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All Journal Jurnal Kesehatan Andalas Buletin Ilmiah Nagari Membangun Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research Health and Medical Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia (JIKSI)

Alexander Kam

Bagian Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Andalas / RSUP Dr. M.Djamil, Padang

Author-ID : 2836505

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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Imunopatogenesis dan Implikasi Klinis Alergi Makanan pada Dewasa Alexander Kam; Raveinal Raveinal
Jurnal Kesehatan Andalas Vol 7 (2018): Supplement 2
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v7i0.842

Alergi makanan adalah gangguan kesehatan yang timbul akibat respon imun spesifik terhadap makanan. Prevalensi alergi makanan pada anak adalah 6%, sementara pada dewasa 3 – 4%. Strategi pencegahan alergi makanan yang belum optimal menjadi salah satu penyebab insiden yang terus meningkat. Imunopatogenesis pada alergi makanan melibatkan reaksi antara alergen dengan antibodi yang dimediasi oleh immunoglobulin E, non-immunoglobulin E, atau kedua-duanya. Implikasi klinis alergi makanan pada dewasa bisa mengenai sistem gastrointestinal, kutaneus, respirasi, dan sistemik. Standar baku emas diagnosis alergi makanan adalah oral food challenge. Tatalaksana yang paling tepat adalah menghindari faktor pencetus. Terapi spesifik dan nonspesifik terhadap alergen dapat diberikan walaupun masih dalam perdebatan.

The Profile of COVID-19 Patients in Semen Padang Hospital Indonesia Fauzar Fauzar; Roza Kurniati; Farhan Abdullah; Alexander Kam
Jurnal Kesehatan Andalas Vol 10, No 1 (2021): Online March 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i1.1684

The rapid increase in the number of Coronavirus Disease 2019 (COVID-19) cases, including in Padang, has led the government to designate several hospitals as referrals for COVID-19 patients. The profile of COVID-19 patients is needed to describe the pattern of this disease in Padang. Objectives: To revealed the profile of COVID-19 patients in SPH, Indonesia. Methods: This was a retrospective study. This study was conducted and collected data of COVID-19 patients from March to June 2020. Results: There are 54 patients with mean age of 50.93 (14.6) years old, 43% male and 57% female. The clinical manifestations are cough (74%), fever (37%), sore throat (22%), and fatigue (35%). There are 82% of patients admitted that they have contacted with other COVID-19 patients or have activities in COVID-19 cluster area, and only 7% have traveled to other cities. The mean length of stay is 31.91 (14.87) days. The mean laboratory data: Hemoglobin 13.7 (1.39) gr/dl, WBC 8,037.04 (2,846.27) /mm3, platelet 274,389 (75,053.80) /mm3, and NLR 3.16 (3.37). Chest radiograph results are bronchopneumonia (22.22%), cardiomegaly (7.41%), and normal (70.37%). Conclusion: The profile of COVID-19 patients in SPH is more in female patients, cough is the most clinical manifestation that appeared, the mean laboratory data (hemoglobin, WBC, and platelet) are normal, and normal chest radiography is the most chest radiograph results in these patients.Kata kunci: COVID-19, Padang, profile

Dampak Klinis Thyroid-Stimulating Hormone Eva Decroli; Alexander Kam
Jurnal Kesehatan Andalas Vol 6, No 1 (2017)
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v6i1.674

Thyroid-Stimulating Hormone (TSH), yang disebut juga dengan tirotropin, adalah glikoprotein yang disekresikan oleh bagian anterior dari kelenjar hipofisis. Sintesis dan sekresi dari TSH diatur oleh faktor dari hipotalamus yang didominasi oleh thyrotropin-releasing hormone (TRH) dan faktor perifer yang didominasi oleh kadar hormon tiroid. Setelah disintesis, TSH disekresikan, lalu akan berikatan dengan reseptor yang disebut Thyroid-Stimulating Hormone Receptor (TSHR). Ikatan TSH-TSHR akan memberikan dampak klinis terhadap jaringan dan organ tempat terjadinya ikatan tersebut. Ikatan tersebut bisa terjadi pada kelenjar tiroid dan jaringan ekstratiroid. Jaringan yang sudah dikenal mengekspresikan TSHR adalah jaringan adiposa, hipotalamus, hipofisis anterior, tulang, hati dan sistem imun.

Hubungan Lama Rawat Inap dengan Usia dan Komorbiditas Pasien COVID-19 di Semen Padang Hospital dari Maret hingga Juli 2020 Akbar Shiddiq; Fauzar Fauzar; Roza Kurniati; Alexander Kam
Health and Medical Journal Vol 4, No 1 (2022): HEME January 2022
Publisher : Universitas Baiturrahmah

Abstrak Pendahuluan: Penyakit Coronavirus 2019 (COVID-19) merupakan salah satu penyakit yang sedang menjadi pandemi. Berdasarkan data World Health Organization (WHO) hingga Juli 2020, ditemukan angka kejadian mencapai lebih dari 17 juta di dunia. Sebagian besar orang sekitar 80% sembuh tanpa memerlukan perawatan khusus, tetapi beberapa orang yang memiliki penyakit penyerta dapat menyebabkan gejala yang berat. Sekitar 1 dari setiap 5 orang yang terinfeksi COVID-19 membutuhkan perawatan di rumah sakit dan lama perawatan yang berbeda. Tujuan: Penelitian ini bertujuan untuk mengetahui distribusi usia dan komorbiditas, hubungan lama rawat inap dengan usia dan komorbiditas pasien COVID-19 di Semen Padang Hospital. Metode: Penelitian ini adalah deskriptif korelatif dengan desain cross sectional. Dari pengumpulan data didapatkan 60 pasien COVID-19 dari bulan Maret hingga Juni 2020. Hasil: Didapatkan 6 pasien pada kelompok usia 0-18 tahun (10%), 38 pasien pada kelompok usia 19-59 tahun (63,3 %), dan 16 pasien pada kelompok usia ≥ 60 tahun (26,7 %). Berdasarkan analisis bivariat diperoleh hasil p = 0,599 (p > 0,05). Terdapat 17 pasien dengan komorbiditas (28,3 %) dan 43 pasien tanpa komorbiditas (71,7 %). Hasil yang diperoleh p = 0,513 (p > 0,05). Simpulan: Didapatkan bahwa tidak ada hubungan lama rawat inap dengan usia dan komorbiditas. Distribusi prevalensi COVID-19 terbanyak didapatkan pada pasien tanpa komorbiditas dan pada kelompok dewasa usia 19-59 tahun.Katakunci — COVID-19, lama rawat inap, usia, komorbiditas Abstract Introduction: Coronavirus disease 2019 (COVID-19) is a disease that is currently becoming a pandemic. Based on data from the World Health Organization (WHO) until July 2020, it was found that the incidence reached more than 17 million in the world. Most people about 80% recover without needing special treatment, but some people who have co-morbidities can cause severe symptoms. About 1 in every 5 people infected with COVID-19 requires hospitalization and a different length of treatment. Aims: This study aims to determine the distribution of age and comorbidities, the relationship between length of stay and age and comorbidities of COVID-19 patients at Semen Padang Hospital. Methods: This research is descriptive correlative with cross sectional design. From data collection, there were 60 COVID-19 patients from March to June 2020. Results: There were 6 patients in the 0-18 years age group (10%), 38 patients in the 19-59 year age group (63.3 %), and 16 patients in the age group 60 years (26.7 %). Based on the bivariate analysis, the results were p = 0.599 (p > 0.05). There were 17 patients with comorbidities (28.3%) and 43 patients without comorbidities (71.7%). The results obtained were p = 0.513 (p > 0.05). Conclusion: It was found that there was no relationship between length of hospitalization with age and comorbidities. The highest prevalence distribution of COVID-19 was found in patients without comorbidities and in the adult group aged 19-59 years.Keywords— COVID 19, length of stay, age, comorbidity

COVID-19 dengan Komorbid Tuberkulosis Paru dan Diabetes Melitus Muthia Faurin; Fauzar Fauzar; Roza Kurniati; Alexander Kam; Eva Decroli
Jurnal Ilmu Kesehatan Indonesia Vol 1 No 3 (2020): November 2020
Publisher : Fakultas Kedokteran, Universitas Andalas

A 61-year-old man was admitted a confirmed COVID-19 with comorbid pulmonary tuberculosis and type 2 diabetes mellitus. The patient was given favipiravir therapy, category 1 of antituberculosis drug, and insulin therapy. The patient responded well to therapy with improved clinical and laboratory indicators. Key words: COVID-19, pulmonary tuberculosis, diabetes mellitus

Terapi Controller pada Asma Alexander Kam; Fauzar Fauzar; Roza Kurniati; Zulkarnain Arsyad
Jurnal Ilmu Kesehatan Indonesia Vol 1 No 3 (2020): November 2020
Publisher : Fakultas Kedokteran, Universitas Andalas

Asthma, according to the National Heart Lung and Blood Institute (NHBLI) in 2002, is a chronic inflammatory disorder of the airways that involves the role of many cells and cellular components. The long-term goals of asthma management are to achieve good symptom control and maintain normal living activities and to minimize the risk of exacerbations, airway obstruction, and side effects. The drugs available for asthma therapy are divided into long-term control or controller medication and rapid-acting or reliever medication based on their pharmacodynamics and clinical effects. Controller is a therapy given to reduce chronic airway inflammation, control symptoms, and reduce the risk of exacerbations and decreased lung function. There are several asthma controller drug options that have their respective advantages and disadvantages. Selection of the right controller will provide good asthma control. Keyword: Ashtma, therapy, controller

Sindrom Vena Kava Superior pada Pasien dengan Timoma Stadium III Jersivindo Ranazeri; Alexander Kam; Roza Kurniati; Fauzar Fauzar
Jurnal Ilmu Kesehatan Indonesia Vol 2 No 1 (2021): Maret 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

A 50 year old man presented with superior vena cava syndrome. Superior vena cava syndrome is one of the emergency oncology cases. After the diagnostic procedure, the patient was diagnosed with stage III thymoma. With chemotherapy regimens of cisplatin 50 mg/m2, doxorubicin 50 mg/m2 and cyclophosphamide 500 mg/m2, the patient experienced clinical improvement.

Risiko Perdarahan Saluran Cerna pada Pasien COVID-19 berdasarkan Jenis Obat Antivirus di Rumah Sakit Umum Pusat Dr. M. Djamil Padang Arnelis Arnelis; Saptino Miro; Nasrul Zubir; Vesri Yoga; Andry Kurniawan; Alexander Kam; Abdul Alim Rahimi; Jersivindo Ranazeri; R. Ifan Arief Fahrurozi
Jurnal Kesehatan Andalas Vol 11, No 2 (2022): Online July 2022
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v11i2.2042

Coronavirus disease 2019 (COVID-19) has become a global pandemic to date. Some studies reported gastrointestinal tract (GIT) bleeding occurs in several patients hospitalized with COVID-19. Medications known to be associated with an increased risk of GIT bleeding were not associated with GIT bleeding in COVID-19 patients. Objectives: To examined the risk of gastrointestinal tract (GIT) bleeding in COVID-19 patients based on antiviral drugs at Dr. M. Djamil General Hospital Padang. Methods: A nested cohort study was conducted in Dr. M. Djamil General Hospital Padang from May until October 2021. All COVID-19 patients who received antiviral drugs with GIT bleeding with onset days 0 - 7 were included. COVID-19 was confirmed by RT-PCR swab. Data entry and analysis were conducted by computerized. Results: 30 patients were involved in this study. 43,3% COVID-19 Moderate stage and 56,7% Severe stage. 63,3% were treated with remdesivir and 36,7% were treated with favipiravir. Onset on GIT tract bleeding at day 4 (23,3%), day 5 (26.7%), day 6 (30%), and day 7 (20%). The Chi-square test to determine the factors associated with GIT bleeding in COVID-19 patients including COVID-19 severity, type of antiviral drugs, anticoagulant, and corticosteroid revealed that none of all potential factors above related to GI bleeding. Conclusion: The type of antiviral drugs was not related to GIT bleeding in COVID-19 patients.Keywords: antiviral drugs, COVID-19, gastrointestinal tract bleeding

Comorbidities of Gestational Diabetes Mellitus and Urinary Tract Infection: A Case Report Dinda Aprilia; Eva Decroli; Alexander Kam; Robby Satria Putra
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 4 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i4.804

Background: Gestational diabetes mellitus (GDM) is defined as a condition of glucose intolerance that is found during pregnancy. In pregnant women, urinary tract infection (UTI) is one of the most common bacterial infections that can be found. The infection can be worsened by diabetes as it was shown that the risk of UTI in pregnant women with diabetes (27.6%) is higher than those without diabetes (3%-10.1%). This study aimed to present a case of gestational diabetes mellitus and urinary tract infection. Case presentation: A pregnant woman aged 38 years old with a 15-16 weeks gestational age was admitted with gestational diabetes mellitus and urinary tract infection. The patient was treated with an intravenous insulin drip and antibiotic. The patient was discharged after there was a clinical improvement. Conclusion: There are many risk factors that can contribute to the development of UTI in pregnant women, with one of those being inadequate glycemic control. The treatment of UTI in pregnant women with GDM is generally the same as in those without GDM.

Evans Syndrome in a Forty-Four Years Old Male Patient: A Case Report Rudy Afriant; Avino Mulana Fikri; Alexander Kam
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 4 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i4.805

Background: Evans syndrome (ES) is an autoimmune disease characterized by the presence of autoimmune hemolytic anemia (AIHA) and idiopathic thrombocytopenic purpura (ITP), together with unknown causes. ES disease is the least common, diagnosed in only 0.8% - 3.7% of all patients with AIHA or ITP. This study aimed to describe Evans syndrome in a 44-year-old male patient. Case presentation: A 44-year-old male patient was reported with complaints of weakness and fatigue, red spots, a history of bleeding gums, a history of bleeding from the nose, and a history of red urination. A routine blood examination revealed mild anemia, reticulocytosis, and thrombocytopenia, and the peripheral blood showed polychromatic erythrocytes. Other laboratory examinations revealed an increase in LDH. The results of a positive Comb’s test and antibody screening examination showed the impression of warm-type AIHA. The diagnosis of Evans syndrome in this patient was confirmed by the presence of AIHA and ITP, which co-occur and are primarily due to unknown causes. Conclusion: ES is a rare disorder and a diagnosis of exclusion. The diagnosis of ES was established by the presence of signs and symptoms of AIHA and ITP accompanied by a positive direct antiglobulin test with no other etiology found.

Co-Authors Abdul Alim Rahimi Abdul Alim Rahimi Akbar Shiddiq Andry Kurniawan Arina Widya Murni Arnelis Arnelis Auliangi Tamayo Avino Mulana Fikri Avino Mulana Fikri Deka Viotra Dinda Aprilia Drajad Priyono Dwitya Elvira, Dwitya Eva Decroli Farhan Abdullah Fauzar Fauzar Fauzar Fauzar Fauzar Fauzar Fauzar Fauzar Fauzar Harun Harnavi Jersivindo Ranazeri Jersivindo Ranazeri Jersivindo Ranazeri Muthia Faurin Nasrul Zubir R. Ifan Arief Fahrurozi Raveinal Raveinal Raveinal Raveinal Robby Satria Putra Roza Kurniati Roza Kurniati Roza Kurniati Roza Kurniati Roza Kurniati Rudy Afriant Saptino Miro Vesri Yoga Zaki Mahmudi Dasril Zulkarnain Arsyad

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