levels, increase serum TRH and TSH levels.

Pengaruh Pemberian Ekstrak Ubi Jalar Ungu terhadap Kadar Glukosa Darah dan MDA Hepar Tikus Hiperglikemia Annisa Pratiwi; Yustini Alioes; Dinda Aprilia
Jurnal Ilmu Kesehatan Indonesia Vol 1 No 2 (2020): Juli 2020
Publisher : Fakultas Kedokteran, Universitas Andalas

Latar Belakang. Ubi jalar ungu mengandung senyawa antioksidan berupa antosianin, asam fenolat, vitamin A, C, dan E. Antioksidan dapat meredam kerusakan oksidatif pada sel beta pankreas sehingga mampu meningkatkan sekresi insulin serta mengurangi stres oksidatif pada DM. Objektif. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak ubi jalar ungu terhadap kadar glukosa darah dan MDA hepar tikus hiperglikemia. Metode. Penelitian ini merupakan true experimental dengan post-test only control group design. Sebanyak 24 ekor tikus dibagi menjadi empat kelompok, yaitu kontrol negatif (K-), kontrol positif (K+), perlakuan satu (P1), dan perlakuan dua (P2). Kelompok P1 dan P2 diinduksi aloksan dan diberikan ekstrak ubi jalar ungu dosis 150 mg/kgBB dan 200 mg/kgBB selama 21 hari. Hasil. Terdapat perbedaan signifikan kadar glukosa darah antara kelompok P1 dan P2 dengan kelompok K+ dengan nilai p = 0,000. Terdapat perbedaan signifikan kadar MDA hepar antara kelompok P1 dibandingkan K- dan K+ dengan nilai p = 0,001 dan p = 0,046, kelompok P2 dibandingkan K- dan K+ dengan nilai p = 0,037 dan p = 0,001. Kesimpulan. Ekstrak ubi jalar ungu berpengaruh dalam menurunkan kadar glukosa darah dan MDA hepar tikus hiperglikemia. Kata kunci: ubi jalar ungu, glukosa darah, MDA hepar Background. Purple sweet potato contains antioxidant compounds such as anthocyanin, phenolic acid, vitamin A, C, and E. Antioxidants can reduce oxidative damaged of mitochondria in pancreatic beta cell resulting an increase in insulin secretion and a decrease oxidative stress in DM patients. Objective. This study aimed to determine the effect of giving purple sweet potato extract on blood glucose levels and liver MDA in hyperglycemic rats. Methods. This study was true experimental with post-test only control group design. A total of 24 rats were divided into 4 groups, namely negative control (K-), positive control (K+), treatment one (P1), and treatment two (P2). P1 and P2 group were induced by alloxan and given purple sweet potato extract dose of 150 mg/kgBB and 200 mg/kgBB for 21 days. Result. There were significant differences between P1 and P2 with K+ group with p value = 0,000. There were significant difference between P1 group with the K- and K+ group with p value = 0.001 and 0,046, P2 compared to K- and K+ group with p value = 0.037 and p = 0,001. Conclusion. Purple sweet potato extract can reduce the level of blood glucose level and MDA in liver tissues.

Gambaran Pemeriksaan Ultrasonografi pada Pasien Struma di Bagian/SMF Radiologi RSUP DR. M. Djamil Periode Januari–Desember 2019 Irfan Fadilah; Dina Arfiani Rusjdi; Dinda Aprilia
Jurnal Ilmu Kesehatan Indonesia Vol 2 No 1 (2021): Maret 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Background: A goiter is an enlargement of the thyroid gland caused by abnormalities of the thyroid gland in the form of malfunctioning or disorders of the structure of the gland and its morphology. According to WHO, the incidence of goiter is still quite high with iodine deficiency as the main cause. Objective: This study aims to determine the description of ultrasound examinations in goiter patients in Department of Radiology DR. M. Djamil January-December 2019 period. Method: This research was a retrospective descriptive study using cross sectional method using secondary data on 123 patients with thyroid goiter who meet the inclusion criteria in RSUP DR. M. Djamil Padang period January 2019-December 2019. The sampling method used a total sampling technique. Result: The results showed that 112 patients with thyroid goiter disorders met the inclusion criteria. The most clinical diagnosis results were goiter nodusa as many as 61 people (54.5%). The highest incidence was in the age range 41-50 years with 35 people (31.3%). The most gender was 88 women (78.6%). The results of ultrasonography in most goiter patients were diffuse in 43 people (38%).Conclusion: The conclusion of this study, it was found that the most age group of patients suffering from goitre were 41-50 years old, the majority of goiters occurred in the female compared to the male and the results of the most thyroid ultrasound images were diffuse goiter

Comorbidities of Gestational Diabetes Mellitus and Urinary Tract Infection: A Case Report Dinda Aprilia; Eva Decroli; Alexander Kam; Robby Satria Putra
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 4 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i4.804

Background: Gestational diabetes mellitus (GDM) is defined as a condition of glucose intolerance that is found during pregnancy. In pregnant women, urinary tract infection (UTI) is one of the most common bacterial infections that can be found. The infection can be worsened by diabetes as it was shown that the risk of UTI in pregnant women with diabetes (27.6%) is higher than those without diabetes (3%-10.1%). This study aimed to present a case of gestational diabetes mellitus and urinary tract infection. Case presentation: A pregnant woman aged 38 years old with a 15-16 weeks gestational age was admitted with gestational diabetes mellitus and urinary tract infection. The patient was treated with an intravenous insulin drip and antibiotic. The patient was discharged after there was a clinical improvement. Conclusion: There are many risk factors that can contribute to the development of UTI in pregnant women, with one of those being inadequate glycemic control. The treatment of UTI in pregnant women with GDM is generally the same as in those without GDM.

Pengaruh Ekstrak Kemangi (Ocimum basilicum) Terhadap Ekspresi Interleukin-6 Tikus Diabetes Melitus Gestasional Wahyu Agnata Surya; Hirowati Ali; Dinda Aprilia
Jurnal Ilmu Kesehatan Indonesia Vol 4 No 2 (2023): Juni 2023
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v4i2.756

Latar Belakang: Diabetes melitus gestasional (DMG) merupakan penyakit metabolik berupa gangguan toleransi karbohidrat dengan onset pertama terjadi saat kehamilan. Interleukin-6 (IL-6) diketahui terlibat dalam inflamasi pada DMG. Kemangi (Ocimum basilicum) dilaporkan sebagai tanaman herbal yang mengandung zat aktif yang bersifat anti-inflamasi Objektif: Penelitian ini bertujuan melihat efek ekstrak kemangi terhadap ekspresi IL-6 pada tikus model DMG. Metode: Sampel RNA leukosit berasal dari tikus DMG yang diinduksi streptozotosin sebelumnya. RNA berasal dari tikus hamil normal (K-; n=6), tikus DMG tanpa perlakuan (K+; n=6), tikus DMG yang diberikan ekstrak kemangi secara oral dengan dosis 100 mg/kg (P1; n=6) dan 200 mg/kg (P2; n=6) selama 14 hari. Ekspresi RNA IL-6 dan GAPDH (kontrol internal) diukur menggunakan PCR secara semi-kuantitatif dan visualisasi elektroforesis menggunakan ImageJ. Analisis data menggunakan uji one-way ANOVA dan post-hoc Bonferroni Hasil: Hasil penelitian menunjukkan terdapat perbedaan signifikan penurunan ekspresi IL-6 antara K+ dengan P2 (p<0,01) dan antara P1 dengan P2 (- p<0,001). Kesimpulan: Kesimpulan yang didapat adalah terdapat pengaruh pemberian ekstrak kemangi terhadap ekspresi IL-6 pada tikus DMG.

Tiroiditis Hashimoto dan Sindrom Gitelman Dinda Aprilia; Eva Decroli; Alexander Kam; Auliangi Tamayo
Majalah Kedokteran Andalas Vol 46, No 4 (2023): Online Juli 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i4.p772-775.2023

Seorang perempuan usia 34 tahun datang dengan keluhan lemah pada kedua tangan dan kaki, benjolan di leher, riwayat berdebar-debar, penurunan berat badan dan siklus menstruasi yang tidak teratur. Pasien didiagnosis dengan tiroiditis Hashimoto dan sindrom Gitelman. Pasien diterapi dengan levotiroksin dan koreksi elektrolit. Pasien kemudian pulang dalam keadaan perbaikan klinis.

Marine-Lenhart Syndrome: Current Perspectives on Diagnosis and Management Alexander Kam; Yanne Pradwi Efendi; Dinda Aprilia; Eva Decroli; Syafril Syahbuddin; Suci Berlian Hemilton
Scientific Journal Vol. 4 No. 5 (2025): SCIENA Volume IV No 5, September 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i5.264

Marine-Lenhart syndrome (MLS) is an uncommon disorder characterised by the concurrent presence of Graves’ disease and hyperfunctioning thyroid nodules. Its global prevalence ranges between 2.7- 4.1% of Graves’ disease cases, presenting significant challenges in diagnosis and management. MLS is often difficult to detect due to limitations in autoimmune serology tests, thyroid ultrasonography, and access to nuclear medicine facilities. Diagnosis relies on a combination of clinical hyperthyroidism symptoms, the presence of specific thyroid antibodies, and scintigraphy findings that reveal "hot" or "cold" nodules. The primary therapeutic options for MLS include antithyroid drugs, radioactive iodine (RAI) therapy, and surgery. RAI is commonly employed as definitive treatment, often requiring higher doses to address the resistance of hyperfunctioning nodules. Surgery is indicated in cases involving large nodules, compressive symptoms, or suspected malignancies. Treatment strategies should be tailored to the individual clinical characteristics of each patient to minimize complications and ensure optimal outcomes. Advancing the diagnosis and management of MLS requires enhanced access to advanced diagnostic technologies and improved healthcare provider proficiency in identifying and treating the syndrome. A multidisciplinary and integrated approach is essential for achieving favorable clinical outcomes for MLS patients.

Liothyronine Therapy in Hypothyroidism Dinda Aprilia; Eva Decroli; Alexander Kam; Jonggara Oktaviandra Siahaan
Scientific Journal Vol. 4 No. 5 (2025): SCIENA Volume IV No 5, September 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i5.277

Hypothyroidism is a clinical condition characterized by reduced production of thyroid hormones and is among the most common endocrine disorders, affecting about 3% of the general population, with a higher prevalence in women (5.1%) than in men (0.9%). In Indonesia, the prevalence of hypothyroidism is estimated at 5-10%. Despite achieving normal thyroid stimulating hormone (TSH) levels with levothyroxine (LT4) therapy, many patients continue to experience symptoms like fatigue, depression, and cognitive impairment, which impact their quality of life. A study of 969 hypothyroid patients found that 77.6% were dissatisfied with their treatment and reported low quality of life scores. Although LT4 has been the standard therapy for nearly 50 years due to its stability and the peripheral conversion of thyroxine (T4) to triiodothyronine (T3), recent recommendations from experts in developed countries suggest using liothyronine (LT3) monotherapy or a combination of LT3 and LT4 in selected cases.

Emerging Biomarkers for Prediabetes : A Review Dinda Aprilia; Eva Decroli; Alexander Kam; Putri Deas Hadilofyani
Scientific Journal Vol. 4 No. 6 (2025): SCIENA Volume IV No 6, November 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i6.278

Prediabetes is a global health concern marked by elevated blood glucose levels that do not yet meet the threshold for type 2 diabetes mellitus (T2DM). It is often underdiagnosed despite being associated with insulin resistance, beta-cell dysfunction, and increased cardiovascular risk. Improved strategies for early detection are crucial to prevent disease progression. This review aims to explore novel biomarkers associated with prediabetes and evaluate their potential clinical applications in early diagnosis and risk stratification. A literature search was conducted on English and Indonesian language publications, including original research, case reports, and expert guidelines, focusing on emerging molecular and metabolic biomarkers related to prediabetes. Several promising biomarkers have been identified, including adiponectin, microRNAs, fetuin A, alpha-hydroxybutyrate (α-HB), and Protein Z. Adiponectin demonstrates an inverse relationship with insulin resistance. Specific microRNAs, such as miR-192 and miR-193b, are implicated in glucose metabolism and beta-cell function. Elevated fetuin A levels are linked to hepatic insulin resistance, while increased α-HB levels reflect early metabolic shifts in glucose utilization. Additionally, altered Protein Z concentrations may contribute to prothrombotic states in individuals with prediabetes. In conclusion, these biomarkers offer valuable insight into the pathophysiology of prediabetes and hold potential for enhancing early detection and prevention strategies. However, further validation through large-scale studies is needed before their integration into clinical practice

The Role of Genomic Sequencing in Diabetes Mellitus Yanne Pradwi Efendi; Alexander Kam; Eva Decroli; Dinda Aprilia; Syafril Syahbuddin
Scientific Journal Vol. 4 No. 5 (2025): SCIENA Volume IV No 5, September 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i5.279

Diabetes Mellitus is a chronic metabolic disorder caused by impaired insulin secretion and/or insulin resistance. Genetic testing through genomic sequencing is one of the modalities available for diabetes mellitus. Genomic sequencing is the process of analysing DNA obtained from a blood sample (or alternatively from tissue samples). Broadly, genomic sequencing plays two major roles in diabetes mellitus: supporting diagnosis and guiding therapeutic approaches. In its development, genomic sequencing has proven valuable for diagnostic investigation in type 1 diabetes and maturity-onset diabetes of the young (MODY), as well as for assessing the polygenic risk score (PRS) in type 2 diabetes. Establishing a definitive diagnosis allows for the selection of individualised therapy. Several randomised controlled trials have demonstrated that the risk of developing diabetes can be reduced by up to half if detected at an earlier stage. Moreover, genomic sequencing can identify genetic variants that influence responsiveness to antidiabetic treatments. At present, several potential antidiabetic agents targeting novel pathways are under development and in various stages of clinical trials. The application of genomic sequencing thus facilitates the implementation of individualised therapy, ultimately contributing to the realisation of precision medicine.

Co-Authors Alexander Kam Annisa Pratiwi Athari Fadhila Namanda Putri Athari Fadhila Namanda Putri Auliangi Tamayo Dina Arfiani Rusjdi Dwitya Elvira, Dwitya Eka Nofita Eti Yerizel Eva Decroli Eva Decroli Fadrian Fadrian, Fadrian Harun Harnavi Hirowati Ali Husna Yetti Irfan Fadilah Jonggara Oktaviandra Siahaan Lukman Nurhakim Mohamad Reza Munsyi Nares Wari Naufal Fathi Ashari Putri Deas Hadilofyani Robby Satria Putra Rozi Abdullah Rudy Afriant Russilawati SM Rezvi Suci Berlian Hemilton Syafril Syahbuddin Syafril Syahbuddin Wahyu Agnata Surya Wati, Westi Permata Yanne Pradwi Efendi Yanne Pradwi Efendi Yanne Pradwi Efendi Yustini Alioes Zhira Shada Athaya

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