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All Journal UNEJ e-Proceeding Jurnal Kesehatan Islam : Islamic Health Journal Jurnal Ilmu Kefarmasian Indonesia
Budipratiwi Wisudyaningsih
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Medicine & Pharmacology Public Health

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COCRYSTAL OF ATORVASTATIN CALCIUM – MALONIC ACID Yudi Wicaksono; Budipratiwi Wisudyaningsih; Tri Agus Siswoyo
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Abstract

Cocrystal is a relatively new solid form of activepharmaceutical ingredient that offers an alternativeplatform in improving physicochemical properties ofactive pharmaceutical ingredients Padrela et al.,2009; Mashhadi et al., 2004. Cocrystal is defined asa stoichiometric multi-component system connectedby non-covalent interactions where all thecomponents neutral and solid under ambientconditions Thakuria et al., 2013. Cocrystal can beconstructed through interaction hydrogen bonding,pi-stacking, and van der Waals forces  Mashhadi etal., 2004. A pharmaceutical cocrystal is composed ofan API and an appropriate coformer as carboxylicacids and amides Qiao et al., 2011.Cocrystallization of active pharmaceutical ingredientis an opportunity for enhancement of importantphysiochemical properties of an activepharmaceutical ingredient without changing itsmolecular structure Maeno et al., 2014.Atorvastatin Calcium (AC), ([(R-(R*,R*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid), calcium salt (2:1)trihydrate ([C33H34FN2O5]2Ca.3H2O), is considered asone of the most effective of synthetic lipid loweringagent Shete et al., 2010. The drug is orally used toreduce of total cholesterol, low density lipoproteinand triglycerides Anwar et al., 2011. There are 42crystalline structures of AC Shayanfar et al., 2013.However, chance to create AC into another crystalstructure to improving physicochemical properties ofAC is still fully open Chadha et al., 2012.In the present study, we explored cocrystallization ofAC by solvent evaporation method. This study aimedto confirm whether AC was able to form cocrystalwith malonic acid (MA) as coformer. AC-MAcocrystal was prepared by solvent evaporationmethod by using methanol as solvent.Characterization of cocrystal was done by powder Xraydiffractometry (PXRD), differential scanningcalorimetry (DSC), fourier transform infrared (FTIR)spectroscopy and scanning electron microscopy(SEM).
Pengembangan Essence dari Ekstrak Kayu Secang (Caesalpinia sappan L.) Lidya Ameliana; Budipratiwi Wisudyaningsih; Dwi Nurahmanto; Yenika Ayu Mega Dianatri
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 1 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i1.1139

Abstract

Sappan wood (Caesalpinia sappan L.) was reported to have natural antioxidant properties. Brazillin is the compound responsible for its antioxidant effect. Antioxidants are needed to prevent premature aging of the skin. Essence is a cosmetic that contains topical antioxidants. Essence has advantages over other skincare products, and essence is easier to absorb into the skin. The objective of the present study was to optimize and evaluate the Essence of sappan wood ethanolic extract for treatment as a cosmetic antioxidant. Simplex lattice design was adopted to evaluate the effect of butylene glycol and glycerin concentration on Essence characteristics. The method used in the extraction is maceration with ethanol solvent. The results showed that both butylene glycol and glycerin significantly enhanced the viscosity and pH value of the sappan essence formulation. The optimum Essence formula consisted of 10% butylene glycol with a predicted viscosity value of 2,944 dPas and a pH of 5,075. The characteristics of the optimum formula of sappan wood extract Essence have a thick texture, a characteristic odor of colored extract brownish yellow, homogeneous, and has a spreadabillity of 14 cm.
OPTIMASI SODIUM STARCH GLYCOLATE DAN POLYVINYLPYRROLIDONE K-30 DALAM SEDIAAN ORALLY DISINTEGRATING TABLET SALBUTAMOL SULFAT Budipratiwi Wisudyaningsih; Lusia Oktora Kumala Sari; Tiara Puspita Arisanti
Jurnal Kesehatan Islam : Islamic Health Journal Vol. 12 No. 2 (2023): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v12i2.20838

Abstract

ABSTRACT Difficulty in swallowing drug and slow onset of action of drug are common problems of conventional tablet. Orally disintegrating tablet (ODT) is an innovative dosage form to overcome the problem of swallowing drug and provide quick onset of action of drug because it can disintegrates quickly when contact with saliva in less than 3 minutes. This study formulate and evaluate ODT containing salbutamol sulphate to relieve the respiratory disorders immediately. Materials that affect the disintegration time of ODT are superdisintegrants and binders. Sodium Starch Glycolate (SSG) is a superdisintegrant that has high swelling capacity and its efficiency is not affected by compression and hydrophobic materials. PVP K-30 is a water soluble binder that effective to increase hardness and decrease friability of ODT without prolonging the disintegration time. The aim of this study is to optimize SSG and PVP K-30 to get the optimum formula of ODT salbutamol sulphate. ODT salbutamol sulphate was made by direct compression method. The optimization was carried out using two-level and two-factor of factorial design. Disintegration time, hardness, and friability of ODT were responses that evaluated to get the optimum formula of ODT salbutamol sulphate. The result showed that SSG affected in increasing of disintegration time of ODT. PVP K-30 affected in increasing of disintegration time, decreasing friability, and increasing hardness of ODT. The optimum formula contained 4% of SSG and 1,5% of PVP K-30 resulted in 37,58 seconds of disintegration time, 4,713 kg/cm2 of hardness, and 0,6298% of friability. The optimum formula dissolved 92.296 % after 30 minute. Keywords : Orally disintegrating tablet; salbutamol sulphate; SSG; PVP K-30
Co-Authors Ameliana, Lidya Dwi Nurahmanto Lusia Oktora Kumala Sari Tiara Puspita Arisanti Tri Agus Siswoyo Yenika Ayu Mega Dianatri Yudi Wicaksono