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Mamat Rachmat
Departemen Farmasi Fakultas Matematika dan Ilmu Pengetahuan Alam Institut Teknologi Bandung
Agriculture, Biological Sciences & Forestry Decision Sciences, Operations Research & Management Materials Science & Nanotechnology Mathematics

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Farmakokinetik dan Ketersediaan Hayati Relatif Sediaan Kapsul, Tablet Salut Enterik dan Supositoria Ketoprofen Yeyet C. Sumirtapura; Badruzzaman Saungnage; Mamat Rachmat
Jurnal Matematika & Sains Vol 7, No 1 (2002)
Publisher : Institut Teknologi Bandung

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Abstract

Pharmacokinetics and relative bioavailability of ketoprofen in capsule, enteric coated tablet and suppository, following si ngle dose administration (50 mg for capsule and tablet, and 100 mg for suppository), had been studied in six healthy Indonesian volunteers with three-way crossover design. The drug concentrations in the plasma samples were assayed by a TLC -densitometric method. The results showed that ketoprofen was rapidly absorbed from the gastro-intestinal tract after administration of capsule with peak plasma concentration of about 3.7 mg/ml, which was reached in about one hour following the drug administration. Mean peak plasma concentrations of about 4.3 and 4.6 mg/ml were attained in relatively delayed time, i.e. about 2 and 1.5 hours, respectively after administration of enteric coated tablet and suppository. Ketoprofen was eliminated rapidly from the body with an el imination half-life of about 2.5 hours. The highest absorption efficiency was showed by the enteric coated tablet, followed by the capsule and the suppository.
KEMUNGKINAN PENGGUNAAN NANO KARBON DARI LIGNOSELULOSA SEBAGAI BIOSENSOR Gustan Pari; Adi Santoso; Djeni Hendra; Buchari; Akhirudin Maddu; Mamat Rachmat; Muji Harsini; Bunga Ayu Safitri; Teddi Heriyanto; Saptadi Darmawan
Jurnal Penelitian Hasil Hutan Vol. 34 No. 2 (2016): Jurnal Penelitian Hasil Hutan
Publisher : BRIN Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20886/jphh.2016.34.2.111-125

Abstract

In the forest products field, the nano technology that can be developed is among others nano carbon derived from lignocellulosic stuffs. In relevant, this paper observes information and technology on the charcoal processing from lignocellulosic stuffs into nano carbon. The lignocellulosic stuffs used in this research consisted of teak wood, further carbonized into charcoal at 400-500 C using drum kiln and then purified by re-carbonizing it at 800 C for 60 minutes by using steam and sodium hydroxide (KOH) 15% as activation agent. Prior to purification, the charcoal sustained the doping (intercalation) process with Nicel and re-carbonize again at 900 C for 60 minutes. The qualities and structure of all the resulting carbon were evaluated using nano scale device pyrolysis-gas chromatography mass spectrophotomtry (PyGCMS), scanning electron microscope-energy disverse spectrophotometry (SEM-EDS and X-ray diffraction (XRD), and examined as well of their dielectric characteristics. Result show charcoal was examined of its physical and chemical properties. Manufacture of biosensor by using molecularly imprinted polimer (MIP) system based on carbon paste and optimizing. Results show that nano carbon from lignocellulose can be made for biosensor with MIP system. Optimized formulation were mixed with15% MIP, 45% carbon and 40% parafine with nernst factor of 49 mV/decade and limit detection of 1.02x10-6 M at pH4.
KARAKTERISASI STRUKTUR NANO KARBON DARI LIGNOSELLULOSA Gustan Pari; Adi Santoso; Djeni Hendra; Buchari; Akhirudin Maddu; Mamat Rachmat; Muji Harsini; Teddi Heryanto; Saptadi Darmawan
Jurnal Penelitian Hasil Hutan Vol. 31 No. 1 (2013): Jurnal Penelitian Hasil Hutan
Publisher : BRIN Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20886/jphh.2013.31.1.75-91

Abstract

The science advancement in this century is such that in the future it will enter the nano technology. More specifically in the forest products field, the nano technology that can be developed is among others nano carbon derived from lignocelulosic stuffs. In relevant, this research aims to provide information and technology on the charcoal processing from lignocellulosic stuffs into nano carbon. The lignocellulosic stuffs used in this research consisted of teak wood and bamboo, further carbonized into charcoal at 400-500°C using drum kiln. The resulting charcoal was examined of its physical and chemical properties, crystalinity degree and dielectric characteristics, and then purified by re-carbonizing it at 800°C for 60 minutes. Prior to the purification, the charcoal sustained the doping (intercalation) process with Zn, Ni and Cu metals each respectively. After the purification, the charcoal was ground to very tiny particels using HEM (high energy machine) device for 48 bours. In this way, the charcoal with high crystalinity was yielded, and further sintered using spark plasma at 1,300 C into the nano carbon. The qualities and structure of all the resulting carbon (carbonized charcoal, re-carbonized charcoal, intercalated charcoal and sintered nano carbon) were evaluated using nano scale device (Py-GCMS, SEM-EDX and XRD), and examined as well of their dielectric characteristics. In turns out that the best quality charcoal was obtained from teak wood charcoal carbonized at 800°C, intercalated with Ni atoms at the ratio 1:5. The resulting charcoal afforded high crystalinity (78.98%), low electric resistance (0.17 2), and high conductivity 175.52 2'm Qualities of the corresponding nano carbon (after sintering) were such that its crystalinity spectaculary reached 81.87%, resistance (R) 0.01 & with very bigh conductivity 1067.262'm'. The nano carbon that resulted seems favorably prospective for bio-censor, bio-battery, and bio-electrode. Accordingly futher related research deserves carrying out.
POTENSI STRUKTUR NANO KARBON DARI BAHAN LIGNOSELULOSA KAYU JATI DAN BAMBU Gustan Pari; Adi Santoso; Djeni Hendra; Buchari; Akhirudin Maddu; Mamat Rachmat; Muji Harsini; Teddi Her anto; Saptadi Darmawan
Jurnal Penelitian Hasil Hutan Vol. 34 No. 4 (2016): Jurnal Penelitian Hasil Hutan
Publisher : BRIN Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20886/jphh.2016.34.4.309-322

Abstract

Nanotechnology research in the realm of forest products can be exploited from lignocellulose into nano carbon. The research was aimed to provide the potency of nano carbon structure from lignosellulose as bioenergy or biosensor material. O The materials of teak wood and bamboo were carbonized into charcoal at 400-500 C followed by activation using O chemical and physical processes at 800 C for 60 minutes. This process produced charcoal with high crystalinity and surface area. After purification and activation, the activated charcoal was subsequently doped process with Zn and Ni metals which O then followed by sintering using spark plasma at 1300 C. The qualities and structure of all the resulting carbon were evaluated using nano scale devices i.e. Pyrolysis Gas Chromatography Mass Spectrometer, Scanning Electron Microscope Energy Diffraction X-ray Spectrometer, X-ray Diffractometer, I-V meter and potensiometer. Results showed that the best activated charcoal produced from the chemical-physical activation (KOH steam) possessed high fixed carbon of 84.29%; 2 surface area of 850.5 m /g, crystallinity of 38,99% and resistancy of 0.10. The teak activated charcoal which intercalated by Ni at ratio of 1:5 produced the best properties with crystallinity degree of 73.45% and conductivity of 433.86 S/m. The sintered teak activated charcoal had crystallinity degree of 78.29% with I-V meter pattern in sigmoid shape and the potentiometer response formed a slope approaching the Nerst factors. Nano carbon produced from lignocellulose is a semiconductor and more suitably use for biosensors, particularly the one derived from teak wood.
Co-Authors ADI SANTOSO Akhirudin Maddu Badruzzaman Saungnage Buchari Bunga Ayu Safitri Djeni Hendra Gustan Pari Muji Harsini Saptadi Darmawan Teddi Her anto Teddi Heriyanto Teddi Heryanto Yeyet C. Sumirtapura