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All Journal Berkala Kedokteran Universa Medicina Jurnal Ilmu Kefarmasian Indonesia Prosiding Seminar Nasional Program Pengabdian Masyarakat JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Jurnal Kedokteran Hewan
Dwi Nur Ahsani
Departemen Histologi Fakultas Kedokteran Universitas Islam Indonesia.
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Economics, Econometrics & Finance Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Veterinary

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Age-related changes of malondialdehyde, body weight and organ weight in male mice Ahsani, Dwi Nur; Fidianingsih, Ika
Universa Medicina Vol 37, No 2 (2018)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2018.v37.115-126

Abstract

IntroductionAging is characterized by gradual impairment in all physiological functions. Increases in free radicals and changes in organ morphology occur with aging. The purpose of this study was to determine age-related changes in serum free radicals, body weight, organ weights, and relative organ weights in male mice. MethodsAn experimental animal study was performed on 25 male mice (Mus musculus), which were randomized into 5 groups according to age at termination, i.e. 12 (group K1), 24 (K2), 32 (K3), 40 (K4) and 48 weeks (K5), respectively. Retro-orbital venous blood was taken for examination of malondialdehyde (MDA) levels. After termination, liver, heart, kidneys, testes, brain, thymus and spleen were weighed using an analytical balance. ANOVA and Kruskal Wallis tests were used to analyze the data, with p<0.05 being considered significant. ResultsSignificant changes were found with age in serum MDA level (p=0.000), body weight (p=0.000), and weights of all organs except thymus (p>0.05) (liver p=0.023, heart p=0.000, kidneys p=0.002, testes p=0.000, brain p=0.012 and spleen p=0.006). Significant changes in relative weight of brain (p=0.001) and spleen (p=0.049) were also found with age. ConclusionThis study demonstrated increases in serum MDA levels, body weight, and weights of the liver, heart, kidneys, testes, brain and spleen with age. Peak increases in weights of kidneys and thymus were found earlier than those in MDA levels and weights of other organs.
Protective effect of ethanolic Feronia elephantum Correa fruit extract on high-fat diet induced steatohepatitis in rats Diarti, Maruni Wiwin; Harmi, Khoviya Yuwina Selinada; Ahsani, Dwi Nur
Universa Medicina Vol. 40 No. 1 (2021)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2021.v40.36-44

Abstract

BACKGROUND A high-fat diet can lead to hyperlipidemia which will end up as liver damage (steatohepatitis). Ethanolic Feronia elephantum Correa fruit extract (EFEC) has an antioxidant activity which is expected to overcome hyperlipidemia in the liver. The objective of this study was to determine the effects of EFEC on liver function and morphological changes in rats.METHODSThis was an experimental study with a post-test only group design. A total of 20 male Wistar rats aged 2-4 months were randomized into 5 groups, A= negative control, B= positive control (high fat diet + 10 mg/kgBW simvastatin), C = high fat diet + 500 mg/kgBW EFEC fruit extract, D = high fat diet + 600 mg/kgBW EFEC, and E = high fat diet + 700 mg/kgBW EFEC). High-fat diet was given for 4 weeks (quail egg yolks, 10ml/200gBW). EFEC was administered for 4 weeks after induction of hypercholesterolemia. Examination of liver serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) was performed on rat blood serum and histopathological examination was carried out using steatohepatitis grading. One way ANOVA test and Post-Hoc Tamhane’s test were used to analyze the data. RESULTSAdministration of EFEC at 700 mg/kgBW improved the liver enzymes (p=0.00 for SGPT and SGOT) and steatohepatitis grading in high-fat diet induced rats (mild condition, E = 75% vs A = 100% mild)CONCLUSIONEthanolic Feronia elephantum Correa fruit extract at 700 mg/kgBW was able to improve steatohepatitis in high-fat diet induced rats.
Ethanol Extract of Areca Nuts was Able to Improve the Histopathological Features of P. Berghei-Induced Liver Damage in Mice Alissa Anna Safira; Ika Fidianingsih; Dwi Nur Ahsani
Berkala Kedokteran Vol 17, No 2 (2021)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (296.206 KB) | DOI: 10.20527/jbk.v17i2.11664

Abstract

Abstract: Adequate therapy is necessary to prevent further damage to the liver infected with Plasmodium sp. Areca catechu and curcumin have the potential for malaria therapy, and scientific evidence is required to examine such potential either alone or in combination. This experimental study used a posttest-only group design involving 24 male Swiss mice (Mus musculus) as the subjects divided into 6 groups (@4 mice). P. berghei was injected intraperitoneally in 5 groups, and different types of treatment (4 days, feeding tube) were administered to 4 groups (K1 = chloroquine, K3 = ethanol extract of Areca nuts + curcumin, K4 = ethanol extract of Areca nuts, K5 = curcumin). The doses were 0.012mg/kgBW of chloroquine, 150mg/kgBW of Areca nut ethanol extract, and 30mg/kgBW of curcumin. K2 was the unhealthy group (infected with P. berghei without therapy), while K6 was the normal/healthy group. Parasitemia was examined in 3 days after induction by P. berghei (inclusion criterion: parasitemia >5%, exclusion criterion: parasitemia >15%). The liver was embedded in paraffin blocks and stained with HE. Observations were made to identify the presence of necrosis, portal inflammation, and hemosiderin. The data of histopathological changes in the liver was expressed in percentages. The administration of Areca nut ethanol extract was able to provide better histopathological features than curcumin therapy alone, in combination, or chloroquine therapy (K4, no necrosis; mild portal inflammation = 50%, moderate = 25%; hemosiderin = 25%). Areca nut ethanol extract had yet to show histopathological features that resembled a healthy condition (K6 = normal inflammation, mild, moderate = 50%, 50%, 0%, respectively; hemosiderin = 0%). The ethanol extract of Areca nuts alone was shortly able to improve the histopathological features of P. berghei-induced liver damage in mice. Keywords: Areca nuts, Plasmodium berghei, histopathology of liver
RESPON IMUN PADA INFEKSI JAMUR Dwi Nur Ahsani
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 6, No 2, (2014)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol6.Iss2.Art2

Abstract

Jamur merupakan organisme saprofit yang dapat menyebabkan infeksi sistemik pada pasien imunokompromais. Tiap spesies jamur memiliki respon mekanisme yang berbeda- beda untuk dapat menghindari sistem imun host. Upaya penghindaran dari sistem imun host berlangsung tidak hanya terbatas pada modifikasi molekul permukaan saja, tetapi juga modifikasi pada bentuk morfologis dan modulasi pada sistem imun humoral. Artikel ini bertujuan untuk memahami lebih jauh bagaimana sistem imun host terhadap infeksi jamur, serta mempelajari bagaimana respon jamur untuk menghindar dari sistem imun host. Kata kunci : infeksi jamur, imunokompromais, sistem imun humoral.
MITOKONDRIA SEBAGAI TARGET TERAPI KANKER Dwi Nur Ahsani
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 6, No 1, (2014)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol6.Iss1.Art2

Abstract

ABSTRAKSel kanker merupakan sel yang memiliki karakteristik yang khas, yang mampu bertahan terhadap induksi apoptosis sel. Mitokondria merupakan organela yang berperan penting dalam induksi apoptosis sel pada jalur endogen.Pelepasan sitokrom C dan berbagai protein proapoptosis dari mitokondria ke sitoplasma dihambat oleh sel kanker melalui mekanisme stabilisasi permeabilitas mitokondria dan metabolic reprogramming.Dewasa ini telah dikembangkan berbagai terapi sel kanker berdasarkan target spesifik. Mitokondria merupakan salah satu target yang poten dalam terapi sel kanker. Dengan mengetahui karakteristik alamiah sel kanker terhadap mitokondria, diharapkan dapat dikembangkan terapi sel kanker berbasis organela spesifik (mitokondria) yang mampu meningkatkan apoptosis sel kanker tanpa mengakibatkan apoptosis pada sel normal.Naskah ini bertujuan untuk memahami lebih jauh bagaimana mekanisme sel kanker dalam memodulasi aktivitas mitokondria untuk dapat menghindari respon apoptosis sel, serta untuk mempelajari mekanisme terapi sel kanker berbasis mitokondria. Kata kunci : sel kanker, permeabilitas mitokondria, metabolic reprogramming, apoptosis sel, sitokrom C, protein proapoptosis. ABSTRACTCancer cells have distinct characteristics from normal cells, which able to withstand to cell apoptosis induction. Mitochondria are organelles that play an important role in the endogenous pathway of cells apoptosis. Release of cytochrome C and other proapoptosis proteins from the mitochondria to the cytoplasm were inhibit by cancer cells through mitochondrial permeability stabilization mechanism and metabolic reprogramming. Today various cancer cell therapies were developed on a specific targets. Mitochondria is a potent target in the treatment of cancer cells. By knowing the natural characteristics of mitochondrial cancer cells, a development of cell based cancer therapies by specific organelles were expected to increase cancer cells apoptosis without causing normal cells apoptosis. Aims of this manuscripstare to further understand about cancer cells mechanism in modulating mitochondrial activity to avoid mitochondrial apoptotic cells response, as well as to study the mechanism of cell based cancer therapies by mitokondria.Keywords :cancer cells, mitochondrial permeability, metabolic reprogramming, cells apoptosis, cytocrome C, proapoptotic cells
Knowing Cholesterol Effects on Alzheimer’s Disease Dwi Nur Ahsani
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 7, No 1, (2015)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol7.Iss1.art1

Abstract

No Abstract
Reactive oxygen species and Covid-19 Dwi Nur Ahsani
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 2, (2020)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol11.Iss2.art2

Abstract

No Abstract
Studi Toksisitas Nanopartikel Organ Limpa pada Hewan Percobaan, Tinjauan Scoping Review Dodi Faras Ilmiawan Sutomo; Dwi Nur Ahsani; Ika Fidianingsih
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 2 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i2.1082

Abstract

Nanotechnology has been developing in the medical field, but some nanoparticles have toxic effects on the body, including the spleen. This scoping review represents an attempt to take stock of existing research results related to the presence or absence of toxicity to the spleen caused by nanoparticles involving experimental animals. A scoping review was conducted to synthesize and map the toxicity of nanoparticles. It has been searched on PubMed databases for spleen or lien and toxic or toxicity, and nanoparticles or dendrimers or "metal nanoparticles" or “magnetite nanoparticles” or nanoshells or “multifunctional nanoparticles” or nanocapsules or nanoconjugates or nanodiamonds or nanogels or nanospheres. Seventeen studies met our inclusion criteria. In conclusion, it showed that 13 nanoparticles could cause toxicity in rodent spleen and as many as 4 nanoparticles did not cause toxicity in rodent spleen.
Pembinaan Ibu-Ibu Kader PKK Mengenai Pengelolaan Gangguan Metabolik di Sleman, DIY Sherly Usman; Muhammad Khotibuddin; Dwi Nur Ahsani
Prosiding Seminar Nasional Program Pengabdian Masyarakat 2022: 3. Kesehatan Keluarga dan Masyarakat
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/ppm.53.1123

Abstract

Sindrom metabolik merupakan kumpulan faktor risiko penyakit kardiovaskular yang terjadi bersamaan, yaitu peningkatan glukosa darah puasa, obesitas sentral, dislipidemia, dan hipertensi. Di Indonesia, prevalensi kejadian mencapai 23,34%. Pola konsumsi, usia, dan aktifitas fisik berpengaruh pada risiko sindrom metabolik. Pengelolaan resiko penting untuk mengurangi angka prevalensi kejadian. Pengetahuan yang baik mengenai sindrom metabolik dan pengelolaannya dapat menurunkan kejadian. Informasi mengenai pengelolaan kesehatan metabolik bisa disampaikan oleh ibu-ibu kader Pemberdayaan dan Kesejahteraan Keluarga (PKK) di dusun yang mendapatkan pelatihan dan pendampingan oleh tim kesehatan. Tujuan kegiatan ini untuk memberikan Pendampingan dan penyuluhan kepada ibu-ibu PKK di dusun mengenai gangguan metabolik sehingga meningkatkan pengelolaan gangguan metabolik masyarakat di dusun. Kegiatan diawali pemberian pretest untuk screening pengetahuan awal. Kegiatan dilanjutkan dengan pendampingan dan penyuluhan secara periodik baik secara luring dan daring oleh tim pengabdi. Pendampingan diberikan berupa pemberian materi mengenai sindrom metabolik, kajian pengelolaan nutrisi, dan aktifitas fisik dengan pakar di bidang kesehatan umum dan bidang gizi. Akhir kegiatan dilakukan post-test untuk evaluasi. Pemberian pretest untuk screening awal menunjukan nilai rata-rata 34,38. Nilai post-test menunjukkan nilai rata-rata 78,13. Hasil ini menunjukkan terdapat peningkatan pengetahuan peserta terhadap pengelolaan gangguan metabolik setelah dilakukan pembinaan dan pemdampingan dengan uji willcoxon menunjukkan perbedaan yang bermakna antara nilai rata-rata pretes dan postes. Implikasi kegiatan penting dilakukan kegiatan pemeriksaan kesehatan warga Ngemplak yang melibatkan peserta yang mendapatkan pelatihan
COFFEE CONSUMPTION MAY DECREASE THE SERUM CREATININE AND PLASMA MALONDIALDEHYDE LEVELS IN RATS WITH HYPERURICEMIA INDUCED BY A HIGH PURINE DIET Hilmi Ardian Sudiarto; Rahma Yuantari; Dwi Nur Ahsani
Jurnal Kedokteran Hewan Vol 15, No 2 (2021): June
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (546.774 KB) | DOI: 10.21157/j.ked.hewan.v15i2.19141

Abstract

The aim of this research was to determine the effect of coffee on creatinine and plasma malondialdehyde (MDA) level in rats fed on high purine diet. A total of 24 male Wistar rats divided into 4 groups of 6 rats each. Beef broth were given to 3 groups (K1, P1, P2) for thirty days. Beef broth administration were followed by giving coffee (caffeinated= P1 or by a decaffeinated= P2, 144 mg/200 g BW). Serum creatinine levels and plasma MDA were examined periodically on day 0, 15, and 30. Data were analyzed by multivariate analysis of variance or MANOVA test (CI= 95%, P0.05). Coffee administration (caffeinated and decaffeinated) may decrease the serum creatinine (day-30, K1= 3.17+ 0.69; P1= 1.63+0.11; P2= 1.14+0.08) and MDA levels (day-30, K1= 9.8+0.28; P1= 5.80+0.55, P2= 3.87+3.26) after 30 days of treatment (P= 0.000 for creatinine and MDA levels in K1, P1, P2 groups). A lower serum creatinine and MDA levels can be found in decaffeinated coffee grup. Coffee consumption for 30 days (especially decaffeinated) may decrease serum creatinine and plasma MDA in rat induced by a high purine diet.
Co-Authors Alissa Anna Safira Dodi Faras Ilmiawan Sutomo Harmi, Khoviya Yuwina Selinada Hilmi Ardian Sudiarto Ika Fidianingsih Khotibuddin, Muhammad Maruni Wiwin Diarti Miranti Dewi Pramaningtyas Pamungkas, Katon RIZKI FAJAR UTAMI Safira, Nazala Sherly Usman Yuantari, Rahma