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All Journal Berkala Kedokteran Health Research Journal of Indonesia
Alissa Anna Safira
Universitas Islam Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Ethanol Extract of Areca Nuts was Able to Improve the Histopathological Features of P. Berghei-Induced Liver Damage in Mice Alissa Anna Safira; Ika Fidianingsih; Dwi Nur Ahsani
Berkala Kedokteran Vol 17, No 2 (2021)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (296.206 KB) | DOI: 10.20527/jbk.v17i2.11664

Abstract

Abstract: Adequate therapy is necessary to prevent further damage to the liver infected with Plasmodium sp. Areca catechu and curcumin have the potential for malaria therapy, and scientific evidence is required to examine such potential either alone or in combination. This experimental study used a posttest-only group design involving 24 male Swiss mice (Mus musculus) as the subjects divided into 6 groups (@4 mice). P. berghei was injected intraperitoneally in 5 groups, and different types of treatment (4 days, feeding tube) were administered to 4 groups (K1 = chloroquine, K3 = ethanol extract of Areca nuts + curcumin, K4 = ethanol extract of Areca nuts, K5 = curcumin). The doses were 0.012mg/kgBW of chloroquine, 150mg/kgBW of Areca nut ethanol extract, and 30mg/kgBW of curcumin. K2 was the unhealthy group (infected with P. berghei without therapy), while K6 was the normal/healthy group. Parasitemia was examined in 3 days after induction by P. berghei (inclusion criterion: parasitemia >5%, exclusion criterion: parasitemia >15%). The liver was embedded in paraffin blocks and stained with HE. Observations were made to identify the presence of necrosis, portal inflammation, and hemosiderin. The data of histopathological changes in the liver was expressed in percentages. The administration of Areca nut ethanol extract was able to provide better histopathological features than curcumin therapy alone, in combination, or chloroquine therapy (K4, no necrosis; mild portal inflammation = 50%, moderate = 25%; hemosiderin = 25%). Areca nut ethanol extract had yet to show histopathological features that resembled a healthy condition (K6 = normal inflammation, mild, moderate = 50%, 50%, 0%, respectively; hemosiderin = 0%). The ethanol extract of Areca nuts alone was shortly able to improve the histopathological features of P. berghei-induced liver damage in mice. Keywords: Areca nuts, Plasmodium berghei, histopathology of liver
HbA1c Levels and Ureum Creatinine Levels Among T2DM Patients in Indonesia: A Systematic Review Satria Akbar Putra Asmara; Kahaya Ainin Asya; Alissa Anna Safira; Cinta Putri Aulia Nugroho; Muhammad Rio Al Faridzky
Health Research Journal of Indonesia Vol 4 No 6 (2026): Health Research Journal of Indonesia
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63004/hrji.v4i6.1593

Abstract

Pendahuluan: Diabetes mellitus tipe 2 (DMT2) merupakan penyebab utama penyakit ginjal kronis yang diakibatkan oleh hiperglikemia kronis, yang dapat menyebabkan kerusakan glomerulus. Tinjauan sistematis ini bertujuan untuk menganalisis hubungan antara kadar HbA1c dengan kadar ureum dan kreatinin pada pasien DMT2 di Indonesia.  Metode: Tinjauan sistematis dilakukan sesuai dengan pedoman PRISMA 2020. Pencarian literatur dilakukan menggunakan Google Scholar, Garuda, PubMed, EBSCO, dan Scopus. Risiko bias dievaluasi menggunakan JBI critical appraisal. Data diekstraksi dan disintesis secara naratif. Hasil: Sebanyak sembilan studi potong lintang yang diterbitkan antara tahun 2020 dan 2025 memenuhi kriteria inklusi, melibatkan total 3.872 peserta. Kesembilan studi tersebut menunjukkan hasil yang bervariasi. Ada studi yang menganalisis kadar ureum saja dan ada pula yang menganalisis kadar ureum dan kreatinin secara bersamaan: 3 studi menunjukkan hubungan yang signifikan dengan kadar ureum. 5 studi menunjukkan hubungan yang signifikan dengan kreatinin. Namun, 4 studi tidak menunjukkan hubungan yang signifikan antara HbA1c dan kreatinin. Kesimpulan: Sebagian besar bukti menunjukkan adanya hubungan antara kontrol glikemik yang buruk dan perubahan parameter fungsi ginjal pada pasien dengan DM Tipe 2. Pemantauan HbA1c bersamaan dengan kadar ureum dan kreatinin berpotensi mendukung deteksi dini nefropati diabetik di Indonesia.
Co-Authors Cinta Putri Aulia Nugroho Dwi Nur Ahsani Ika Fidianingsih Kahaya Ainin Asya Muhammad Rio Al Faridzky Satria Akbar Putra Asmara