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HEMODYNAMIC STABILITY AND RECOVERY TIME OF PROPOFOL AND SEVOFLURANE IN ULIN GENERAL HOSPITAL BANJARMASIN Rina Lesiana; Kenanga Marwan Sikumbang; Istiana Istiana; Oky Susianto; Erida Wydiamala
Berkala Kedokteran Vol 13, No 2 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: The main interest in general anesthesia is safety and the well being of the patient especially the stability of hemodynamic during induction until extubation. The most common causes of prolonging awakening are residual effects of drugs either anesthetics, sedatives, and analgesics. This study aimed to compare hemodynamic stability and recovery time between propofol and sevoflurane at Ulin General Hospital Banjarmasin. This was an observational analytic study conducted in July until November 2016 on 31 patients. The result showed that mean systolic blood pressure, diastolic blood pressure and heart rate for 90 minutes maintenance were no significant difference in group-A (propofol) compare with group-B (sevoflurane), post hoc Bonferroni test showing p>0.05. Mean recovery time to consciousness was faster in group-A (10,46 minutes) than group-B (15,59 minutes), there was no significant difference in two group. In conclusion, there was no significant difference in hemodynamic stability and recovery time between propofol and sevoflurane. Keywords: hemodynamic stability, recovery time, propofol, sevoflurane.

UJI EFEKTIVITAS EKSTRAK ETANOL DAUN RAMANIA (Bouea macrophylla Griffith) TERHADAP MORTALITAS LARVA Artemia salina Leach Gusti Rifda Aqiila; Irham Taufiqurrahman; Erida Wydiamala
Dentino : Jurnal Kedokteran Gigi Vol 2, No 2 (2017)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v2i2.3995

Background: Ramania is a typical local plant of Borneo. Ramania leaves contain secondary metabolic compounds i.e. flavonoid, saponin and triterpenoidwhich expected to be one of the alternatives for cancer treatment. Purpose: To analyzing the effectiveness of ethanol extract of ramania leaves against Artemia salina Leach larvae’s mortality using Brine Shrimp Lethality Test (BSLT). Methods: A true experimental research with post test only with control group design, using 8 treatment groups obtained by a preliminary test. Eight groups consisting of 7 extract concentrations i.e 156,25; 312,5; 625; 1250; 2500; 5000 dan 10000 mg/L and 1 control negative. Results: LC50 value by probit analysis test is 408,950 mg/L. The p-value of Kruskall-Wallis test is 0,000, there is a significant effect of ethanol extract of ramania leaves against Artemia salina Leach larvae’s mortality. The p-value of Mann-Whitney test is 0,021, there is a significant difference between negative control with all treatment groups. Conclusion: Ethanol extract of ramania leaves has effectiveness against Artemia salina Leach larvae’s mortality using Brine Shrimp Lethality Test (BSLT) with LC50 values of 408.950 mg/L.

Efektivitas Ekstrak Etanol Kulit Buah Mangga Kasturi (Mangifera casturi Kosterm.) Sebagai Larvasida terhadap Larva Aedes aegypti Nisa Febiana; Erida Wydiamala; Lisda Hayatie
Homeostasis Vol 4, No 2 (2021)
Publisher : Homeostasis

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Abstract: Kasturi mango skin (Mangifera casturi Kosterm.) has potentially secondary metabolites as larvicides. The aim of this study was to analyze effectivity of kasturi mango skin ethanol extract as larvicide toward Aedes aegypti larvae. The experimental study used post-test only with control group design method with seven trials consist of five treatment group, is a serial concentration obtained from the preliminary test: concentration 0,1%, 0,2%, 0,4%,0,8% and 1,6%, positive control (temefos 1%), and negative control (pure water) which was given exposure 48 hour with 4 replications. Probit test resulted in LC50=0,328% and LC90=0,733%. Kruskal-Wallis test p=0,000, significant differences larvae mean mortality between the treatment groups and the control group and Mann-Whitney test p=1,000, no significant difference between concentraion 1,6%% with positive control. The conclusion of this experimental is kasturi mango skin (Mangifera casturi Kosterm) ethanol extract has effectiveness as a larvicide equivalent to temephos 1% at a concentration of 1,6%. Keywords: kasturi mango skin, larvicide, Aedes aegypti Abstrak: Kulit buah mangga kasturi mengandung metabolit sekunder yang berpotensi sebagai larvasida. Tujuan studi ini guna menganalisis efektivitas ekstrak etanol kulit buah mangga kasturi (Mangifera casturi Kosterm.) terhadap larva Aedes aegypti. Penelitian eksperimental menggunakan metode post-test only with control group design dengan tujuh kelompok percobaan yang tediri dari lima kelompok perlakuan yaitu serial konsentrasi yang diperoleh dari uji pendahuluan: konsentrasi 0,1%, 0,2%, 0,4%,0,8% dan 1,6%, kontrol positif (temefos 1%), dan kontrol negatif (air murni) yang diberikan paparan selama 48 jam dengan 4 kali ulangan. Hasil uji probit diperoleh nilai LC50=0,328% dan LC90=0,733%. Hasil uji Kruskal-Wallis diperoleh p=0,000, yang mengindikasikan adanya beda nyata pada rerata kematian larva pada kelompok perlakuan dan kontrol, adapun hasil pengujian Mann-Whitney diperoleh p=1,000, yang menunjukkan tidak ada beda nyata pada konsentrasi 1,6% dengan kontrol positif. Sehingga, dapat disimpulkan bahwa ekstrak etanol kulit buah mangga kasturi memiliki efektivitas sebagai larvasida yang setara dengan temefos 1% pada konsentrasi 1,6%. Kata-kata kunci: kulit buah mangga kasturi, larvasida, Aedes aegypti

Aktivitas Ekstrak Etanol Daun Pucuk Merah (Syzygium myrtifolium Walp.) sebagai Ovisida dan Insect Growth Regulator terhadap Aedes aegypti Fernanda Rizky Maulidy; Erida Wydiamala; Agung Biworo
Homeostasis Vol 4, No 2 (2021)
Publisher : Homeostasis

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Abstract: Pucuk Merah leaves has several secondary metabolic compunds content like flavonoid that affect insect’s development. The purpose are to find out the activity of ovicide and IGR on pucuk merah leaves ethanol extract. This experiment using experimental type with posttest-only control group design method using eight groups for the preliminary test, seven groups for ovicide and IGR with 4 replication. The groups are 1%, 0,5%, 0,25%, 0,125%, 0,0625%, 0,03125%, negative control (water), positive control. Probit analysis obtained LC10, LC25, LC50, LC90, LC99 with each point are 0,190%, 0,264%, 0,382%, 0,769%, 1,359%. Kruskal-wallis test obtained P=0.002. Mann-whitney test towards the negative control are P=0,147, P=0,114, and P=0,136 and data from the laboratory obtained that there is an ovicide activity from pucuk merah leaves and has a similarity with positive control. IGR activity concentrations of 0,2%, 0,3%, 0,4%, 0,8%, 1,4% obtained IGR activity respectively 78%, 89%, 89%, 91%, 100%. Keyword: ovicide, insect growth regulator, pucuk merah leaves, Aedes aegypti Abstrak: Daun Pucuk Merah memiliki kandungan senyawa metabolit sekunder flavonoid yang memiliki pengaruh pada perkembangan serangga. Tujuan penelitian ini untuk mengetahui aktivitas ovisida dan IGR ekstrak etanol daun pucuk merah, menggunakan jenis eksperimental metode posttest-only with control group design menggunakan delapan kelompok untuk uji pendahuluan, tujuh kelompok untuk ovisida dan IGR dengan 4 replikasi. Delapan kelompok, 1%, 0,5%, 0,25% 0,125%, 0,0625%, 0,03125% kontrol negatif, dan kontrol positif. Uji probit didapatkan nilai LC10, LC25, LC50, LC90, dan LC99 sebesar 0,190%, 0,264%, 0,382%, 0,769%, dan 1,359%. Uji Kruskal-wallis didapatkan nilai P= 0.002. Uji Mann-whitney seluruh konsentrasi terhadap kontrol negatif didapatkan p=0,147, p=0,114, dan p=0,136, dan berdasarkan data laboratorium didapatkan jika ada aktivitas ovisida pada daun pucuk merah, dan memiliki kesetaraan dengan kontrol yang digunakan. Aktivitas IGR konsentrasi 0,2%, 0,3%, 0,4%, 0,8%, 1,4% didapatkan aktivitas IGR berturut-turut 78%, 89%, 89%, 91%, 100%. Kata kunci: ovisida, insect growth regulator, daun pucuk merah, Aedes aegypti.

Uji Aktivitas Ekstrak Etanol Daun Bunga Pukul Empat (Mirabilis jalapa) sebagai Larvasida dan Insect Growth Regulator terhadap Larva Aedes aegypti Alfina Hilma; Erida Wydiamala; Lisda Hayatie
Homeostasis Vol 4, No 2 (2021)
Publisher : Homeostasis

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Abstract: Mirabilis jalapa leaves are known to have secondary metabolic content in the form of alkaloid, flavonoid, saponin, and tannin which have the potential as larvicides and insect growth regulators. The purpose of this study was to determine the larvicidal activity and insect growth regulator of Mirabilis jalapa leaves ethanol extract against Aedes aegypti larvae. The concentration used in this study were six treatment groups for the larvicide test using a concentration of 1%, 0.5%, 0.25%, 0.125%, 0.0625%, 0.03125, with pure water as a negative control (K-) , and temefos 1% as positive control (K +). Five treatment groups for the insect growth regulator test used concentrations of 1%, 0.2%, 0.4%, 1.2%, 2.5%, with pure water as a negative control (K-), and pyriproxyfen as a positive control ( K +) uses 4 replications. The probit analysis results obtained the value of LC10 at a concentration of 0.141% (0.065% -0.209%), LC25 0.228% (0.134% -0.305%), LC50 0.389% (0.286% -0.488%), LC90 1.074% (0.811% -1.777%) , and LC99 2.458% (1.552% -6.226%). The results of the One-way Anova test showed that the value of p = 0.000 showed the effect of the ethanol extract of Mirabilis jalapa leaves on Aedes aegypti larvae. The results of the post-hoc test using LSD showed p value = 0.276, there was no significant difference between the 1% concentration and the positive control. The ethanol extract Mirabilis jalapa leaves on the insect growth regulator test obtained IE% results were 96% at a concentration of 0.1% and IE% were 100% at a concentration of 0.2%, 0.4%, 1.2%, and 2.5%. The conclusion of this study is the ethanol extract Mirabilis jalapa leaves has activity as a larvicide and insect growth regulator against Aedes aegpyti larvae. Keywords: larvacide, insect growth regulator, pukul empat leaves, Aedes aegypti Abstrak: Daun Bunga Pukul Empat diketahui memiliki kandungan metabolik sekunder berupa alkaloid, flavonoid, saponin, dan tanin yang berpotensi sebagai larvasida dan insect growth regulator. Tujuan penelitian ini adalah untuk mengetahui aktivitas larvasida dan insect growth regulator esktrak etanol daun bunga pukul empat terhadap larva Aedes aegypti. Konsentrasi yang digunakan dalam penelitian ini adalah enam kelompok perlakuan untuk uji larvasida menggunakan konsentrasi 1%, 0,5%, 0,25%, 0,125%, 0,0625%, 0,03125, dengan air murni sebagai kontrol negatif (K-), dan temefos 1% sebagai kontrol positif (K+). Lima kelompok perlakuan untuk uji insect growth regulator menggunakan konsentrasi 1%, 0,2%, 0,4%, 1,2%, 2,5%, dengan air murni sebagai kontrol negatif (K-), dan pyriproxyfen sebagai kontrol positif (K+) menggunakan 4 replikasi. Hasil analisis probit didapatkan nilai LC10 pada konsentrasi 0,141% (0,065%-0,209%), LC25 0,228% (0,134%-0,305%), LC50 0,389% (0,286%-0,488%), LC90 1,074% (0,811%-1,777%), dan LC99 2,458% (1,552%-6,226%). Hasil uji Oneway Anova didapatkan nilai p=0,000 terdapat pengaruh ekstrak etanol daun bunga pukul empat terhadap larva Aedes aegypti. Hasil uji post-hoc menggunakan LSD didapatkan nilai p=0,276 tidak terdapat perbedaan signifikan antara konsentrasi 1% dengan kontrol positif. Ekstrak etanol daun bunga pukul empat pada uji insect growth regulator didapatkan hasil IE% sebesar 96% pada kosentrasi 0,1% dan IE% sebesar 100% pada konsentrasi 0,2%, 0,4%, 1,2%, dan 2,5%. Kesimpulan dari penelitian ini adalah ekstrak etanol daun bunga pukul empat memiliki aktivitas sebagai larvasida dan insect growth regulator terhadap larva Aedes aegpyti. Kata kunci: larvasida, insect growth regulator, daun bunga pukul empat, Aedes aegypti

KADAR HAMBAT MINIMAL DAN KADAR BUNUH MINIMAL EKSTRAK KULIT BATANG Xylocarpus granatum TERHADAP Staphylococcus aureus DAN Escherichia coli Shahiba Inayati Maghfira; Agung Biworo; Lia Yulia Budiarti; Erida Wydiamala; Joharman Joharman
Homeostasis Vol 6, No 2 (2023)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v6i2.10006

Tanaman Xylocarpus granatum (X. granatum) memiliki potensi sebagai antimikroba.Â Bagian kulit batangnya dilaporkan banyak mengandung senyawa antibakteri dan aktivitasnya dipengaruhi asal habitatnya. Penelitian ini menginformasikan daya antibakteri X. granatum asal Hutan Mangrove Pulau Burung, Kalimantan Selatan. Penelitian eksperimental secara in vitro ini menggunakan metode dilusi, mengujikan ekstrak etanol kulit batang X. granatum (EKBXG) 3,125%, 6,25%, 12,5%, 25%, 50%, dan 100% terhadap Staphylococcus aureus ATCC 25923 (S. aureus) dan Escherichia coli ATCC 25922 (E. coli). Parameter penelitian diamati secara visual dan kultur hasil perlakuan EKBXG pada kedua bakteri uji adalah kadar hambat minimum (KHM) dan kadar bunuh minimum (KBM. Perlakuan dan pengamatan dilakukan pada 3 kali ulangan. Hasilnya didapatkan nilai KHM dari EKBXG terhadap S. aureus adalah 6,25% dan KBM 12,5% nilai KHM dari EKBXG terhadap E. coli adalah 12,5% dan KBM 25%. Simpulan, berdasarkan nilai KHM dan KBM, daya antibakteri ekstrak kulit batang Xylocarpus granatum terhadap Staphylococcus aureus adalah 6,25% dan 12,5% serta terhadap Escherichia coli adalah 12,5% dan 25%.

TOXICITY TEST OF KELAKAI LEAF EXTRACT (Stenochlaena palustris) TOWARD WISTAR RATS LIVER (Rattus norvegicus) Krisna Erlangga Putra Ramadhani; I Wayan Arya Krishnawan Firdaus; Yusrinie Wasiaturrahmah; Didit Aspriyanto; Erida Wydiamala
Dentino: Jurnal Kedokteran Gigi Vol 10, No 1 (2025)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v10i1.22200

Background: Kelakai leaf extract can be used as an alternative wound healing medicine because it contains flavonoid and phenolic compounds that act as antioxidants. Before use, herbal plants must ensure the level of safety that can be obtained from toxicity tests, one of which is in vivo which can be seen from their effect on the liver of Wistar rats based on SGOT and SGPT levels. Purpose: Proving there is no toxic effect from the administration of kelakai leaf extract doses of 2,000, 2,500, and 3,000 mg/kgBW on the liver of Wistar rats based on SGOT and SGPT levels. Method: Pure laboratory experimental research with posttest-only design with control group design, consisting of 16 wistar rats divided into 4 groups with 1 negative control group given distilled water and 3 treatment groups given doses of kelakai leaf extract 2,000, 2,500 and 3,000 mg/kgBW twice a day every morning and evening for 28 days. Results: SGOT and SGPT levels after 28 days were still in the normal range. SGOT levels in treatment groups 1, 2, and 3 were 61.244 U/L, 58.953 U/L, and 53.536 U/L. SGPT levels in treatment groups 1, 2 and 3 were 25.137 U/L, 23.331 U/L, and 21.179 U/L. Based on statistical tests, there were significant differences in all treatment groups. Conclusion: There is no toxic effect from the administration of kelakai leaf extract doses of 2,000, 2,500, 3,000 mg/kgBW orally for 28 days on the liver of Wistar rats based on SGOT and SGPT levels.

EFFECT OF IRONWOOD BARK EXTRACT GEL ON LYMPHOCYTE COUNT IN BUCCAL MUCOSA WOUND HEALING RATS Mahmud Muhlisin; I Wayan Arya Krishnawan Firdaus; Maharani Lailyza Apriasari; Juliyatin Putri Utami; Erida Wydiamala
Dentino: Jurnal Kedokteran Gigi Vol 10, No 2 (2025)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v10i2.24161

Background: Wounds are disruptions caused by chemical or physical trauma, resulting in tissue damage. During the healing process of oral mucosal wounds, the body initiates defensive and protective immune responses against injury. The acute inflammatory phase is the initial stage of wound healing, marked by the body’s response to injury within a few hours. Lymphocyte cells play a crucial role in the inflammatory phase as part of the adaptive immune system in wound healing. Secondary metabolites in the ironwood bark extract gel, such as proanthocyanidins, phenolics, and flavonoids, function as immunomodulators to enhance immune activity and act as anti-inflammatory and antioxidant agents to accelerate wound healing. Purpose: To prove the effect of ironwood bark extract gel at concentrations 5%, 12.5%, and 20% on lymphocyte cell number in the buccal mucosa incision wounds of male Wistar rats on days 3, 5, and 7. Methods: This study employed a pure experimental design with a post-test only with a control group design, using 36 male Wistar rats divided into treatment and negative control groups. Results: Two-way ANOVA tests revealed significant effects based on treatment and observation days (p < 0.05). Conclusion: Ironwood bark extract gel at concentrations of 5%, 12.5%, and 20% increased lymphocyte cell number on day 3, peaked on day 5 and decreased on day 7 compared to the control group (gel base). Keywords: eusideroxylon zwageri gel, lymphocyte cells, oral mucosal wound healing,

TOXICITY TEST OF Eusideroxylon zwageri BARK EXTRACT ON LIVER HISTOPATHOLOGY PARENCHYMATOUS DEGENERATION AND FATTY DEGENERATION Nurul A'idah; Didit Aspriyanto; I Wayan Arya Krishnawan Firdaus; Bayu Indra Sukmana; Erida Wydiamala
Dentino: Jurnal Kedokteran Gigi Vol 10, No 1 (2025)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v10i1.22203

Background: Ironwood bark extract can be developed into an alternative herbal medicine for wound healing because it contains phenolics, flavonoids, and proanthocyanidins which can act as an antioxidant. Before being used as an herbal medicine, it is necessary to ensure its safety through an toxicity test. Purpose: To find out whether there is no toxic effect on the orally administration of ironwood bark extract (Eusideroxylon zwageri) at the doses of 1,250 mg/kgBW, 2,750 mg/kgBW, and 4,750 mg/kgBW to the livers of Wistar rats (Rattus norvegicus) based on histopathological appearance of parenchymatous degeneration and fatty degeneration. Methods: This research is purely experimental with a posttest only with control design. The sample in this study were 16 Wistar rats which were divided into 4 groups, namely the control group which was only administered distilled water and the treatment groups P1, P2, P3 which were administered ironwood bark extrac at the doses of 1,250 mg/kg BW, 2,750 mg/kg BW, and 4,750 mg/kgBW of 2x1 ml every 24 hours for 14 days. Results: The average percentages of histopathological appearance of parenchymatous degeneration and fatty degeneration in the K, P1, P2, and P3 groups showed a score of 0 which was categorized as normal. Data analysis showed that there were no significant differences between groups P1, P2, and P3 with the control group. Conclusion: Ironwood bark extract doses of 1,250 mg/kg BW, 2,750 mg/kg BW, and 4,750 mg/kg BW had no toxic effect on the liver of Wistar rats based on histopathological appearance of parenchymatous degeneration and fatty degeneration.

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