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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN
Jubhar C. Mangimbulude
Pascasarjana Biologi UKSW, Salatiga
Health Professions Medicine & Pharmacology

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Merokok dan Oksidasi DNA Fitria, Fitria; Triandhini, R.I.N.K Retno; Mangimbulude, Jubhar C.; Karwur, Ferry Fredy
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 5, No 2 (2013): July-December 2013
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (368.856 KB) | DOI: 10.30659/sainsmed.v5i2.352

Abstract

Cigarette smoke consists of a mix of chemical substances in the form of gases and dispersed particles. Recently, more than 4000 compounds presented incigarette smoke have been isolated. Most of these compounds are toxic to our body’s cells. Toxic gases including carbon monoxide (CO), hydrogen cyanide(HCN), nitrogen oxides, and volatile chemicals such as nitrosamines, formaldehyde are found in in cigarette smoke. besides toxic compounds, cigarettesmoke also containsfree radicalsincluding peroxynitrite, hydrogen peroxide, and superoxide. These free radicals may accelerate cellular damage due tooxidative stress. Targets od free radical attacks include DNA, protein and lipids. The harmful chemicals in form of gases and volatile substances in cigarettescause multiple genetic mutations. the combination of genetic mutations and DNA damage lead to genetic instability and it may cause cancer. OxidativeDNA damage caused by cigarette smoke can be identified with the presence of 8-oxoguanosine used as one of the biomarkers for oxidative DNA damage.Increased concentration of 8-oxoguanosine in DNA has an important role in carcinogenesis and triggers tumor cells. both active and passive smokers havebeen reported to have an elevated concentration of 8-oxoguanosine in their lung tissue and peripheral leukocytes as well as for passive smokers. This paperprovide informations and understanding of the effects of smoking on the genetic stability, especially in the DNA molecule.
Komponen Senyawa Aktif pada Udang Serta Aplikasinya dalam Pangan Ngginak, James; Semangun, Haryono; Mangimbulude, Jubhar C.; Rondonuwu, Ferdy S.
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 5, No 2 (2013): July-December 2013
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (614.761 KB) | DOI: 10.30659/sainsmed.v5i2.354

Abstract

Indonesian water area is vast and has a great potential of natural resources. Most of the Indonesian people working as fisherman describes that oceanis place of making a living. Watery area resources Indonesian watery area is vast and has a great potential incude shrimps, fish, and other organism tosupport human life. Ocean organism has been known to contain nutrition which is good for human’s health. Shrimps contains omega 3, mineral, fat,citin, carotenoide (astaxanthin) and vitamin. The active compound have an ability to prevent disease and meet the nutritional need of body. Omega3 andastaxantin for example are active compounds found in shrimps. These compound play a role as antioxidant and free radicals scavenger can be supplementfor pregnant women and baby. Omega 3 and antaksantine are found in various shrimps and fish. Thus, the development of product from this organismincludes supplement, margarine, cake, souse, bread, kerupuk, flour and salt. In this review, the writer describes the the functional compound and itsusage as food product.
Co-Authors Ferdy S. Rondonuwu Ferry Fredy Karwur Fitria Fitria Haryono Semangun Hengky K. Baransano James Ngginak R.I.N.K Retno Triandhini